Nicotine is a highly addictive drug found in tobacco products. Smoking causes both short-term effects like increased heart rate and long-term health risks like cancer, emphysema, and heart disease. Secondhand smoke also endangers nonsmokers by increasing their risk of lung cancer and respiratory illnesses. Smoking during pregnancy can lead to miscarriage, premature birth, and learning difficulties in children. Tobacco use places financial burdens on both families and society through increased medical costs and lost wages. Withdrawal symptoms occur when dependent smokers try to quit.
It gives insight into why tobacco smoking is harful and what strategies one should adpot to quit smoking. Some interesting snapshots makes the point clear to all
It is a slide show about tobacco. It can be used for college seminars & other seminar related to cancer or tobacco......For description you can collect info's from internet of all slides.....A little editing is required as your need....
the following work may be used as a teaching unit in favour of a smokefree society ! Students might get more aware about the consequences of active and passive smoke .
It gives insight into why tobacco smoking is harful and what strategies one should adpot to quit smoking. Some interesting snapshots makes the point clear to all
It is a slide show about tobacco. It can be used for college seminars & other seminar related to cancer or tobacco......For description you can collect info's from internet of all slides.....A little editing is required as your need....
the following work may be used as a teaching unit in favour of a smokefree society ! Students might get more aware about the consequences of active and passive smoke .
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. What is nicotine?
• The addictive drug that is found in all
tobacco products
– Low doses = mild stimulant, muscle relaxant
– Higher doses = nerve poison
• 60 mg. enough to kill most people; 1-2
mg. is inhaled when cigarette is smoked
3. Key terms
• Nicotine: a highly addictive drug that is found
in all tobacco products
• Carcinogen: any chemical or agent that causes
cancer
• Tar: a sticky, black substance in tobacco smoke
that coats the inside of the airways and that
contains many carcinogens
• Carbon monoxide: a gas that blocks oxygen
from getting into the blood stream
4. What is in cigarettes?
• 4,800 chemicals
– 69 of the chemicals are carcinogens (cancer causing
agents/chemicals)
• Tar: sticky black substance that coats the insides of the
airways and contains many carcinogens
– Cyanide: poisonous gas used to develop photographs
– Formaldehyde: substance used to preserve lab animals and as
embalming fluid
– Lead: dangerous metal
– Vinyl chloride: a flammable gas used to make plastic products
– Carbon monoxide: gas that blocks oxygen from getting into
the bloodstream
– Ammonia: chemical found in bathroom cleaners
5. Smokeless tobacco
• Snuff (dip)
• Chewing tobacco
– Arsenic
– Nickel
– Benzopyrene
– Polonium (gives off radiation)
• Can lead to mouth sores and oral cancer
9. Objectives
State: The short-term effects of tobacco use.
Summarize: The long-term health risks associated with
tobacco use.
State:The effects of secondhand smoke on a nonsmoker.
Describe: How smoking affects unborn children whose mothers
smoke during pregnancy.
List: Three reasons you would give a friend to encourage him or her not
to smoke.
10. Key Terms
• Emphysema: A respiratory disease in which air cannot move in
and out of alveoli because they become blocked or lose their
elasticity.
• Sidestream Smoke: Smoke that’s escapes from the tip of a
cigarette and then exhaled by a cigarette smokers.
• Mainstream Smoke: smoke that’s is inhaled through a cigarette
and then exhaled by a cigarette smoker
• Environmental tobacco smoke (second hand smoke): a
combination of exhaled mainstream smoke and sidestream
smoke
11. What are the short-term effects of
Tobacco use?
•Stimulates the brain reward system
•Increases heart rate and blood pressure
•Increases breathing rate
•Increases blood sugar levels
•Stimulates the vomit reflex
12. It predominantly works on the pleasure centres within your brain
stimulating both serotonin and dopamine centres, so in effect you have
a very powerful reward system within your mind. Every time you smoke
a cigarette so it’s plain to see why it can be hard to get rid of your
nicotine addiction.
13. What are the long-term effects of
tobacco use?
• Addiction
• Bronchitis
– an acute inflammation of the air passages
within the lungs
• Emphysema
– A respiratory disease in which air cannot
move in and out of the lungs because the
alveoli become blocked or lose their elasticity
14. • Heart and artery disease
• Cancer
• Immune system suppression
• Damages stomach’s ability to neutralize
acids
– Leads to ulcers and cancer
15.
16. Effects of smoke to nonsmokers
• Sidestream smoke
– Smoke that escapes from the tip of the cigarette or
cigar
• Mainstream smoke
– Smoke that is inhaled through a tobacco product and
exhaled by a tobacco smoker
• Environmental tobacco smoke (secondhand
smoke)
– Exhaled mainstream smoke and sidestream smoke
• Inhaled by anyone near the smoker
17. Did you know?
• It is illegal to smoke in a car with a child
(anyone under 18 years of age)
18. Dangers of secondhand smoke
• Lung cancer caused by environmental tobacco
smoke kills 3,000 nonsmokers in the U.S.. each
year
• Illnesses
– Heart function in healthy young men is reduced
– Headaches
– Nausea
– Dizziness
– Children of smokers suffer more: lower respiratory
infections, asthma, ear infections
19.
20. Dangers of tobacco use during
pregnancy
• Risk of miscarriage
• Risk of premature birth
• Low birth weight
• Slow growth rate
• Risk of sudden infant death syndrome
(SIDS)
• Risk of developing respiratory illness
• Risk of developing learning difficulties
21. Why do people use tobacco?
• Family and friends
• Misconceptions
– Messages aren’t clear
– Messages about the dangers are incorrect
• Advertising
– They make it look “cool”
• Curiosity
• Rebellion
– To go against your parents, etc.
22. How does tobacco use affect family
and society?
• Costs to families
– Over $1,500 per year
– Lost wages due to illness
– Medical bills
– Funeral costs
• Costs to society
– Medical costs increase to pay the fees of
smoker