VITAMIN B6 [MEDICINAL CHEMISTRY] BY P.RAVISANKAR. SOURCES,STRUCTURES OF PYRIDOXINE,PYRIDOXAL,PYRIDOXAMINE,DEFICIENCY OF VITAMIN B6,PYRIDOXINE ANTAGONISTS, METABOLISM,PHYSIOGICAL IMPORTANCE,SYNTHESIS OF PYRIDOXALAND PYRIDOXAMINE,VITAMIN B6 USES.
this presentation is about Vitamin B6 which include structure , biochemical function , biochemical reaction, effect of deficiency of vitamin B6, Toxicity and function of Vitamin B6.
VITAMINB2[RIBOFLAVIN] MEDICINAL CHEMISTRY,BY P.RAVISANKAR [SOURCES OF VITAMI...Dr. Ravi Sankar
VITAMINB2[RIBOFLAVIN] MEDICINAL CHEMISTRY,BY P.RAVISANKAR [SOURCES OF VITAMIN B2,CHEMISTRY OF VITAMIN B2,PHYSIOLOGICAL IMPORTANCE,SYNTHESIS OF RIBOFLAVIN,REACTIONS, VITAMIN B2 DEFICIENCY SYMPTOMS,FUNCTIONS,USES OF RIBOFLAVIN.
BY P.RAVISANKAR,VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR, ANDHRA PRADESH, INDIA.
VITAMIN B1 [THIAMINE] MEDICINAL CHEMISTRY BY P. RAVISANKAR [ SOURCE, STRUCTUR...Dr. Ravi Sankar
VITAMIN B1 [THIAMINE] MEDICINAL CHEMISTRY BY P. RAVISANKAR [ SOURCE, STRUCTURES AND CHEMISTRY OF VITAMIN B1, HYSTORY OF VITAMIN B1, SOURCES OF VITAMIN B1, RDA, PHYSIOLOGICAL IMPORTANCE(ROLE) OF VITAMIN B1, SYNTHESIS OF VITAMIN B1, OXIDATION OF THIAMINE TO THIOCROME, THERAPEUTIC USES ,DEFICIENCY OF VITAMIN B1.
BY P.RAVISANKAR
VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR, A.P, INDIA.
Water soluble vitamin pyridoxine (vitamin B6) introduction, Chemistry of vitamin B6, Biochemical role of vitamin B6, active form of vitamin B 6 (pyridoxal phosphate) synthesis and their role, Recommended dietary allowance of vitamin B6, Dietary sources of vitamin B 6, Deficiency symptoms of Vitamin B6.
Vitamine B1 Thaimine Pyrophosphate ,Types of cofactors ,Co enzymes, The functional role of Co enzymes is to act as transporters of chemical group, Chemistry,
Co enzyme: thiamine Pyrophosphate
this presentation is about Vitamin B6 which include structure , biochemical function , biochemical reaction, effect of deficiency of vitamin B6, Toxicity and function of Vitamin B6.
VITAMINB2[RIBOFLAVIN] MEDICINAL CHEMISTRY,BY P.RAVISANKAR [SOURCES OF VITAMI...Dr. Ravi Sankar
VITAMINB2[RIBOFLAVIN] MEDICINAL CHEMISTRY,BY P.RAVISANKAR [SOURCES OF VITAMIN B2,CHEMISTRY OF VITAMIN B2,PHYSIOLOGICAL IMPORTANCE,SYNTHESIS OF RIBOFLAVIN,REACTIONS, VITAMIN B2 DEFICIENCY SYMPTOMS,FUNCTIONS,USES OF RIBOFLAVIN.
BY P.RAVISANKAR,VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR, ANDHRA PRADESH, INDIA.
VITAMIN B1 [THIAMINE] MEDICINAL CHEMISTRY BY P. RAVISANKAR [ SOURCE, STRUCTUR...Dr. Ravi Sankar
VITAMIN B1 [THIAMINE] MEDICINAL CHEMISTRY BY P. RAVISANKAR [ SOURCE, STRUCTURES AND CHEMISTRY OF VITAMIN B1, HYSTORY OF VITAMIN B1, SOURCES OF VITAMIN B1, RDA, PHYSIOLOGICAL IMPORTANCE(ROLE) OF VITAMIN B1, SYNTHESIS OF VITAMIN B1, OXIDATION OF THIAMINE TO THIOCROME, THERAPEUTIC USES ,DEFICIENCY OF VITAMIN B1.
BY P.RAVISANKAR
VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR, A.P, INDIA.
Water soluble vitamin pyridoxine (vitamin B6) introduction, Chemistry of vitamin B6, Biochemical role of vitamin B6, active form of vitamin B 6 (pyridoxal phosphate) synthesis and their role, Recommended dietary allowance of vitamin B6, Dietary sources of vitamin B 6, Deficiency symptoms of Vitamin B6.
Vitamine B1 Thaimine Pyrophosphate ,Types of cofactors ,Co enzymes, The functional role of Co enzymes is to act as transporters of chemical group, Chemistry,
Co enzyme: thiamine Pyrophosphate
ALL ABOUT VITAMINS VITAMIN B6, B7, B12 AND FOLIC ACIDSKYFALL
Vitamins are nutrients which are required in micro grams.They are essential for normal function of the body.They act as cofactors and prosthetic groups for enzymes
PYRIDOXINE INDUCED PERIPHERAL NEUROPATHY A DETAILED REVIEW.PARUL UNIVERSITY
Vitamin B6 a water-soluble vitamin, also known as pyridoxine that the body needs for several important
functions. It is significant to protein, fat, and carbohydrate metabolism and the creation of red blood cells and
neurotransmitters. Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid
metabolism. It is also recommended as a co-factor to improve the conversion of glyoxylic acid into glycine in
ethylene glycol poisoning. Pyridoxine is active in its phosphorylated form of pyridoxal-5-phosphate. Peripheral
neuropathy refers to the conditions that result when nerves that carry messages to and from the brain and spinal
cord from and to the rest of the body are damaged or diseased. Although the family of B vitamins is often nontoxic, high doses of pyridoxine cause peripheral sensory nerve damage. There are some case reports of sensory
neuropathies at doses of less than 500 mg per day in patients taking supplements for months. However, none of
the studies had sensory nerve damage at daily intake below 200 mg pyridoxine per day.Thus, intake of doses
greater than 100-300mg/d or even 50 mg/d used for longer than 6 months would be deemed harmful.
ALL ABOUT VITAMINS VITAMIN B6, B7, B12 AND FOLIC ACIDSKYFALL
Vitamins are nutrients which are required in micro grams.They are essential for normal function of the body.They act as cofactors and prosthetic groups for enzymes
Similar to VITAMIN B6 [MEDICINAL CHEMISTRY] BY P.RAVISANKAR. SOURCES,STRUCTURES OF PYRIDOXINE,PYRIDOXAL,PYRIDOXAMINE,DEFICIENCY OF VITAMIN B6,PYRIDOXINE ANTAGONISTS, METABOLISM,PHYSIOGICAL IMPORTANCE,SYNTHESIS OF PYRIDOXALAND PYRIDOXAMINE,VITAMIN B6 USES.
PYRIDOXINE INDUCED PERIPHERAL NEUROPATHY A DETAILED REVIEW.PARUL UNIVERSITY
Vitamin B6 a water-soluble vitamin, also known as pyridoxine that the body needs for several important
functions. It is significant to protein, fat, and carbohydrate metabolism and the creation of red blood cells and
neurotransmitters. Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid
metabolism. It is also recommended as a co-factor to improve the conversion of glyoxylic acid into glycine in
ethylene glycol poisoning. Pyridoxine is active in its phosphorylated form of pyridoxal-5-phosphate. Peripheral
neuropathy refers to the conditions that result when nerves that carry messages to and from the brain and spinal
cord from and to the rest of the body are damaged or diseased. Although the family of B vitamins is often nontoxic, high doses of pyridoxine cause peripheral sensory nerve damage. There are some case reports of sensory
neuropathies at doses of less than 500 mg per day in patients taking supplements for months. However, none of
the studies had sensory nerve damage at daily intake below 200 mg pyridoxine per day.Thus, intake of doses
greater than 100-300mg/d or even 50 mg/d used for longer than 6 months would be deemed harmful.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the vitamins and there deficiencies.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
Similar to VITAMIN B6 [MEDICINAL CHEMISTRY] BY P.RAVISANKAR. SOURCES,STRUCTURES OF PYRIDOXINE,PYRIDOXAL,PYRIDOXAMINE,DEFICIENCY OF VITAMIN B6,PYRIDOXINE ANTAGONISTS, METABOLISM,PHYSIOGICAL IMPORTANCE,SYNTHESIS OF PYRIDOXALAND PYRIDOXAMINE,VITAMIN B6 USES. (20)
002. Cephalosporins for students 2023 Prof. P. Ravisankar.pdfDr. Ravi Sankar
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1a. Prof. P. Ravisankar, Vignan Pharmacy College, Vadlamudi, Guntur, AP., Ind...Dr. Ravi Sankar
Antibiotics, characteristics of an antibiotic, Brief historical background of antibiotics, Modern History of antibiotics, Classification of antibiotics, four groups of beta-lactam antibiotics, Classification of Penicillins, Penicillinase resistant Penicillins, Narrow spectrum anti-staphylococcal Penicillins, Amino Penicillins, Nomenclature of Penicillins, Stereochemistry of Penicillins, Hydrolysis of Penicillins, SAR of Penicillins, Mechanism of Penicillins, Beta-lactamase inhibitors, Therapeutic uses of Penicillins, Penicillin advantages, and disadvantages, Hypersensitivity or allergic reactions of Penicillins.
Tetracyclines are Octahydro napthacene derivatives which are bacteriostatic potent broad spectrum antibiotics and are the most widely prescribed form of antibiotic after penicillins.
TETRA means = four
CYCL means = hydrocarbon rings
INE means = derivation.
Tetracyclines are introduced 50 years ago as potent broad spectrum antibiotics.
They are biosynthesized form acetic acid and propionic acid units in microorganisms.
Finally, one of the best ways of reducing cancer is …..
Cancer prevention is an essential component of all cancer control plans because about 40 % of cancers are preventable.
Firstly…Public education campaigns are important in highlighting the dangers of smoking because possibly as many as 22 % (in the UK 30%) of cancers are caused by smoking.
Secondly, another 30% of cancers are diet-related. Decades of research have clearly shown that by living a healthy life, people can reduce the risk of developing the disease.
Screening tests help in finding Cancer earlier before developing any symptoms.
The benefits of eating high-fiber foods, fruit, and vegetables.
Epigallocatechin gallate, an antioxidant present in green tea, is another potential protective agent.
Finally, The new research funded by the UK and USA which aims to show the number of cancer cases could be prevented by known lifestyle and environmental factors,
like being a non-smoker, keeping a healthy weight, drinking less alcohol, eating a healthy balanced diet, and avoiding being exposed to certain infections or radiation.
Every country, regardless of resource level, can take steps to curb the cancer epidemic, save lives and prevent unnecessary suffering.
Finally, cancer prevention efforts should be preceded by a systematic planning process on cancer control.
Antibiotics definition, Early and modern history, classification of antibiotics, Mechanism of antibacterial action, bacterial cell and drug targets, penicillins nomenclature, degradation reactions of penicillins, medical classification of penicillins, SAR of penicillins, Mechanism of penicillins, Betalactamase inhibitors, Therapeutic uses of penicillins, toxicity of penicillins, Side effects of penicillins.
NOVEL SEPARATION AND QUANTITATIVE DETERMINATION OF LEVOFLOXACIN, PRULIFLOXACI...Dr. Ravi Sankar
The core AIM of the present study is to develop a novel, rapid, precise and accurate RP-HPLC method for simultaneous separation and quantification of six fluoroquinolones OF LEVOFLOXACIN (LEVO), PRULIFLOXACIN (PRFX), GATIFLOXACIN (GATI), SPARFLOXACIN (SPAR), MOXIFLOXAXIN (MOXI) AND BALOFLOXACIN (BALO) for the the day to day analysis.
The author felt that a novel single method for separation and quantification of all the above said drugs on single chromatographic system without any minor changes in detection wavelength and mobile phase composition.
To develop rapid, sensitive and economical analytical method based on HPLC for separation and estimation of six fluoroquinolones pharmaceutical dosage forms.
To develop method with shorter run time and better sensitivity.
Reducing the solvent consumption to make it more eco-friendly.
Avoid the column damage by minimizing the buffer strength and pH of mobile phase than reported methods.
To validate the method for different parameters like Accuracy, Precision, Linearity, specificity, Robustness International Conference on Harmonization ICH Q2(R1) guidelines..
To apply the developed RP-HPLC method in the analysis of pharmaceutical formulations.
Analytical method development and validation of novel Levofloxacin, Pruliflox...Dr. Ravi Sankar
For the first time simple, selective, sensitive RP-HPLC method was developed for the separation and quantitative development of LEVO, PRFX, GATI, SPAR, MOXI and BALO relating to fluoroquinolone anti bacterials in pharmaceutical dosage forms. The most important advantage of developed method was that the 6 separate drugs can be determined on a single chromatographic system without modifications in detection wavelength and mobile phase by RP-HPLC. The chromatographic separation of the selected drugs was carried out on Welchrom C18 column consisting of 250 mm X 4.6 mm, 5 µm particle size utilizing mixture of 10 mM phosphate buffer (pH 3.1): Acetonitrile in the ratio of 70:30,v/v as mobile phase at the flow rate of 1mL/min with detection wave length at 293 nm by using UV spectrophotometric detector with total run time of 10 minutes and 3.613, 4.230, 4.707, 5.497, 5.880 and 6.253 minutes of retention time obtained for LEVO, PRFX, GATI, SPAR, MOXI and BALO respectively. All calibration curves for six drugs showed indicated linearity over a concentration range of 2-10 µg/mL. The results regarding to limit of detection (LOD) and limit of quantitation (LOQ) for LEVO, PRFX, GATI, SPAR, MOXI and BALO were found to be 0.116 µg/mL and 0.348 µg/mL; 0.152 µg/mL and 0.460 µg/mL; 0.084 µg/mL and 0.255 µg/mL; 0.186 µg/mL and 0.558 µg/mL, 0.162 and 0.493, 0.112 and 0.390 respectively. These results clearly show low values of LOD and LOQ. The said developed method was ultimately utilized for quantification of marketed formulation.
NOVEL SIMULTANEOUS SEPARATION AND QUANTITATIVE DETERMINATION OF FOUR SARTANS...Dr. Ravi Sankar
The core AIM of the present study is to develop a novel, rapid, precise and accurate RP-HPLC method for simultaneous separation and quantification of Hydrochlorothiazide along with four sartans Telmisartan(TELM), Losartan(LOSA), Olmesartan(OLME) and Valsartan(VALS).
To develop Novel methods for separation and quantification of all the above said drugs on single chromatographic system without any minor changes in detection wavelength and mobile phase composition.
Total quality management (TQM), and current Good Manufacturing Practice (cGMP...Dr. Ravi Sankar
TQM, cGMP, Introduction, Definition, Importance, TQM frame work, Key concepts (Principles) of TQM, specific steps in the cycle, Benefits of TQM, cGMP, principles of GMP, Improtance of GMP, why GMP established?, difference between GMP and cGMP, GMP and cGMP regulations, code of federal regulations.
Tetracyclines BY Dr. P. Ravisankar M. Pharm., Ph.D.Dr. Ravi Sankar
Tetracyclines by Dr. P. Ravisankar M. Pharm., Ph.D.
Definition
Introduction
Classification
Historical background
Sources
Chemistry
SAR of tetracyclines
Mechanism of action of tetracyclines
Spectrum of activity
Uses of tetracyclines
Side effects of tetracyclines
Dr. P. Ravisankar M. Pharm., Ph.D.
Vitamin A
Vitamin D
Vitamin E
Vitamin K
Definition
Introduction
Classification
Structures,Functions,Deficiency,Diseases,Toxicity and uses.
Introduction to diuretics.
Therapeutic approaches.
Normal physiology of urine formation.
Classification of drugs .
Mechanism of action of Acetazolamide.
Mechanism of action of Thiazides.
Mechanism of action of Loop diuretics.
Mechanism of action of potassium sparing diuretics &aldosterone antagonists.
A Strategic Approach: GenAI in EducationPeter Windle
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
VITAMIN B6 [MEDICINAL CHEMISTRY] BY P.RAVISANKAR. SOURCES,STRUCTURES OF PYRIDOXINE,PYRIDOXAL,PYRIDOXAMINE,DEFICIENCY OF VITAMIN B6,PYRIDOXINE ANTAGONISTS, METABOLISM,PHYSIOGICAL IMPORTANCE,SYNTHESIS OF PYRIDOXALAND PYRIDOXAMINE,VITAMIN B6 USES.
2. Vitamin B 6 is a water-soluble vitamin present in three major chemical
forms:
pyridoxine, pyridoxal,pyridoxamine
These three are interconvertible in their phosphorylated form.
It is also called Adermin,because it is used as an antidermatitic factor
(acrodynia factor )for rats.
The plant sources mainly contain pyridoxal,pyridoxamine and animal
sources contain Pyridoxine.
Active form is pyridoxal phosphate
It is essential coenzyme for trans amination and decarboxylation of
amino acids.
N
CH2OH
CH2OHHO
H3C
PYRIDOXINE
N
CHO
CH2OHHO
H3C N
CH2NH2
CH2OHHO
H3C
PYRIDOXAMINEPYRIXOXAL
Collectively, pyridoxine, pyridoxal and pyridoxamine are known as vitamin B6.
(Pyridoxol)
[2-methyl-3-hydroxy-4-5
di(hydroxymethyl)-Pyridine]
1
2
3 4 5
6
3. Chick peas
Wholegrain breads and cereals are rich in Vitamin B6
Wholegrain breads and cereals are rich
in Vitamin B6
Sweet potatoes
4. The best source of vitamin B6 is through the foods you eat. Foods rich in vitamin B6 include:
Avocado (raw),Baked potato (flesh and skin)
Fortified cereals, beans, Lima beans,Peanut butter ,Poultry ,Spinach, Soybeans, Sunflower
seeds Tomato juice, Walnuts
bananas
beef
Brewer's Yeast
brown rice husks
cabbage
dried fruits
eggs
fish, fatty, whitefish
green leafy vegetables
maize
meats
milk
nuts, oats
organ meats, especially pig liver
potatoes
pulses, such as lentils
root vegetables
soy products, peppers
wheat bran
wheat germ
whole grain
•
5. Deficiency leads to
In humans vitaminB6 deficiency leads to neurological symptoms like
depression,irritability,nervousness,mental confusion.
Dermatitis in rats and other animals due to pyridoxosis.
Anemia
confusion
convulsions( due to decreased synthesis of serotonin,GABA,catacholamines)
Depression
Sore tongue,defective sexual behaviour,decreased heam synthesis.
Since most of us easily get enough B6 in our diets, then who should take B6
supplements? :
Alcoholics (Alcohol also helps to deplete B6 from the body)
Asthmatic children who take theophylline because it too depletes stores of B6 from the
body
Elderly.
General guidelines recommend keeping your B6 intake to less than 100 mg
daily. This includes B6 from both dietary sources as well as supplements.
However, as we age, our need for vitamin B6 increases, and 1.9 mg is the RDA
for pregnant women, and it goes up to 2.0 mg for lactating women.
6. •pyridoxine is stable in acid solution, but unstable in neutral or
alkaline solutions (destroyed by light).
N
N
NH-NH2
Hydralazine (antihypertensive)
N
C
O NH
NH2
isoniazid (antitubercular)
O
N
OH2N
H
cycloserine (antitubercular)
CC
CH3 H
COOHHS
CH3 NH2
penicillamine (antirheumatic; Wilson's disease)
Pyridoxine antagonists.
increasing renal excretion of pyridoxine; recommended intakes for pyridoxine
may be increased in patients receiving these medications
The taking of certain drugs (as isoniazid, hydrolazine, penicillamine) that
inactivate the vitamin.
7. Levodopa (concurrent use with pyridoxine is not recommended since
levodopa's antiparkinsonian effects are reversed by as little as 5 mg of
pyridoxine orally; this problem does not occur with the carbidopa-levodopa
combination.
Pyridoxine (vitamin B 6) has been found to reduce the effects of levodopa
when levodopa is taken by itself.
Metabolism
Metabolized in the liver and converted to 4-pyridoxic acid metabolite.
Elimination
Excreted mostly as 4-pyridoxic acid in the urine. The t ½ is 15 to 20 days.
Parenteral use is indicated when oral therapy is not feasible.
Parenteral use is indicated when oral therapy is not feasible.
Vitamin B6 is usually safe, at intakes up to 200 mg per day in adults.
However, vitamin B6 can cause neurological disorders, such as loss of
sensation in legs and imbalance, when taken in high doses (200 mg or
more per day) over a long period of time
8. Physiological importance:
Physiologically active form of vitamin B6 is pyridoxal-5-phosphate.It acts as
coenzyme for the enzymes that are involved in the biosynthesis of niacin,
coenzyme A and haemoglobin.
It is also involved in reactions like transamination,amino acid
decorboxylation,desulphuration and metabolism of unsaturated fatty acids.
Pyridoxal-5-phosphate also acts as coenzyme in the formation of serotonin
from tryptophan,cystine from methionine.
vitamin B6 function as co-carboxylase in the decarboxylation of dopa to
dopamine.
essential for protein metabolism
essential for the formation of hemoglobin, the pigment in the blood that carries
oxygen around the body.
essential for utilization of proteins and fats
helps in normal function of nervous system
is needed also by certain bacteria
necessary for production of red blood cells and antibodies which fight disease
needed for many body functions
9. Decarboxylation of amino acids
Transaminase reactions
Racemization reactions
Aldol cleavage reactions
Transulfuration reactions
Conversion of tryptophan to niacin
Conversion of linoleic acid into arachidonic acid (prostaglandin
precursor)
Formation of sphingolipids
SERINE ETHANOLAMINE ACETYLCHOLINE
TYROSINE DOPA DOPAMINE EPINEPHRINE
TRYPTOPHAN 5-HT SEROTONIN
HISTIDINE HISTAMINE
GLUTAMIC ACID GAMMA AMINOBUTYRIC ACID (GABA)
CYSTEINE CYSTEINE SULFINIC ACID TAURINE
- CO2
- CO2
- CO2
- CO2
- CO2
- CO2
(Decarboxylation)
Serine
-NH3
+ H20
Pyruvic acid (Elimination)
10. L-Glutamin acid
Glutamin acid racemase
D-Glutamic acid.
L-DOPA L-DOPA L-dopamine
L-dopamine
CO2
Brain
B6 stimulates
this reaction outside
of the brain
use carbidopa: an inhibitor of DOPA decarboxylase
in combination with DOPA: Sinemet 10/100 or Sinemet 25/250
Pyridoxine can antagonize the antiparkinsonian use of
L-DOPA
13. vitamin B6 will help maintain the natural colour in your hair -- and ward off
graying.
VITAMIN B6 IS USED FOR
nerve disorder
red blood formation
body immunity
hand numbness
metabolism of protein and fat
kidney stones
anemia
asthma
convulsions
depression
mental retardation
premenstrual syndrome(headache,depression,irritability,weight gain)
urticaria
It is used to treat or prevent the deficiency of vitaminB6 deficiency.
It is also given in combination with isoniazid and cylcoserine to reduce
their toxicity.
It is also used in the treatment of sideroblastic anaemia.
Treatment of Hydrazine and isoniazid poisoning.
14. Vitamin B6 is indicated for the treatment of sideroblast anemia, neurologic
disturbances, seborrhoeic dermatitis, and cheilosis. In combination with
folic acid and vitamin B12, vitamin B6 lowers homocysteine levels which is
an amino acid linked to heart disease and stroke, and possibly other
diseases as well, such as osteoporosis, and Alzheimer's disease.
Pyridoxine is required for the balancing of hormonal changes in women as
well as assisting the immune system and the growth of new cells. Vitamin
B6 may be helpful in some women with premenstrual dysphoric disorder,
also known as premenstrual syndrome (PMS), and may be useful in some
cases of gestational diabetes and for protection against metabolic
imbalances associated with the use of some oral contraceptives. Vitamin
B6 promotes iron excretion and this has been used as a rationale for
treatment in iron storage diseases