NY Prostate Cancer Conference - A. Vickers - Session 8: Debate 2: Categorical staging versus continuous prediction: How can we integrate predictive models into the staging systems? (Categorical staging vs prediction models: what is the evidence?)
Clinical Trials for Metastatic Breast Cancerbkling
Courtney Hudson, CEO and Co-Founder of EmergingMed, explains the latest clinical trials for metastatic breast cancer and how to find them. Learn how to identify appropriate clinical trials, determine eligibility and "must ask" questions for the researchers, find strategies to determine your best options, and figure out which questions to ask when making your decisions.
Association between genomic recurrence risk and well-being among breast cance...Enrique Moreno Gonzalez
Gene expression profiling (GEP) is increasingly used in the rapidly evolving field of personalized medicine. We sought to evaluate the association between GEP-assessed of breast cancer recurrence risk and patients’ well-being.
Clinical Trials for Metastatic Breast Cancerbkling
Courtney Hudson, CEO and Co-Founder of EmergingMed, explains the latest clinical trials for metastatic breast cancer and how to find them. Learn how to identify appropriate clinical trials, determine eligibility and "must ask" questions for the researchers, find strategies to determine your best options, and figure out which questions to ask when making your decisions.
Association between genomic recurrence risk and well-being among breast cance...Enrique Moreno Gonzalez
Gene expression profiling (GEP) is increasingly used in the rapidly evolving field of personalized medicine. We sought to evaluate the association between GEP-assessed of breast cancer recurrence risk and patients’ well-being.
Cost-Effectiveness of Contralateral Prophylactic
Mastectomy Versus Routine Surveillance in Patients
With Unilateral Breast Cancer
Benjamin Zendejas, James P. Moriarty, Jamie O’Byrne, Amy C. Degnim, David R. Farley, and Judy C. Boughey
Cancer de mama
Clinica Ruber
Dr Juan Carlos Meneu
Venous thromboembolism (VTE) may be the earliest sign of cancer.
Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked VTE .
We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography(CT) of the abdomen and pelvis in patients who had a first unprovoked VTE .
Everywhere in Europe the survival rate of cancer has improved. As of today, there are around 10 million European cancer survivors of which more than a third are of working age. Although not being a death sentence anymore, cancer risks to remain a life sentence preventing survivors to resume normal life. Research shows a higher unemployment rate in cancer survivors as compared to the cancer-free population. Also, individual testimonies illustrate challenges in obtaining health/life insurance, loans and mortgage.
Using novel individualized algorithms, insurance companies may better define the risk of covering patients with pas history of cancer. Herein is described a novel tool to offer individualized risk assessment for patients with history of cancer.
In breast cancer the severity of the disease can be seen and reported by PrognostiCheck® and guide the patient to the level of care they need sooner and easier
Join international leader in Palliative Medicine, Dr. Cleary, as he discusses a variety of unique issues faced by late stage colorectal cancer patients, including the integration of palliative care, end of life planning, keeping hope alive, and more.
Presentation given in March 2014 as an invited speaker at the PIMA Medical Society (http://www.pimamedicalsociety.org/schedule/). These society presentations are widely attended by physicians in the Tucson area. The topic was innovation in CT surgery at UA.
Ben Richardson - Driving change in the NHS - what are the solutions? Age UK
Ben Richardson, Principal, McKinsey and Company - presentation at Age UK's For Later Life conference on 25th April.
For more information: www.ageuk/org.uk/forlaterlife
Cost-Effectiveness of Contralateral Prophylactic
Mastectomy Versus Routine Surveillance in Patients
With Unilateral Breast Cancer
Benjamin Zendejas, James P. Moriarty, Jamie O’Byrne, Amy C. Degnim, David R. Farley, and Judy C. Boughey
Cancer de mama
Clinica Ruber
Dr Juan Carlos Meneu
Venous thromboembolism (VTE) may be the earliest sign of cancer.
Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked VTE .
We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography(CT) of the abdomen and pelvis in patients who had a first unprovoked VTE .
Everywhere in Europe the survival rate of cancer has improved. As of today, there are around 10 million European cancer survivors of which more than a third are of working age. Although not being a death sentence anymore, cancer risks to remain a life sentence preventing survivors to resume normal life. Research shows a higher unemployment rate in cancer survivors as compared to the cancer-free population. Also, individual testimonies illustrate challenges in obtaining health/life insurance, loans and mortgage.
Using novel individualized algorithms, insurance companies may better define the risk of covering patients with pas history of cancer. Herein is described a novel tool to offer individualized risk assessment for patients with history of cancer.
In breast cancer the severity of the disease can be seen and reported by PrognostiCheck® and guide the patient to the level of care they need sooner and easier
Join international leader in Palliative Medicine, Dr. Cleary, as he discusses a variety of unique issues faced by late stage colorectal cancer patients, including the integration of palliative care, end of life planning, keeping hope alive, and more.
Presentation given in March 2014 as an invited speaker at the PIMA Medical Society (http://www.pimamedicalsociety.org/schedule/). These society presentations are widely attended by physicians in the Tucson area. The topic was innovation in CT surgery at UA.
Ben Richardson - Driving change in the NHS - what are the solutions? Age UK
Ben Richardson, Principal, McKinsey and Company - presentation at Age UK's For Later Life conference on 25th April.
For more information: www.ageuk/org.uk/forlaterlife
Similar to NY Prostate Cancer Conference - A. Vickers - Session 8: Debate 2: Categorical staging versus continuous prediction: How can we integrate predictive models into the staging systems? (Categorical staging vs prediction models: what is the evidence?)
Lecture on causal inference to the pediatric hematology/oncology fellows at Texas Children's hospital as part of their Biostatistics for Busy Clinicians lecture seriers.
Presented at PhUSE 2013
The evaluation of efficacy in oncology studies, in particular for solid tumors, is pretty standard and well defined by several regulatory guidance (e.g. EMA and FDA), including some specific cancer type guidance (e.g. NSCLC from FDA).
Although some references will be also given for non-solid tumors, the paper will mainly focus on solid tumors efficacy
endpoints.
Overall Survival, Best Overall Response as per RECIST criteria, Progression Free Survival (PFS), Time to Progression (TTP), Best Overall Response Rate are some of the key efficacy indicators that will be discussed.
Improve Outcome in Major Abdominal Surgery with ProAQTpicco2
In 1988 Shoemaker developed the first principles of goal directed therapy and its superiority regarding
outcome.This concept has been adopted ever since and new perioperative indications such as general, abdominal,
cardiac, orthopaedic surgery have evolved. Improved outcome through GDT was proven in several
publications.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...JohnJulie1
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...NainaAnon
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Appropriteness Criteria for Coronary RevascularizationLalit Kapoor
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
NY Prostate Cancer Conference - A. Vickers - Session 8: Debate 2: Categorical staging versus continuous prediction: How can we integrate predictive models into the staging systems? (Categorical staging vs prediction models: what is the evidence?)
1. Categorical staging vs. prediction models: what is the evidence? Andrew J. Vickers, Ph.D. Assistant Attending Research Methodologist Memorial Sloan-Kettering Cancer Center
2. How do we normally assess risk in cancer? We don’t do so explicitly We use stage as an approximate surrogate
3. Clinical decisions based on stage Adjuvant chemotherapy for stage II but not stage I gastric cancer Why is chemotherapy effective if “tumor invades into the muscularis propria layer” but not if it “extends only into the muscularis mucosa”?
4. Some basic decision theory We want to know a patient’s risk to help determine treatment e.g.: High risk of recurrence: adjuvant therapy Low risk of recurrence: no adjuvant therapy The more accurately we estimate risk, the better our decisions
5. Statistical model vs. AJCC: Gastric cancer AJCC IV (32) IIIB (24) IIIA (69) II (117) IB (115) IA (102)
7. As the man on the Clapham ominbus would tell you… More information => better prediction A man with low grade cancer might have positive lymph nodes and high PSA suggesting metastases A man with high grade cancer might have very localized disease curable by prostatectomy
8. Risk group approach Based on features, we make a crude tree. Most cancer staging systems do this. High grade N Y High PSA & high stage Y HIGH RISK LOW RISK N
10. Theory vs. Practice Risk modeling sounds like a great idea, but what data do we have that it actually helps? Typical study: Obtain a data set with predictors and outcome Compare predictive accuracy of model and AJCC stage or other risk grouping
14. “In this single institution study that involved data dependent variable selection, a small change in effect size is unlikely to withstand external validation.”
17. Prediction models vs. risk groups Have the benefits of prediction models really been demonstrated? BUT: Prediction modeling allows rational decision making.
18. Rational decision making Prostate biopsy if: PSA > 4 ng / ml? Risk of prostate cancer > 20%? Harms and benefits of biopsy can be considered to choose a risk threshold Risk threshold can be individualized
19. Ultimately, we must towards prediction modeling To facilitate optimal decision making