Cardinal Wolsey, the powerful favorite of King Henry VIII, fell from power due to a combination of factors: - Wolsey's efforts to obtain an annulment of Henry's marriage to Katherine of Aragon in order to allow Henry to marry Anne Boleyn failed, angering Henry. - Wolsey had also made enemies among the nobility through his close relationship with the king and dominance of government. - When the opportunity arose for Wolsey's opponents, including the Dukes of Norfolk and Suffolk and Anne Boleyn, to bring him down over the divorce issue, they seized upon it, weakening Wolsey's position and ultimately causing his arrest and death.