Vitamin B6, also known as pyridoxine, is important for many metabolic processes in the body. It acts as a coenzyme in reactions involving transamination, deamination, and decarboxylation. A lack of vitamin B6 can lead to abnormal growth, anemia, high blood pressure, dermatitis, and pellagra. Risk factors for vitamin B6 deficiency include a low vitamin intake, pregnancy, alcohol or smoking, older age, antibiotic use, and diabetes.

1. Vit B6
PYRIDOXINE
Rat antidematitis

2. Pyridoxine & pyridoxol (PN)
Pyridoxal (PL)
caaPyridoxamine (PM)
STRUCTURE

4. Pyridoxal
phosphate

5. PYRIDOXINE [B6]

6. Phosphorate •Intestine
alkaline
Deposohated •In blood
Phosphorate
Deposohated
In live by
kinase
In bloodPl PLP
Pyridoxine kinase
Alkaline phosphatase

7. Sensitive to high temperature

8. Transamination
Deamination
Decarboxylation
Desulfuration
Production of Niacin
Glycogenolysis
Healthy skin
Healthy mucous
membrane
Metabolism and
formation RBCs
In nervous and immune
system
Maintain blood glucose
level
Convert blood
carbohydrate to glycose

9. Reaction
type Example
Deamination Serine → pyruvate + NH3
Threonine → propionic acid + NH3
Decarboxylation glutamic → ϒ amino butyric acid (GABA)
-amino ẞ-keto adipic → ϒ amino levulonic acid
desulfuration cysteine → pyruvic acid
‫عليه‬ ‫السهم‬plp

10. Abnormal growth
Anemia
High blood pressure
Dermatitis
Pellagra
Vomition of early
progenance

11. Low vitamin intake
Pregnancy
Alcoholics & smoker
Older people
Antibiotic
Diabetes

12. For kidney stone
Improve CNS
Vomition during pregnancy

13. Vit B7(biotin )
Vit h
Coenzyme r
Growth factor
Anti egg white injury factor

14. Heterocyclic sulfur
Consist of imidazole ring + thiophene ring

15. It is widely
distributed in the
foods
Liver, kidney,
vegetables and egg
yolk are important
source
Biotin also
synthesized by
intestinal bacteria
Chocolate
Royal jelly
Yeast
Mushrooms
BIOTIN - SOURCES

16. BIOTIN - FUNCTIONS
Cell growth
Hair & skin &
mucous membrane
Co2 fixation
Production of fatty
acid
Maintains of blood
sugar level
Acetyl coA → methyl coA → in synthesis of fatty acid
Propionyl COA → methyl malonl COA
Acetyl co carboxylase
Propionyl COA carboxylase

17. BIOTIN DEFICIENCY
1) Hair loss
2) Muscle pains
3) Dermatitis
4) Vomition

18. CAUSES
• Smoking
• Poor diet
• Kidney failure
• Older people
• Antibiotic
• Diabetes illness