Hemostasis is the physiological process that limits blood loss from damaged blood vessels. It involves vasoconstriction, platelet plug formation, and fibrin clot formation and stabilization. Thrombophilia refers to inherited or acquired conditions that predispose to thrombosis. Common inherited thrombophilias include deficiencies of antithrombin, protein C, protein S, factor V Leiden mutation, and prothrombin gene mutation. Thrombophilias increase the risk of venous thromboembolism during pregnancy. Testing for thrombophilia should be considered for women with a history of VTE, recurrent pregnancy loss, or other risk factors. Management may include antenatal low molecular weight heparin and post