Tetracyclines are broad-spectrum antibiotics derived from Streptomyces bacteria, first discovered in 1945. They inhibit bacterial protein synthesis and have various mechanisms of resistance, including enzymatic inactivation and efflux. Tetracyclines are used to treat a range of infections and diseases, and should be stored in a cool, dry place away from light.

1. TETRACYCLINE

2. CONTENTS
• Introduction
• Classification
• Structure of tetracycline
• Mechanism of action
• Mechanism of resistance
• Production
• Uses of tetracycline
• Storage

3. INTRODUCTION
• Tetracycline are broad spectrum antibiotics, which are
chemical substances produced by a microorganism that are
able to kill other microorganisms without being toxic to the
person, animal or plant.
• Tetracyclines were derived from Streptomyces bacteria.
• Tetracyclines were discovered as natural products by
Benjamin Minge Duggar in 1945 and first prescribed in 1948.

4. CLASSIFICATION OF TETRACYCLINE
Tetracyclines
)(according to the during of action
Short-acting
half( -life is 6-8 hrs)
Tetracycline
chlortetracycline
Intermediate-acting
(half-life 12 hrs)
Demeclocycline
methacycline
Long-acting
(half-life 16 hrs)
Doxycycline
minocycline

5. STRUCTURE OF TETRACYCLINE
• Amphoteric compounds, forming salts with acid or base.
• Zwitter ions in neutral solution
• They are yellow in colour

6. MECHANISM OF ACTION
• Inhibitors of bacterial protein synthesis

7. MECHANISM OF RESISTANCE
Cell become resistant to tetracycline 3 mechanisms
• Enzymatic rarest type of resistance, where an acetyl group is
added to the molecule , causing inactivation of drug.
• Efflux resistance gene encodes a membrane protein that
actively pumps tetracycline out of the cell.
• Ribosomal protection which blocking tetracycline from
binding to the ribosome

9. USES OF TETRACYCLINE
• Antibacterial resistance
• Non antibacterial resistance like inflammation
• Tissue destructive disease like antifibrilogenics
• Parkinson and other neurodegeneration disease
• Antiviral and anti cancer
• Upper/lower respiratory tract infections
• Skin and soft tissue infections
• Relapsing fever
• Cholera
• Urinary tract infection
• anthrax

10. STORAGE
• Keep at room temperature 65-85 °F (18-29 °C)
• Keep away from heat, moisture and light.