This document summarizes two Ayurvedic herbal formulations - Gokshuradi Guggulu and Panchathikthaka Guggulu. Gokshuradi Guggulu contains nine ingredients used to treat disorders of the male reproductive and urinary systems. It has diuretic, anti-inflammatory, and aphrodisiac properties. Panchathikthaka Guggulu contains guggulu and five bitter herbs used to treat bone, joint, and skin diseases by reducing inflammation and toxicity. Both formulations are used according to Ayurvedic dosha theory and have been studied for treating conditions like nephropathy, urinary stones, and osteoarthritis.

1. YOGAREVIEW ON
GOKSHURAADIGUGGULUAND
PANCHATHIKTHAKAGUGGULU
By ANJANA .P
Final year PG
R&B DEPARTMENT
GOVT.AYURVEDA COLLEGE TRIPUNITHURA KERALA

2. Deals with
• INTRODUCTION
• LITERARY REVIEW
• INGREDIENTS
• METHOD OF PREPARATION
• PHARMACOLOGICAL PROPERTIES
• THERAPEUTIC ACTION
• DISCUSSION
• CONCLUSION

3. Introduction
• Gokshuradi Guggulu is an Ayurvedic multi herbal formulation, consisting of nine
ingredients which is used in the treatment of several disorders in male reproductive
system and urinary system of both males and females
• In reproductive field, it is used in the treatment of spermatorrhoea, nocturnal
eneuresis,premature ejaculation and loss of sexual desire
• Among urinary disorders it is recommended for nephritis, albuminuria, urinary
infections, cystitis, and bladder stones etc.
• It is also recommended by Ayurvedic, traditional and folkloric medicine to be used
as a diuretic.

6. Preparation
• 28 pala of Gokshura is boiled in six times of water and reduced to half.
Seven palas of Guggulu are added and when the mass becomes solid,
powders of triphala, Trikatu and musta (seven palas in total )are added
and rolled into pills.

8. Constituents:
• Tribuloside, saponin, alkaloids, potassium nitrate, kaempferol, aspartic and glutamic
acids, Tannins
• Alkaloids- sennoside,Ascorbic acid, Bioflavonoids, Vitamin C, Mucilage,
• Essential oils - camphene, eugenol, gingerols, Alkaloids- piperine,piperlongumine,
Steroids-guggulsterones (lipid soluble) , oleoresins
• Dosage :
Not specified in the Yoga ( Saana Pramana ).

9. Therapeutic indications
• Ayurvedic Action:
• Lekhana - scrapes toxins, Shodhana - purifies the blood, Mutrala - diuretic, Vrukka
Ashmarihara - treats renal calculi,
• Vrishya - increases sexual potency, Pramehahara - anti-diabetic, Vatavyadhi -
alleviates neurological disorders,
• Shweta pradara -treats leucorrhoea, Mutra kricchra - alleviates painful urination,
Vatarakta - anti-gout
• In short it has Diuretic, anti-inflammatory, anti-bacterial, lithagogue, aphrodisiac
activities

10. Indications:
Urine: A traditional tonic for the genito-urinary tract. Indicated in infections; cystitis,
nephritis, incontinence with burning sensation ,frequency, cloudy urine, albuminuria,
excessive or obstructed urination.( Vatapitta predominance).
Used to prevent and reduce stones caused by kapha Dosa mainly.
Reproductive: Specific application in male sexual dysfunction; premature ejaculation,
spermatorrhoea. Used for prostatitis and Benign Prostatic Hypertrophy. Also used in
female disorders such as lucorrhoea,endometriosis and infertility.
Back pain: Lower back problems, lumbago and kidney disorders.

11. Discussions..
• • Gokshura guides the other herbs to the genitourinary system.
• • Guggulu acts as a cleaning resin that purifies all accumulations of Ama.
• • Triphala clears ama and detoxifies the bladder and kidneys via the
Mutravahasrotas.
• • Trikatu possess Agnideepana property .

12. • • Musta specifically acts in Mootravaha, Aarthavaha and Shukravaha srotas
and therefore supports Gokshura in its action.
• • Musta – Vatapitta hara and prevents Dhathus from Kshaya caused by Vata
prakopa.
• • It reduces the adhesions and accumulations of kapha by Lekhana property.
• Tridosha samana .

13. • Most of the ingredients in the formulation are vatakapha hara and Kaphapittahara
• So it helps to heal inflammatory conditions like urinary infections.
• Moreover mootrala and Vatanulomana property of Gokshura and other ingredients
helps to cure Mootrasmari ,Pradara and Sukra Doshas
• Vatakapha hara property helps in the samprapti Vighatana of Mootrasmari,
kricchra and Prameha.

14. Articles on Gokshuradi Guggulu
• 1. Effect of Ayurvedic management in 130 patients of diabetic nephropathy by Kalapi
Patel, 1 S. N. Gupta,2 and Namrata Shah3, Ayu. 2011 Jan-Mar; 32(1): 55–58;doi:
[10.4103/0974-8520.85727]
• 2. Ayurvedic Management of Pediatric Urolithiasis(Mutrashmari) : A case Report by
Shubhashree M. N et al, Interanational Journal of Research in Ayurveda Pharma, B(1),
Jan- Feb 2017, [DOI- 10.7897/2277-4343.08116]

15. Other studies..
• Studies on Gokshura has proved its Ant cancerous, Nephroprotective,
Hepatoprotective, lithotriptic and diuretic activity.
• Also studies on Guggulu has proved its effect in obesity, atherosclerotic lesions,
inflammations, arthritis, hypercholestrolemia etc.

16. PANCHATIKATAKA GUGGULU
• Guggulu thikthakam Ghrita is vataghna and it is being used for treatment of asthi
majja Kshaya .
• The drug is mentioned in AH and Bhaishajya Ratnavali in the management of bones
and associated disorders.

17. Reference
• Bhaishajya ratnavali, Chapter 54, kushta roga chikiltsa, verse: 233 – 236.
• Ashtanga hridayam, chikitsa sthana, chapter 21, vatavyadhi chikitsa adyaya, verse 58-
61

20. Preparation
• Guggulu is purified by Dola Yantra Swedana in Triphala kwatha.
• Decoction is prepared by adding prescribed quantity of Nimbu, Patola, Guduchi,
Vasaka, and Kantakari by adding 8 times of water and reduced to one fourth.
• Sudha Guggulu is taken in an iron pan with prescribed quantity of Ghrita and
Kashaya.
• The mixture is heated and simmered until it becomes thick Avaleha consistency.
• After that other powdered ingredients were added and mixed well to obtain a
homogenous mixture.

21. • After that pills of 3g size were prepared by rolling.
• The prepared tablets were properly dried and stored in air tight containers.

22. Indications
 Vata rogas ( Sandhi, Asthi, Majja Gata)
 Kutsa, Nadivrana, Arbuda, Bhangandhara
 Gandamaala
 Gulma
 Gudaja rogas
 Prameha
 Rajayakshma
 Swasa, Peenasa, Kasa, Soola
 Hridroga, Pandu, Vidradi, Vatarakta

23. Pharmacologycal actions
• Ingredients in panchathikta ghrita guggulu act on bone
joints,muscles,skin,lymph glands,spine,intestine,nerves,bone marrow etc
• Therefore, it is useful in diseases related to these organs
• Mainly it is anti-inflammatory ,anti-toxic,and anti-pruritic.

24. Medicinal properties
• Antitoxic
• Anti pruritic
• Neuro protective
• Anti-inflammatory
• Analgesic
• Anti-cancer
• Anti tumour
• Anti-ulcerogenic
• Cardioprotective
• Haematinic(increases hb levels)

25. Ayurvedic properties & Therapeutic indications
• Dosha karma- pacifies tridosha ,but mainly beneficial for vata and pitta doshas
• It has effect on rasa ,raktha,asthi,majja
• Main indications - skin disorders and diseases of musculoskeletal system and nervous system.
• ‘Panchtikta Ghrita Guggulu’ possess Vata pacifying property thus, reduces intensity of pain, stiffness
and discomfort in cervical region. Also, the formulation has balya and rasayana i.e rejuvenating action
on bony tissues thus, arrests osteo porosis and degenerative process probably by promoting calcium
binding capacity of cells.reduces the inflammation by the presence of thiktha rasa dravyas

26. Dosage and administration
• Chidren : 1.5 to 6 gm(once or twice a day)
• Adults : 3 to 12 gm(once or twice a day)
• Time of administration :
• On empty stomach in the morning and late afternoon .

27. Studies on guggulu thikthakam gritham
• Article_. Management of ‘Manyashrit Vata’ by phytotherapy-‘Panchtikta Ghrit Guggulu’ –
w.s.r. to cervical spondylosis. MA Lahankar1, *Amarprakash Dwivedi
• In this study ‘Panchatikta Ghrit Guggulu’-Nasya (nasal insufflations) and Internal use(20 ml twice a
day for 2 months) was prescribed.
• ‘Panchatikta’ group of herbs (Nimb, Amruta, Vrush, Patol, Nidigdhika) are the best herbs (Rasayana)
for bony tissues i.e.Asthi dhatu.
• When ‘Panchtikta Ghriat Guggulu’ is administered though ‘Nasya’, it stimulates the optic nerve
fibers which helps in pacifying the supply of nutrients to the adjacent muscle fibers and cervical
vertebrae,forms newer healthier tissues thus, help in arresting degenerative process and strengthens
the muscles and boney tissue.

28. • Quality control studies on panchathikthaka guggulu kwatha curnam-V Gopinath
• Role of guggulu thikthakam gritha in the management of osteo arthritis W.S.R to knee
joint-Babasaheb D Patil

29. Thank you