1) The document describes a case study of a child diagnosed with autism and the various treatment modalities used.
2) These included homeopathy, probiotics, speech therapy, and occupational therapy which improved the child's sleep, social skills, and communication.
3) The document discusses effective treatment combinations of allopathy, homeopathy, ayurveda, therapies and emphasizes the need for a multipronged approach tailored to each child's needs.
This document discusses different types of allergies including food allergy, drug allergy, and chemical allergy. Food allergy is an immunologic reaction to specific food proteins with symptoms that can include hives, difficulty breathing, and anaphylaxis. Common food allergens for children are milk, eggs, peanuts, wheat and soy, while for adults it is peanuts, tree nuts, fish and shellfish. Drug allergy is an immunologic response to pharmaceutical agents with risk factors like age, genetics and previous drug reactions. Common causes are antibiotics, aspirin, and chemotherapy. Chemical allergy involves hypersensitivity to chemicals like formaldehyde, pesticides and solvents. Diagnosis is via tests while treatment
This document provides information for school nurses on food allergies, including an overview of common food allergies, signs and symptoms of anaphylaxis, emergency treatment of anaphylaxis with epinephrine, and developing a food allergy action plan and management plan for students with food allergies. It also discusses a case example of a fatal food-induced anaphylaxis and risk factors. The goal is to educate nurses on recognizing and treating allergic reactions and ensuring safe participation of students with food allergies in all school activities.
Clinical features, mechanism of development of cow milk protein allergy.
Diagnostic algorithm and review of available data about cow milk protein allergy.
Ellen Kamhi PhD, RN, AHG, AHN-BC, The Natural Nurse discusses food allergies, histamine release, leaky gut syndrome, testing for leaky gut, natural therapies and herbs for allergies, nettles, quercitin, Vitamin C
The document contains 20 multiple choice nursing questions related to various topics including: total parenteral nutrition, diabetes management, medication administration, wound care, and more. The questions assess understanding of appropriate nursing interventions, assessments, teaching, and rationales. Correct answers are provided along with explanations of the rationale behind each answer.
Case Study.IBCCES Autism Certification ProgramsJean Blosser
This document discusses the International Board of Credentialing and Continuing Education (IBCCES) and their efforts to address the critical shortage of qualified autism professionals. IBCCES aims to build a network of support for individuals with autism by identifying key competencies, making certification accessible to multiple disciplines, and engaging in outreach. The certification programs benefit individual providers, schools, clinical organizations, and the public sector by preparing professionals and validating their expertise in autism. Case studies highlight how specific schools and organizations have partnered with IBCCES to provide training and certification to entire staffs to better serve students and clients with autism.
Sensory processing disorder affects how the brain processes sensory information from the environment. It can cause individuals to be over-responsive or under-responsive to sensory input like touch, sound, and movement. A sensory room is designed to help individuals with SPD by providing controlled sensory activities and equipment tailored to their needs, with the goal of improving their ability to regulate and respond to sensory stimulation.
The document discusses the connections between the immune system, gut, and autism. It suggests that:
1) Autism may be linked to abnormal immune responses and neuroimmune interactions beginning in early development.
2) Factors like genetics, environment, immunology, and neurology are thought to influence autism, and the immune system is connected to the nervous system.
3) Dysregulation of the immune system, especially at mucosal surfaces like the gut, may contribute to conditions like inflammation and permeability issues that could affect brain development and function in autism.
This document discusses different types of allergies including food allergy, drug allergy, and chemical allergy. Food allergy is an immunologic reaction to specific food proteins with symptoms that can include hives, difficulty breathing, and anaphylaxis. Common food allergens for children are milk, eggs, peanuts, wheat and soy, while for adults it is peanuts, tree nuts, fish and shellfish. Drug allergy is an immunologic response to pharmaceutical agents with risk factors like age, genetics and previous drug reactions. Common causes are antibiotics, aspirin, and chemotherapy. Chemical allergy involves hypersensitivity to chemicals like formaldehyde, pesticides and solvents. Diagnosis is via tests while treatment
This document provides information for school nurses on food allergies, including an overview of common food allergies, signs and symptoms of anaphylaxis, emergency treatment of anaphylaxis with epinephrine, and developing a food allergy action plan and management plan for students with food allergies. It also discusses a case example of a fatal food-induced anaphylaxis and risk factors. The goal is to educate nurses on recognizing and treating allergic reactions and ensuring safe participation of students with food allergies in all school activities.
Clinical features, mechanism of development of cow milk protein allergy.
Diagnostic algorithm and review of available data about cow milk protein allergy.
Ellen Kamhi PhD, RN, AHG, AHN-BC, The Natural Nurse discusses food allergies, histamine release, leaky gut syndrome, testing for leaky gut, natural therapies and herbs for allergies, nettles, quercitin, Vitamin C
The document contains 20 multiple choice nursing questions related to various topics including: total parenteral nutrition, diabetes management, medication administration, wound care, and more. The questions assess understanding of appropriate nursing interventions, assessments, teaching, and rationales. Correct answers are provided along with explanations of the rationale behind each answer.
Case Study.IBCCES Autism Certification ProgramsJean Blosser
This document discusses the International Board of Credentialing and Continuing Education (IBCCES) and their efforts to address the critical shortage of qualified autism professionals. IBCCES aims to build a network of support for individuals with autism by identifying key competencies, making certification accessible to multiple disciplines, and engaging in outreach. The certification programs benefit individual providers, schools, clinical organizations, and the public sector by preparing professionals and validating their expertise in autism. Case studies highlight how specific schools and organizations have partnered with IBCCES to provide training and certification to entire staffs to better serve students and clients with autism.
Sensory processing disorder affects how the brain processes sensory information from the environment. It can cause individuals to be over-responsive or under-responsive to sensory input like touch, sound, and movement. A sensory room is designed to help individuals with SPD by providing controlled sensory activities and equipment tailored to their needs, with the goal of improving their ability to regulate and respond to sensory stimulation.
The document discusses the connections between the immune system, gut, and autism. It suggests that:
1) Autism may be linked to abnormal immune responses and neuroimmune interactions beginning in early development.
2) Factors like genetics, environment, immunology, and neurology are thought to influence autism, and the immune system is connected to the nervous system.
3) Dysregulation of the immune system, especially at mucosal surfaces like the gut, may contribute to conditions like inflammation and permeability issues that could affect brain development and function in autism.
البكتريا Bacteria
اعداد مجموعة طلاب قسم الاحياء كلية التربية جامعة دنقلا
اشراف: د: عمر بشارة احمد بشارة
Dr. Omer Bushara Ahmed, University of Dongola, Sudan
This document discusses how gut microbiota can be an etiological factor in Autism Spectrum Disorder (ASD). It describes how early colonization and homeostasis of gut microbiota is important for health. Dysbiosis or imbalance of gut microbiota has been associated with ASD and various dietary and environmental factors can influence the development and composition of gut microbiota in infants and children. The document examines how factors like maternal stress, breastfeeding, diet, and use of probiotics/prebiotics can help manipulate imbalanced gut microbiota and potentially help with symptoms of ASD.
Vitamin D has widespread effects beyond bone health. It acts as a pleiotropic hormone that regulates over 200 genes and has important immunomodulatory properties. Maintaining optimal vitamin D levels may help reduce the risk of infections like tuberculosis and exacerbations of COPD, as well as cancers, cardiovascular disease, fractures and autoimmune disorders. More research is still needed but achieving a serum 25(OH)D level of at least 30 ng/mL through supplementation appears to provide the most benefits.
The document provides an overview of vitamin D, including its history, sources, functions, deficiency, testing, and effects on bones and teeth. Vitamin D is important for calcium absorption and bone mineralization, and deficiency can lead to conditions like rickets and osteomalacia, causing bone deformities and increased risk of fractures. The document discusses various forms of vitamin D, recommended intake levels, biomarkers used to indicate status, laboratory testing methods, and dental considerations related to vitamin D deficiency.
Vitamin A deficiency can lead to several health issues:
1) It can cause night blindness and poor vision due to inflammation of the eye.
2) It suppresses the immune system and increases risk of infections like colds.
3) Severe deficiency can cause xerophthalmia, a dryness of the eye, and keratomalacia, a softening and ulceration of the cornea.
This document from the Pennington Biomedical Research Center provides information on omega-3 fatty acids. It defines omega-3 fatty acids and describes their main types: ALA, EPA, and DHA. Sources of each type are outlined. The roles of DHA in visual development and EPA/DHA in cardiovascular health are summarized. Studies on omega-3's relationships to coronary heart disease, stroke, cancer, diabetes, inflammatory diseases, depression and other conditions are highlighted at a high level.
Sensory integration is a neurological process that allows individuals to make sense of sensations from their body and environment. Sensory integration disorder occurs when this process is not functioning properly, making it difficult for individuals to respond appropriately. Sensory integration therapy aims to stimulate the senses through activities involving movement, touch, sound, and vision to help brains better process sensory information. Research suggests this therapy can help brains of children with sensory integration disorder change and develop through rich sensory experiences.
Vitamin a presentation, Vitamin A Deficiency, Vitamin A toxicityDhruvendra Pandey
This presentation contains Importance of vitamin A, Sources of Vitamin A, Absorption,Transport and Excretion of Vitamin A, Vitamin A Deficiency, Vitamin A Toxicity, Required dose of Vitamin A, Nutrition, Nutrition deficiency
Vitamin A deficiency can cause xerophthalmia, which is a medical condition where the eye fails to produce tears. It is a leading cause of preventable blindness in children worldwide. The document discusses vitamin A's role in vision and other body processes. Populations most at risk for deficiency include children aged 6 months to 6 years, pregnant and lactating women, and those in developing countries or with malabsorption issues. Signs of xerophthalmia include dryness of the eyes, conjunctival spots, and corneal ulceration or keratomalacia in severe cases. Treatment involves high doses of vitamin A supplementation, while prevention focuses on food fortification, nutrition education, and immunization programs.
This document provides an overview of the gut microbiome and how it can become disrupted or "messed up". It discusses the role of ancestral diets and fermented foods in supporting a healthy gut biome. When the gut is compromised, it can lead to issues like small intestinal bacterial overgrowth (SIBO) and leaky gut, which are associated with many chronic health conditions. The document outlines approaches for assessing dysbiosis, eliminating pathogens, and recolonizing the gut with beneficial bacteria in order to restore health.
This document summarizes research on potential biological causes and treatments for autism spectrum disorders and other neurodevelopmental conditions. It discusses findings of intestinal and immune system abnormalities, nutritional deficiencies, toxic metals, and the potential roles of infections, vaccines, and mercury exposure. Treatments addressed include specialized diets, supplements, chelation, and targeting specific biomarkers like ammonia levels and essential fatty acids.
This document summarizes research on potential biological causes and treatments for autism spectrum disorders and other neurodevelopmental conditions. It discusses intestinal and immune system abnormalities, nutritional deficiencies, toxic metals, and the rationale for treating these factors through dietary changes and supplements. Specific treatments mentioned include gluten/casein-free diets, probiotics, sulfur supplements, chelation therapy, and targeting yeast, parasites, and Clostridia overgrowth. Concerns about mercury in vaccines and their relationship to autism prevalence are also outlined.
البكتريا Bacteria
اعداد مجموعة طلاب قسم الاحياء كلية التربية جامعة دنقلا
اشراف: د: عمر بشارة احمد بشارة
Dr. Omer Bushara Ahmed, University of Dongola, Sudan
This document discusses how gut microbiota can be an etiological factor in Autism Spectrum Disorder (ASD). It describes how early colonization and homeostasis of gut microbiota is important for health. Dysbiosis or imbalance of gut microbiota has been associated with ASD and various dietary and environmental factors can influence the development and composition of gut microbiota in infants and children. The document examines how factors like maternal stress, breastfeeding, diet, and use of probiotics/prebiotics can help manipulate imbalanced gut microbiota and potentially help with symptoms of ASD.
Vitamin D has widespread effects beyond bone health. It acts as a pleiotropic hormone that regulates over 200 genes and has important immunomodulatory properties. Maintaining optimal vitamin D levels may help reduce the risk of infections like tuberculosis and exacerbations of COPD, as well as cancers, cardiovascular disease, fractures and autoimmune disorders. More research is still needed but achieving a serum 25(OH)D level of at least 30 ng/mL through supplementation appears to provide the most benefits.
The document provides an overview of vitamin D, including its history, sources, functions, deficiency, testing, and effects on bones and teeth. Vitamin D is important for calcium absorption and bone mineralization, and deficiency can lead to conditions like rickets and osteomalacia, causing bone deformities and increased risk of fractures. The document discusses various forms of vitamin D, recommended intake levels, biomarkers used to indicate status, laboratory testing methods, and dental considerations related to vitamin D deficiency.
Vitamin A deficiency can lead to several health issues:
1) It can cause night blindness and poor vision due to inflammation of the eye.
2) It suppresses the immune system and increases risk of infections like colds.
3) Severe deficiency can cause xerophthalmia, a dryness of the eye, and keratomalacia, a softening and ulceration of the cornea.
This document from the Pennington Biomedical Research Center provides information on omega-3 fatty acids. It defines omega-3 fatty acids and describes their main types: ALA, EPA, and DHA. Sources of each type are outlined. The roles of DHA in visual development and EPA/DHA in cardiovascular health are summarized. Studies on omega-3's relationships to coronary heart disease, stroke, cancer, diabetes, inflammatory diseases, depression and other conditions are highlighted at a high level.
Sensory integration is a neurological process that allows individuals to make sense of sensations from their body and environment. Sensory integration disorder occurs when this process is not functioning properly, making it difficult for individuals to respond appropriately. Sensory integration therapy aims to stimulate the senses through activities involving movement, touch, sound, and vision to help brains better process sensory information. Research suggests this therapy can help brains of children with sensory integration disorder change and develop through rich sensory experiences.
Vitamin a presentation, Vitamin A Deficiency, Vitamin A toxicityDhruvendra Pandey
This presentation contains Importance of vitamin A, Sources of Vitamin A, Absorption,Transport and Excretion of Vitamin A, Vitamin A Deficiency, Vitamin A Toxicity, Required dose of Vitamin A, Nutrition, Nutrition deficiency
Vitamin A deficiency can cause xerophthalmia, which is a medical condition where the eye fails to produce tears. It is a leading cause of preventable blindness in children worldwide. The document discusses vitamin A's role in vision and other body processes. Populations most at risk for deficiency include children aged 6 months to 6 years, pregnant and lactating women, and those in developing countries or with malabsorption issues. Signs of xerophthalmia include dryness of the eyes, conjunctival spots, and corneal ulceration or keratomalacia in severe cases. Treatment involves high doses of vitamin A supplementation, while prevention focuses on food fortification, nutrition education, and immunization programs.
This document provides an overview of the gut microbiome and how it can become disrupted or "messed up". It discusses the role of ancestral diets and fermented foods in supporting a healthy gut biome. When the gut is compromised, it can lead to issues like small intestinal bacterial overgrowth (SIBO) and leaky gut, which are associated with many chronic health conditions. The document outlines approaches for assessing dysbiosis, eliminating pathogens, and recolonizing the gut with beneficial bacteria in order to restore health.
This document summarizes research on potential biological causes and treatments for autism spectrum disorders and other neurodevelopmental conditions. It discusses findings of intestinal and immune system abnormalities, nutritional deficiencies, toxic metals, and the potential roles of infections, vaccines, and mercury exposure. Treatments addressed include specialized diets, supplements, chelation, and targeting specific biomarkers like ammonia levels and essential fatty acids.
This document summarizes research on potential biological causes and treatments for autism spectrum disorders and other neurodevelopmental conditions. It discusses intestinal and immune system abnormalities, nutritional deficiencies, toxic metals, and the rationale for treating these factors through dietary changes and supplements. Specific treatments mentioned include gluten/casein-free diets, probiotics, sulfur supplements, chelation therapy, and targeting yeast, parasites, and Clostridia overgrowth. Concerns about mercury in vaccines and their relationship to autism prevalence are also outlined.
Case Studies (Clinical Pharmacy Assignment)
Case Studies
Case Study 1. Drug Related Problem
Case Study 2. Alcohol Toxicity
Case Study 3. Patient Counseling
Case Study 4. Peptic Ulcer
Case Study 5. Drug and the Newborn
Case Study 6. Night time Anxiety
Case Study 7. Clostridium Difficile
Case Study 8. Epilepsy and Pregnancy
Case Study 9. Parkinsonism
Case Study 10. Treatment May Be Worse Than Condition
Dr. Patrick Garrett is a chiropractor and functional medicine physician specializing in reversing chronic conditions like diabetes, asthma, allergies, eczema, psoriasis, and migraines using lifestyle and dietary interventions. He has over 12 years of experience in functional lifestyle medicine and sees patients from around the world. Dr. Garrett believes that food sensitivities are the cause of most eczema and psoriasis cases. He recommends identifying sensitivities using an IgG food panel and eliminating those foods to cure the conditions naturally long-term by rebuilding the immune system and addressing the gut microbiome.
Alternative approaches to conventional anti epileptic drugs in management of ...Vijay Sardana
The document discusses alternative approaches to conventional antiepileptic drugs for managing pediatric epilepsy. It describes various non-pharmacological options including ketogenic diets, epilepsy surgery, vagus nerve stimulation, lifestyle changes, and complementary/alternative therapies. The ketogenic diet and epilepsy surgery have the strongest evidence bases as effective alternatives for intractable epilepsy or unacceptable side effects from antiepileptic drugs.
Nephrotic syndrome is a kidney disorder that causes protein to leak into the urine and can develop between ages 2 to 6 years. It is characterized by hypoalbuminemia, hyperlipidemia, edema, and massive proteinuria. The most common type is primary nephrotic syndrome, which accounts for about 99% of cases and responds well to immunosuppressive therapy. Management focuses on reducing protein in the urine using corticosteroids as the first line treatment. Nurses play an important role in monitoring the child's condition and fluid balance, preventing infections, administering medications, and providing emotional support.
Allergy is an adverse immune reaction to an allergen, which is normally harmless. Allergies are classified based on the symptoms they produce, such as skin, respiratory, and food allergies. Allergies can be hereditary and exposure to allergens can contribute to their development. Allergens enter the body through the skin, injections, ingestion, or inhalation. Symptoms and treatments depend on the type of allergy. While allergies cannot be prevented, environmental control, medication, immunotherapy, and alternative therapies can help treat and manage symptoms. Probiotics may offer an alternative treatment for allergies by modifying the immune response.
Personalized nutrition takes into account many individual factors like genetics, metabolism, microbiome, lifestyle and more to determine the optimal diet for health and well-being. It aims to manage and prevent chronic diseases through personalized sciences, guidance, and education. A personalized nutrition care model assesses individual data through tests and screens, interprets the results, designs targeted interventions like dietary changes, and monitors outcomes. Nutritional genomics and epigenetics research how genes and environment interact to influence health and disease, helping personalized nutrition better address individual needs.
1. Epilepsy in women can be affected by hormonal changes during menarche, the menstrual cycle, pregnancy, and menopause. Seizure frequency may increase or decrease depending on the phase of the menstrual cycle or pregnancy.
2. Certain antiepileptic drugs can interact with hormonal contraceptives, increasing the risk of contraceptive failure. Changes in weight are also a common side effect of many antiepileptic medications in women.
3. Pregnancy poses risks to both mother and fetus related to seizures and effects of antiepileptic drugs, including an increased risk of malformations, developmental issues, preterm birth, and low birth weight. Careful preconception
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
4--Child health care and preventive pediatrics{4}.pptShamiPokhrel2
This document discusses various feeding problems in infants during the first two years of life, including underfeeding, overfeeding, regurgitation and vomiting, constipation, and feeding during the second year. It provides information on causes and treatments for each issue. For example, it states that underfeeding may be caused by problems with feeding mechanics or bonding, and overfeeding can result from high-fat or high-carbohydrate diets. It also outlines recommendations for healthy eating habits and snacks as infants age.
The vagus nerve plays a key role in modulating inflammation and the immune system. Stimulating the vagus nerve through devices or certain activities can help treat inflammatory conditions like rheumatoid arthritis. Higher vagal tone, measured by heart rate variability during breathing, is associated with better health outcomes including reduced inflammation. The vagus nerve acts as a bidirectional communicator between the gut and the brain, reading signals from the gut microbiome and modulating inflammation. Maintaining a healthy gut microbiome and increasing vagal tone through practices like breathing and cold water can thus promote whole body health and relaxation.
Primary health care aims to make essential health care universally accessible through community-based services. The document outlines several key family health programs in the Philippines, including maternal health, family planning, child health, immunizations, and nutrition. The goals are to improve survival, health, and well-being for family members and reduce morbidity and mortality rates. Services described include antenatal care, immunizations, breastfeeding promotion, and various modern and traditional family planning methods. The health and nutrition of mothers and children are top priorities for primary health care in the Philippines.
This document discusses various topics related to ophthalmic drugs including antibiotics, steroids, and drugs used to treat glaucoma. It provides details on the mechanisms of action, indications, and side effects of different drug classes. It describes commonly used antibiotics like aminoglycosides, macrolides, and quinolones. It also outlines steroid drugs and their anti-inflammatory mechanisms and ocular uses. The document discusses various agents used to lower intraocular pressure in glaucoma including parasympathomimetics, sympathomimetics, alpha-agonists, and beta-blockers.
This document is a newsletter for naturopathic practitioners discussing various topics related to pediatrics. It includes articles on childhood obesity, food allergies and sensitivities, naturopathic support for vaccinations, recommended supplements for children, and herbal and homeopathic options for common childhood conditions. It also features advertisements for pediatric supplement products from a naturopathic company.
The document discusses the Philippine primary health care system and family health programs. It outlines the goals of maternal health, family planning, child health, immunization, and nutrition programs to improve health outcomes. The key objectives are to reduce morbidity and mortality rates and improve survival, health, and well-being of family members.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. A case study
M a 3rd
child born to an upper middle class urban family of non
consanguinous parents
He was alright except for persistent allergic symptoms- allergic rhinitis ,
Otitis media, ET tube catarrh etc . He was administerd 3 or 4 courses
of antibiotics
He faced intense sibling rivalry from his sister who wanted attention so
that he was mostly kept in front of Television with poopy ,manjady etc
At 9 months he began to call Umma clearly.
His father being a paediatrician gave him MMR instead of the usual
measles at 9 m.
In that month he developed HFMD which got aggravated with
amoxyclav.
Within 2 weeks he developed diarrhoea which was prolonged with
slight foul smel which subsided only with folic acid
After this he gradually regressed to moderate to severe autism .
3. Course
His father diagnosed him as autism by 1.5 yrs. By that time 2nd
dose of MMR was
also taken
He had no sensitivity to milk products in particular. He was given lactogen , Anchor
etc
Gradually problems came with irritability, Sleepless nights , crying without reason,
abdominal colic etc
By Gods grace his mother detected an expert homeo specialising only on autism in
mumbai who was consulted & medicines began
With the starting of homeo med Sleep became normal, allergies subsided, irritability
decreased
With the starting of probiotics along with homeo & sending to nearby playschool
eye contact improved considerably & socialization improved
But the main problem was lack of adequate therapist in trivandrum. Hence had to
be shifted to ernakulam where a combined speech+behavioural + Occupational
therapy was began.
Now he is improving .GRADUALLY, COMPREHENSION HAS COME . Vocalizing
single words. Beginning interactive play. He is being administered Vit D &
sunshine as addl treatment.
6. Related Therapies
Speech therapy
Behavioural therapy
Occupational Therapy
Sensory integration therapy
Music Therapy
Berhard Auditory integration training
Chelation Therapy
Aquatic therapy
7. Alternative therapy
Allergy desensitization
Pet therapy
Art therapy
Lowaas Method-ABA
Anthrosophical Camphill T
Drama therapy
Dance / Movement therapy
Specific carbohydrate diet
Helminthic therapy
Floortime Therapy
8. Relationship development intervention
Kaufman speech to language protocol
Transcranial magnetic stimulation
HANDLE-
Homotoxicology
Enzyme based therapy
Integrated Play groups model
Tecnology based interventions
9. Principles
A multipronged approach is definitely needed
One single therapy is not superior to other. Each has its advantages
& disadvantages
Moreover all children do not respond similarly to the same therapy
or drug.
Allopathic practitioners should let go of their Ego when treating
children as there is no known definite cure for autism till now
There are recently 3 potential cures which are in preclinical &
clinical trials.
No miracle cure but Hard work & persistence yields results
While allowing alternative or complementary medicine we should
also protect our patients from potentially harmful therapies like
chelation therapy, unnecessary use of risperidone etc
10. COMBOs
Ideal is a combination of
Allopathy + Homeopathy + Therapies
Allopathy+ Ayurveda+ Therapies
Therapies mean either Applied behavioural
analysis done for 6 hours a day by therapist
+ mother
OR
Speech therapy+Behavioural +Occupational
therapy
11. Pharmacotherapy
Megavitamin Therapy
Vitamin C 500mg once daily for 1 month followed by thrice
weekly for 1 year
Folinic acid trial – calcium folinate(Leukovorin) daily for 1
month- If there is dramatic response continue, otherwise switch
to plain folic acid & continue
Pyridoxine 25-40mg daily for 6 months . Give a break of 1
month & continue another 6 months
Change over from polished rice to Chamba rice to get
adequate thiamine. Bitter
Methyl cobalamin 500-2000 microgram daily for 1 year
12. Probiotics
The bacterial strains most useful are Lactobacillus &
Bifidobacterium species which bring balance to the microbiome
of intestine
They produce an acidic environment unfavourable to the
growth of clostridia which produce several neurotoxins
The worsening of autistic symptoms when given antibiotics is
due to the clostridial 7 candidal overgrowth
Certain toxins elaborated by candida have structure similar to
LSD
The ideal combination would be a combination of 4 bacteria
which is given by Darolac+Prowell daily
13. GFCF diet
Gluten free Casein free diet
That is avoidance of all milk & related products & also all wheat
& maida related products
This is because the there is Leaky inflammed gut in Autism
colonized by pathologic bacteria due to antibiotic use
These will degrade milk protein casein into toxic peptides which
cause neurotoxicity
Regarding gluten everyone knows the intestinal & neural
damage it cause In coeliac disease . Leaky gut leads high
chance of anti gliadin & antineuronal antibody formation
14. Mitiochondrial Boosters
In many cases of autism it is seen that there is a mitochondrial
dysfunction to varying degrees
This is shown by the elevated Lactate & Ammonia levels
Mitochondrial dysfunction can contribute to intellectual
,Behavioural, speech disturbances
Moreover many autistic & epileptic children may harbour IEMs like
urea cycle disorders
The cocktail that is useful is a combo of
Thiamine+ Carnitine+ Coenzyme Q10+ Riboflavin which is
available individually & in combinations.
Palatabilty is a problem with certain preparations. Hence alternate
day treatment is best eg HiQ plus, Calco Q,etc
15. Instead of giving seperately a combination of folic
acid , methylcobalamin, & pyridoxal phosphate is
available called tetrafol plus ,or folvite MP etc
Another point is you can powder 3
neurovitamins,VitaminC & biotin together in
ayurvedic bowl & dissolve it in half glass water to
which Probiotic mixture can be added.
This will convert 5 drugs to a single decoction which
is tasty due to orange flavour of vitaminC
16. Ca –Mg therapy
High dose magnesium has been useful in certain
children with Autism
This can be given using a calcium magnesium syrup
containing higher magnesium concentration or
preparation like magvion 600
Similar Mag-C is a drug used by homeopaths in
improving core symptoms of autism.
Magnesium has roles in brain energy metabolism ,
formation & regulation of neurotransmitters ,
antiepileptic effect & also synaptogenesis.
17. DMG,Super neu thera, Neuroprotek, L-
Glutathione
These are neutraceutical preparations used world over for the relief of
core features of autism
DMG- dimethyl glycine a normal metabolite in high doses has been
found useful by many mothers in reversing certain features
Neuroprotek is a Quercetin containing preparation usseful in
neuroprotection & relief
L glutathione acts in reducing oxidative damage to brain caused by
free radicals & brain inflammation in autism
Glutathione also inactivates heavy metals in brain . So has almost the
same effect of chelation
VitaminD deficiency leads to reduced glutathione in brain by genetic
mechanisms
Many of these are imported from outside via Kirkman labs, ebay or
Akhil health solutions bombay.
18. Biofilm protocol
This concept is that neurotoxic or pathogenic
bacteria in gut form Biofilms in gut which are self
reliant apartment complexes of bacteria with
channels for circulation of nutrients
These biofilms are unapproachable to antibiotics &
hence these bacteria freely produce neurotoxins
which pass to the brain via the leaky gut producing
sustained brain inflammation
Biofilm protocol aims at using Kaolin, Activated
charcoal &, purgatives & locally acting antibiotics to
destroy these biofilms so that the child recovers from
autism.
19. Vancomycin & IVIG
Vancomycin when administered orally is not absorbed &
selectively decimates the clostridial bcteria thus freein gut –
Brain system from neuro toxins
Studies have shown that a 4-6 week oral course was capabl eo
producing much improvement in all parameters but many cases
regressed back within next 3 months
The same situation holds good for IVIG with difference that it is
given as 400mg/kg every month over 6 months
It was especially found useful in OCD & tics of PANDAS
20. Antifungal treatment
The mechanism is that in autistic children there is a
higher incidence of candida infections of skin & gut
due to 2 reasons
Reduced local gut immunity, reduced macrophage
function & use of antibiotics
Hence it is advised that Fluconazole given for 2
weeks to 3 months is able to eliminate candida &
produce remarkable improvement
Because of risk of hepatotoxicity I give a 14 day
course of 5mg/kg once daily every 2 months .
21. Vitamin D & Autism
A growing body of literature suggests that higher serum 25-hydroxyvitamin
D [25(OH)D] concentrations, either in utero or in early life, may reduce the
risk of autism.
VitaminD Deficiency & inadequate sunlight exposure in the mothers
are risk factors for Autism & speech delay in children
The critical periods are after 6 months of pregnancy & the period of rapid
brain growth & synaptogenesis ie 1st
2 yrs
In a recent study, children with autism had lower serum 25(OH)D
concentrations than did control subjects (19 vs. 33 ng/ml), despite parents
of each group reporting the same amount of sun exposure.
The same study found highly significant inverse correlations between
25(OH)D and autism rating scales and between 25(OH)D and levels of an
antineuronal antibody.
This finding indicates that higher serum 25(OH)D concentrations may
reduce the symptoms of established autism.
22. Mechanism
Calcitriol acts as a molecular switch activating many target genes via
the vitaminD receptor(VDR)
Most organs in the body show evidence of end organ responsiveness
to calcitriol including multiple brain areas
Because activated vitamin D, a secosteroid, upregulates DNA-repair
genes, vitamin D deficiency during development may inhibit the repair
of de novo DNA mutations in fetuses and infants and thus contribute to
risk of autism.
Vitamin D might also reduce the risk or severity of autism through its
Anti-inflammatory actions, Antioxidant, Antiautoimmune effects,
increasing seizure threshold, increasing T-regulatory cells, protecting
the mitochondria, etc
It is seen that in Autism the normal Immunity ie both cellular , humoral
& macrophage mediated immunity is reduced while abnormal immunity
ie Atopy ,autoimmune antibodies etc are increased
23. Vitamin D & Autism
Quantitative genetic variations (not qualitative mutations ) in
some facets of VitaminD metabolism such as VDR or the
enzyme activating VitD may explain the heritability of autism
The mechanism is similar to the schnatz study which found a
strong negative association between the number of VDR in
coronaries & Atherosclerosis
Suppose a child who inherits a smaller number of VDR in brain,
if his mother avoids sunlight & does not take fish & the child
also does not get adequate VitD from weaning foods.( 200ml
cow milk provides only 100 iu of D).
24. Genetic aspect
The low VitD level will interact with the low number of
VDR to produce or allow brain injury Autism
susceptibility by DNA damage, mitochondrial damage &
oxidative damage
Remember that > 95% of indian population are deficient
in VitaminD ie famine in the midst of plenty
In USA the incidence has risen 10 fold over last 7 yrs
after women were directed by AMA to avoid sunlight &
outdoor activity to avoid skin cancer.
25. De novo mutations – cause/effect?
You may well have a genetic disease that you did not inherit
One may develop de novo genetic mutation such as those
seen in Autism & schizophrenia while you were living
The MC finding in Autism is multiple small genetic de novo
mutations
Correlate this with the fact that there are at least 5 Vitamin D
dependant genes which code for DNA repair proteins whose
only job is to fix mutated DNA
Thus the widespread point mutations seen in Autism could be
the effect rather than the cause ie VitD (d) is the FATHER of
both Autism susceptibility & these denovo mutations
26. DNA Repair –Genomic Guard
Calcitriol protects cells by upregulating DNA repair
genes which even repair double stranded breaks
In a recent RCT in humans a small dose of 800iu
VitD reduced the level of 8-OHdG a marker of
Oxidative DNA damage by 25%
In another RCT VitD significantly increased levels of
Bax which helps stop mutations by promoting
apoptosis
VitD also regulates the activity of PARP another fast
acting DNA repair enzyme
27. Prevention of DNA damage
Chatterjee etal reports that VitD protects cell
membranes, cell proteins & DNA against oxidative
damage
It stabilizes the chromosomee structure & prevents
double stranded breaks-
Hence VitD def is associated with DNA damage due
to various cellular stresses & obtaining adequate
VitD is imp in preventing DNA damage
Adequate VITD is that found in hunter gatherers in
the equatorial regions (50ng/ml) rather than that
found in Polar region indoor workers (20ng/ml)
28. Antioxidants
It also upregulates gamma glutamyl transpeptidase
which is the rate limiting step in glutathione
synthesis
Glutathione scavenges oxidative by-products and
chelates (captures and excretes) heavy metals like
Iron ,Zinc & mercury.
Glutathione thus protects nerve cells & nerve
conduction
VitD also upregulates Superoxide dismutase &
Thioredoxin reductase which protects mitochondria
from oxidative damage.
29. Allergy
Vitamin D deficiency during pregnancy and
childhood is a widespread and growing epidemic.
Maternal & childhood vitamin D deficiency is an
important risk factor for Allergic diathesis & Asthma.
It is seen that most of the autistic children have
Allergy which causes rec infn Antibiotic use
worsens autism
So here also Vit D def is the father of both allergy &
brain dysfunction in autistic children
Hence in Asthma & atopies it is best to correct Vit D
deficiency & keep levels above 40
30. Antinflammatory action
Overall effect of VitD is to serve as an Immunomodulator or
regulator which reduces inflammation while enhancing
protective immune responses
Calcitriol modulates various immune cells including Monocytes,
macrophages, dendritic cells T &B lymphocytes
Proinflammatory chemokines such as MCP-1 & TNF-Alpha are
consistently elevated in autism
Supplementation with VitD consistently & markedly reduced
both
Calcitriol inhibits the synthesis & actions of proinflam PGs
which are elevated in autism
It inhibits NF-Kb activity which causes inflammation & aberrant
signalling in autuistic brains.
31. Serotonin metabolism
Recent research shows that VitD upregulates the genetic
expression of Tryptophan Hydroxylase-2 in brain &
downregulates Tryptophan hydroxylase-1 in peripheral tissues
like Resp tract, GIT etc
This leads to increased serotonin in brain leading to positive
effects on behaviour ,mood,sleep, Emotions etc
Remember that in autism there is very low serotonin in CNS
while blood levels of serotonin are high(paradox)
VitD suppresses peripheral serotonin levels leading to reduced
inflammation , Resp Allergy ,reduced GI Inflammation & leaky
gut
Just remember carcinoid syndrome where there is inflammation
& allergy in the GI & resp tracts
32. Auto immunity in Autism
Autism is one of the 160 autoimmune diseases in that
Antibodies to brain are seen & their levels correlate with autism
severity
Most AUTO ID so far studied are somehow involved with VitD
def & large body of multi subject evidence indicates that the
VitaminD ssteroid system helps to establish & manintain
immunological tolerance
In animal models of these diseases Vit D supplementation
produces therapeutic effects
A recent human study inversely correlated Anti Myelin
asociated glycoprotein antibody levels with 25OH D levels
33. Researchers in China administered 1.5 lakh vitamin D per
month for 2 months along with daily supplements of 400 iu to
an severe autistic child who dramatically improved in all core
features.
This report appeared in AAP-pediatrics, Dec 2014.Further long
term trials are needed in this direction.
Autism speaks is closely supporting research in this direction
Vitamin D also upregulates synthesis of Vasopressin &
oxytocin which are imp in behaviour & emotions.
34. GcMAF
A sharjah boy of 4 yrs recovered completely from autistic
features & integrated with normal children over a period of 6
months in 2013 on being given GcMAF injection once weekly
for 24 weeks. Dr.Bariah Dardaari is treating doctor.
Gc protein is the carrier protein of vitamin D in blood
Activated macrophages are important both in brain organisation
& anticancer surveillance
GcMAF is used in preclinical trial of autism & clinical trials of
Anticancer treatment & has yielded beneficial effects.
VitaminD receptors are seen in Brain, macrophages,
lymphocytes,Spermatogonia among others.
35. Seizures & VitaminD
In a recent open study 8 out of 13 seizure
patients were extremely vitamin D deficient &
all 13 were given 40000-2 lakh units stat
dose foll by 2000 units per day for 3 months .
This reduced seizures by 40% . One pt no of
seizures dropped from 450 to 30.
So VitaminD def in all seizure patients should
be corrected incl autism withseizures
36. T reg cells & neurotrophins
Treg are suppressor T cells which calm the immune
system & maintain ntolerance to self & arecent
study demonstrated their def in 74% of Autism
patients.
VitaminD increased Treg from 4.8% to 5.9 over 1
months when administerds a total 3 lakhs vit d in 2
portions 4 weeks apart
Neurotrophins like NGF,GDNF induce the devpt ,
function & survival of brain & nerve cells & Vit D
upregulates them by 5 fold
So could this repair the damaged brain in autism?
37. Diabetes ,obesity & vitaminD
Diabetes is more common in autistic children
In astudy of 85 autistic children Insulin resistance
was 7 fold higher in those with Vitd level below 10
when compared with levels above 30
Another famous prospective study showed that
VitaminD suppl in 1st
year reduced the risk of Type 1
diabetes significantly
In adults it is well proven that Vit D increases insulin
sensitivity by 40%
Also Vit D increases adiponectin levels which
inverselrsel asdd with obesity
38. Psychoactive drugs in Autism
FDA approved drug is Risperidone which is used for various
autistic features like hyperactivity,self injury, iritability, poor
sleep , stereotypies etc
Naltrexone has been used in very low dose 3mg for
stereotypies & aggression in autism
Atomoxetine hs been effective in some but not all patients with
ADHD co with autism
Melatonin is a safe Hypnotic for insomnia & normalisation of
circadian rhythm in autism.
Piracetam has 2 uses in autism. It reduces irritability & also
has stimulant action on language circuitry. Action not always
consistent.
39. AAP- PAEDIATRICS
In their report, autism specialists at China’s First Hospital of Jilin
University describe a toddler they diagnosed at 32 months with
autism spectrum disorder (ASD).
They describe how the boy did not respond to his name or
instructions and spoke only a few isolated words. He didn’t play with
toys, but instead compulsively smelled objects and shredded paper.
He ran in circles “endlessly” and suffered from tantrums that
involved head banging.
Blood tests showed that the boy had borderline low blood levels of
vitamin D (12.5 ng/mL). The doctors administered a monthly
injection of vitamin D3 (150,000 IU) and prescribed a daily oral
supplement (400 IU).
40. Improvement
After two months, the boy’s vitamin D blood levels had risen to
81.2 ng/mL, and his parents were reporting clear
improvements.
The boy had stopped running in circles and banging his head.
He was responding to his name, playing with toys and asking
his parents to hold him in their arms. Re-evaluation with a
diagnostic checklist likewise showed significant improvements
in all areas of core autism symptoms.
“It is important to note that this single case observation cannot
be generalized to all patients with ASD,” the doctors write. “It is
hoped that this case report will encourage researchers to
conduct further long-term controlled clinical trials.”
41. Autism with epilepsy
Always be on the look out for underlying IEM in this situation as a
significant proportion has IEM
Iems commonly seen are Urea cycle D,Mitochondrial D, Cerebral
folate d
Biotin pyridoxine & carnitine metabolism Defects
Epilepsy may be refractory to AEDs if these are not treated.
Mitochondrial dysfunction in autism is seen in both nervous system
& immune system.
The development of CNS & immune system occur in parallel &Vit D
is imp to both
An increased vulnerability to oxidative stress is responsible for the
mitochondrial dysfuncytion in autism.
VitaminD upregulates expression of antioxidants like glutathione &
also DNA repair genes.
42. Egyptian study
Objective: The aim of this study was to investigate the potential role of
vitamin D in autism through serum levelassessment.
Design: This was a case-controlled cross-sectional study.
Results: Children with autism had significantly lower 25(OH)D
( p<0.00001) and 1,25(OH)2D (p<0.005) as well as lower calcium
( p<0.0001) serum values than the controls.
A significant positive correlation was obtainedbetween 25(OH)D and
calcium (correlation coefficient r¼0.309, p<0.01) within the children
with autism. No significant difference was found on comparison of birth
month and season of birth between children with autism and healthy
controls.
Furthermore, associations linking parental consanguinity or convulsions
with vitamin Dcould not be established.
Conclusions: Serum values of 25(OH)D in the children with autism of
this study could classify them as being
‘‘vitamin D inadequate,’’ which lends support to the hypothesis that
autism is a vitamin D deficiency disorder.
43. References
Pubmed
Autism asociations
Vitamind council
NIH
Cutting edge therapies in Autism 2011-2012
by Ken siri & Tony lyons
My experiences with Autism
44.
45. THANK YOU & God bless all of us in our
fight against Autism & Cancer