The document provides an overview of syphilis, including its causative agent Treponema pallidum, transmission methods, and incubation period. It outlines the clinical features and phases of syphilis: primary, secondary, and tertiary, detailing symptoms and progression. Diagnosis and treatment options are also discussed, emphasizing the need for serological testing post-treatment.

1. Syphillis
Dr. Yashika

2. Introduction
• Causative agent : Treponema pallidium
• Transmission : Abraded skin / mucosal surface.
• Spreads through direct contact.
• Incubation period : 9 -90 days.

3. Clinical features
Phases of syphilis :
1. Primary syphilis
2. Secondary syphilis
3. Tertiary syphilis

4. Primary syphilis
• Lesion / Chancre : Single/ Multiple
Site : Labia, fourchette, anus, cervix or
nipples.
• Small papule gets eroded into an ulcer.
The margins of ulcer are raised and floor
is smooth and shiny.
• Healing of primary chancre takes place in
1-8 weeks.

5. Secondary Syphilis
• Secondary syphilis is evident in form of
Condyloma lata in vulva.
• Condyloma lata : coarse, flat topped,
moist, necrotic lesions.
• Maculopapular rashes : Palms and soles.
• Alopecia, lymphadenopathy, mucosal
ulcers.

6. Latent Syphilis
• Quiescence phase.
• Duration : 2 -20 years.

7. Tertiary Syphilis
• Progression of tertiary syphilis occurs
only in condition of untreated syphilis.
• Damages CNS, CVS, Musculoskeletal
system.
• Cranial nerve palsies III, VI, VII and
VIII.
• Gummatous ulcer : deep punched ulcer
with rolled out margins. Painless with
moist leather base.

8. Diagnosis
• History of exposure.
• Identification of organism.

9. Serological test
• VDRL (Venereal disease research laboratory)
• TPHA (Treponoma pallidum haemagglutination)
• EIA (Enzyme immunoassay)
• FTA (Fluorescent treponomal Antibody)
• TPI (Treponoma pallidum immobilisation)

10. Treatment
• Benzathine penicillin IM
• Tetracycline 500 mg
• Doxycycline 100 mg
Serological test should be performed 1, 3, 6 and 12
month after treatment of syphilis.