This document discusses shelf life and preservation of Ayurvedic drugs and formulations. It provides classical Ayurvedic references for the shelf life of various dosage forms such as choorna (2 months), taila and ghrita (16 months), gutika and lehya (12 months). Factors affecting shelf life include time, environmental factors, infections, and improper storage. Commonly used preservatives include benzoic acid, boric acid, methyl paraben and sodium benzovate. Proper packaging, storage, and avoiding moisture are important for preserving formulations.
Raseswara Darsana is the 9th of the 15 philosophies discussed in the ancient text Sarva Darsana Sangraha. It believes that liberation or mukti can be attained in living state, or jeevanmukti, through the use of mercury or parada. Other philosophies only recognize mukti as achievable after death. Raseswara Darsana describes the stages of parada processing and 18 samskaras required to make it suitable for ingestion. Its goal is to attain a divine, immortal body through mercury in order to achieve mukti while still alive through knowledge and removal of ignorance.
Saviryata avadhi - SHELF LIFE in Ayurveda and Modern point of ViewHariaumshree Nair
Shelf Life Period According to Acharyas mentioned in Samhitas in Ayurvedic Context as well as Modern Basics of Packaging labelling and Storage has been Discussed in it.
Sandhana kalpana is the preparation of self generated alcohol. All the preparations that are resulting from FERMENTATION procedure come under SANDHANA KALPANA.
Sandhana kalpana is a special technique to prepare most effective medicines like Asava and Aristas. The medicines prepared through Sandhana kriya are quick in action, long shelf life, palatability and has nutritive value.The self-generated alcohol is the key factor behind the success of Sandhana kalpana.
This document provides a classification and overview of various types of Rasakalpa compounds based on their method of preparation. It discusses four main classifications - Kharaliya, Koopipakwa, Parpati, and Pottali Rasayanas. For each classification, it provides two examples including their ingredients, indications, doses, and properties. It also discusses the preparation methods and analyses of some of the compounds.
This document provides information on Parada (mercury) according to Ayurvedic texts, including its synonyms, types, natural impurities, and Ashtasamskaras (eight purification processes). It defines Parada, lists its many Sanskrit synonyms, and describes its ideal color and appearance. The document outlines five types of Parada based on origin, five modes of movement, its eight natural impurities, and seven external impurities/coverings. It concludes by detailing each of the eight purification processes (Svedana, Mardana, Murchana, Utthapana, Patana etc.) involved in preparing Parada for medicinal use according to classical Ayurvedic texts.
Sasyaka, also known as tuttha or blue vitriol, is the 6th mineral drug in the maharasa group. It is chemically identified as copper sulfate with the chemical formula CuSO4. The document discusses the various Sanskrit and regional names of sasyaka, its natural occurrences, mineralogical identification, historical references, types, purification process, therapeutic properties and uses when consumed in its purified or bhasma form. It describes how sasyaka bhasma is useful for treating diseases like kushta, netraroga and various skin disorders.
This document provides information on Musha, which is a crucible-like device used in Rasashastra to remove impurities from materials heated within it. It describes different types of Musha based on their composition, color, and shape. The key types discussed are Samanya Musha, Vajra Musha, Vara Musha, and Gara Musha. It also provides details on the ideal characteristics of the soil used to make Musha and its various applications.
Raseswara Darsana is the 9th of the 15 philosophies discussed in the ancient text Sarva Darsana Sangraha. It believes that liberation or mukti can be attained in living state, or jeevanmukti, through the use of mercury or parada. Other philosophies only recognize mukti as achievable after death. Raseswara Darsana describes the stages of parada processing and 18 samskaras required to make it suitable for ingestion. Its goal is to attain a divine, immortal body through mercury in order to achieve mukti while still alive through knowledge and removal of ignorance.
Saviryata avadhi - SHELF LIFE in Ayurveda and Modern point of ViewHariaumshree Nair
Shelf Life Period According to Acharyas mentioned in Samhitas in Ayurvedic Context as well as Modern Basics of Packaging labelling and Storage has been Discussed in it.
Sandhana kalpana is the preparation of self generated alcohol. All the preparations that are resulting from FERMENTATION procedure come under SANDHANA KALPANA.
Sandhana kalpana is a special technique to prepare most effective medicines like Asava and Aristas. The medicines prepared through Sandhana kriya are quick in action, long shelf life, palatability and has nutritive value.The self-generated alcohol is the key factor behind the success of Sandhana kalpana.
This document provides a classification and overview of various types of Rasakalpa compounds based on their method of preparation. It discusses four main classifications - Kharaliya, Koopipakwa, Parpati, and Pottali Rasayanas. For each classification, it provides two examples including their ingredients, indications, doses, and properties. It also discusses the preparation methods and analyses of some of the compounds.
This document provides information on Parada (mercury) according to Ayurvedic texts, including its synonyms, types, natural impurities, and Ashtasamskaras (eight purification processes). It defines Parada, lists its many Sanskrit synonyms, and describes its ideal color and appearance. The document outlines five types of Parada based on origin, five modes of movement, its eight natural impurities, and seven external impurities/coverings. It concludes by detailing each of the eight purification processes (Svedana, Mardana, Murchana, Utthapana, Patana etc.) involved in preparing Parada for medicinal use according to classical Ayurvedic texts.
Sasyaka, also known as tuttha or blue vitriol, is the 6th mineral drug in the maharasa group. It is chemically identified as copper sulfate with the chemical formula CuSO4. The document discusses the various Sanskrit and regional names of sasyaka, its natural occurrences, mineralogical identification, historical references, types, purification process, therapeutic properties and uses when consumed in its purified or bhasma form. It describes how sasyaka bhasma is useful for treating diseases like kushta, netraroga and various skin disorders.
This document provides information on Musha, which is a crucible-like device used in Rasashastra to remove impurities from materials heated within it. It describes different types of Musha based on their composition, color, and shape. The key types discussed are Samanya Musha, Vajra Musha, Vara Musha, and Gara Musha. It also provides details on the ideal characteristics of the soil used to make Musha and its various applications.
This is the second part of presentation regarding definitions in Rasa shastra. An attempt is made to clarify the definitions in more clear way also useful images are added to further improvise the presentation.
This document provides an overview of Sneha Kalpana, the Ayurvedic process of preparing medicated oils and ghees. It defines Sneha Kalpana, discusses the types of bases used like ghee and oils, and the aims of the process. Key steps in the general method of preparation are outlined, including rules for ingredients proportions. Signs of proper maturation and characteristics of the final products are also described. Various techniques like Murchana, Avartana, and using rasa drugs are summarized.
Aushadha sewan marga ( routes of drug administrationnehajambla
The document discusses the various routes of drug administration according to Ayurveda and modern medicine. It outlines 10 main routes in Ayurveda - basti, nasya, dhumpaan, gandoosh, kawal, pratisarana, aalep, shir abhayanga, shirovasti, and rakht nirharana. It also discusses 7 types of netra marga (eye treatments). For modern medicine, it lists the main parenteral and other routes including oral, sublingual, rectal, pulmonary, nasal, cutaneous, ocular, and vaginal. The document emphasizes that physicians must be aware of all routes to properly administer drugs based
This document provides information on Kupi Pakwa preparations in Ayurveda. It discusses the evolution and history of Kupi Pakwa in classical texts from the 13th century to the 19th century. It covers the specifications, classifications, methodology, and rationale behind where the finished product is deposited. Several common Kupi Pakwa preparations are described including their ingredients and references. The document concludes by discussing the therapeutic uses and market availability of these preparations.
PARIBHASHA OF RASASHASTRA BY DR AJITH KUMARDR AJITH KUMAR
The document discusses the importance of technical terminology or paribhasha in Rasashastra (Ayurvedic alchemy). It provides definitions and examples of important terms used in purification techniques like Shodhana. Shodhana aims to remove impurities from materials using various processing methods such as Mardhana, Bhavana, Swedana and is a crucial first step in Rasashastra.
The document provides information on Panchavidha Kashaya Kalpana, the five basic forms of water-based pharmaceutical preparations in Ayurveda. It describes the five types - Swarasa (expressed juice), Kalka (paste), Churna (powder), Kwatha (decoction), and Sheeta/Hima (cold infusion). For each type, it details the method of preparation, examples of common medicines, dosage, and importance. It explains that these five were selected because they could be prepared easily with limited resources and had a shelf life of 24 hours, allowing preparation as needed in the past.
Kupipakwa Rasayan by Mohd Ehsan B.Pharm(Ayurveda) Mohd Ehsan
The document discusses Kupipakwa rasayan, a unique Ayurvedic preparation. It begins by providing historical context for the development of rasashastra as a branch of Ayurveda. It then defines key terms like kajjali, jarana, and murcchana used in the Kupipakwa process. The document outlines the typical materials, steps, and observations involved in the preparation method. These include using a kupi vessel placed in a valuka yantra and applying different levels of heat. The summary concludes that Kupipakwa rasayan formulations are effective treatments due to the high heat applied during processing.
The document summarizes a presentation on the Ayurvedic text Yogaratnakara. It provides an introduction to the text, discusses its contents and structure, notable formulations and contributions. Some key points:
- Yogaratnakara is a late 17th century text that builds on earlier works in the Yoga series of texts.
- It covers diagnosis, treatment of diseases, formulations for cleansing and rejuvenation. Notable sections on women's health and pulse examination.
- It introduces some new formulations and describes properties of ingredients like tobacco in detail.
- Examples are provided of formulations from the text used to treat conditions like diarrhea, piles and indigestion. Single herb uses
1. The document discusses the preparation method of Pottali Rasayana, an emergency medicine in Ayurveda.
2. Pottali involves compacting herbs and metals like mercury and sulfur inside silk cloth using heat treatment. It has benefits like easy administration, long shelf life, and potent effects from minimal doses.
3. The presentation outlines the detailed method of preparation involving steps like identification of ingredients, heating the ingredients inside cloth in a sulfur bath, and assessing the end point. It also discusses the therapeutic uses of several Pottali formulations and rationales behind the techniques used.
Rasa ratna samuchchaya have dedicated a separate chapter for rasashala which can be corelated to GMP in present era.
It is important to keep in mind that all of these texts were written between the first and the sixteenth centuries. Hence everything is ideally provided in such a description, including the choice of location, water and light facilities, raw material availability, air ventilation, etc. Not only that, but careful consideration is also given to precise and well-considered instructions about staffing levels, financial requirements, and security in various departments in rasashala.
Rasamandap in present era mimics the R&D sector. Just as Rasamandap is designated as a confidential and sterile space, the R&D sector similarly emphasizes the importance of maintaining confidentiality in drug development or research works conducted and also aseptic conditions has to be maintained in that sector.
1. The document discusses several herbs and minerals used in Ayurveda including sulfur, ochre, green vitriol, potash alum, yellow arsenic, realgar, collyrium, and Gamboge tree. It provides the Sanskrit names, properties, purification and processing methods, uses, and formulations for each.
2. Purification methods generally involve treatments with liquids like milk, honey, or plant juices and decoctions. Minerals may be given heat treatments. Some undergo processing to make them into fine powders or colors.
3. The herbs and minerals are used to treat diseases like skin disorders, fevers, digestive issues, and eye conditions. They have warming, detox
This document discusses different types of lavana kalpana (salt-based pharmaceutical preparations). Lavana has properties like being light, unctuous, and cool, with a cold potency. The process of agni samskara (ignition) enriches the preparation with therapeutic properties of lavana and added medicinal drugs. Lavana kalpana involves igniting lavana and selected medicinal substances together in a closed vessel to obtain a medicinal ash product. Examples given are narikela lavana and arka lavana, along with methods for preparing each. Other lavana preparations discussed include vida lavana and souvarchala lavana.
This document discusses Rasa Sindura, a Kupipakwa Rasa preparation mentioned in Ayurvedic texts. It describes the types of Kupipakwa Rasa Kalpa, the ingredients and properties of Rasa Sindura, recommended dosages according to age, appropriate anupanas (adjuvants) for various diseases, and the conclusion that Rasa Sindura can treat many conditions when administered with the right anupana based on the disease. The document references several Ayurvedic texts to support the information provided on Rasa Sindura.
The document summarizes the Ayurvedic text Chakradutta by Chakrapani Datta. It provides an overview of the author, date, sources cited, and structure of the text. The text contains 4800 verses divided into 79 chapters discussing the treatment of various diseases following the order of Madhava Nidana. It includes herbal formulations, procedures like Panchakarma and Rasayana. While focusing on therapeutics, it provides guidance still applicable for Ayurvedic practitioners and research.
Fundamental principles of bhaishajya kalpana. The word Bhaishajya Kalpana is composed of two words – Bhaishajya and Kalpana. The word Bhaishajya means – relating to Bheshaja (medicine). Kalpana refers to formulation or designing of medicine. There are some fundamental principles, according to which all ayurvedi medicines are prepared.
This document provides information on various minerals and metals used in Ayurvedic medicine, including their Sanskrit names, properties, purification processes, and uses. It discusses Abhraka (mica), Vaikranta (tourmaline), Makshika (copper pyrite), Vimala (iron pyrite), Shilajatu (mineral pitch), Sasyaka (copper sulphate), and Chapala (bismuth). For each substance, it describes characteristics, purification by processes like heating and herbal decoction baths, methods of powdering into bhasma or satva forms, and therapeutic applications.
This document discusses sneha kalpana (Ayurvedic medicated oils) and their preparation methods. It notes that the key ingredients in sneha kalpana are taila (oil), kalka (paste), and drava (liquid). Various plant materials and processing techniques are outlined for making different types of medicated oils to be used for purposes like nasya, abhyanga, and internal administration. Quality testing parameters for sneha kalpana are also presented, as well as liposomes as a modern adaptation.
The Concept of Pakshachedhana in Ayurveda RasasastraEbinuday
'Pakshachedhana' simply means 'Cutting the wings'. In Ayurveda Rasasastra , Parada ( Mercury) is subjected to Pakshachedhana , through which the stability and heat sustaining capacity of Parada is attained . Pakshachinna Parada can thus be used accordingly in various efficient formulations.
This document defines preservatives and discusses their use and classification. Preservatives are added to foods and pharmaceuticals to prolong shelf life by preventing microbial growth. They are classified as antimicrobials, which kill microbes, or antioxidants, which prevent oxidation. Important criteria for selecting preservatives include effectiveness against microbes, stability, nontoxicity, and compatibility. Common antimicrobial types are alcohols, acids like benzoic acid, esters like parabens, and quaternary ammonium compounds.
This is the second part of presentation regarding definitions in Rasa shastra. An attempt is made to clarify the definitions in more clear way also useful images are added to further improvise the presentation.
This document provides an overview of Sneha Kalpana, the Ayurvedic process of preparing medicated oils and ghees. It defines Sneha Kalpana, discusses the types of bases used like ghee and oils, and the aims of the process. Key steps in the general method of preparation are outlined, including rules for ingredients proportions. Signs of proper maturation and characteristics of the final products are also described. Various techniques like Murchana, Avartana, and using rasa drugs are summarized.
Aushadha sewan marga ( routes of drug administrationnehajambla
The document discusses the various routes of drug administration according to Ayurveda and modern medicine. It outlines 10 main routes in Ayurveda - basti, nasya, dhumpaan, gandoosh, kawal, pratisarana, aalep, shir abhayanga, shirovasti, and rakht nirharana. It also discusses 7 types of netra marga (eye treatments). For modern medicine, it lists the main parenteral and other routes including oral, sublingual, rectal, pulmonary, nasal, cutaneous, ocular, and vaginal. The document emphasizes that physicians must be aware of all routes to properly administer drugs based
This document provides information on Kupi Pakwa preparations in Ayurveda. It discusses the evolution and history of Kupi Pakwa in classical texts from the 13th century to the 19th century. It covers the specifications, classifications, methodology, and rationale behind where the finished product is deposited. Several common Kupi Pakwa preparations are described including their ingredients and references. The document concludes by discussing the therapeutic uses and market availability of these preparations.
PARIBHASHA OF RASASHASTRA BY DR AJITH KUMARDR AJITH KUMAR
The document discusses the importance of technical terminology or paribhasha in Rasashastra (Ayurvedic alchemy). It provides definitions and examples of important terms used in purification techniques like Shodhana. Shodhana aims to remove impurities from materials using various processing methods such as Mardhana, Bhavana, Swedana and is a crucial first step in Rasashastra.
The document provides information on Panchavidha Kashaya Kalpana, the five basic forms of water-based pharmaceutical preparations in Ayurveda. It describes the five types - Swarasa (expressed juice), Kalka (paste), Churna (powder), Kwatha (decoction), and Sheeta/Hima (cold infusion). For each type, it details the method of preparation, examples of common medicines, dosage, and importance. It explains that these five were selected because they could be prepared easily with limited resources and had a shelf life of 24 hours, allowing preparation as needed in the past.
Kupipakwa Rasayan by Mohd Ehsan B.Pharm(Ayurveda) Mohd Ehsan
The document discusses Kupipakwa rasayan, a unique Ayurvedic preparation. It begins by providing historical context for the development of rasashastra as a branch of Ayurveda. It then defines key terms like kajjali, jarana, and murcchana used in the Kupipakwa process. The document outlines the typical materials, steps, and observations involved in the preparation method. These include using a kupi vessel placed in a valuka yantra and applying different levels of heat. The summary concludes that Kupipakwa rasayan formulations are effective treatments due to the high heat applied during processing.
The document summarizes a presentation on the Ayurvedic text Yogaratnakara. It provides an introduction to the text, discusses its contents and structure, notable formulations and contributions. Some key points:
- Yogaratnakara is a late 17th century text that builds on earlier works in the Yoga series of texts.
- It covers diagnosis, treatment of diseases, formulations for cleansing and rejuvenation. Notable sections on women's health and pulse examination.
- It introduces some new formulations and describes properties of ingredients like tobacco in detail.
- Examples are provided of formulations from the text used to treat conditions like diarrhea, piles and indigestion. Single herb uses
1. The document discusses the preparation method of Pottali Rasayana, an emergency medicine in Ayurveda.
2. Pottali involves compacting herbs and metals like mercury and sulfur inside silk cloth using heat treatment. It has benefits like easy administration, long shelf life, and potent effects from minimal doses.
3. The presentation outlines the detailed method of preparation involving steps like identification of ingredients, heating the ingredients inside cloth in a sulfur bath, and assessing the end point. It also discusses the therapeutic uses of several Pottali formulations and rationales behind the techniques used.
Rasa ratna samuchchaya have dedicated a separate chapter for rasashala which can be corelated to GMP in present era.
It is important to keep in mind that all of these texts were written between the first and the sixteenth centuries. Hence everything is ideally provided in such a description, including the choice of location, water and light facilities, raw material availability, air ventilation, etc. Not only that, but careful consideration is also given to precise and well-considered instructions about staffing levels, financial requirements, and security in various departments in rasashala.
Rasamandap in present era mimics the R&D sector. Just as Rasamandap is designated as a confidential and sterile space, the R&D sector similarly emphasizes the importance of maintaining confidentiality in drug development or research works conducted and also aseptic conditions has to be maintained in that sector.
1. The document discusses several herbs and minerals used in Ayurveda including sulfur, ochre, green vitriol, potash alum, yellow arsenic, realgar, collyrium, and Gamboge tree. It provides the Sanskrit names, properties, purification and processing methods, uses, and formulations for each.
2. Purification methods generally involve treatments with liquids like milk, honey, or plant juices and decoctions. Minerals may be given heat treatments. Some undergo processing to make them into fine powders or colors.
3. The herbs and minerals are used to treat diseases like skin disorders, fevers, digestive issues, and eye conditions. They have warming, detox
This document discusses different types of lavana kalpana (salt-based pharmaceutical preparations). Lavana has properties like being light, unctuous, and cool, with a cold potency. The process of agni samskara (ignition) enriches the preparation with therapeutic properties of lavana and added medicinal drugs. Lavana kalpana involves igniting lavana and selected medicinal substances together in a closed vessel to obtain a medicinal ash product. Examples given are narikela lavana and arka lavana, along with methods for preparing each. Other lavana preparations discussed include vida lavana and souvarchala lavana.
This document discusses Rasa Sindura, a Kupipakwa Rasa preparation mentioned in Ayurvedic texts. It describes the types of Kupipakwa Rasa Kalpa, the ingredients and properties of Rasa Sindura, recommended dosages according to age, appropriate anupanas (adjuvants) for various diseases, and the conclusion that Rasa Sindura can treat many conditions when administered with the right anupana based on the disease. The document references several Ayurvedic texts to support the information provided on Rasa Sindura.
The document summarizes the Ayurvedic text Chakradutta by Chakrapani Datta. It provides an overview of the author, date, sources cited, and structure of the text. The text contains 4800 verses divided into 79 chapters discussing the treatment of various diseases following the order of Madhava Nidana. It includes herbal formulations, procedures like Panchakarma and Rasayana. While focusing on therapeutics, it provides guidance still applicable for Ayurvedic practitioners and research.
Fundamental principles of bhaishajya kalpana. The word Bhaishajya Kalpana is composed of two words – Bhaishajya and Kalpana. The word Bhaishajya means – relating to Bheshaja (medicine). Kalpana refers to formulation or designing of medicine. There are some fundamental principles, according to which all ayurvedi medicines are prepared.
This document provides information on various minerals and metals used in Ayurvedic medicine, including their Sanskrit names, properties, purification processes, and uses. It discusses Abhraka (mica), Vaikranta (tourmaline), Makshika (copper pyrite), Vimala (iron pyrite), Shilajatu (mineral pitch), Sasyaka (copper sulphate), and Chapala (bismuth). For each substance, it describes characteristics, purification by processes like heating and herbal decoction baths, methods of powdering into bhasma or satva forms, and therapeutic applications.
This document discusses sneha kalpana (Ayurvedic medicated oils) and their preparation methods. It notes that the key ingredients in sneha kalpana are taila (oil), kalka (paste), and drava (liquid). Various plant materials and processing techniques are outlined for making different types of medicated oils to be used for purposes like nasya, abhyanga, and internal administration. Quality testing parameters for sneha kalpana are also presented, as well as liposomes as a modern adaptation.
The Concept of Pakshachedhana in Ayurveda RasasastraEbinuday
'Pakshachedhana' simply means 'Cutting the wings'. In Ayurveda Rasasastra , Parada ( Mercury) is subjected to Pakshachedhana , through which the stability and heat sustaining capacity of Parada is attained . Pakshachinna Parada can thus be used accordingly in various efficient formulations.
This document defines preservatives and discusses their use and classification. Preservatives are added to foods and pharmaceuticals to prolong shelf life by preventing microbial growth. They are classified as antimicrobials, which kill microbes, or antioxidants, which prevent oxidation. Important criteria for selecting preservatives include effectiveness against microbes, stability, nontoxicity, and compatibility. Common antimicrobial types are alcohols, acids like benzoic acid, esters like parabens, and quaternary ammonium compounds.
This document discusses the perishability of different types of foods based on their moisture content and pH levels. It defines three categories of foods: perishable foods that spoil within 1-2 days, semi-perishable foods that can be stored for weeks to months, and non-perishable foods that can be stored for months to years. Examples are provided for each category along with best storage practices. The document also discusses how pH levels affect microbial growth in foods and the body's ability to maintain blood pH within a narrow range.
Preservation of Pharmaceutical Products.pptxkhadeejaahmad4
Pharmaceutical products require preservation to inhibit microbial spoilage during storage and multi-dose use. Antimicrobial preservatives play a vital role by preventing the growth of microorganisms that can contaminate products. Effective preservatives must be non-toxic, soluble, heat stable, and chemically compatible with formulations. Common preservative types include cationic detergents, alcohols, phenolic compounds, and organic acids. Preservatives provide protection by inhibiting microbial cell walls, protein synthesis, and DNA/RNA synthesis.
Basic Principle and technique of food preservationSarnali Paul
This document provides an overview of basic food science and preservation techniques. It discusses key topics like shelf life, factors that affect perishability, the relationship between pH and shelf life, and various preservation methods. These include canning, pasteurization and types, freezing and types, drying and classification, and blanching. The principles and effects of these techniques on food quality are also reviewed. The overall document serves as an introduction to fundamental concepts in food science and preservation.
Preservatives are added to pharmaceutical products to prevent microbial growth and extend shelf life. An ideal preservative kills microbes rapidly at low concentrations, is non-toxic, stable, and does not interact negatively with the product ingredients. A preservative efficacy test evaluates the ability of a preservative system to inhibit microbial growth when challenged with common test microbes like S. aureus and P. aeruginosa over 28 days. The test involves inoculating product samples, incubating them, and conducting plate counts to determine microbial survival rates over time. This ensures the preservative maintains effective antimicrobial activity as required by pharmacopeia standards.
1. Contaminated pharmaceutical products can present health hazards ranging from local infections to life-threatening systemic infections depending on the type and amount of contamination as well as the patient's susceptibility.
2. Gram-negative bacteria are a particular concern as they have caused numerous outbreaks through contaminated products and can produce endotoxins. Routes of administration like ophthalmic and parenteral introduce the highest risk.
3. The effects of contaminated product use may vary between patients depending on the microbial contaminant, administration route, and individual patient resistance and immune status. Immunocompromised patients are most at risk.
This document provides an overview of large and small volume parenteral preparations. It begins with definitions of parenteral preparations and routes of administration. Advantages and disadvantages of the parenteral route are discussed. General requirements for parenteral dosage forms like containers, glass types, closures, and aseptic areas are covered. Parenteral preparations are classified based on volume as small volume parenterals (SVP) and large volume parenterals (LVP). Physiological considerations like pH, buffer, tonicity, and stabilizers are explained. Formulation considerations for various parenteral preparations are provided. The manufacturing process including cleaning, preparation, filtration, filling, sealing, and sterilization is outlined. Key evaluation tests like sterility testing,
This presentation summarizes containers and closures used for pharmaceutical products. It defines containers as mechanisms for holding drugs and closures as protecting drugs from contamination. Types of containers discussed include well-closed, single-dose, multi-dosage, light-resistant, airtight, and child-resistant containers. Plastic and glass containers are described along with potential drug interactions. Biological tests for containers including systemic injection, intracutaneous, and eye irritation tests in mice and rabbits are summarized. The conclusion states that dosage form properties determine the suitable container and closure selection.
This document discusses various methods for preserving fruits and vegetables, including prevention of microbial growth through asepsis, low temperatures, drying, chemicals/spices; killing microbes through heat or radiation; preventing enzyme activity through blanching; and preventing damage from insects or animals through packaging. Specific preservation methods covered are filtration, fermentation/pickling, carbonation, irradiation, refrigeration, use of sugar/salt/oils as natural preservatives, high temperature treatments like pasteurization and sterilization, and drying/dehydration.
Shankha Churnam is a herbo mineral kharaliya formulation mentioned under Shularogadhikara in the text Bhaishajya ratnavali. It has ingredients like shankha bhasma, panchalavana, yavaani, yavakshara, shatapushpa, trikatu, jaatiphala, tankana and hingu. Shankha bhasma is the main ingredient. In the present study, shankha churnam was prepared as per the guidelines given in the classical text book Bhaishajya ratnavali and Physico chemical analysis was carried out. Shankha churnam was prepared in the pharmacy of TGAMC, Ballari, Karnataka and was subjected to analysis on parameters like Organoleptic Characters, Loss on drying, Total Ash, Acid insoluble Ash, Water soluble ash, etc. The study showed significant result. Dr. Renuka Dharane | Dr. Ravi R. Chavan "Analytical Evaluation of Shankha Churnam" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd47640.pdf Paper URL : https://www.ijtsrd.com/biological-science/other/47640/analytical-evaluation-of-shankha-churnam/dr-renuka-dharane
This document discusses various methods for preserving pure microbial cultures, including short-term and long-term methods. Short-term methods include periodic transfer to fresh media, storage in paraffin or mineral oil, preservation using glycerol, and storage through drying or refrigeration. Long-term methods allow for extended preservation and involve oil storage, saline suspension, immersion in water, storage in soil, lyophilization, or cryopreservation through freezing in liquid nitrogen. Whichever preservation technique is used, it is important to routinely check the quality of preserved microbial stocks to ensure their viability and characteristics remain unchanged over long periods of storage.
This presentation is brief introduction about preservatives employed in pharmaceutical dosage forms to prevent formulation from oxidation and microbial attack during storage and patient usage.it includes classification of preservatives, uses and method of analysis of preservatives and also introduction about pharmacopoeial evaluation of preservatives that is preservative activity test (PAT)
Active packaging technologies can help extend the shelf life of foods and maintain quality. There are various types of active packaging systems that interact with the packaged product including oxygen scavengers, CO2 emitters, moisture absorbers, odor/flavor absorbers, antimicrobials, and antioxidant releasers. These systems are used for applications in meat, seafood, bakery goods and other products. Future trends in active packaging may include self-heating and self-cooling systems as well as technologies that can heat or chill food on demand.
This document provides an overview of various food preservation methods for short and long shelf life foods. It discusses techniques such as heating, cooling, drying, adding natural preservatives like salt or sugar, and using chemical preservatives. It explains how each method works to control microorganisms, deactivate enzymes, and prevent spoilage reactions. Specific methods like drying, acidification, sugar/salt addition, and smoke exposure are then described in more detail regarding their mechanisms and considerations.
This document discusses various principles and methods of food preservation. It defines preservation as preventing decay or spoilage to allow food to be stored for future use. The key principles outlined are preventing microbial decomposition through methods like asepsis, low temperature, drying, chemicals/antibiotics. It also discusses specific preservation methods like high temperature processing (pasteurization, sterilization), low temperature storage (refrigeration, freezing), drying, use of chemicals (sulphur dioxide, benzoic acid), filtration, carbonation, sugar, fermentation, salt, acid, oil/spices, antibiotics, and irradiation.
Food Processing and Preservation Presentation.pptxdengejnr13
The presentation covers key areas on food processing and preservation highlighting the traditional methods and the current, modern methods applicable worldwide for both small and large scale.
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2. SAVIRYATAAVADHI :-
Time period during which the virya or
potency of any drug remains unaffected due to
environmental or microbial deterioration.
The period of potency is labelled as expiry date.
3. SHELF LIFE :-
Used to indicate the time period
during which an API ( Active pharmaceutical
ingradient ) or FPP ( Finished pharmaceutical
product ) is expected to remain within the approved
stability specification provided that it is stored
under the conditions defined on the container label.
4. According to Susruta , a drug whether it is fresh or old
can be utilized for therapeutic purpose up to which
qualities ( appearance, taste, smell etc. ) remain intact.
This reference directs that shelf life of any drug can be
considered up to that period until which it attains the
sub potent level and not up to its deterioration.
5. Shelf life is to be understood in 2 dimensions
Raw drugs Formulations
6. Factors affecting shelf life of raw drugs :-
Natural factors -
1. Time
2. Environmental factors
3. Infections
Unnatural factors –
1. Drug adulteration
2. Drug substitutions
7. Shelf life of formulations –
1. Method of preparation
2. Packing
3. Storage
8. There is no clear idea about shelf life of different
Ayurvedic dosage forms in the classical texts before
11th century A.D .
After 12th century only descriptions about the specific
shelf life or stability period of different preparations.
Acharya Sarangadhara ( 13th A.D) is the first one to
mention the shelf life of formulations .
9. As per Sarangadhara , prathama khanda ,1/ 51-52
1. Choorna – 2months
2. Taila & Ghrita -- 16 months
3. Gutika & Lehya -- 12 months
4. Laghu paka aushadies – 12 months
5. Asava
Arista
Rasa preparations - indefinite / long term
11. As per Vangasena,
Guda / Avaleha - 12 months
Ghrita / taila - 6 months
As per G.S.P ( Good Storage Practises ) of the
National Medicinal Plant Board of Central
government
12.
13. CHOORNA KALPANA :-
2months
If airtight containers are used - up to 6 months
More exposed surface area chances of oxidation &
hydrolysis.
Exception – Lavana bhaskara choorna
14. If the raw drugs are measured according to the recipe we
get a large quantity of Lavana bhaskara choorna .
Main precaution to be taken is in proper storing.
15. GUTIKA , VATI KALPANA –
Complete removal of water content
If protected from adverse atmospheric factors maintain
quality for longer periods .
16. LEHA KALPANA –
Presence of sweetening agent
Little water content .
Preservative methods are adopted nowadays to prolong
the shelf life.
17. OUSHADI , TRICHUR ,
Most commonly added preservatives in Lehya
preparations like Manibhadra gulam, Panchajeeraka
gudam, Koosmanda rasayana, Dasamoola rasayana ,
etc are - Methyl parabensodium & Propyl
parabensodium.
18. SNEHA KALPANA :-
Slow growth of microbes in fat medium
Processed in rainy season is liable to lose its potency
quickly due to increased moisture content.
Medicated Ghrita retains its potency for 4 months only
19. Therefore up to one year quality decreases gradually
and beyond one year it is not useful.
Taila kalpana keeps its potency for a longer period.
Proper packaging and storage must be provided.
vaidyaparibhasa pradeep
20. SHELF LIFE OF ASAVAAND ARISTA :-
Resistant to deterioration
1. removal of starch material by fermentation.
2. presence of self generated alcohol .
Adequate temperature maintainance ( 30-35 *c).
Adding kwatha or Hima of of Dhataki puspha to prevent fungal
growth to maximum extent.
21. Rainy season – chances of frequent fungal growth.
According to classics – Vasantha , Sarad
Between March – May and September – November.
22. PRESERVATIVES
Preservatives are substances added to various pharmaceutical dosage
forms and cosmetic preparations to prevent or inhibit microbial
growth.
An ideal preservative would be effective at low concentrations
against all possible microorganisms.
They must be non toxic and compatible with other constituent of the
preparation and be stable for the shelf life of the preparation.
26. BENZOIC ACID :-
Food preservative
Inhibit growth of moulds, yeast , and some bacteria.
Externally – Antiseptic
27. BORIC ACID :-
Weak acid
Also known as Orthoboric acid
Colourless crystal, soluble in water
Antiseptic , insecticide and flame retardant.
28. METHYL PARABEN :-
White crystalline powder , freely soluble in water & alcohol.
Antiseptic
Used in cosmetic preparations containing vegetable and animal fats
& oils that are susceptible to decomposition.
29. ETHYL PARABEN :-
White crystalline powder slightly soluble in water.
Soluble in water and in most of organic solvents.
pharmaceutical preservative & food additives.
30. SODIUM BENZOVATE :-
Extensively used as food & pharmaceutical preservatives.
It is not a bactericidal, only a bacteriostatic agent.
Fungistatic activity.
32. PRESERVATIVES IN LIQUID PHARMACEUTICAL
PREPARATIONS
Liquids preparations are susceptible to microbial growth because of
the nature of their ingredients.
Such preparations are protected by the addition of preservatives that
prevent the alteration and degradation of the formulation.
Most commonly added preservatives are Sodium benzovate ,
Potassium sorbate , Methyl hydroxy benzovate or Methyl paraben etc.
33. Typical allowed concentration range of these preservatives are
Sodium benzovate – 0.1 to 0.2 %
Potassium sorbate - 0.1 to 0.2 %
Methyl paraben - 0.1 to 0.25 %
• More than the allowable range ,
• Topically induce rashes, urticarial, or contact dermatitis.
• On ingestion - may induce allergic potential , oestrogenic potential
of parabens , genotoxicity activity potential of sodium benzovate.
34. ESTIMATION OF SODIUM BENZOVATE IN KASHAYA
PREPARATION :-
Most commonly used preservative .
No standard procedure was known for the estimation.
Titrimetric estimation – of Benzoic acid using NaOH , can be
used as a standard method for its estimation.
35. Concentration of Sodium benzovate in Amritottaram ksh – 0.10 to 0.12
%.
Concentration in Nayopayam ksh – 0.10 to 0.12 %.
Daily intake of < 0.5gm is tolerable to humans.
No accumulation of Benzoic acid occurs in body < up to 4g/ day.
Metabolized , excreted through urine as Hippuric acid or glucuronic
acid .
36. The maximum allowed concentration as per FDA is o.1 %
study conducted at department of
chemistry P.R.N.S.S College Mattanur – published in Asian journal of
chemistry.
37.
38. PRESERVATION OF FORMULATIONS:
Protection against physical factors –
Minimize moisture content
strict and careful processing
wet preparation converted to unhydrous products
e.g. : swarasa – dry extract ; kalka – choorna, leha,
tablets etc.
39. Finished products should be kept in airtight containers
to avoid contact with moisture and oxygen
During dispensing care should be taken to avoid
moisture contact
Containers , measuring equipments, spoon etc should
be dried
Time of the containers kept opened should be
minimized.
40. Small packing and dosage packing will help
considerably in this regard
Eg : blister packing of tablets
sachet packing for powders
Light may bring about decomposition of ingradients
such as glycosides, vitamins etc .
So the products should be stored in dark or opaque or
amber glass containers.
41. Enzymatic activity will be more rapid in slightly
increased temperature and may cause changes in the
products.
Protection from temperature is attained by storing the
container in a cool place.
Packing in air tight container helps to prevent oxidation
of products like oil, Ghrita, Asava, Arista etc.
The container should be completely filled to avoid air
space.
42. Dehydrating agents like silica gel can be placed in the
container as small packets to avoid deterioration by
moisture
Selection of containers for storage
must be inert to the medicine
Glass vessels are considered to be safe
43. Protection against infections –
Living organisms like bacteria, fungus, and moulds may
cause deterioration of the formulation
Every step of processing ie from raw drug to the packing
should be conducted under strictly sterilized conditions.
By using antimicrobial preservatives eg Benzoic acid
44. PACKAGING :-
Packaging can be described as a coordinated system
of preparing goods for transport , warehousing,
storage and end use.
It is a science , art and technology of enclosing or
protecting products.
46. Desirable characteristics of a packaging material
Non reactive with the product
Not impart taste or odour to the product
Non toxic
Adoptable to commonly employed high speed
packaging equipments.
Meet applicable Tamper Resistance Requirements
47. TYPES OF PACKAGING –
Primary packaging – the material that first envelops the
product and holds it.
Secondary packaging – outside the primary packaging ,
used to group primary packages together .
Tertiary packaging – used for bulk handling . The most
common form is a palletized unit load that packs
tightly in to containers.
48. Strip packaging
Bottle packaging
Blister packaging – type of pre formed plastic
packaging used for small consumer goods
2 components – cavity and lidding
Cavity contains the product , lidding – seals the
product
49. 4 basic components
Forming film – receives the product in deep drawn
pockets
Monolayer PVC films, PVC/PVDC duplex etc
commonly used.
Aluminium blister foil etc
50. Lidding material – provides base or main structural
component up on which the final blister package is
built.
Paper aluminium, paper /PET/ aluminium
52. Current status –
Till date no specific guidelines are available regarding
the stability life estimation of pure Ayurvedic
formulations from any Government organization
Except a Gazette notification issued by Government of
India on 20th October 2009 with slight modification in
the earlier draft notification issued on 26th November
2005.
53. In this notification the department of AYUSH ,
Ministry of health & Family welfare has implemented
the rule namely 161B to display the date of expiry of
the ASU drugs and propose shelf life of the Ayurvedic
formulations.
54. CONCLUSION
In the present scenario saviryata avadhi can be
consider as an indicative of best before use .
This is the time limit after which one or more
properties of the formulations would have shown
considerable changes or degradation which can
be perceived by patients and lead to doubts about
the quality and efficacy of the product.
55. Though Ayurveda has judiciously explained the
subjective criteria for assessment of virya of a drug but
those are not sufficient to assess the potency.
Those parameters described by them in that period were
really admirable , scientific and show their keen
observation
But in todays era such parameters are not sufficient and
hence new objective parameters for measuring these
properties are to be search out.
56. In the ancient period when there was no
industrialization and the Vaidyas themselves used to
prepare the drug in smaller scale
Their main objective was to achieve the desire action
rather than shelf life and palatability.
Today in the era of globalization and large scale
production there is need to re determine the revised
stability period of these kinds of preparations by
following a suitable guidelines.