Immunosuppression is a reduction of the activation or efficiency of the immune system. There are different types of immunosuppression, including induced immunosuppression which can occur during transplantation procedures due to genetic differences between donor and recipient tissues. Autoimmunosuppression or immunodeficiency is when the immune system does not respond properly to antigens, allowing pathogens to affect the body. Immunosuppressive drugs are a class of drugs that suppress the strength of the immune system and are used to treat autoimmune diseases and prevent rejection after organ transplantation, but can have adverse effects such as increased risk of infection, diabetes, and high blood pressure.

1. REACCREDITED WITH B GRADE WITH A CGPA OF 2.71 IN THE SECOND CYCLE OF NAAC
AFFILIATED TO MANOMANIUM SUNDARANAR UNIVERSITY, TIRUNELVELI.
ALWARKURICHI 627 412, TAMIL NADU, INDIA
POST GRADUATE & RESEARCH CENTRE
DEPARTMENT OF MICROBIOLOGY
(Government Aided)
ACADEMIC YEAR 2021-2022
I SEM CORE: MICROBIAL PHYSIOLOGY AND METABOLISM - (ZMBM13)
UNIT- 5
IMMUNOSUPPRESSION
SUBMITTED BY,
A.MANI BHARATHI
REG NO:20211232516113
I M.SC MICROBIOLOGY
ASSIGNED ON: 05/12/2021
TAKEN ON:10/01/2022
SUBMITTED TO
GUIDE:
DR.S.VISWANATHAN
ASSISTANT PROFESSOR &
HEAD.

2. synopsis
 IMMUNOSUPRESSION
 TYPES OF IMMUNOSUPPRESSION
 INDUCED IMMUNOSUPPRESSION
 AUTO IMMUNOSUPPRESSION
 IMMUNE TOLERANCE
 IMMUNO SUPRESSIVE DRUGS
 ADVERSE EFFECTS OF IMMUNOSUPPRESSANTS
 CONCLUSION
 REFERENCE

3. Immunosuppression
Immunosuppression is a reduction
of the activation or efficiency of
the immune system

5. Immunosuppression
Induced Immunosuppression
Auto Immunosuppression

6. Induced Immunosuppression
 In any transplantation procedure, genetic differences
between donor and recipient can lead to immune-based
rejection reactions
 Aside from host rejection of transplanted tissue (host versus
graft), lymphocytes conveyed to the recipient via the graft
can attack the recipient’s tissues, thereby causing graft
versus- host disease (GVHD)

7. Auto Immunosuppression
 Auto Immunosuppression or Immunodeficiency is
knows the immune system of the body is not
responding to the antigen entering into the body
 In HIV the body’s immune response is very low
and it causes the pathogens to affect the body

8. Auto immune disease : A disease in which the
body immune responds against the healthy cells
such as
 Rheumatoid arthritis
 Myasthenia Gravis
 Lupus

10. Immune tolerance
 In Maternal immune tolerance is the immune
tolerance shown towards the fetus and placenta
during pregnancy.
 The placenta acts as a immunological barrier
between the mother and fetus, creating an
immunological privileged site.
 It is achieved by inhibiting the maternal cytotoxic t
cells by inhibiting the response to interleukin

13. Immunosuppressive Drugs
 Immunosuppressant drugs are a class
of drugs that suppress, or reduce, the
strength of the body's immune system

14.  Immunosuppressive drugs are of four
classes:
 Calcineurin Inhibitors
 Antiproliferative agents
 mTOR inhibitor
 glucocorticoids
 Biological agents

16. Adverse effects of Immunosuppressants
 Acne
 Diabetes
 Fatigue
 Hair loss of Growth
 Headaches
 High Blood pressure
 Mouth sores
 Thinning Bones
 Tremors

20. CONCLUSION

24. THANKYOU
The chairman.
The Secretary.
Management committee.
The Principal,Sri paramakalyani college.
The head – department of microbiology
The staff members – department of microbiology
THANKS TO