In breast cancer the severity of the disease can be seen and reported by PrognostiCheck® and guide the patient to the level of care they need sooner and easier
There has been an increase of prophylactic contralateral mastectomies due to the fear of recurrence of breast cancer, surveys say. FirstHealth Moore Regional Hospital offers breast cancer treatment to patients in the Pinehurst, Raeford, Sanford, Lumberton, Laurinburg, Rockingham and Troy regions of NC.
Hysterectomy can help prevent ovarian cancer with or without the removal of t...Clarence_Klein
Ovarian cancer remains one of the common causes of death among women in the United States. According to the American Cancer Society (ACS), at least 22,000 women will be diagnosed of the condition in 2018. Around the same time, more than 13,500 will die.
ASCO 2014 Highlights: Breast Cancer, Prostate Cancer; AI diagnosingdianecleverley
American Society of Clinical Oncology, 2014.
ALTTO: all groups did well.
IOM reports: Out-of-pocket costs, termed financial toxicity, are a side effect of this disease.
Obese women with ER+ breast cancer are at a greater risk.
WATSON-like Artificial Intelligence computer program useful in as daignosis aid
Incorporating data for management of breast cancerAjeet Gandhi
The guidelines are mostly western and in many scenarios, it is difficult to apply them to Indian population. We need to take in to consideration many factors while applying the data
Obesity, Outcomes and Quality of Care: BMI Increases the Risk of Wound-Relate...Ramzi Amri
Abstract, Academic Surgical Congress 2013:
See also paper: http://www.ncbi.nlm.nih.gov/pubmed/24139555
Introduction:
Hospitals and surgeons are constantly striving to improve their outcomes. SCIP measures and guidelines to improve the quality of care are now commonplace. However, factors that are beyond the control of the medical community play an important role in outcomes. The United States continues to struggle with obesity. Obesity increases resection difficulty and could be predictive of a complicated postoperative course. Body Mass Index (BMI) is a continuous numeric expression of body habitus and allows for a quantification of the effect of body habitus on postsurgical complications. The aim of this study is therefore to measure the effect of BMI on the risk of wound-related postoperative complications.
Methods:
851 patients were operated on for colonic adenocarcinoma at our tertiary care center between 2004 and 2011. Binomial logistic regression was used to assess for relationships between complications and incremental increases in BMI. We controlled in a separate univariate analysis for possibly significant predictive covariates, including age, gender, Charlson comorbidity score, approach, and intersurgeon variation.
Results:
After correction for statistically significant covariates, BMI proved to be a significant predictor of several wound-related complications. Using the same approach, all other major and minor complications within 30 days postoperatively did not show a significant relationship with BMI.
In wound-related complications, the risk increase was independent on whether the approach was laparoscopic or open. Figure 1 shows the p-values for each complication that was significantly related to BMI and the Odds Ratio for each increase of one BMI unit (1 kg/m2).
Conclusions:
Obesity has a direct effect on wound complications in both open and laparoscopic procedures. Furthermore, BMI-related risk of wound-related complications increases exponentially with increasing weight. This incremental effect illustrates how an increasingly obese US population relates to an independently growing risk of surgical complications. As the surgical community strives to improve the quality of care, patient controllable factors will clearly play an increasingly important role in cost containment and quality improvement.
There has been an increase of prophylactic contralateral mastectomies due to the fear of recurrence of breast cancer, surveys say. FirstHealth Moore Regional Hospital offers breast cancer treatment to patients in the Pinehurst, Raeford, Sanford, Lumberton, Laurinburg, Rockingham and Troy regions of NC.
Hysterectomy can help prevent ovarian cancer with or without the removal of t...Clarence_Klein
Ovarian cancer remains one of the common causes of death among women in the United States. According to the American Cancer Society (ACS), at least 22,000 women will be diagnosed of the condition in 2018. Around the same time, more than 13,500 will die.
ASCO 2014 Highlights: Breast Cancer, Prostate Cancer; AI diagnosingdianecleverley
American Society of Clinical Oncology, 2014.
ALTTO: all groups did well.
IOM reports: Out-of-pocket costs, termed financial toxicity, are a side effect of this disease.
Obese women with ER+ breast cancer are at a greater risk.
WATSON-like Artificial Intelligence computer program useful in as daignosis aid
Incorporating data for management of breast cancerAjeet Gandhi
The guidelines are mostly western and in many scenarios, it is difficult to apply them to Indian population. We need to take in to consideration many factors while applying the data
Obesity, Outcomes and Quality of Care: BMI Increases the Risk of Wound-Relate...Ramzi Amri
Abstract, Academic Surgical Congress 2013:
See also paper: http://www.ncbi.nlm.nih.gov/pubmed/24139555
Introduction:
Hospitals and surgeons are constantly striving to improve their outcomes. SCIP measures and guidelines to improve the quality of care are now commonplace. However, factors that are beyond the control of the medical community play an important role in outcomes. The United States continues to struggle with obesity. Obesity increases resection difficulty and could be predictive of a complicated postoperative course. Body Mass Index (BMI) is a continuous numeric expression of body habitus and allows for a quantification of the effect of body habitus on postsurgical complications. The aim of this study is therefore to measure the effect of BMI on the risk of wound-related postoperative complications.
Methods:
851 patients were operated on for colonic adenocarcinoma at our tertiary care center between 2004 and 2011. Binomial logistic regression was used to assess for relationships between complications and incremental increases in BMI. We controlled in a separate univariate analysis for possibly significant predictive covariates, including age, gender, Charlson comorbidity score, approach, and intersurgeon variation.
Results:
After correction for statistically significant covariates, BMI proved to be a significant predictor of several wound-related complications. Using the same approach, all other major and minor complications within 30 days postoperatively did not show a significant relationship with BMI.
In wound-related complications, the risk increase was independent on whether the approach was laparoscopic or open. Figure 1 shows the p-values for each complication that was significantly related to BMI and the Odds Ratio for each increase of one BMI unit (1 kg/m2).
Conclusions:
Obesity has a direct effect on wound complications in both open and laparoscopic procedures. Furthermore, BMI-related risk of wound-related complications increases exponentially with increasing weight. This incremental effect illustrates how an increasingly obese US population relates to an independently growing risk of surgical complications. As the surgical community strives to improve the quality of care, patient controllable factors will clearly play an increasingly important role in cost containment and quality improvement.
Paul Coplan, VP, Johnson & Johnson_mHealth IsraelLevi Shapiro
Pesentation, October 19th, 2021: What’s Next in RWE for Medical Devices: The Art of the Possible. Presented by Paul Coplan, ScD, MBA, FISPE, Vice President, Med Device Epidemiology and RWD Sciences, Johnson & Johnson; Adjunct Professor, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Perelman School of Medicine; Fellow of the International Society of Pharmacoepidemiology
- Why RWE is Important for Medical Devices: Challenges with Clinical Trials of Medical Devices (Blinding, Surgeon skill/technique, Hospital process, Product modifications, Long term Follow up, Enrolment challenges)
- Types of Real-World Data Sources (Complaints like MAUDE, Eudramed and Company Databases, Hospital Databases, Electronic Health Records, Claims, Registries, Patient surveys, Surgeon surveys, PROs, Patient Preferences, wearables, sensors, social media, Surgical videos, device generated data, radiographic images)
- FDA CDRH Report on RWE Examples for Regulatory Decisions
- J&J Med Device Epidemiology & Real-World Data Sciences
- US National Evaluation System for Health Technology (NEST)
- RWE for Safety Assessments: Cobalt in Implants and at Work and Risk of Cancer
- Summary of Cobalt Exposure and All-Site Cancer Risk, by Study Type
- Comparative Effectiveness Studies Using RWE
- Summary
a. Use of RWE is important to benefit patients globally and enhance the safety and innovation of medical devices
b. Regulators are interested in using RWE for regulatory decisions but data quality and evidence needs to be regulatory grade
c. NEST has been a useful forum to advance the use of RWE for regulatory decisions in the US
d. RWE can be used for safety assessments, regulatory decisions, comparative effectiveness research, and R&D of products
CardiovaScUlar toxicity in cancer and improvement In recoverydirectoricos
Patient charts should be reviewed for suspected cardiac events at each follow up time point.
Site PI’s will likely need to go through the form with the coordinators for the first 10 patients to ensure accuracy of data entered.
In Arm 1: Visit Data, there is a suspected cardiac event form to be completed at each follow up time point.
This form is basically just asking if you reviewed the patient’s chart for suspected cardiac events.
If the patient does have a suspected cardiac event, you would then complete Arm 3: Suspected Cardiac Events for that patient.
When entering information into Arm 3: Suspected Cardiac Events, the first part of the form is assessing the event from a cardiology perspective. The second part of the form is assessing the event based on CTCAE v5.0 criteria.
PROactive evaluation of function to Avoid CardioToxicitydirectoricos
This study is intended to evaluate a new more in-depth and higher resolution cardiac MRI, MyoStrain®, to
transform the early detection of cardiac damage that can occur frequently as a result of cancer
chemotherapy. By detecting cardiac damage early, cardiologists can provide optimal cardio-protection
and allow continued use of life-saving cancer treatment for patients.
Understanding and Predicting Breast Cancer Events After Treatmentdirectoricos
our primary outcomes will help define the relationships between cancer therapy,
CV injury, exercise intolerance and fatigue, while also accounting for the relative contributions of age,
menopause status, race/ethnicity, radiation therapy, and psychosocial and behavioral risk factors. In
addition, we will assess pre-existing cardiac risk factors (hypertension, smoking, diabetes, coronary artery
disease, dynamic changes in body mass
index, blood pressure, serum lipids and
fasting glucose, physical activity, and
chemo- and immunotherapy).
General principal is that all patients with good functional capacity should proceed to surgery and coronary assessment should only be performed if the results would change management•For patients with recent MI, 2014 AHA/ACC guidelines recommend 3 month delay before stopping DAPT although anticipated updates may require only 1 month for newer DES•Several risk scores have been studied for risk MICA
Paul Coplan, VP, Johnson & Johnson_mHealth IsraelLevi Shapiro
Pesentation, October 19th, 2021: What’s Next in RWE for Medical Devices: The Art of the Possible. Presented by Paul Coplan, ScD, MBA, FISPE, Vice President, Med Device Epidemiology and RWD Sciences, Johnson & Johnson; Adjunct Professor, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Perelman School of Medicine; Fellow of the International Society of Pharmacoepidemiology
- Why RWE is Important for Medical Devices: Challenges with Clinical Trials of Medical Devices (Blinding, Surgeon skill/technique, Hospital process, Product modifications, Long term Follow up, Enrolment challenges)
- Types of Real-World Data Sources (Complaints like MAUDE, Eudramed and Company Databases, Hospital Databases, Electronic Health Records, Claims, Registries, Patient surveys, Surgeon surveys, PROs, Patient Preferences, wearables, sensors, social media, Surgical videos, device generated data, radiographic images)
- FDA CDRH Report on RWE Examples for Regulatory Decisions
- J&J Med Device Epidemiology & Real-World Data Sciences
- US National Evaluation System for Health Technology (NEST)
- RWE for Safety Assessments: Cobalt in Implants and at Work and Risk of Cancer
- Summary of Cobalt Exposure and All-Site Cancer Risk, by Study Type
- Comparative Effectiveness Studies Using RWE
- Summary
a. Use of RWE is important to benefit patients globally and enhance the safety and innovation of medical devices
b. Regulators are interested in using RWE for regulatory decisions but data quality and evidence needs to be regulatory grade
c. NEST has been a useful forum to advance the use of RWE for regulatory decisions in the US
d. RWE can be used for safety assessments, regulatory decisions, comparative effectiveness research, and R&D of products
CardiovaScUlar toxicity in cancer and improvement In recoverydirectoricos
Patient charts should be reviewed for suspected cardiac events at each follow up time point.
Site PI’s will likely need to go through the form with the coordinators for the first 10 patients to ensure accuracy of data entered.
In Arm 1: Visit Data, there is a suspected cardiac event form to be completed at each follow up time point.
This form is basically just asking if you reviewed the patient’s chart for suspected cardiac events.
If the patient does have a suspected cardiac event, you would then complete Arm 3: Suspected Cardiac Events for that patient.
When entering information into Arm 3: Suspected Cardiac Events, the first part of the form is assessing the event from a cardiology perspective. The second part of the form is assessing the event based on CTCAE v5.0 criteria.
PROactive evaluation of function to Avoid CardioToxicitydirectoricos
This study is intended to evaluate a new more in-depth and higher resolution cardiac MRI, MyoStrain®, to
transform the early detection of cardiac damage that can occur frequently as a result of cancer
chemotherapy. By detecting cardiac damage early, cardiologists can provide optimal cardio-protection
and allow continued use of life-saving cancer treatment for patients.
Understanding and Predicting Breast Cancer Events After Treatmentdirectoricos
our primary outcomes will help define the relationships between cancer therapy,
CV injury, exercise intolerance and fatigue, while also accounting for the relative contributions of age,
menopause status, race/ethnicity, radiation therapy, and psychosocial and behavioral risk factors. In
addition, we will assess pre-existing cardiac risk factors (hypertension, smoking, diabetes, coronary artery
disease, dynamic changes in body mass
index, blood pressure, serum lipids and
fasting glucose, physical activity, and
chemo- and immunotherapy).
General principal is that all patients with good functional capacity should proceed to surgery and coronary assessment should only be performed if the results would change management•For patients with recent MI, 2014 AHA/ACC guidelines recommend 3 month delay before stopping DAPT although anticipated updates may require only 1 month for newer DES•Several risk scores have been studied for risk MICA
EFresh(R) device measures food freshness, juiciness and food quality.IPGDx LLC
Measures the freshness and palatability (tenderness / flavorfulness / juiciness) of foods (meat / fish / poultry / fruits / vegetables) and identifies fresh versus previously frozen.
A lung cancer prognosis is an medical opinion about the outcome of the disease in a patient. The score from the PrognostiCheck® test provides a clear illustration of how the individual patient is doing.
Global breast cancer vaccine clinical trial insightKuicK Research
“Global Breast Cancer Vaccine Clinical Trial Insight” Report Highlight:
Global Breast Cancer Vaccine Market Overview
Global Breast Cancer Vaccine Clinical Pipeline by Company, Phase & Country
Mechanism of Breast Cancer Vaccine & Personalized Cancer Vaccines
Detailed Clinical Insight on Breast Cancer Vaccine Pipeline: 35 Vaccines
Majority in PHASE-I Clinical Trial: 12 Vaccines
Highest Clinical Phase is PHASE-III: 2 Vaccines (NeuVax & OBI-822)
Background/Objective: The purpose of this study was to discuss some risk factors which may increase risk of infectious morbidity
after cesarean section despite of applying prophylactic measures including skin cleansing and prophylactic antibiotic.
Methods: This single randomized controlled study was conducted at the Obstetrics and Gynecology department, El Minya general hospital, El Minya, Egypt, from January 2017 to January 2018.
— This study was conducted to find out if AFI ≤ 5 cms has any clinical significance in identifying the subsequent fetal distress & associated maternal & perinatal outcomes, in pregnancies beyond 37 weeks. Methodology: This is a prospective case control study done from July 2010 to July 2012 (24 months) at Dr Vasantrao Pawar Medical College, Hospital and Research Center. Adgaon, Nashik. It study the pregnancy outcome comparison of 58 Anenatal Cases(ANCs)as Study Group with diangosis of oligohydramnios (AFI ≤ 5 cms) by ultrasound after 37 completed weeks of gestation w e r e compared with 58 ANCs (Control Group) with no oligohydramnios (AFI > 5 cms). These two groups were matched for other variables like age, parity, gestational age and any pregnancy complication. Results: There was significant difference between two groups. Hypertension and Preeclampsia were found significantly more in ANCs with oligohydramnios. FHR deceleration was also significantly higher in women with oligohydramnios. Women require LSCS were also significantly more in women with oligohydramnios. Newborn borned by women with oligohydramnios had significantly more chances to admit in NICU than in newborn born by women without oligohydramnios. Conclusion: It can be concluded from this study that women with oligohydramnios poor pregancy outcomes. Determination of AFI can be used as an adjunct to other fetal surveillance methods. Determination of AFI can be used as valuable screening test for predicting fetal distress in labour, requiring caesarean section.
Original StudyType of Breast Cancer Diagnosis, Screening,a.docxvannagoforth
Original Study
Type of Breast Cancer Diagnosis, Screening,
and Survival
Carla Cedolini,1 Serena Bertozzi,1 Ambrogio P. Londero,2 Sergio Bernardi,3,4
Luca Seriau,1 Serena Concina,1 Federico Cattin,1 Andrea Risaliti1
Abstract
Organized, invitational breast cancer screening in our population succeeded in detecting early-stage tumors,
which have been consequently treated more frequently with breast and axillary conservative surgery, com-
plementary breast irradiation, and eventual hormonal therapy. The diagnosis of invasive cancer with screening
in our population resulted in a survival gain at 5 years from the diagnosis.
Introduction: Breast cancer screening is known to reduce mortality. In the present study, we analyzed the prevalence
of breast cancers detected through screening, before and after introduction of an organized screening, and we
evaluated the overall survival of these patients in comparison with women with an extrascreening imaging-detected
breast cancer or those with palpable breast cancers. Materials and Methods: We collected data about all women
who underwent a breast operation for cancer in our department between 2001 and 2008, focusing on type of tumor
diagnosis, tumor characteristics, therapies administered, and patient outcome in terms of overall survival, and re-
currences. Data was analyzed by R (version 2.15.2), and P < .05 was considered significant. Results: Among the 2070
cases of invasive breast cancer we considered, 157 were detected by regional mammographic screening (group A),
843 by extrascreening breast imaging (group B: 507 by mammography and 336 by ultrasound), and 1070 by extra-
screening breast objective examination (group C). The 5-year overall survival in groups A, B, and C were, respectively,
99% (95% CI, 98%-100%), 98% (95% CI, 97%-99%), and 91% (95% CI, 90%-93%), with a significant difference
between the first 2 groups and the third (P < .05) and a trend between groups A and B (P ¼ .081). Conclusion: The
diagnosis of invasive breast cancer with screening in our population resulted in a survival gain at 5 years from the
diagnosis, but a longer follow-up is necessary to confirm this data.
Clinical Breast Cancer, Vol. 14, No. 4, 235-40 ª 2014 Elsevier Inc. All rights reserved.
Keywords: Breast cancer, Breast cancer screening, Invasive breast cancer, Mammographic screening, Overall survival
Introduction
Because of the detection of early-stage tumors, breast cancer
screening reduced breast cancer mortality in Europe by 25%-31%
in patients who were invited for screening and by 38%-48% in
those who were actually screened during the last decade of the
twentieth century and the first decade of the twenty-first.1 In our
region of Italy, an organized breast cancer screening was firstly intro-
duced in 2005, but despite the high compliance of invited women
1Clinic of Surgery
2Clinic of Obstetrics and Gynecology
University of Udine, Udine, Italy
3Department of Surgery, Ospedale Civile di Latisana, Udine, Italy
4 ...
Adenocarcinoma is a carcinoma that begins in cells lining glandular types of internal organs (glandular epithelium tissue ) such as the lungs, breasts, colon, prostate, stomach, pancreas, and cervix and has gland-like properties
Mesothelioma is a form of Cancer that most frequently arises from the cells lining the sacs of the chest (the pleura) or the abdomen (the peritoneum) and almost always caused by exposure to asbestos
Americans count on the safety of their food. There are too many food recalls today. President Barack Obama has created a Food Safety Working Group to coordinate Federal efforts and develop short- and long-term agendas to make food safer.
EFresh(R)-can help make the food supply safer.
PrognostiCheck® device measures prognosis. Reliable, Objective and Noninvasive.IPGDx LLC
Prognostic scoring system objectively and accurately detects the presence and severity of illness, the effectiveness of treatment, the existing burden of illness, the progression of disease and the timing of non-acute death.
PrognostiCheck ® - The Biological CompassIPGDx LLC
Prognostic scoring system objectively and accurately detects the presence and severity of illness, the effectiveness of treatment, the existing burden of illness, the progression of disease and the timing of non-acute death.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. PrognostiCheck® uses phase angle from impedance analysis to detect the presence and severity of breast cancer, the effectiveness of treatment and survival of breast cancer patients who have the disease. www.ipgdx.com
3. In a recent study of 259 breast cancer patients, 81 that were newly diagnosed, 178 that had received prior treatment 56 with stage - I disease at diagnosis, 110 with stage - II, 46 with stage - III and 34 with stage - IV. www.ipgdx.com http://www.virtualcancercentre.com/uploads/VMC/TreatmentImages/1247_Breast_Mid.jpg
4. Their ages ranged from 25 to 74 years old. The median phase angle was 5.6 degrees . www.ipgdx.com
5. Patients with phase angle less than or equal to 5.6° had a median survival of only 23.1 months, while those greater than 5.6° had 49.9 months. www.ipgdx.com http://www.virtualmedicalcentre.com/uploads/VMC/DiseaseImages/1250_Breast_LCIS_Med.jpg
6. It can be used to provide critically important information to patients, their families and physicians on survival in breast cancer and all other diseases. PrognostiCheck® is a scoring system that interprets a measured electrical value that illustrates the health of the cell membrane. www.ipgdx.com
7. By measuring these values PrognostiCheck® reports information heretofore not available to patients, families and their physicians. The measurement of phase angle includes the combined effects of the body’s fluids and cells specifically the cellular membranes of the human body. www.ipgdx.com
8. Lower phase angle values indicate illnesses by seeing cell death or decreased cell integrity, while higher phase angle values indicate more intact cell membranes and a healthier person. www.ipgdx.com http://graphics8.nytimes.com/images/2007/08/01/health/adam/9294.jpg
9. In breast cancer the severity of the disease can be seen and reported by PrognostiCheck® and guide the patient to the level of care they need sooner and easier. www.ipgdx.com http://www.medindia.net/patients/patientInfo/images/Breast_cancer.gif
10. The PrognostiCheck® results come from a simple noninvasive test that is quickly done has no side effects and is easily repeated to show change over time. www.ipgdx.com
11. It is especially sensitive to changes and precise with nearly perfect test re-test reliability (0.98 out of 1). www.ipgdx.com The device used for the test is an FDA 510(k) approved Class II medical instrument.