This presentation is about the various characterization methods of polymers, polymerization techniques and various applications of these polymers in Pharmacy

1. POLYMERS
SUBMITTED BY: SHILPI SAXENA
M.PHARM I.P
.
42/MIP/SPS/2021
SUBMITTED TO: Dr. SUSHMA
TALEGAONKAR

2. CONTENT
S
 INTRODUCTION
 IMPORTANCE OF CHARACTERIZATIO
 CHARACTERISATION METHODS
 POLYMERISATION TECHNIQUES
 APPLICATIONS IN CDDS
 REFERENCES

5. MOLECULAR
SURFACE
THERMAL
INTERFACE
MECHANICAL
1. MOLECULAR WEIGHT
Light scattering technique
Viscometry
Size-exclusion chromatography
2. MICRO-STRUCTURAL
COMPOSITION
Spectroscopies like IR,
RAMAN, NMR, UV,
Flouroscency
3. CRYSTALLINITY
X-Ray Diffraction
• IR
• RAMAN
• SURFACE
ROUGHNESS
• SEM
• OPTICAL
MICROSCOPY
• DSC/DTA
• TMA
• TGA
• Single fiber
composite test
• Micro bead test
• Micro indentation test
• Inter-laminar shear test
Tensile strength
Young’s modulous
Impact strength
Compressive streng

6. ROLE
important for polymers that are
used
as plastics for packaging
purposes

11. PHYSICAL
CHEMICAL
 MELTING
 GLASS TRANSITION
 CRYSTALLIZATION
 OXIDATION
 DECOMPOSITION
 CURING

13. EXO
ENDO
H

20. W%
T
ONSET = 450 C
FINAL = 590 C THERMOGRAM
OF
POLYSTYRENE

21. TGA INSTRUMENTATION

35. Powder X-Ray diffraction Diffractogram of HPMC, PVP 30 & EUD

36. SURFACE CHARACTERISATION
The properties of a polymer surface can be decisive for the function of the polymer. Because surfaces
of many biomaterials are synthetic polymers or proteins capable of metastable states of surface
relaxation and
restructuring, analytical methods must account for possible “chameleon-like” changes in surfaces.
SOME COMMON TECHNIQUES FOR SURFACE CHARACTERIZATION:
1. IR
2. NMR
3. RAMAN
4. SEM

37. SEM photograph of
(a) plain HPMC E5
(b) drug-loaded inserts of
HPMC E5
SEM photograph of
(c) plain Na CMC
(d) drug-loaded
inserts of Na CMC

38. POLYMERISATION TECHNIQUES

48. EXAMPLES OF ADDITION POLYMERS

57. REFERENCES
1. https://www.researchgate.net/publication/305390104_Polymer_characterization_II
2. https://www.researchgate.net/publication/351515174_OVERVIEW_ON_PHARMACEUTICAL_POLYMERS
3. https://youtu.be/P3-81C5mOuk
4. https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118950623.app1
5. https://youtu.be/UOqg_xvQ_CE
6. CromptonT.R. (1993) Polymer Microstructure. In: Practical Polymer Analysis. Springer, Boston, MA.
https://doi.org/10.1007/978-1-4615-2874-6_10
7. https://slideplayer.com/slide/10576080/
8. https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.pdfprof.com%2FPDF_Image.php%3Fidt%3D7
4965%26t%3D28&psig=AOvVaw1jg7qhMIACkgDbVRwZw62I&ust=1644925102330000&source=images&cd=
vfe&ved=0CAsQjRxqFwoTCPjg6NiR__UCFQAAAAAdAAAAABB
9. http://www.wright.edu/~nikolai.priezjev/papers/Lecture_notes_Ch_2_Polymerization_Techniques.pdf
10. Polymers 2014, 6, 2037-2050; doi:10.3390/polym6072037

58. THANK YOU