vitamin B3
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Niacin, also known as vitamin B3, plays important roles in the body including acting as a coenzyme in energy production and fatty acid and cholesterol synthesis. It is absorbed in the small intestine through both active and passive transport mechanisms depending on concentration levels. A deficiency in niacin can be caused by poor diet, smoking, kidney failure or other illnesses and can result in symptoms like headaches, skin issues, and high cholesterol levels. Niacin is used to treat conditions like pellagra and heart attacks.
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vitamin B3
- 2. NIACIN B3
- 3. Structure : Ring : pyridine 3-carboxy Nicotinic acid = niacin Nicotinic acid Nicotinamide
- 6. 1) Absorbed in small intestine(duodenum) 2) Low concentration : active transport 3) High concentration : passive transport
- 7. 1) In dehydrogenation reaction (oxidation) 2) Respiratory chain 3) Energy NAPH 4) Fatty acid synthesis 5) Purine & pyrimidine synthesis 6) Cholesterol synthesis Nicotic acid 7) Vasodilation 8) Stimulation C.N.S 9) Decrease plasma lipid concentration
- 9. CAUSES • Smoking • Poor diet • Kidney failure • Older people • Antibiotic • Diabetes illness
- 12. Lipoic acid
- 13. $ Sulfur contain vitamin $ function : oxidation of -keto acid e.g. pyruvic acid S S OH O
- 15. Structure : B-alanine & pantoic acid CH2 C OH CH3 CH3 CH OH C O N CH2 CH2 CooH B-alanine pantoic acid Properties : Affected by heat
- 16. ACTIVE FORMS Coenzyme-A [CoA-SH] Acyl carrier protein [ACP]
- 17. COOH
- 18. SOURCE
- 19. 1) Oxidative 2) Stimuli growth 3) Formation of active acetate (acetyl co) 4) Synthesis fatty acid 5) Synthesis acetylcholine 6) Synthesis cholesterol 7) Hermon 8) Acetyl carrier protein
- 20. 1) Anemia 2) Sleeplessness 3) Abnormal growth 4)Fatty liver 5) Nervous manifestation 6) Gastrointestinal manifestation 7) Change in skin Deficiency
- 21. Uses • Diabetes • paralytic ileus • Hair • burns at skin • neuron