Prokarotic ribosome amazing

1. Dr. Hesham Abdulla
By
h.Gandal
*
Ribosomes

4. *CONTENT
1-INTRODUCTION TO PROKARYOTIC RIBOSOMES
2- STRUCTUER OF PROKARYOTIC RIBOSOMES
3-FUNCTION OF PROKARYOTIC RIBOSOMES
(Protein Synthesis)
4- ANTIBIOTICS TARGET RIBOSOMES

5. *INTRODUCTION
 Cell have tiny granular structures known
as Ribosomes
 Ribosomes are Ribonucleo-Protein Particles
 Ribosomes serves as workbenches, with mRNA
acting as the blueprint in the process of protein
synthesis
 Quantity of ribosomes vary depend upon
the type of cell e.g.,
 Bacteria = 20,000

6. 6
*J
* Palade was the first person to study
them in 1955

7. *  The number of Ribosomes differs greatly
 A rapidly growing E.colicell may have as many as
15,000 to 20,000 ribosomes, about 15% of the cell
mass

8. *TYPE OF RIBOSOMES
 Matrix Ribosomes: These synthesize proteins destined
to remain within the cell
 Plasma Membrane Ribosomes:These make proteins
for transport to the outside
 covered with a protein coat

9. STRUCTUER OF
PROKARYOTIC
RIBOSOMES

11. 11

12. *STRUCTUER OF RIBOSOES
Structure
PROKARYOTIC SUBUNITS:
 larger subunit =50 S Consists of a singleRNAstrands
 smaller subunit=30 S Consists of two RNA strands
 Total ribosomal complex = 80 S
 Total ribosomal complex = 70 S

19. Protein Synthesis
In prokarotic cell

21. *• Translation proceeds in 3
phases:
– initiation
– elongation
– termination

22. *TOOLS OF TRANSLATION
• Mainly :Ribosomes, tRNA
• mRNA, Initiation factors
elongation factors,
termination factors,

31. ANTIBIOTICS
TARGET
RIBOSOMES

34. Tetracyclines binds
reversibly to the
30S subunit of
the bacterial
ribosome,
thereby blocking
access of the
amino acyl-tRNA
to the mRNA-
ribosome
complex at the