This document discusses various polymer-based drug delivery technologies, including hydrogels for controlled drug delivery and polymeric micelles. It provides information on what polymers are, how they are constructed, and examples of natural and synthetic polymers. It then describes different polymer technologies for modifying drug release profiles from formulations, such as film coatings, capsules, microcapsules, gels, and matrix systems that release drugs through dissolution, diffusion, or degradation. Specific technologies like hydrogels, pulsincaps, and ringcap systems are explained. In conclusion, polymer drug delivery is seen as having great potential for mimicking natural products and further development requires extensive safety testing.

2. CONTENTS
 Hydro gels Controlled Drug
Delivery
 Polymeric Micelles

3. What are the
Polymers??

4. A polymer is a large molecule constructed from
many small structural units called monomers,
covalently bounded together in any possible
pattern

6. Polymerization catalysts
Double bond broken
resultant extra single bond
carbon atom in another ethylene

7. Condensation Polymers

8. Natural Synthetic

9.  Rubber
 Plastic
 Food


10. • Method of administering a pharmaceutical
compound
• To achieve a therapeutic effect in humans
• Technologies modify drug release profile,
absorption, distribution and elimination
• Improving product efficiency and safety
• Drug release is from: diffusion,
degradation, swelling.

13. Film Coating
Anti adherent
Lubricant
Disintegrate
Binder

14. Hydro gels Controlled Drug Delivery
Hydrogels are water swollen
polymeric material with huge
tendency to absorb water there
ability to swell under physiological
condition makes them ideal
material.

15. TechnologyActionDosage Form
 Tablets Coating
 Capsule
 Granules/
Pallets
 Microcapsule
 Gel
 Protective
 Site Specific
 Matrix
Dissolution
 Matrix
Diffusion

16. Ring cap Technology
• Tablet (usually film coated)
• Series of “rings”
• insoluble polymer does not degrade
• thickness of rings control
• rate of release of drug
• final dosage form

17. Pulsincap
Hydrogel polymer rapidly expelling
Water insoluble capsule body
Soluble cap Degrade
Hydrogel swells
pushes out drug

18. Drug released by
dissolution
In dissolution system the rate controlling step is
dissolution.
The drug is embedded slowly dissolving erodible matrix
or by coating with slowly dissolving substance.

19. Drug release by diffusion

21. Polymeric Micelles

23. Conclusion
 Great potential in drug delivery application
 Closest imitating of natural products
 Practice to potential---FDA approval requires
extensive toxicity investigation

24. REFERENCES
• Banker G. S. and C. T. Rhodes. 2013. Modern Pharmaceutics. Informa Health
care, 4: 167-169.
• Duncan R. 2007. Designing Polymer conjugates as
lysosmotropicnanomedicines. Biochemical society Transaction, 35, 124-128.
• Girish Y. and S. Punitha. 2009. Polymers in muco adhesive buccal. Int. J. Res.
Pharm. Sci. 2, 170-1865
• Heller J., 2010. The use of Polymer is construction of Controlled Release
Devices”,National Institute on Drug Abuse Research monograph series. 769-
772.
• Hoshino Y., T. Urakani and J. K. Shea. 2011. Design of Synthetic Polymer NP
that capture & neutralize a toxic peptide. Wiley Interscience, 12.
• Jain N. K., 2007. Pharmaceutical Product Development. Cbs Publishers &
Distributors. 111-117.
• Jain N. K., 2010. Progress in Controlled & Novel Drug Delivery systems. CBS
Publishers & Distributors 43: 124-131.

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