PG AND RESEARCH DEPARTMENT OF MICROBIOLOGY, SRI PARAMAKALYANI COLLEGE, ALWARKURUCHI.

1. REACCREDITED WITH B GRADE WITH A CGPA OF 2.71 IN THE SECOND CYCLE OF NAAC
AFFILIATED TO MANOMANIUM SUNDARANAR UNIVERSITY, TIRUNELVELI.
ALWARKURICHI 627 412, TAMIL NADU, INDIA
POST GRADUATE & RESEARCH CENTRE
DEPARTMENT OF MICROBIOLOGY
(Government Aided)
ACADEMIC YEAR 2021-2022
I SEM CORE: MICROBIAL PHYSIOLOGY AND METABOLISM - (ZMBM13)
UNIT- 5
IMMUNOSUPPRESSION
SUBMITTED BY,
A.MANI BHARATHI
REG NO:20211232516113
I M.SC MICROBIOLOGY
ASSIGNED ON: 05/12/2021
TAKEN ON:10/01/2022
SUBMITTED TO
GUIDE:
DR.S.VISWANATHAN
ASSISTANT PROFESSOR &
HEAD.

2. synopsis
 IMMUNOSUPRESSION
 TYPES OF IMMUNOSUPPRESSION
 INDUCED IMMUNOSUPPRESSION
 AUTO IMMUNOSUPPRESSION
 IMMUNE TOLERANCE
 IMMUNO SUPRESSIVE DRUGS
 ADVERSE EFFECTS OF IMMUNOSUPPRESSANTS
 CONCLUSION
 REFERENCE

3. Immunosuppression
Immunosuppression is a reduction
of the activation or efficiency of
the immune system

5. Immunosuppression
Induced Immunosuppression
Auto Immunosuppression

6. Induced Immunosuppression
 In any transplantation procedure, genetic differences
between donor and recipient can lead to immune-based
rejection reactions
 Aside from host rejection of transplanted tissue (host versus
graft), lymphocytes conveyed to the recipient via the graft
can attack the recipient’s tissues, thereby causing graft
versus- host disease (GVHD)

7. Auto Immunosuppression
 Auto Immunosuppression or Immunodeficiency is
knows the immune system of the body is not
responding to the antigen entering into the body
 In HIV the body’s immune response is very low
and it causes the pathogens to affect the body

8. Auto immune disease : A disease in which the
body immune responds against the healthy cells
such as
 Rheumatoid arthritis
 Myasthenia Gravis
 Lupus

10. Immune tolerance
 In Maternal immune tolerance is the immune
tolerance shown towards the fetus and placenta
during pregnancy.
 The placenta acts as a immunological barrier
between the mother and fetus, creating an
immunological privileged site.
 It is achieved by inhibiting the maternal cytotoxic t
cells by inhibiting the response to interleukin

13. Immunosuppressive Drugs
 Immunosuppressant drugs are a class
of drugs that suppress, or reduce, the
strength of the body's immune system

14.  Immunosuppressive drugs are of four
classes:
 Calcineurin Inhibitors
 Antiproliferative agents
 mTOR inhibitor
 glucocorticoids
 Biological agents

16. Adverse effects of Immunosuppressants
 Acne
 Diabetes
 Fatigue
 Hair loss of Growth
 Headaches
 High Blood pressure
 Mouth sores
 Thinning Bones
 Tremors

20. CONCLUSION

24. THANKYOU
The chairman.
The Secretary.
Management committee.
The Principal,Sri paramakalyani college.
The head – department of microbiology
The staff members – department of microbiology
THANKS TO