presented by HAFIZ M WASEEM university of education LAHORE Pakistan i am from mailsi vehari and studied in lahore bsc in science college multan msc from lahore

2. HAFIZ M WASEEM UNIVERSITY OF
EDUCATION LAHORE

3. •
•TOPIC: EOSINOPHILIA
•

4. TOPIC
•
•
• EOSINOPHILIA

5. CONTENTS
• Introduction
• Definition
• Types
• Hypereosinophilic syndromes
• Causes
• Symptoms
• Diagnosis
• preventions
• Conclusion
• Refrences

6. INTRODUCTION
• Eosinophils are specific white blood cells that are a normal part
of the cellular immune system.
• play a role in normal physiologic processes and host defense,
and participate in allergic reactions and the defense against
parasitic infections.
• The amount of the eosinophils increased due to certain reasons
like It can be caused by common things like nasal allergy or
more serious conditions, such as cancer. It is discovered by
blood testing.

7. DEFINITION
• “ Eosinophilia refers to a condition of
having an increased numbers of eosinophils
in the peripheral blood.”
• Occur when there are greater than 500
eosinophils per microliter.
• Eosinophilia can be considered mild,
moderate or severe.

8. MILD. (450--- 1500 eosinophils per microliter)
MODERATE. (1500---5000 eosinophils per microliter)
SEVERE. (Greater than 5000 eosinophils per microliter)

9. TYPES
• Following are the types of eosinophilia
• 1. BLOOD EOSINOPHILIA -high level of
eosinophils in blood.
• 2. TISSUE EOSINOPHILIA- high level of
eosinophils at the site of infection or
inflammation.

10. • Blood eosinophilia can be further
characterized as
• a). Primary eosinophilia
• b). Idiopathic eosinophilia
• c). Secondary eosinophilia

11. • PRIMARY EOSINOPHILIA:
• Primary eosinophilia results in increased number of
proginators leading to the increased number of eosinophils in
the bone marrow and blood.
• IDIOPATHIC EOSINOPHILIA:
• Idiopathic eosinophilia is associated with moderate to
severe eosinophilia with no identifiable causes.

12. • SECONDARY EOSINOPHILIA:
• The most common form of eosinophilia.
• Result of other disorders not associated with bone
marrow proliferation, such as atopy, asthma, and most
commonly helminthic infestations.
• Due to the response of other primary disease
processes such as overproduction of cytokinin IL5
which leads to the increased number of eosinophils.
•

13. HYPER EOSINOPHILIC
SYNDROME
“Hypereosinophilic syndromes are group of disorder which is
due to the high level of eosinophils which damage the organs like
skin, lungs, heart and gastrointestinal tract.”
SYMPTOMS:
Symptoms of HES are based on the area effected:
Lungs- cough, shortness of breath, wheezing
Skin- thickening of skin, hives
Heart- chest pain, difficulty in breathing
Gastrointestinal tract- abdominal pain, vomiting, diarrhea

14. CAUSES
• Following are the causes which cause the EOSINOPHILIA:
• ✓ PARASITE INFECTIONS(parasite infection include schistosomiasis,
trichinosis, strongyloidiasis, and ascariasis.)
• ✓ DRUG REACTIONS(like pencilin, aspirin and ibuprofen)
• ✓ ATOPY(Atopy is a particular reaction that occurs in the body. Typically,
atopy refers to asthma, seasonal allergies )
• ✓ EOSINOPHILIA ESOPHAGITIS
• ✓ CANCER
• ✓CHURGE-STAUSS SYNDROME

15. • EOSINOPHILIA ESOPHAGITIS:
• This is a disorder characterized by eosinophils spreading to
esophagus which normally does not contain eosinophils. It is caused
by body immune response to certain allergens.
• It may include food like dairy or soy and environmental allergen like
pollens.
• Many people having EoE have higher expression of gene eotaxin-3.
This gene help to control eosinophils production. Higher expression of
gene means more production of eosinophils that cause
EOSINOPHILIA ESOPHAGITIS.

16. • CHURGE- STAUSS SYNDROME:
• Churg-Stauss vasculitis, can cause
eosiniophilia. People with this condition
present with asthma and other lung issues
initially, then develop eosinophilia, and
eventually vasculitis, inflammation of the
blood vessels.

17. SYMPTOMS
• Symptoms of eosinophilia vary based on the underlying conditions.
• ASTHMA
• Frequent wheezing and breathlessness are symptoms typical to
eosinophilia caused due to asthma.
• PARASITIC INFECTION:
• Abdominal pain,Diarrhea,Fever,Cough,Rashes
• Frequent infections,,Pneumonia,Mouth sores.

18. •
• OTHER SYMPTOMS:
• Few other symptoms of eosinophilia include
• Weight loss,Night sweats,Enlargement of lymph
nodes,Skin rashes and
•

19. DIAGNOSIS
• Like most blood disorders, eosinophilia is
identified on complete blood count (CBC).
•

20. TREATMENT
• Treatment of EOSINOPHILIA depends upon the cause of the
condition.
• Stopping certain medications (in the case of drug reactions).
• Avoiding certain foods (in the case of esophagitis).
• Taking an anti-infective or anti-inflammatory medication.

21. • PREVENTIONS:
• Cause of eosinophilia is not always clear. As a result, there
are no specific steps to prevent eosinophilia.
• CONCLUSION:
• EOSINOPHILIA is a condition in which the number of
eosinophils are increased in the blood . This disease caused
by several factors like allergens, drug reactions and parasitic
reaction . It is treatable easily by using certain medication .

22. REFRENCES
• REFRENCES:
• 1. https://diseasesdic.com/eosinophilia-definition-causes-and-treatment/amp/
• 2. https://www.verywellhealth.com/what-is-eosinophilia-401339
• 3. An Overview of Eosinophilia A review of causes, diagnosis, and treatment of
eosinophilia By Amber Yates, MD Medically reviewed by Douglas A. Nelson, MD
Updated on July 27, 2020
• 4. https://www.mayoclinic.org/symptoms/eosinophilia/basics/definition/sym-
20050752
• 5. https://my.clevelandclinic.org/health/diseases/17710-eosinophilia
• 6. https://en.wikipedia.org/w/index.php? title=Eosinophilia&oldid=995115200
• 7. Eosinophilic Esophagitis" . 16 January 2015.
• 8. Eosinophilic Disorders" . Merck & Co. Retrieved 2012-11-02.
•
•