This document discusses uterine abnormalities, including their definition, classification, incidence, etiology, diagnostic measures, complications, and management. Uterine abnormalities result from abnormal development of the Mullerian ducts during embryogenesis and range in symptoms from amenorrhea and infertility to normal functioning depending on the defect. The American Fertility Society classification includes 7 classes of abnormalities: hypoplastic/agenetic uterus, unicornuate uterus, didelphus uterus, bicornuate uterus, septate uterus, arcuate uterus, and DES-related anomalies. Complications can include infertility, pregnancy loss, uterine rupture, and malpresentations. Diagnosis involves physical examination, ultrasound, and hysteroscopy. Surgical
Hydatidiform Mole (HM) is a rare mass or growth that forms inside the uterus at the beginning of a pregnancy. It is a type of gestational trophoblastic disease (GTD).
When a normal sperm cell fertilizes one of these oocytes, the resulting embryo has only one set of chromosomes. Because the embryo has no genes from the mother, the pregnancy cannot develop normally, resulting in a hydatidiform mole.
Hydatidiform Mole (HM) is a rare mass or growth that forms inside the uterus at the beginning of a pregnancy. It is a type of gestational trophoblastic disease (GTD).
When a normal sperm cell fertilizes one of these oocytes, the resulting embryo has only one set of chromosomes. Because the embryo has no genes from the mother, the pregnancy cannot develop normally, resulting in a hydatidiform mole.
This topic contains detailed description about labour, its definition, date of onset of labour, calculations of date of delivery, causes of onset of labour, physiology of normal labour, and events, clinical course and management of each stages of labour.
Definition-
The destructive operations are designed to diminish the bulk of the fetus so as to facilitate easy delivery through the birth canal
types
Craniotomy
Eviceration
Decapitation
Cleidotomy
CRANIOTOMY
Definition
It is an operation to make a perforation on the fetal head to evacuate the contents followed by extraction of the fetus
DECAPITATION
Definition
It is a destructive operation whereby the fetal head is severed from the trunk and the delivery is completed with the extraction of the trunk and that of the decapitated head per vaginam
CLEIDOTOMY
Definition
The operation consist of reduction in the bulk of the shoulder girdle by division of one or both the clavicles
Indications
Dead fetus with shoulder dystocia
Procedure
The clavicles are divided by the embryotomy scissors or long straight scissors introduced under the guidance of left two fingers placed inside the vagina
This topic contains detailed description about labour, its definition, date of onset of labour, calculations of date of delivery, causes of onset of labour, physiology of normal labour, and events, clinical course and management of each stages of labour.
Definition-
The destructive operations are designed to diminish the bulk of the fetus so as to facilitate easy delivery through the birth canal
types
Craniotomy
Eviceration
Decapitation
Cleidotomy
CRANIOTOMY
Definition
It is an operation to make a perforation on the fetal head to evacuate the contents followed by extraction of the fetus
DECAPITATION
Definition
It is a destructive operation whereby the fetal head is severed from the trunk and the delivery is completed with the extraction of the trunk and that of the decapitated head per vaginam
CLEIDOTOMY
Definition
The operation consist of reduction in the bulk of the shoulder girdle by division of one or both the clavicles
Indications
Dead fetus with shoulder dystocia
Procedure
The clavicles are divided by the embryotomy scissors or long straight scissors introduced under the guidance of left two fingers placed inside the vagina
OBSTETRICS AND GYNAECOLOGICAL NURSING- HIGH RISK PREGNANCY ABORTION.pptxmagie12
The students will be able to
*define abortion
*Identify the difference between various types of abortion
*Perform medical induction for abortion
*Describe various surgical techniques used for abortion
*Detect the consequences that occur by abortion and provide appropriate care
Abortion or pregnancy loss is accounts to spontaneous events or through legal termination.
The first large scale study on abortions and unintended pregnancies conducted by The Lancet in 2017 said one in three of the 48.1 million pregnancies in India end in an abortion with 15.6 million taking place in 2015.
*Definition
*Types of abortion- Spontaneous, Induced, Complete abortion, Incomplete abortion, Missed abortion, Recurrent abortion, Induced abortion
*Risk factors,
*etiology, mechanism,
* clinical manifestations of each type
*Management – medical & surgical
Nursing management
Abortion is the expulsion or extraction from its mother of an embryo or fetus weighing 500 gm or less when it is not capable of independent survival
-WHO
The 500gm of fetal development is attained
approximately at 22 weeks(154 days of gestation).
The expelled embryo or fetus is called abortus
Abortion is the cause for bleeding in early pregnancy.
Abortion occurring without medical or mechanical means to empty the uterus is referred to as spontaneous.
Another widely used term is miscarriage.
10-20% of cases of all clinical pregnancies end in miscarriage.
About 75%miscarriages –before 16th week
About 80% occur –before 12th week of pregnancy.
Increases with parity
Increased maternal and paternal age
The frequency of abortion increases from 12% in women younger than 20 years to 26% in those older than 40 years
Women conceiving within 3 months following a term birth, have a higher incidence of abortion
Anembryonic Gestational sac
- Positive HCG test as placenta secretes HCG and stops later
Presents in first few weeks of pregnancy
Removal through medical or surgical induction
Uncommon causes of abortion in human
Listeria monocytogenes
Clamydia trachomatis
Mycoplasma hominis
Ureaplasma urealyticum
Toxoplasma gondii
Diabetes mellitus
Celiac sprue
Cause both male and female infertility and recurrent abortions
ENDOCRINE ABNORMALITIES
Hypothyroidism
Thyroid autoantibodies → incidence of abortion is high
Diabetes mellitus
Poor glucose control → incidence of abortion increased
Progesterone deficiency
Luteal phase defect
Insufficient progesterone secretion by the corpus luteum or placenta
DRUG USE AND ENVIRONMENTAL FACTORS
Recurrent pregnancy loss patients : 15%
Antiphospholipid antibody : most significant
LCA (lupus anticoagulant), ACA (anticardiolipin Ab)
ALLOIMMUNE FACTORS
- Inherited thrombophilia
Uterine synechiae (Asherman syndrome)
Partial or complete obliteration of the uterine cavity by adherence of uterine wall
The retention power of the cervix(Internal os) may be impaired functionally and or anatomically in an incompetent cervix
Etiology
Previous trauma during pregnancy
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
3. INTRODUCTION
A Uterine abnormalities are malformations of the uterus that develop
during embryogenic life. Uterine abnormalities occur in less then 5%
of all women, but have been noted in upto 25% of women who have
had miscarriages and/or deliveries of premature babies.
When a women is in her mother’s womb, her uterus develops as to
separate halves that fuse together before she is born. When a
womens uterus develops differently from most women, it is called
uterine anomaly.
4. DEFINITION
A uterine abnormalities is a type of female genital malformation
resulting from an abnormal development of Mullerian ducts during
embryogenesis.
Symptoms range from amenorrhoea, infertility, recurrent pregnancy
loss, and pain, to normal functioning depending on the nature of the
defect.
5. INCIDENCE
The prevalence of uterine malformation is
estimated to be 6.7% in the general
population, slightly higher 7.3% in the
infertility population, and significantly higher
in a population of women with the history of
recurrent miscarriages ( 16%).
Prevalence in general
population 1 in 201 (0.5%)
Distribution : 7% arcuate, 34%
septate, 39% bicornuate, 11%
didelphic, 5% unicornuate, 4%
hypoplastic and other forms.
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7. TYPES
AMERICAN FERTILITY SOCIETY
CLASSIFICATION----
Class 1: Hypoplasia uterus or Agenesis:
Segmental or complete (absent uterus).
Class2: Unicornuate uterus with or
without rudimentary horn (a one-
sided uterus).
Class3: Didelphus uterus also uterus
didelphis (double uterus) .
Class4: Bicornuate uterus: Complete or
partial ( uterus with two horns).
Class5: Septate uterus: Complete or partial
(uterine septum or partition).
Class6: Arcuate uterus: There is a concave
dimple in the uterus fundus within the cavity.
Class7: Des related uterus: The uterine
cavity has a “t-shaped” as a result of fetal
exposure to diethylstilbestrol.
8. o CLASS 1: VAGINAL AGENESIS/
HYPOPLASIA--
It is characterised by an absence or
hypoplasia of the uterus, proximal
vagina and sometimes the fallopian
tube.
Diagnosed at the age of 15-18 yr
Assessment and physical
examination
Treatment : Surgical correction-
Plastic surgery
9. • o CLASS 2: UNICORNUATE
UTERUS--
• The unicornuate uterus forms
when one mullerian duct fail to
elongated but the another one
develops normally.
• TREATMENT:
• No surgical intervention is
required unless endometrial
tissue in a rudimentary horn
results in pain or a pelvic mass or
unless an incompetent cervix is
suspected during pregnancy.
10. o CLASS 3: DIDELPHUS UTERUS--
It is a rare congenital anomaly and is a
consequence of unilateral or bilateral
mullerian duct duplication.
It’s exact cause is unknown but it is
generally present from birth, though
often becomes noticeable after
puberty .
Diagnosis is carried out using a
physical examination alongside USG
and 3D USG more recently.
There is no treatment as such for the
condition, but it must be managed
especially during pregnancy.
11. o CLASS 4: BICORNUATE
UTERUS—
When the mullerians duct fuse
incompletely at the level of the
fundus then bicornuate formed.
The lower uterus and cervix are
completely fused resulting in 2
separate but communicating
endometrial cavities with a single
cervix and vagina.
Pre-term birth: The rate of
preterm delivery is 15 to 25%.
A pregnancy may not be
reach full term in a
bicornuate uterus when the
baby begins to grow in either
12. o CLASS 5: SEPTATE
UTERUS—
Most common form of
mullerian duct defect .
From incomplete
resorption of the medial
septum after the
complete fusion of the
mullerian duct has
occurred.
It is not considered
necessary to remove a
septum that has not
caused problems,
especially in women
who are not considering
pregnancy.
13. ARCUATE UTERUS
Characterised by a small septate indentation
the superior aspect of the uterine cavity in the
fundus.
Many patient with an arcuate uterus will not
experience any reproductive problems and do
not require any surgery. In patients with
recurrent
pregnancy loss thought to be caused by an
arcuate uterus hysteroscopic resection can be
performed.
14. O CLASS 7: DES RELATED
ANOMALIES—
DES is a synthetic
estrogen that was
prescribed to women for
recurrent miscarriage and
premature delivery
during the year 1940-
early 1970.
The uterine cavity has a “T-
shape” as a result of fetal
exposure to
diethylstilbestrol.
15. CLINICAL FEATURES
No any symptoms
Difficulty in getting pregnant
Pelvic pain
Dysmenorrhea
Uterine rupture during pregnancy
Recurrent pregnancy loss
Concurrent renal abnormalities
Imperforated hymen
21. COMPLICATION
I. Infertility
II. Early pregnancy loss
III. Uterine rupture due to its poor development
IV. Malpresentations
V. Prolonged obstructed labor
VI. Abortion
VII. Weak uterine action
22. MANAGEMENT
1. No non-surgical treatment is present only symptomatic
treatment is done.
2. Surgical intervention is considered when a septate uterus is found.
3. Bicornuate, unicornuate and didelphic uteri rarely require surgical
management.