To tell about the sexually transmitted disease like syphilis and treatment of disease stages of the syphilis. symptoms and introduction of the bacteria and causative agents. drug dose and usage of the medications
syphilis, pathophysiology of syphilis, symptoms of syphilis, mode of transmission of syphilis, complications of syphilis, stages of syphilis, diagnosis of syphilis, pathology of syphilis, syphilis symptoms, syphilis diagnosis, cause of syphilis
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
syphilis, pathophysiology of syphilis, symptoms of syphilis, mode of transmission of syphilis, complications of syphilis, stages of syphilis, diagnosis of syphilis, pathology of syphilis, syphilis symptoms, syphilis diagnosis, cause of syphilis
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
Gonorrhea
is a sexually transmitted disease (STD) caused by a bacterium.
Gonorrhea can grow easily in the warm, moist areas of the reproductive
tract, including the cervix (opening to the womb), uterus (womb), and
fallopian tubes (egg canals) in women, and in the urethra (urine canal)
in women and men. The bacterium can also grow in the mouth, throat,
eyes, and anus.
People get gonorrhea by having sex with someone who has the disease.
“Having sex” means anal, vaginal, or oral sex. Gonorrhea can still be
transmitted via fluids even if a man does not ejaculate. Gonorrhea can
also be spread from an untreated mother to her baby during childbirth.
People who have had gonorrhea and have been treated may get infected
again if they have sexual contact with a person infected with
gonorrhea.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary).
Gonorrhea
is a sexually transmitted disease (STD) caused by a bacterium.
Gonorrhea can grow easily in the warm, moist areas of the reproductive
tract, including the cervix (opening to the womb), uterus (womb), and
fallopian tubes (egg canals) in women, and in the urethra (urine canal)
in women and men. The bacterium can also grow in the mouth, throat,
eyes, and anus.
People get gonorrhea by having sex with someone who has the disease.
“Having sex” means anal, vaginal, or oral sex. Gonorrhea can still be
transmitted via fluids even if a man does not ejaculate. Gonorrhea can
also be spread from an untreated mother to her baby during childbirth.
People who have had gonorrhea and have been treated may get infected
again if they have sexual contact with a person infected with
gonorrhea.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary).
This PowerPoint presentation was compiled and prepared by Platon S. Plakar, Jr a student majoring in Physician Assistant at Cuttington University. This presentation provides a brief understanding of Syphilis, an infectious disease condition that affects people exposed to sexual contact.
The slides explains about the sexually transmitted disease called syphilis. It gives an idea of the symptoms, diagnosis, treatment and prevention of the disease
Medicinal plants and syphlysis A series of LecturesByMr. Allah Dad Khan f...Mr.Allah Dad Khan
A series of LecturesByMr. Allah Dad Khan former DG Agriculture Extension KP Province and Visiting Professor the University of Agriculture Peshawar allahdad52@gmail.com
In this slides included clinical pharmacy introduction and pharmaceutical care, also explanation about the goals and objectives of the clinical pharmacy requirements
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
1. Dr. B.Venkata Subbareddy Pharm.D
Asst.Professor
Sri Lakshmi Venkateswara Pharmaceutical Sciences, Proddatur
2.
3. Syphilis is one of the better-known sexually transmitted infections (STIs), also referred
to as a sexually transmitted disease (STDs). It is caused by the bacterium Treponema
pallidum and can often be recognized by the appearance of an open ulcerative sore,
known as a chancre, on the genitals, mouth, anus, or rectum.
4.
5. Aetiology
Causative agent- Spirochaete Spicess
It is a Unicellular organism.
Which is elongated and tightly coiled and
undergoes reproduction every 30hrs.
Human being is the only natural host and the
organism can not survive its host.
Once it gains entry into the body, it can infect any
organ including central nervous system.
7. The disease is usually transmitted by having
sexual contact with an infected person.
8. Transmission of human blood and by kissing or
touching active lesions of infected person
9. Sharing food or utensils of infected person or from using tubes ,
pools or toilets used by the infected person.
10. The disease can also be transmitted from mother to
infant during pregnancy.
.
11.
12.
13. Primary Stage
During the first (primary) stage of
syphilis, you may notice a single sore
or multiple sores. The sore is the
location where syphilis entered your
body. Sores are usually (but not
always) firm, round, and painless.
Because the sore is painless, it can
easily go unnoticed. The sore usually
lasts 3 to 6 weeks and heals regardless
of whether or not you receive
treatment. Even after the sore goes
away, you must still receive treatment.
This will stop your infection from
moving to the secondary stage
14. Secondary Stage
During the secondary stage, you may have skin rashes
and or mucous membrane lesions. Mucous membrane
lesions are sores in your mouth, vagina, or anus. This
stage usually starts with a rash on one or more areas of
your body. The rash can show up when your primary
sore is healing or several weeks after the sore has
healed. The rash can look like rough, red, or reddish
brown spots on the palms of your hands and/or the
bottoms of your feet. The rash usually won’t itch and it
is sometimes so faint that you won’t notice it. Other
symptoms you may have can include fever, swollen
lymph glands, sore throat, patchy hair loss, headaches,
weight loss, muscle aches, and fatigue (feeling very
tired). The symptoms from this stage will go away
whether or not you receive treatment. Without the right
treatment, your infection will move to the latent and
possibly tertiary stages of syphilis
15. Tertiary Stage
Most people with untreated syphilis do
not develop tertiary syphilis. However,
when it does happen it can affect many
different organ systems. These include
the heart and blood vessels, and the
brain and nervous system. Tertiary
syphilis is very serious and would
occur 10–30 years after your infection
began. In tertiary syphilis, the disease
damages your internal organs and can
result in death.
16. Neurosyphilis and Ocular Syphilis
Without treatment, syphilis can spread to the brain and
nervous system (neurosyphilis) or to the eye (ocular syphilis).
This can happen during any of the stages described above.
Symptoms of neurosyphilis include:
severe headache;
difficulty coordinating muscle movements;
paralysis (not able to move certain parts of your body);
numbness; and
dementia (mental disorder).
Symptoms of ocular syphilis include:changes in your vision
and even blindness.
Latent syphilis:
If you aren't treated for syphilis, the disease moves from the secondary to the latent (hidden)
stage, when you have no symptoms. The latent stage can last for years. Signs and symptoms
may never return, or the disease may progress to the tertiary (third) stage.
17. Diagnosis
• Syphilis can be diagnosed by testing samples of:
• Blood. Blood tests can confirm the presence of antibodies that
the body produces to fight infection. The antibodies to the
bacteria that cause syphilis remain in your body for years, so
the test can be used to determine a current or past infection.
• Cerebral spinal fluid. If it's suspected that you have nervous
system complications of syphilis, your doctor may also
suggest collecting a sample of cerebrospinal fluid through a
procedure called a lumbar puncture (spinal tap).
18. Diagnostic tests
1.Visual microscopic examination.
a) DFA testing (Dark field antigen)
b) Immunofluoresence
c) Silver staining
2.Non treponemal serological antigen testing.
a)VDRL (Venereal disease research laboratory)
b)RPR (Rapid plasma reagin)
c)TRUST (Toluidine red unheated serum test)
3.Treponemal serological antigen testing
a) FTA-ABS Test (Fluorescent treponemal antibody test)
b) TP-PA Test (Treponema pallidum –particle
agglutination test)
19. Treatment
• Have periodic blood tests and exams to make
sure you're responding to the usual dosage of
penicillin
• Avoid sexual contact until the treatment is
completed and blood tests indicate the
infection has been cured
• Notify your sex partners so that they can be
tested and get treatment if necessary
• Be tested for HIV infection
20. SYPHILIS DRUG DOSAGE AND ROUTE
Syphilis of >1 year
(Primary and secondary
syphilis)
Procaine Penicillin+
Probenecid
A single daily I.M injection of
60,00,000 units+10mg oral
Probenecid given for 10days.
Benzathine penicillin
Two injections given by I.M
each injection of 1.2 mega
units of each.
In case of allergy to
penicillin: Doxycycline
100mg twice a day.
Erythromycin
Oral administration of 500mg
q.i.d for 2 weeks on empty
stomach.
Syphilis of<1 year
(Cardio vascular syphilis)
Procaine Penicillin+
Probenecid
A single daily I.M injection of
60,00,000 units+10mg oral
Probenecid given for 15days,
Benzathine penicillin 2.4 mega unit by I.M given
once a week & Continued for
3 weeks
21. SYPHILIS DOSE DOASAGE AND ROUTE
Nuerosyphilis
Procaine Penicillin+
Probenecid
A singel daily 2-4 million
units+10mg oral Probenecid
for 10days.
PenicillinG Daily dose of 12mega units
for divided doses for about 2
weeks.
Congenital Syphilis Procaine Penicillin G
Aqueous Penicillin G
Daily I.M injection of
1,00,000 units given for
10days.
Two daily divided doses of
50,000 units/kg