The document discusses the importance of research data repositories and enabling FAIR (findable, accessible, interoperable, reusable) data. There are essentially two types of repositories - discipline specific repositories that are curated by domain experts and require discipline specific metadata, and generalist repositories that accept all types of data without limitations. Finding an appropriate repository can be challenging. Some research communities have mandates requiring data deposition in specific repositories. Efforts are underway to increase data interoperability and adherence to standards like the TRUST principles for digital repositories.
B2FIND - How to find data objects and collections using EUDAT's B2FIND | www....EUDAT
| www.eudat.eu | B2FIND is a simple, user-friendly discovery service based on metadata steadily harvested from research data collections from EUDAT data centres and other repositories.
Buildvoc Introduction to linked data digital construction week 2018Phil Stacey ICIOB
Learning outcomes
• structured data how can it be used in the building industry
• controlled vocabulary benefits
• standard naming convention (SMP)
• linked data vocabulary with document repository
• live demonstration of linked data knowledge library
B2FIND - How to find data objects and collections using EUDAT's B2FIND | www....EUDAT
| www.eudat.eu | B2FIND is a simple, user-friendly discovery service based on metadata steadily harvested from research data collections from EUDAT data centres and other repositories.
Buildvoc Introduction to linked data digital construction week 2018Phil Stacey ICIOB
Learning outcomes
• structured data how can it be used in the building industry
• controlled vocabulary benefits
• standard naming convention (SMP)
• linked data vocabulary with document repository
• live demonstration of linked data knowledge library
EUDAT Service Suite Overview - EUDAT Summer School (Shaun de Witt, CCFE)EUDAT
Shaun will give an overview to the EUDAT service suite, explaining the key function and role of the different B2 services and how they interconnect. Examples will be given of how each service has been used by communities to explain the nature and scale of the service provision. We show how the B2 Service Suite can be linked to the data lifecycle and the role of each component in any data management planning. By the end of this talk, users should have a good overview of each of the B2 services and how they do, or will, fit together, and how they can be used as a part of a coherent data management plan.
Visit https://eudat.eu/eudat-summer-school
IoT Observatory is a global distributed catalogue of applications and data related to various IoT domains. It supports users from various scientific, administrative and social domains to collaborate, engage and contribute their existing data analytics in a secure way with other users. This can support both academic and industrial domains to create real value of the IoT data in terms of research and economics.
The presentation is about the new version of DSpace-CRIS 7, the enhanced, free, open-source extensions of DSpace adopted by more than one hundred institutions around the world to better collect, manage and disseminate information on their research activities and outputs. DSpace-CRIS has always anticipated the cutting edge innovation and technologies later included in the DSpace mainstream, and version 7 includes functionalities not available in DSpace 7.
ELIXIR Standards and Formats: ISA Tools and FAIRsharingPeter McQuilton
A 15 minute presentation at the ELIXIR Europe/ELIXIR-UK SME Forum at Churchill College, Cambridge UK. This talk focuses on ISA-tools and FAIRsharing.org, around standard use, data sharing and data standard implementation and endorsement.
GBIF in one slide
Where is the infrastructure in GBIF?
Physical infrastructure
Information infrastructure
Capability infrastructure
Infrastructure usage
Overview of the Bioschemas Community Activity providing:
- Description of what Bioschemas is
- Details of adoption of Bioschemas
- Benefits of deploying Bioschemas
Slides presented as the introduction to the Bioschemas Tutorial delivered at ECCB 2018
AFAIR in Astronomy Research - Slides. In this webinar ARDC is partnering with the ADACS project to explore the FAIR data principles in the context of Astronomy research and the ASVO and IVOA as a community exemplars of the implementation of the FAIR data principles.
These slides from: Keith Russell (ARDC): Looking at FAIR
In this talk Keith will provide an overview of the FAIR principles and how it was used in astronomy before it became official. He will conclude the talk by discussing what other disciplines can learn from their approach.
Full Webinar: https://youtu.be/EDhJTCm9RN8
Transcript: https://www.slideshare.net/AustralianNationalDataService/transcript-4-fair-r-for-reusable
Other webinars in the series: http://www.ands.org.au/news-and-events/events/fair-webinar-series
Managing sensitive data at the University of BristolJisc RDM
Presentation on managing sensitive data at the University of Bristol by Kellie Snow, Research Data Librarian for the Research Data Network event, May 2016, Cardiff University.
EUDAT Service Suite Overview - EUDAT Summer School (Shaun de Witt, CCFE)EUDAT
Shaun will give an overview to the EUDAT service suite, explaining the key function and role of the different B2 services and how they interconnect. Examples will be given of how each service has been used by communities to explain the nature and scale of the service provision. We show how the B2 Service Suite can be linked to the data lifecycle and the role of each component in any data management planning. By the end of this talk, users should have a good overview of each of the B2 services and how they do, or will, fit together, and how they can be used as a part of a coherent data management plan.
Visit https://eudat.eu/eudat-summer-school
IoT Observatory is a global distributed catalogue of applications and data related to various IoT domains. It supports users from various scientific, administrative and social domains to collaborate, engage and contribute their existing data analytics in a secure way with other users. This can support both academic and industrial domains to create real value of the IoT data in terms of research and economics.
The presentation is about the new version of DSpace-CRIS 7, the enhanced, free, open-source extensions of DSpace adopted by more than one hundred institutions around the world to better collect, manage and disseminate information on their research activities and outputs. DSpace-CRIS has always anticipated the cutting edge innovation and technologies later included in the DSpace mainstream, and version 7 includes functionalities not available in DSpace 7.
ELIXIR Standards and Formats: ISA Tools and FAIRsharingPeter McQuilton
A 15 minute presentation at the ELIXIR Europe/ELIXIR-UK SME Forum at Churchill College, Cambridge UK. This talk focuses on ISA-tools and FAIRsharing.org, around standard use, data sharing and data standard implementation and endorsement.
GBIF in one slide
Where is the infrastructure in GBIF?
Physical infrastructure
Information infrastructure
Capability infrastructure
Infrastructure usage
Overview of the Bioschemas Community Activity providing:
- Description of what Bioschemas is
- Details of adoption of Bioschemas
- Benefits of deploying Bioschemas
Slides presented as the introduction to the Bioschemas Tutorial delivered at ECCB 2018
AFAIR in Astronomy Research - Slides. In this webinar ARDC is partnering with the ADACS project to explore the FAIR data principles in the context of Astronomy research and the ASVO and IVOA as a community exemplars of the implementation of the FAIR data principles.
These slides from: Keith Russell (ARDC): Looking at FAIR
In this talk Keith will provide an overview of the FAIR principles and how it was used in astronomy before it became official. He will conclude the talk by discussing what other disciplines can learn from their approach.
Full Webinar: https://youtu.be/EDhJTCm9RN8
Transcript: https://www.slideshare.net/AustralianNationalDataService/transcript-4-fair-r-for-reusable
Other webinars in the series: http://www.ands.org.au/news-and-events/events/fair-webinar-series
Managing sensitive data at the University of BristolJisc RDM
Presentation on managing sensitive data at the University of Bristol by Kellie Snow, Research Data Librarian for the Research Data Network event, May 2016, Cardiff University.
What role can publishers play in the open data ecosystem?Varsha Khodiyar
Presentation at session 3 of the NIH workshop 'Role of Generalist Repositories to Enhance Data Discoverability and Reuse' on Feb 11th, at the NIH Main Campus.
EUDAT Research Data Management | www.eudat.eu | EUDAT
| www.eudat.eu | The presentation gives an introduction to Research Data Management, explaining why it is important to manage and share data.
November 2016
Are you a researcher, citizen scientist, institution or community looking for data storage and value-added services? Do you want access to tools to make your research data more FAIR (findable, accessible, interoperable, and reusable)? Interested in seeing how the future European Open Science Cloud could support research data and practically foster cross-border, cross-disciplinary collaboration? Then this webinar is for you!
OU Library Research Support webinar: Data sharingDaniel Crane
Slides from a webinar delivered on 06th February 2018 for OU research staff and students. Covers data sharing policies; Benefits of data sharing; Data repositories; Preparing data for sharing; and Re-using data.
Researchers require infrastructures that ensure a maximum of accessibility, stability and reliability to facilitate working with and sharing of research data. Such infrastructures are being increasingly summarised under the term Research Data Repositories (RDR). The project re3data.org – Registry of Research Data Repositories – began to index research data repositories in 2012 and offers researchers, funding organisations, libraries and publishers an overview of the heterogeneous research data repository landscape. In December 2014 re3data.org listed more than 1,030 research data repositories, which are described in detail using the re3data.org schema (http://dx.doi.org/10.2312/re3.003). Information icons help researchers to identify easily an adequate repository for the storage and reuse of their data. This talk describes the heterogeneous RDR landscape and presents a typology of institutional, disciplinary, multidisciplinary and project-specific RDR. Further, it outlines the features of re3data. org and it shows current developments for integration into data management planning tools and other services.
By the end of 2015 re3data.org and Databib (Purdue University, USA) will merge their services, which will then be managed under the auspices of DataCite. The aim of this merger is to reduce duplication of effort and to serve the research community better with a single, sustainable registry of research data repositories. The talk will present this organisational development as a best practice example for the development of international research information services.
Digital transformation to enable a FAIR approach for health data scienceVarsha Khodiyar
Invited talk for ConTech Pharma on 1st March 2022
Abstract
Health Data Research UK is the UK’s national institute for health data science, with a mission to unite the UK’s health data to enable discoveries that improve people’s lives. In this talk, Dr Varsha Khodiyar will outline how HDR UK is bringing together disparate health data from all four countries of the United Kingdom, creating the infrastructure to enable discovery of and access to health data, and the convening standards making bodies to improve data linkage and data reuse. Varsha will also discuss how HDR UK is moving beyond the traditional confines of FAIR data to also ensure that data sharing and data use is transparent and ‘fair’ for the patients and lay public who are the subjects of these datasets.
Lessons from the UK: Data access, patient trust & real-world impact with heal...Varsha Khodiyar
Slides supporting presentation given at the virtual Beilstein Open Science Symposium in October 2021.
Abstract:
Health Data Research UK’s mission is to unite the UK’s health data to enable discoveries that improve people’s lives. Our 20-year vision is for large scale data and advanced analytics to benefit every patient interaction, clinical trial, biomedical discovery and enhance public health. A key part of HDR UK’s vision is our data portal, the Innovation Gateway. The Gateway facilitates discovery of healthcare data and simplifies data request procedures across multiple data custodians. The Gateway contains metadata on a variety of datasets, including those related to COVID-19, cardiovascular, maternal health, emergency care, primary care, secondary care, acute care, palliative care, biobanks, research cohorts and deeply phenotyped patient cohorts.
From the outset HDR UK has sought the voices, views and experiences of patient and lay-public groups to ensure there is transparency and clear public benefit in the use of the UK’s health data. Patient and public involvement is key to making the Gateway accessible, transparent and to ensure public confidence in research access to health data. The importance of public outreach combined with providing research access to data is illustrated with HDR UK’s contribution to the UK’s coronavirus pandemic response. HDR UK was tasked by the UK’s Chief Scientific Office to build and facilitate the infrastructure to support the National Core Studies, providing key insights on the evolving situation to UK policy makers during the course of the pandemic.
In this talk, I will show how HDR UK is enabling open science by facilitating the discovery of health data, and simplifying the process of requesting access to multiple datasets. I’ll discuss HDR UK’s approach to embedding transparency on research data usage for patients and public, and summarise some of the key ways in which HDR UK has contributed to the coronavirus pandemic.
The information in this slide deck was presented at the Covid Crisis in India - Information & Appeal on Sunday 23rd May 2021.
If you find the information in this slide deck useful, please donate to https://justgiving.com/fundraising/covidcrisisinindia
Data citation and sharing during article publicationVarsha Khodiyar
Deck presented to CHORUS forum on 21st Jan 2021, as part of panel on Data Citations & Sharing (https://www.chorusaccess.org/events/chorus-forum-new-connections/)
New approaches to data management: supporting FAIR data sharing at Springer N...Varsha Khodiyar
Presentation given at Biocuration 2019 Session 5 (Data standards and ontologies: Making data FAIR)
Abstract:
Since 2016, academic publishers including Springer Nature, Elsevier and Taylor & Francis have been providing standard research data policies to journal authors, reflecting key aspects of the FAIR Principles’ practical applications: sharing data in repositories, using persistent identifiers and citing data appropriately. In spite of the rise of FAIR and good data management practice, recent surveys found that nearly 60% of researchers had never heard of the FAIR Principles, and 46% are not sure how to organise their data in a presentable and useful way. In this presentation we will analyse the results of a white paper which assessed the key challenges faced by researchers in sharing their data, and discuss current initiatives and approaches to support researchers to adopt good data sharing practice.
These include the roll-out of research data policies since 2016, as well as the launch of a Helpdesk service which has provided support to authors and allowed the research data team to capture more granular information on the challenges they face in sharing their data. We will also discuss the development of a third-party curation service which assists authors in depositing their data into appropriate repositories, and drafting data availability statements.
Finally we will assess the impacts of some of these interventions, including an analysis of data availability statements and an overview of the methods authors are currently using to share their data, and how these align with FAIR.
The value of data curation as part of the publishing processVarsha Khodiyar
Presentation given at Biocuration 2019 Session 5 (Interacting with the Research Community)
Abstract:Journals and publishers have an important role to play in the drive to increase the reproducibility of published science. Since its launch in 2014, the Nature Research journal Scientific Data has established a reputation for publishing data papers (‘Data Descriptors’) that are highly reusable, as evidenced by a strong citation record. One of the ways in which Scientific Data ensures maximum reusability of published data is via the in-house data curation workflow applied to every Data Descriptor. In 2017, Springer Nature launched its Research Data Support (RDS) service to provide data curation expertise to researchers publishing at other Springer Nature journals.
During curation at Scientific Data and RDS, our data editors familiarise themselves with the related manuscript and perform a thorough check of each data archive. This ensures the descriptions in the manuscript match the metadata and data at the data repositories. The curation process facilitates the identification of any discrepancies between the manuscript text and the information held at the data repository.
Over the last year, the curation team have been recording the types of discrepancies rectified as a direct result of our curation process. At Scientific Data approximately 10% of the discrepancies the team find are significant enough to potentially have warranted a formal correction had the issue had not been resolved prior to publication.
In this presentation we give an overview of our observed outcomes from embedding data curation within the publishing process. We describe of how we are monitoring the value of our curation work, and show examples of the types of discrepancy most commonly identified through curation at Scientific Data and RDS.
Preparing your data for sharing and publishingVarsha Khodiyar
Talk given as part of the MRC Cognition and Brain Sciences Unit Open Science Day on 20th November 2018 , University of Cambridge (https://www.eventbrite.co.uk/e/open-science-day-at-the-mrc-cbu-tickets-50363553745)
Facilitating good research data management practice as part of scholarly publ...Varsha Khodiyar
Presentation given to the SciDataCon #IDW2018 session: Democratising Data Publishing: A Global Perspective, on Tuesday 6th November 2018, Gaborone, Botswana
Practical challenges for researchers in data sharingVarsha Khodiyar
Presentation given at the Research Data Alliance Plenary 12 session: IG Open Questionnaire for Research Data Sharing Survey, on Tuesday 6th November 2018, Gaborone, Botswana
Update from Data policy standardisation and implementation IGVarsha Khodiyar
Update given to the Research Data Alliance Plenary 12 joint meeting session: WG FAIRSharing Registry and Data Policy Standardisation and Implementation IG, on Monday 5th November 2018, Gaborone, Botswana
The challenge of sharing data well, how publishers can helpVarsha Khodiyar
Researchers, academic institutes and funders are increasingly recognizing the importance of data sharing for reproducible science. However, it is not always straightforward and clear to researchers as to how best to share data in a useful way. At Springer Nature we are working on several initiatives to help facilitate the sharing of research data in a reusable way, with our overarching goal being to publish research that is robust and reproducible. I will talk about the effort that goes into our flagship data journal, Scientific Data, to facilitate best practices in publication and sharing of research data, and share some of our experiences publishing Challenge datasets. I will also describe some of the newer Research Data Services that are now available to help all researchers (not only Springer Nature authors) to share their data in a useful way.
Data Publishing and Institutional RepositoriesVarsha Khodiyar
Slides presented at the Force16 panel discussion on 18th April 2016 "Libraries united in opening new scholarly platforms" https://www.force11.org/meetings/force2016/program/agenda/concurrent-session-libraries-united-opening-new-scholarly
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Cancer cell metabolism: special Reference to Lactate Pathway
The importance of research data repositories
1. The importance of research
data repositories
Varsha Khodiyar, PhD
Indo-GBC Seminar: Data Sharing at a Global
Level
26th October 2020
IllustrationinspiredbytheworkofChienShiungWu
4. 3
Global Data Sharing / 26th Oct 2020
How do we enable FAIR data?
Encourage
the use of
appropriate
repositories
Provide guidance
on data licensing
Ensure the
use of
discipline
specific
standards
Facilitate the
capture of
detailed
metadata
6. 5
Global Data Sharing / 26th Oct 2020
...but there are essentially two types of repository
Type Features Examples
Discipline
specific
● Specific for a type of data
● Technical curation by data-specific
experts
● Require data-specific metadata from
authors during data deposition
● May provide data-specific discovery,
analysis and visualization tools
PANGAEA
The Cancer Imaging Archive
chEMBL
Generalist
● Accept all types of data
● No limitations on file format
● Provide data archiving option when no
appropriate discipline specific
repositories are available
figshare
Institutional data repositories
7. 6
Global Data Sharing / 26th Oct 2020
Finding an appropriate repository is not a trivial task
8. 7
Global Data Sharing / 26th Oct 2020
Some communities have mandates on repository use
http://www.insdc.org/
Genetic and genomic data are subject to a
community mandate, and must be deposited to a
INSDC repository.
9. 8
Global Data Sharing / 26th Oct 2020
Some communities are working to increase data findability and
interoperability
http://www.copdess.org/enabling-fair-data-project/
Signatories agree to ensure that Earth and Space sciences data
are deposited to domain-specific repository, upon article
publication
10. 9
Global Data Sharing / 26th Oct 2020
The TRUST Principles are a useful framework for digital
repositories
Lin, D., Crabtree, J., Dillo, I. et al. The TRUST Principles for digital repositories. Sci Data 7, 144 (2020).
https://doi.org/10.1038/s41597-020-0486-7
Khodiyar, V. Future-proofing research data – it’s a question of TRUST Springboard blog post (2020)
https://www.springernature.com/gp/advancing-discovery/blog/blogposts/future-proofing-data-trust/18044648
11. 10
Global Data Sharing / 26th Oct 2020
Cross-publisher consensus on key repository criteria
http://doi.org/10.5281/zenodo.4084763
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Global Data Sharing / 26th Oct 2020
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The story behind the image
Chien Shiung Wu (1912–1997)
Chien Shiung Wu was a Chinese American experimental
physicist best known for conducting The Wu experiment
that bears her name. This experiment showed that the
conservation of parity was violated by a weak interaction
and it was possible to distinguish between a mirrored
variation of the world and the mirror image of the current
world. This discovery earned Wu the Wolf Prize in Physics
in 1978.
Thank you
Varsha Khodiyar, PhD
Data Curation Manager, Springer Nature
varsha.khodiyar@nature.com
@varsha_khodiyar
For information on Research Data Support and
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