1. Nasal masses can present with symptoms like nasal obstruction, rhinorrhea, congestion, hyposmia, and epistaxis. Physical examination may reveal facial swelling, proptosis, or diplopia depending on site and extent of the mass.
2. Nasal masses can be anatomical variants, inflammatory/infectious, congenital/developmental, or neoplasms. Common nasal masses include nasal polyps, inverted papilloma, juvenile angiofibroma, and lymphocytic hypophysitis.
3. Diagnostic evaluation includes nasal endoscopy, CT scan, and biopsy. CT is helpful for surgical planning. Differential diagnosis depends on clinical features and may
Spaces of middle ear and their surgical importanceDr Soumya Singh
one of the imp topics in ENT that should be understood very thoroughly if u want to pursue as an otologist.I tried to simplify the topic with simple diagrams and models for better understanding .
Spaces of middle ear and their surgical importanceDr Soumya Singh
one of the imp topics in ENT that should be understood very thoroughly if u want to pursue as an otologist.I tried to simplify the topic with simple diagrams and models for better understanding .
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Salivary gland tumours are a relatively rare and morphologically diverse group of lesions. So here are slides containing information about salivary gland tumours with images.
Any dental board exam will ask about bony tumors of the head and neck. I created this study aid when studying for three different dental board examinations.
guideline for long case presentation,include history,examination,,investigation,treatment option,surgical procedure of superficial parotidectomy,short discussion about plemorphic adenoma
Childhood mumps, certain bacterial infections (for example, of the tonsils or teeth), and other diseases that are typically more common among adults (such as AIDS, Sjögren syndrome, diabetes mellitus, sarcoidosis, and bulimia) often cause swelling of the major salivary glands.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
6. Face and o r b i t examination
• Facialswelling , cheek and noseskinthickening indicates tumor involved soft tissue
through anteriorwall.
• Proptosisindicates lamina papyraceainvolvement.
• Diplopiapresent along with proptosis in most cases.
• Visionlossindicates to involvement of O.N.
7. Can be divided as..
Anatomical Inflammation/infect
Congn../developmental neoplasms
Nasalmass
10. Congenital / developmental
Glioma
• Ectopic rests of glial tissue.
• Somevisible out side the nasalvault.
• somecompletely present in nasalcavity.
• No expansion oncrying.
11. Meningocele and Encephalocele.
• Meningesout sidecranialvault .
• Located in areaof foramencaecum.
• Expand oncrying.
• Brain tissuealong with meninges
protrude out the cranialvault.
13. Nasal polyp
▪ Non –neoplastic masses.
▪ Edematous nasal orsinus mucosa.
▪ chronic inflammation leading to stromal
edema and variable cellular infiltrate .
▪ watery rhinorrhea , postnasal drip, hyposmia.
▪ A/R reveals single or multiple pale, grey
polypoid masses arising most middle meatus
and prolapsing into the nasalcavity.
14. Continue…
• X ray wont help, except for
opacification.
• CT scan wil l show the extent
of NP and anatomical
variations and i s essential
i f surgical treatment i s to
be implemented.
18. Who classification of benign nasal mass
Epithelial Soft tissuetumor Boneandcartilage Miscellaneous
Papilloma Myxoma Giant celltumor Juvenile angiofibroma
Salivary gland
adenomas
Leiomyoma Chondroma
Hemangioma osteoma
Schwannoma Osteoid osteoma
Meningioma
neurofibroma
19. Incidence of various mass
120
50
109
50
26
11
Cap
10
9
7
0 400 450
invertedpapilloma
JAF
LCH
400
50 100 150 200 250 300 350
Data from a series of 931 patients treated at the University
Hospitals of Brescia and Varese (Italy) from 1994 to 2013.
20. Inverted papilloma(Schneiderian
papilloma)
• 0.5 to7%of all nasal tumors
• a/c HPV
• From lateral nasal wall (middle meatus mostly +any one
sinus)
• Some times involve septum and involve C/Lcavity
24. Schwannoma
• 25-55yr of age
• Arise from
Schwanncells
• Trigeminal nerve
,Carotid plexus
and
parasympathetic
fibers of
pterygopalatine
ganglion
• Well delineated,
unencapuslated
• Globular
• Firm torubbery
yellow tumor
• Antoni Aand B
bodies
• Endoscopyshows
network of fine
capillaries giving
image ofvascular
tumor.
25. Schwannoma
lesions with a prevalent Antoni A component have
an intermediate signal on both T1- and T2-
weighted images, whereas in those with a
predominant Antoni B pattern, which is related to
a loose myxoid stroma, hyper intensity is observed
on T2-weightedimages.
MRI showing ..A large hyper intense mass obliterates the nasal
fossa and protrudes into the sphenoid and frontal sinus. The
ethmoid roof is eroded, and the crista galli cannot be recognized.
27. Malignant nasal mass
Carcioma
Squamous cell Ca
Adenocarcinoma
Malignant melanoma
Olfactory neuroblastoma
Haemangiopericytoma
Lymphoma
Solitary plasmacytoma
Various types of sarcoma
28. Squamous c e l l CA
▪ m/c malignanttumor
▪ Arise from lateral nasalwall and septum
▪ Grow insidiously with little symptoms.
▪ Pain in maxillaryteeth
▪ Palatal erosion.
▪ Proptosis .
▪ Cheekparesthesia's
29. Adenocarcinoma / adenocystic carcinoma
▪ 4-8 %ofSino nasal tumors
▪ Nasal cavity and ethmoidsinus.
▪ a/c with hardwoodworkers
▪ 3types- papillary, sessile,alveolar
▪ AdenocysticCAm/c minor salivary gland tumor
in Sino nasaltract
▪ m/c inwomen
▪ 3types –cribriform ,tubular , solid
▪ Swiss cheeseapp,
▪ Perineural invasion.
30. Mucosal melanoma
▪ Rapidly lethal
neoplasm.
▪ m/c nasalseptum , inf
turbinate.
▪ Spreadsubmucosally
with little erosion of
bone andcart.
▪ Varies fromnormal to
heavy pigmentation.
▪ IHCs-100 and HMB
45.
31. Esthesioneuroblastoma
▪ From olfactory epith.in
superior nasalvault.
▪ Sup to middleturbinate.
▪ Tumor made of round cells
arranged in to rosettes , pseudo
rosettes andsheets.
▪ Express –NSE, chromogranin
,synaptophysin.
▪ Snowman appearance onCT
scan.
32. Miscellaneous
▪ Rhinolith: Formswhen anintranasal foreign body acts asanidus
upon
▪ which salts from inspissated mucusprecipitate; symptoms include
purulent secretions, recurrent infections, fetid odor, and nasal
obstruction;
▪ canappear asbone-density onCT.