Synthesis of aquasomes
•Download as PPTX, PDF•
0 likes•92 views
Aquasomes are spherical, nanoscale particles ranging from 60-300nm that are used to deliver drugs, antigens, and other biomolecules. They have a ceramic or calcium phosphate core coated with a polyhydroxyl oligomer film. This film stabilizes the nanoparticle and allows for the adsorption of biologically active molecules. Aquasomes mimic the water-like properties of cells, protecting and preserving fragile molecules while maintaining a high degree of surface exposure and targeting ability. They are synthesized by first fabricating the ceramic core, then coating it with carbohydrates like cellobiose or citrate, and finally immobilizing the drug or biomolecule onto the coated surface. Potential applications of aquasomes include vaccine delivery,
Report
Share
Report
Share
![AQUASOMES
• Three layered self assembled structures, containing the particle core
composed of nanocrystalline calcium phosphate or ceramic diamond, and is
covered by a polyhydroxyl oligomeric film to which biochemically active
molecules are adsorbed .
• Aquasomes are spherical 60-300nm particles used for drug and antigen
delivery.
• It was first developed by NIR KOSSOVSKY.
• Aquasomes are called as “ bodies of water ’’
• 1] Their water like properties.
• 2] Protect and preserve fragile biological molecules.
• 3] This property of maintaining conformational integrity as well as high
degree of surface exposure and in targeting of bio-active molecules like
peptide and protein hormones, antigens and genes to specific sites.
• The carbohydrate stabilize nanoparticle of ceramic are known as
“Aquasomes “](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
Aquasome By shubham singh
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. Biologically active molecules are adsorbed onto the coating. They are able to sustainably release molecules and protect fragile molecules from the external environment due to their water-like properties. Aquasomes are prepared through a self-assembly process involving the preparation of a ceramic core through sonication or precipitation, coating the core with carbohydrates through adsorption, and immobilizing drug molecules onto the coating through partial adsorption. They show potential as carriers for vaccines, hemoglobin, drugs, dyes, and enzymes due to their ability to target sites and maintain molecular integrity.
Aquasomes
Three layered self assembled structures, containing the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film to which biochemically active molecules are adsorbed.
Aquasome ppt
Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification.
Aquasomes evaluation
Aquasomes are a nanoparticulate carrier system composed of a central solid nanocrystalline core coated with polyhydroxy oligomers onto which biologically active molecules are absorbed. They are spherical structures between 60-300nm in size that protect and preserve fragile molecules. Aquasomes are prepared using a simple process involving the formation of a ceramic core, coating with carbohydrates, and immobilizing drug molecules. They can be evaluated for characteristics like particle size, drug release kinetics, and loading efficiency. Potential applications of aquasomes include delivery of proteins, peptides, vaccines, and other molecules due to their ability to maintain structural integrity of payloads.
Aquasomes KKR
Intoduction ,Method of preparation of aquasomes by using the ''principle of self assembly'' and characterization of aquasomes.
AQUASOMES: A POTENTIAL DRUG DELIVERY CARRIER
This document summarizes aquasomes, which are spherical nanoparticles used for drug and antigen delivery. Aquasomes have water-like properties that protect and preserve fragile biological molecules. They are composed of a nano crystalline calcium phosphate or ceramic diamond particle core coated with a polyhydroxyl oligomer film. This coating allows for the adsorption of biochemically active molecules. Aquasomes can efficiently load and deliver substantial amounts of agents through various bonding mechanisms. They represent a simple yet novel drug carrier based on self-assembly that shows promise for delivering a variety of molecules like viral antigens, hemoglobin, and insulin while preserving conformational integrity and biochemical stability.
Aquasomes, principle,methods,
Aquasomes are a type of nanoparticle drug delivery system consisting of a solid crystalline core coated with an oligomeric film. They are spherical structures between 60-300 nm in size. Aquasomes are prepared using a self-assembly method involving three steps - preparation of the solid core, coating the core with a carbohydrate, and immobilizing the drug molecule. This allows for non-denaturing encapsulation of peptides, proteins, hormones and other biomolecules for targeted drug delivery.
Aquasomes
This slides contains Introduction about Aquasomes, advantages, proprties, preparation, application and reference.
Recommended
Aquasome By shubham singh
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. Biologically active molecules are adsorbed onto the coating. They are able to sustainably release molecules and protect fragile molecules from the external environment due to their water-like properties. Aquasomes are prepared through a self-assembly process involving the preparation of a ceramic core through sonication or precipitation, coating the core with carbohydrates through adsorption, and immobilizing drug molecules onto the coating through partial adsorption. They show potential as carriers for vaccines, hemoglobin, drugs, dyes, and enzymes due to their ability to target sites and maintain molecular integrity.
Aquasomes
Three layered self assembled structures, containing the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film to which biochemically active molecules are adsorbed.
Aquasome ppt
Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification.
Aquasomes evaluation
Aquasomes are a nanoparticulate carrier system composed of a central solid nanocrystalline core coated with polyhydroxy oligomers onto which biologically active molecules are absorbed. They are spherical structures between 60-300nm in size that protect and preserve fragile molecules. Aquasomes are prepared using a simple process involving the formation of a ceramic core, coating with carbohydrates, and immobilizing drug molecules. They can be evaluated for characteristics like particle size, drug release kinetics, and loading efficiency. Potential applications of aquasomes include delivery of proteins, peptides, vaccines, and other molecules due to their ability to maintain structural integrity of payloads.
Aquasomes KKR
Intoduction ,Method of preparation of aquasomes by using the ''principle of self assembly'' and characterization of aquasomes.
AQUASOMES: A POTENTIAL DRUG DELIVERY CARRIER
This document summarizes aquasomes, which are spherical nanoparticles used for drug and antigen delivery. Aquasomes have water-like properties that protect and preserve fragile biological molecules. They are composed of a nano crystalline calcium phosphate or ceramic diamond particle core coated with a polyhydroxyl oligomer film. This coating allows for the adsorption of biochemically active molecules. Aquasomes can efficiently load and deliver substantial amounts of agents through various bonding mechanisms. They represent a simple yet novel drug carrier based on self-assembly that shows promise for delivering a variety of molecules like viral antigens, hemoglobin, and insulin while preserving conformational integrity and biochemical stability.
Aquasomes, principle,methods,
Aquasomes are a type of nanoparticle drug delivery system consisting of a solid crystalline core coated with an oligomeric film. They are spherical structures between 60-300 nm in size. Aquasomes are prepared using a self-assembly method involving three steps - preparation of the solid core, coating the core with a carbohydrate, and immobilizing the drug molecule. This allows for non-denaturing encapsulation of peptides, proteins, hormones and other biomolecules for targeted drug delivery.
Aquasomes
This slides contains Introduction about Aquasomes, advantages, proprties, preparation, application and reference.
Aquasomes: Basic consideration
Aquasomes are spherical nanoparticles 60-300nm in size that are used to deliver drugs and antigens. They are composed of a central ceramic core coated with carbohydrates to protect and preserve fragile biological molecules. The core is typically made of calcium phosphate prepared using methods like sonication or colloidal precipitation. It is then coated with polyhydroxy oligomers like cellobiose or trehalose to stabilize the nanoparticle. Drugs or antigens are then adsorbed onto the coated core. Aquasomes maintain the structural integrity of molecules and deliver them through controlled release while protecting them from degradation. They have applications in delivering substances like insulin, hemoglobin, antigens, enzymes, and genes.
Aquasomes
Aquasomes are nano particulate carrier systems comprised of a solid crystalline core coated with an oligomeric film for absorbing active molecules. They are spherical structures between 60-300nm that use self-assembly of macromolecules. The core is prepared using materials like tin oxide or calcium phosphate then coated with carbohydrates through lyophilization. Drugs can then be loaded through adsorption. Applications include delivery of vaccines, enzymes, genes, hemoglobin, and insulin where the aquasome protects fragile molecules and targets delivery.
AQUASOME - NANOPARTICULATE DRUG DELIVERY SYSTEMS
This document summarizes a seminar presented by Soumyadip Ghosh on Aquasomes. Aquasomes are spherical nanoparticles between 60-300nm used for drug and antigen delivery. They are comprised of a solid nanocrystalline core coated with an oligomeric film that bioactive molecules can be adsorbed to. Aquasomes are prepared through a three step process - formation of an inorganic core, coating the core with a polyhydroxy oligomer, and loading the drug onto the assembled structure. They have advantages like preserving the integrity of biomolecules and allowing site-specific delivery. Applications include use as vaccines, red blood cell substitutes, and delivery of drugs like insulin.
Electrosome
This document describes electrosomes, which are a novel surface display system that allows multiple electron release from fuel oxidation using a scaffoldin protein and cascade of redox enzymes. Electrosomes consist of a hybrid anode with ethanol-oxidizing enzymes attached to scaffoldin and a hybrid cathode with an oxygen-reducing enzyme also attached to scaffoldin. This allows the electrosomes to function as both an anode and cathode in a biofuel cell. Characterization of the electrosomes showed they were able to catalyze the conversion of chemical energy from ethanol to electricity with high power outputs due to the enzymatic cascades in the anode. Potential applications of electrosomes include use in enzymatic fuel cells, drug targeting
Niosome
Niosomes are non-ionic surfactant-based vesicles that can be used for drug delivery. They self-assemble in aqueous solution and form bilayer structures that can encapsulate both hydrophilic and lipophilic drugs. Niosomes have advantages over liposomes like increased stability and lower toxicity. Various preparation techniques are used to make niosomes with optimal properties for drug loading and release. Niosomes have applications for delivery of drugs, genes, and proteins through various routes of administration including transdermal delivery.
Nttdds
Niosomes, Aquasomes, Phytosomes, and Electrosomes are novel drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer transdermal delivery benefits. Aquasomes are three-layered nanoparticles containing a ceramic core, carbohydrate coating, and adsorbed bioactive molecules. Phytosomes contain phytoconstituents bound to phospholipids to improve absorption of plant-based compounds. Electrosomes are ion channel proteins that span cell membranes and control ion flux, enabling electrical signaling in tissues like the brain, muscles and nervous system.
Cubosome - A Review
This review article covers the detailed about cubosome. Cubosomes are single crystal structures, with visible unilamellar vesicles, dispersed lamellar liquid crystalline phase particles. Increasing polymer to monoolein ratios leads to formation of larger vesicles. Cubosomes are nanoparticles whose size ranges from 10 50nm in diameter they appear like dots square shaped, slightly spherical. Each dot corresponds to the presence of pore containing aqueous phase cubic phases in lipid water system in X ray scattering technique. and also covers some methods of preparation of cubosome along with there characterization methods like Cryo Transmission Electron Microscopy Cryo TEM , Small Angle X ray Scattering SAXS , Particle Size Distribution PSD . Application of cubosome like vehicle activity of biological substances, controlled release of solubilized substances, Treatment of skin, hair, and other body tissue. Melanoma cancer therapy on size delivery system is the key to target cancer through the enhanced permeability and retention effect. With some advantages of cubosome. Vishal B. Patond | Ananta B. Ghonge | Mahesh B. Narkhede "Cubosome - A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31428.pdf Paper Url :https://www.ijtsrd.com/pharmacy/other/31428/cubosome-%E2%80%93-a-review/vishal-b-patond
Aquasomes
Aquasomes are a novel nanoparticle drug delivery system composed of three layers - a solid ceramic or polymeric core, an oligomeric coating, and biologically active molecules adsorbed to the coating. They are spherical structures 60-300nm in size that mimic water-like properties to preserve the conformational integrity and biochemical stability of fragile molecules. Aquasomes have been investigated for delivery of vaccines, genes, insulin, enzymes, and dyes due to their ability to maintain molecule conformation. They show potential as targeted drug carriers with applications including intracellular gene therapy and development of blood substitutes.
Aquasomes
1) Aquasomes are nanoparticulate carrier systems that are self-assembled structures comprising a solid nanocrystalline core coated with polyhydroxy oligomers onto which bioactive molecules are adsorbed.
2) They are able to preserve the integrity of biological molecules due to their water-like properties and can target specific sites in the body.
3) Aquasomes are prepared using a self-assembly process involving preparation of a ceramic core, coating the core with carbohydrates, and immobilizing a drug molecule on the coated core.
Niosomes,aquasomes,electrosomes,phytosomes
The document discusses various drug delivery systems including niosomes, aquasomes, and phytosomes. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer advantages over liposomes such as lower cost and greater stability. Aquasomes are three-layered nanoparticle structures consisting of a ceramic core coated with an oligosaccharide film that can deliver fragile molecules while maintaining their integrity. Phytosomes utilize phospholipids to surround active herbal constituents, improving their absorption and bioavailability compared to traditional herbal extracts.
Cubosomes
Cubosomes are liquid crystalline nanostructured particles formed from the self-assembly of amphiphilic molecules like monoolein. They have a bicontinuous internal structure divided into two separate but non-intersecting hydrophilic regions by a lipid bilayer. Cubosomes can be produced using either a "top-down" method by breaking up a bulk cubic phase or a "bottom-up" method by controlled crystallization from precursor solutions. Their interaction with model cell membranes is sensitive to small changes in surface charge, suggesting they could potentially be optimized to preferentially target cancer cells for drug delivery applications.
Aquasomes
This document discusses Aquasomes, which are nanoparticle carrier systems composed of a central solid nanocrystalline core coated with polyhydroxy oligomers onto which drug molecules can be adsorbed. Aquasomes are spherical particles 60-300nm in size that are used for targeted drug and antigen delivery. They are prepared through a self-assembly process involving the preparation of a ceramic core, coating the core with carbohydrates, and then immobilizing a drug molecule onto the coated core. Aquasomes have properties such as preserving the integrity of biomolecules and avoiding clearance from the body. They can be characterized through techniques like SEM, TEM, FT-IR, and XRD. Potential applications of Aquasomes
Niosomes ppt
niosomes introduction
structure of niosomes
advantages of niosomes
types of niosomes
formulation aspects
different types of surfactants used
different methods of preparation
difference between liposomes and niosomes
loading methods
characterizations of niosomes
modification aspects of niosomes
Liposomes and liposomal drug delivery system( recent advancement)
This document summarizes a seminar presentation on recent trends in pharmaceutical sciences focusing on liposomes. It defines liposomes as concentric bilayered vesicles enclosing an aqueous volume within a phospholipid membrane. The presentation covers the structural components of liposomes including commonly used phospholipids, classification based on lamellarity and size, various preparation methods such as mechanical dispersion, solvent dispersion, and detergent removal. It also discusses characterization, stability considerations, applications in drug delivery, recent advances, and some marketed liposome products.
NIOSOMES
Niosomes are novel drug delivery systems composed of non-ionic surfactants and cholesterol. They can encapsulate both hydrophilic and lipophilic drugs. Niosomes are prepared using methods like ether injection, film hydration, sonication, and microfluidization. Key factors that affect niosome formation include the surfactant used, addition of cholesterol, and hydration temperature. Niosomes offer advantages over liposomes like improved stability and the ability to entrap both hydrophilic and hydrophobic drugs. Niosomes find applications in targeted drug delivery through routes like transdermal, parenteral, oral and for ophthalmic and radiopharmaceutical uses.
Aquasome presentation
This document presents information on aquasomes, a novel carrier for drug delivery. Aquasomes are spherical, nanoparticulate carrier systems composed of a solid nanocrystalline core coated with an oligomeric film. They are capable of stabilizing and delivering delicate biomolecules like proteins, peptides, hormones, and genes. The core provides structural stability while the carbohydrate coating protects molecules from degradation. Characterization techniques like TEM, SEM, and DSC are used to analyze aquasome size, structure, and glass transition temperature. Applications include insulin, enzyme, oxygen, antigen and drug delivery where aquasomes show improved stability and biological activity over unformulated drugs.
Niosomes
This document provides an overview of niosomes, which are non-ionic surfactant-based vesicles used for drug delivery. It defines niosomes and discusses their general characteristics, structure, advantages/disadvantages compared to liposomes, factors affecting formation, types, materials used in preparation, characterization, applications, and recent advances. The key points are that niosomes encapsulate drugs in a bilayer structure for targeted delivery, have advantages over liposomes like stability and lower cost, and can be tailored for different drugs and preparation methods to optimize drug loading and release.
Bacterial Cellulose presentation
Bacterial cellulose is produced by certain bacteria through a four step process: strain selection, culture medium preparation, cultivation, and downstream processing. The conventional culture medium contains glucose, peptone and yeast extract. Recent studies have shown that adding ethanol and acetic acid to this medium can improve bacterial cellulose yield up to 279%. Bacterial cellulose has many applications including use in facial masks, food packaging, biomedical devices, and artificial meat.
Liposomes drug delivery systems
Liposomes are spherical vesicles made of concentric phospholipid bilayers that enclose an aqueous core. The phospholipids are amphipathic molecules with polar heads and nonpolar tails that allow them to form bilayers enclosing water. Cholesterol can be incorporated into the phospholipid bilayers and acts as a fluidity buffer.
Liposomes can be classified based on their size, number of bilayers, and preparation method. Common types include multilamellar vesicles (MLVs), oligolamellar vesicles (OLVs), and unilamellar vesicles (ULVs). Liposomes are characterized physically, chemically, and biologically to ensure predictable performance. Characterization evaluates parameters like size, lamellarity,
Liposome preparation and evaluation
By this you can find out all the method of preparation of liposomes and can know about the chemistry of their lipid.
Aquasomes
Aquasomes are nanoparticulate carrier systems that protect and deliver fragile biological molecules like proteins, peptides, and genes. They are self-assembled structures with a solid ceramic core coated with carbohydrates. This seminar discusses the properties, preparation, and characterization of aquasomes. Aquasomes are prepared via a three-step process - ceramic core fabrication, carbohydrate coating, and drug immobilization using self-assembly. They can effectively deliver vaccines, hemoglobin, enzymes, and other drugs while preserving molecular integrity. Some potential applications mentioned include insulin delivery and an oral enzyme delivery system.
AQUASOMES-RIDA SHARIF F.Y.MPHARM, BVPCOP
Aquasomes are nanoparticle carrier systems composed of a ceramic or calcium phosphate crystalline core coated with polyhydroxy oligomers. They are spherical structures between 60-300 nm in size that can encapsulate biomolecules like proteins, peptides, genes, and drugs. Aquasomes protect and stabilize biomolecules through their water-like properties and allow for targeted delivery and sustained release of their payload.
More Related Content
What's hot
Aquasomes: Basic consideration
Aquasomes are spherical nanoparticles 60-300nm in size that are used to deliver drugs and antigens. They are composed of a central ceramic core coated with carbohydrates to protect and preserve fragile biological molecules. The core is typically made of calcium phosphate prepared using methods like sonication or colloidal precipitation. It is then coated with polyhydroxy oligomers like cellobiose or trehalose to stabilize the nanoparticle. Drugs or antigens are then adsorbed onto the coated core. Aquasomes maintain the structural integrity of molecules and deliver them through controlled release while protecting them from degradation. They have applications in delivering substances like insulin, hemoglobin, antigens, enzymes, and genes.
Aquasomes
Aquasomes are nano particulate carrier systems comprised of a solid crystalline core coated with an oligomeric film for absorbing active molecules. They are spherical structures between 60-300nm that use self-assembly of macromolecules. The core is prepared using materials like tin oxide or calcium phosphate then coated with carbohydrates through lyophilization. Drugs can then be loaded through adsorption. Applications include delivery of vaccines, enzymes, genes, hemoglobin, and insulin where the aquasome protects fragile molecules and targets delivery.
AQUASOME - NANOPARTICULATE DRUG DELIVERY SYSTEMS
This document summarizes a seminar presented by Soumyadip Ghosh on Aquasomes. Aquasomes are spherical nanoparticles between 60-300nm used for drug and antigen delivery. They are comprised of a solid nanocrystalline core coated with an oligomeric film that bioactive molecules can be adsorbed to. Aquasomes are prepared through a three step process - formation of an inorganic core, coating the core with a polyhydroxy oligomer, and loading the drug onto the assembled structure. They have advantages like preserving the integrity of biomolecules and allowing site-specific delivery. Applications include use as vaccines, red blood cell substitutes, and delivery of drugs like insulin.
Electrosome
This document describes electrosomes, which are a novel surface display system that allows multiple electron release from fuel oxidation using a scaffoldin protein and cascade of redox enzymes. Electrosomes consist of a hybrid anode with ethanol-oxidizing enzymes attached to scaffoldin and a hybrid cathode with an oxygen-reducing enzyme also attached to scaffoldin. This allows the electrosomes to function as both an anode and cathode in a biofuel cell. Characterization of the electrosomes showed they were able to catalyze the conversion of chemical energy from ethanol to electricity with high power outputs due to the enzymatic cascades in the anode. Potential applications of electrosomes include use in enzymatic fuel cells, drug targeting
Niosome
Niosomes are non-ionic surfactant-based vesicles that can be used for drug delivery. They self-assemble in aqueous solution and form bilayer structures that can encapsulate both hydrophilic and lipophilic drugs. Niosomes have advantages over liposomes like increased stability and lower toxicity. Various preparation techniques are used to make niosomes with optimal properties for drug loading and release. Niosomes have applications for delivery of drugs, genes, and proteins through various routes of administration including transdermal delivery.
Nttdds
Niosomes, Aquasomes, Phytosomes, and Electrosomes are novel drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer transdermal delivery benefits. Aquasomes are three-layered nanoparticles containing a ceramic core, carbohydrate coating, and adsorbed bioactive molecules. Phytosomes contain phytoconstituents bound to phospholipids to improve absorption of plant-based compounds. Electrosomes are ion channel proteins that span cell membranes and control ion flux, enabling electrical signaling in tissues like the brain, muscles and nervous system.
Cubosome - A Review
This review article covers the detailed about cubosome. Cubosomes are single crystal structures, with visible unilamellar vesicles, dispersed lamellar liquid crystalline phase particles. Increasing polymer to monoolein ratios leads to formation of larger vesicles. Cubosomes are nanoparticles whose size ranges from 10 50nm in diameter they appear like dots square shaped, slightly spherical. Each dot corresponds to the presence of pore containing aqueous phase cubic phases in lipid water system in X ray scattering technique. and also covers some methods of preparation of cubosome along with there characterization methods like Cryo Transmission Electron Microscopy Cryo TEM , Small Angle X ray Scattering SAXS , Particle Size Distribution PSD . Application of cubosome like vehicle activity of biological substances, controlled release of solubilized substances, Treatment of skin, hair, and other body tissue. Melanoma cancer therapy on size delivery system is the key to target cancer through the enhanced permeability and retention effect. With some advantages of cubosome. Vishal B. Patond | Ananta B. Ghonge | Mahesh B. Narkhede "Cubosome - A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31428.pdf Paper Url :https://www.ijtsrd.com/pharmacy/other/31428/cubosome-%E2%80%93-a-review/vishal-b-patond
Aquasomes
Aquasomes are a novel nanoparticle drug delivery system composed of three layers - a solid ceramic or polymeric core, an oligomeric coating, and biologically active molecules adsorbed to the coating. They are spherical structures 60-300nm in size that mimic water-like properties to preserve the conformational integrity and biochemical stability of fragile molecules. Aquasomes have been investigated for delivery of vaccines, genes, insulin, enzymes, and dyes due to their ability to maintain molecule conformation. They show potential as targeted drug carriers with applications including intracellular gene therapy and development of blood substitutes.
Aquasomes
1) Aquasomes are nanoparticulate carrier systems that are self-assembled structures comprising a solid nanocrystalline core coated with polyhydroxy oligomers onto which bioactive molecules are adsorbed.
2) They are able to preserve the integrity of biological molecules due to their water-like properties and can target specific sites in the body.
3) Aquasomes are prepared using a self-assembly process involving preparation of a ceramic core, coating the core with carbohydrates, and immobilizing a drug molecule on the coated core.
Niosomes,aquasomes,electrosomes,phytosomes
The document discusses various drug delivery systems including niosomes, aquasomes, and phytosomes. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer advantages over liposomes such as lower cost and greater stability. Aquasomes are three-layered nanoparticle structures consisting of a ceramic core coated with an oligosaccharide film that can deliver fragile molecules while maintaining their integrity. Phytosomes utilize phospholipids to surround active herbal constituents, improving their absorption and bioavailability compared to traditional herbal extracts.
Cubosomes
Cubosomes are liquid crystalline nanostructured particles formed from the self-assembly of amphiphilic molecules like monoolein. They have a bicontinuous internal structure divided into two separate but non-intersecting hydrophilic regions by a lipid bilayer. Cubosomes can be produced using either a "top-down" method by breaking up a bulk cubic phase or a "bottom-up" method by controlled crystallization from precursor solutions. Their interaction with model cell membranes is sensitive to small changes in surface charge, suggesting they could potentially be optimized to preferentially target cancer cells for drug delivery applications.
Aquasomes
This document discusses Aquasomes, which are nanoparticle carrier systems composed of a central solid nanocrystalline core coated with polyhydroxy oligomers onto which drug molecules can be adsorbed. Aquasomes are spherical particles 60-300nm in size that are used for targeted drug and antigen delivery. They are prepared through a self-assembly process involving the preparation of a ceramic core, coating the core with carbohydrates, and then immobilizing a drug molecule onto the coated core. Aquasomes have properties such as preserving the integrity of biomolecules and avoiding clearance from the body. They can be characterized through techniques like SEM, TEM, FT-IR, and XRD. Potential applications of Aquasomes
Niosomes ppt
niosomes introduction
structure of niosomes
advantages of niosomes
types of niosomes
formulation aspects
different types of surfactants used
different methods of preparation
difference between liposomes and niosomes
loading methods
characterizations of niosomes
modification aspects of niosomes
Liposomes and liposomal drug delivery system( recent advancement)
This document summarizes a seminar presentation on recent trends in pharmaceutical sciences focusing on liposomes. It defines liposomes as concentric bilayered vesicles enclosing an aqueous volume within a phospholipid membrane. The presentation covers the structural components of liposomes including commonly used phospholipids, classification based on lamellarity and size, various preparation methods such as mechanical dispersion, solvent dispersion, and detergent removal. It also discusses characterization, stability considerations, applications in drug delivery, recent advances, and some marketed liposome products.
NIOSOMES
Niosomes are novel drug delivery systems composed of non-ionic surfactants and cholesterol. They can encapsulate both hydrophilic and lipophilic drugs. Niosomes are prepared using methods like ether injection, film hydration, sonication, and microfluidization. Key factors that affect niosome formation include the surfactant used, addition of cholesterol, and hydration temperature. Niosomes offer advantages over liposomes like improved stability and the ability to entrap both hydrophilic and hydrophobic drugs. Niosomes find applications in targeted drug delivery through routes like transdermal, parenteral, oral and for ophthalmic and radiopharmaceutical uses.
Aquasome presentation
This document presents information on aquasomes, a novel carrier for drug delivery. Aquasomes are spherical, nanoparticulate carrier systems composed of a solid nanocrystalline core coated with an oligomeric film. They are capable of stabilizing and delivering delicate biomolecules like proteins, peptides, hormones, and genes. The core provides structural stability while the carbohydrate coating protects molecules from degradation. Characterization techniques like TEM, SEM, and DSC are used to analyze aquasome size, structure, and glass transition temperature. Applications include insulin, enzyme, oxygen, antigen and drug delivery where aquasomes show improved stability and biological activity over unformulated drugs.
Niosomes
This document provides an overview of niosomes, which are non-ionic surfactant-based vesicles used for drug delivery. It defines niosomes and discusses their general characteristics, structure, advantages/disadvantages compared to liposomes, factors affecting formation, types, materials used in preparation, characterization, applications, and recent advances. The key points are that niosomes encapsulate drugs in a bilayer structure for targeted delivery, have advantages over liposomes like stability and lower cost, and can be tailored for different drugs and preparation methods to optimize drug loading and release.
Bacterial Cellulose presentation
Bacterial cellulose is produced by certain bacteria through a four step process: strain selection, culture medium preparation, cultivation, and downstream processing. The conventional culture medium contains glucose, peptone and yeast extract. Recent studies have shown that adding ethanol and acetic acid to this medium can improve bacterial cellulose yield up to 279%. Bacterial cellulose has many applications including use in facial masks, food packaging, biomedical devices, and artificial meat.
Liposomes drug delivery systems
Liposomes are spherical vesicles made of concentric phospholipid bilayers that enclose an aqueous core. The phospholipids are amphipathic molecules with polar heads and nonpolar tails that allow them to form bilayers enclosing water. Cholesterol can be incorporated into the phospholipid bilayers and acts as a fluidity buffer.
Liposomes can be classified based on their size, number of bilayers, and preparation method. Common types include multilamellar vesicles (MLVs), oligolamellar vesicles (OLVs), and unilamellar vesicles (ULVs). Liposomes are characterized physically, chemically, and biologically to ensure predictable performance. Characterization evaluates parameters like size, lamellarity,
Liposome preparation and evaluation
By this you can find out all the method of preparation of liposomes and can know about the chemistry of their lipid.
What's hot (20)
Liposomes and liposomal drug delivery system( recent advancement)
Liposomes and liposomal drug delivery system( recent advancement)
Similar to Synthesis of aquasomes
Aquasomes
Aquasomes are nanoparticulate carrier systems that protect and deliver fragile biological molecules like proteins, peptides, and genes. They are self-assembled structures with a solid ceramic core coated with carbohydrates. This seminar discusses the properties, preparation, and characterization of aquasomes. Aquasomes are prepared via a three-step process - ceramic core fabrication, carbohydrate coating, and drug immobilization using self-assembly. They can effectively deliver vaccines, hemoglobin, enzymes, and other drugs while preserving molecular integrity. Some potential applications mentioned include insulin delivery and an oral enzyme delivery system.
AQUASOMES-RIDA SHARIF F.Y.MPHARM, BVPCOP
Aquasomes are nanoparticle carrier systems composed of a ceramic or calcium phosphate crystalline core coated with polyhydroxy oligomers. They are spherical structures between 60-300 nm in size that can encapsulate biomolecules like proteins, peptides, genes, and drugs. Aquasomes protect and stabilize biomolecules through their water-like properties and allow for targeted delivery and sustained release of their payload.
AQUASOMES: A NOVEL CARRIER FOR DRUG DELIVERY SYSTEM
This document discusses aquasomes, which are spherical nanoparticle carrier systems composed of a solid nanocrystalline core coated with an oligomeric film. Aquasomes are self-assembled using non-covalent and ionic bonds. They are used to deliver and protect delicate biomolecules. The core provides structural stability while the carbohydrate coating protects against dehydration and stabilizes biomolecules. Common methods to prepare aquasomes include precipitating a ceramic core, coating it with disaccharides using sonication, and immobilizing a drug molecule onto the coated particles. Potential applications of aquasomes include insulin delivery, oral enzyme delivery, oxygen transport, antigen delivery, and drug or gene delivery.
Aquasomes ppt.pptx
aquasomes
intro
properties of aquasomes
principle
method of preparation
evaluation
advantages
application
application
AQUASOMES , introduction, principle, applications
Aquasomes are spherical nanoparticles ranging from 60-300nm that are used for drug and antigen delivery. They have a nanocrystalline ceramic core coated with an oligomeric film to which bioactive molecules can be adsorbed. Common core materials include polymers, ceramics, and drugs while coatings include cellobiose, citrate, and trehalose. Aquasomes preserve the conformation of bioactives, provide targeted and sustained release, and can load substantial amounts of cargo onto their active surfaces. They are formulated through a self-assembly process involving the preparation of cores, coating them, and immobilizing drugs or antigens. Potential applications include vaccines, blood substitutes, gene therapy, and delivery of
Aquasomes .pptx
Aquasomes are spherical nanoparticles ranging from 60-300nm that are used for drug and antigen delivery. They are self-assembled structures with a ceramic core coated with polyhydroxyl oligomers to which bioactive molecules can be adsorbed. This coating protects and preserves the drug while allowing release in a sustained manner. Aquasomes are prepared via a simple process involving the formation of an inorganic core, coating with protective oligomers, and then loading the drug molecule. They can be used to deliver various payloads like proteins, enzymes, antigens, and genetic material due to their ability to maintain molecular integrity and target delivery. Characterization techniques confirm their structure, size, and drug loading.
Aquasome
This document summarizes a seminar presented by Soumyadip Ghosh on Aquasomes. Aquasomes are spherical nanoparticles between 60-300nm used for drug and antigen delivery. They are comprised of a solid nanocrystalline core coated with an oligomeric film that bioactive molecules can be adsorbed to. Aquasomes are prepared through a three step process - formation of an inorganic core, coating the core with a polyhydroxy oligomer, and loading the drug onto the assembled structure. They have advantages like preserving the integrity of biomolecules and allowing site-specific delivery. Applications include delivery of vaccines, hemoglobin, insulin, enzymes and more.
aquasomes ppt.pptx
Aquasomes are spherical nanoparticles 60-300nm in size that are used for drug and antigen delivery. They consist of a solid ceramic core like calcium phosphate or diamond, coated with a carbohydrate layer. This three-layered structure is self-assembled via non-covalent bonds. Aquasomes preserve the integrity of biological molecules and can be loaded with drugs via absorption to treat issues like poor bioavailability. They are prepared via methods like colloidal precipitation and sonication to form the core, then coated and loaded with the drug or antigen for targeted delivery applications like vaccines, gene therapy, and oxygen transport.
AQUASOMES (1).pptx
One of the most recently created delivery systems for bioactive chemicals like peptides, proteins, hormones, antigens, and genes is called an aquasome. Aquasomes have circular 60–300 nm-sized particles. Aquasomes are networks of nanoparticulate carriers rather than pure nanoparticles. They are spherical particles made of calcium phosphate or ceramic diamond coated with a polyhydroxy oligomeric layer. A solid phase nanocrystalline core covered in an oligomeric film that adsorbs biochemically active molecules with or without modification makes up the core of the three layers of self-assembled structures. It frequently serves as an implant preparatory tool.
Aquasomes
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They are able to protect fragile biological molecules through water-like properties and high surface exposure. Aquasomes are prepared through a self-assembly process involving interaction of charged groups, hydrogen bonding, and structural stability. This allows active loading of molecules like proteins, antigens, and genes. Characterization techniques confirm the structure, drug loading, and release kinetics of aquasomes, which have applications in delivery of vaccines, hemoglobin, insulin, and enzymes orally and intravenously.
Aquasomes
Molecular Pharmaceutics.
Aquasomes represents promising, simplest and novel drug carrier for delivering broad range of molecules including viral antigens, haemoglobin, insulin,etc.
WHAT ARE AQUASOMES.pdf
Aquasomes are spherical, nanoparticulate carrier systems that are 60-300nm in diameter. They have a three-layered structure comprising a central nanocrystalline core coated with polyhydroxy oligomers onto which biologically active molecules can be adsorbed. Aquasomes protect and preserve fragile molecules due to their water-like properties. They are prepared through self-assembly using sonication or colloidal precipitation to form the core, followed by coating with carbohydrates and immobilization of drug molecules. Due to their size and structure, aquasomes can efficiently deliver drugs, vaccines, proteins and other molecules by avoiding clearance from the body.
Aquasomes.pptx.aquasome a novel drug carrier in pharmaceuticals
Aquasomes are nanoscale, self-assembled particles composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They can encapsulate and protect drugs, allowing for sustained and targeted release. Aquasomes are prepared through a method of self-assembly involving the preparation of a ceramic or polymeric core, coating the core with carbohydrates, and immobilizing a drug molecule. They show potential for applications in cancer treatment, gene therapy, diabetes management, and as oxygen carriers or vaccine delivery systems. However, challenges remain regarding their long-term stability, large-scale production, and potential toxicity. Ongoing research aims to enhance their targeting abilities and develop responsive systems for customized delivery.
Aquasomes as Nanodrugdelivery System M.Pharm
Aquasomes are novel formulation used as carriers in drug delivery of various protein and Antigen Delivery
Aquasome devilal pe 09
Aquasomes are a recently developed nanoparticle drug delivery system composed of three layers: a solid inorganic core coated with an oligomeric film layer to which bioactive molecules such as proteins, peptides, hormones, antigens or genes can be adsorbed. They are spherical structures between 60-300nm in size that self-assemble via non-covalent and ionic bonds. The core provides structural stability while the coating protects and stabilizes the drug. Aquasomes have been used to successfully deliver insulin, hemoglobin and enzymes. They can target delivery of molecules like peptides to specific sites and have applications as vaccines and for delivery of enzymes, blood substitutes and cosmetic pigments.
Aquasomes
Aquasomes are a nanoparticulate carrier system used to deliver bioactive molecules like drugs, vaccines, and enzymes. They are composed of a central crystalline core coated with carbohydrates that can adsorb drug molecules. Aquasomes can be prepared through a simple three-step process involving core preparation through co-precipitation or self-precipitation, carbohydrate coating, and drug immobilization. They offer advantages like protecting drugs, targeting delivery, and sustained release. Potential applications include delivery of insulin, vaccines, enzymes, and poorly soluble drugs.
La Trobe Presentation - Sept 7
The ANFF Biointerface Engineering Hub focuses on using synthetic and biological components to create new materials and surfaces. It has 6 custom plasma reactors and characterization equipment. Previous work included drug-membrane studies and surface patterning. Plasma polymerized cineole films reduced E. coli bacteria and biofilm growth. Modified electrospun fibers with plasma polymers impacted E. coli integration and growth. Plasma polymers also manipulated vesicle adsorption and collapse to form supported lipid bilayers, a cell membrane model. Current projects include preventing bacterial attachment and developing a cell culture platform.
Niosomes and Aquasomes
This document provides an overview of Niosomes and Aquasomes as novel drug delivery systems. Niosomes are vesicle systems composed of non-ionic surfactants that can encapsulate medications. They are prepared using methods like ether injection, thin film hydration, sonication, and offer advantages over liposomes. Aquasomes are three-layered, self-assembled nanoparticle structures with a solid inorganic core coated with oligomers and bioactive molecules. Both systems can be characterized and show applications in targeted drug delivery, diagnostics, and improving drug stability and efficacy.
Application of Biological Assemblies in NanoBiotechnology PPt
The document discusses several applications of biological assemblies in nanobiotechnology. It describes how biological assemblies, such as hemoglobin, are the functional forms of molecules and can be used to build larger structures. It then discusses using drug nanocrystals to improve drug solubility and bioavailability. Next, it covers using nano-containers like liposomes for targeted drug delivery. The document also discusses using protein crystals called S-layers for nanolithography and peptide templates for controlling biomineralization. Finally, it discusses the potential of utilizing biomineralization principles in nanotechnology applications like tissue engineering.
liposome
This document provides an overview of liposomes, including their composition, advantages, classification, preparation methods, characterization, and applications. Liposomes are spherical vesicles composed of phospholipid bilayers that can encapsulate drugs. They range in size from 20nm to several micrometers. Key advantages include biodegradability, protection of encapsulated drugs, and improved drug pharmacokinetics. Common preparation methods include mechanical dispersion, solvent dispersion, and detergent removal. Liposomes are characterized based on size, surface charge, drug entrapment percentage, and lamellarity. They have applications as drug and gene delivery vehicles in cancer therapy, antimicrobial therapy, and more.
Similar to Synthesis of aquasomes (20)
AQUASOMES: A NOVEL CARRIER FOR DRUG DELIVERY SYSTEM
AQUASOMES: A NOVEL CARRIER FOR DRUG DELIVERY SYSTEM
Aquasomes.pptx.aquasome a novel drug carrier in pharmaceuticals
Aquasomes.pptx.aquasome a novel drug carrier in pharmaceuticals
Application of Biological Assemblies in NanoBiotechnology PPt
Application of Biological Assemblies in NanoBiotechnology PPt
Recently uploaded
ASONAM2023_presection_slide_track-recommendation.pdf
Presented at the 2023 IEEE/ACM International Conference on
Advances in Social Networks Analysis and Mining.
Artificial Intelligence, Data and Competition – OECD – June 2024 OECD discussion
Artificial Intelligence, Data and Competition – OECD – June 2024 OECD discussionOECD Directorate for Financial and Enterprise Affairs
This presentation by OECD, OECD Secretariat, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
XP 2024 presentation: A New Look to Leadership
Presentation slides from XP2024 conference, Bolzano IT. The slides describe a new view to leadership and combines it with anthro-complexity (aka cynefin).
Artificial Intelligence, Data and Competition – ČORBA – June 2024 OECD discus...
Artificial Intelligence, Data and Competition – ČORBA – June 2024 OECD discus...OECD Directorate for Financial and Enterprise Affairs
This presentation by Juraj Čorba, Chair of OECD Working Party on Artificial Intelligence Governance (AIGO), was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
Presentatie 8. Joost van der Linde & Daniel Anderton - Eliq 28 mei 2024
Dutch Power Event
“AI – Navigeren naar de toekomst?”
Op 28 mei 2024 bij Info Support.
Tom tresser burning issue.pptx My Burning issue
Addressing the status of black home ownership in America. and what actions are taken to impact these trends.
Pro-competitive Industrial Policy – OECD – June 2024 OECD discussion
Pro-competitive Industrial Policy – OECD – June 2024 OECD discussionOECD Directorate for Financial and Enterprise Affairs
This presentation by OECD, OECD Secretariat, was made during the discussion “Pro-competitive Industrial Policy” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/pcip.
This presentation was uploaded with the author’s consent.
Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie Wells
Insight: In a landscape where traditional narrative structures are giving way to fragmented and non-linear forms of storytelling, there lies immense potential for creativity and exploration.
'Collapsing Narratives: Exploring Non-Linearity' is a micro report from Rosie Wells.
Rosie Wells is an Arts & Cultural Strategist uniquely positioned at the intersection of grassroots and mainstream storytelling.
Their work is focused on developing meaningful and lasting connections that can drive social change.
Please download this presentation to enjoy the hyperlinks!
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
This is a workshop about communication and collaboration. We will experience how we can analyze the reasons for resistance to change (exercise 1) and practice how to improve our conversation style and be more in control and effective in the way we communicate (exercise 2).
This session will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
Abstract:
Let’s talk about powerful conversations! We all know how to lead a constructive conversation, right? Then why is it so difficult to have those conversations with people at work, especially those in powerful positions that show resistance to change?
Learning to control and direct conversations takes understanding and practice.
We can combine our innate empathy with our analytical skills to gain a deeper understanding of complex situations at work. Join this session to learn how to prepare for difficult conversations and how to improve our agile conversations in order to be more influential without power. We will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
In the session you will experience how preparing and reflecting on your conversation can help you be more influential at work. You will learn how to communicate more effectively with the people needed to achieve positive change. You will leave with a self-revised version of a difficult conversation and a practical model to use when you get back to work.
Come learn more on how to become a real influencer!
Updated diagnosis. Cause and treatment of hypothyroidism
Types, classification, causes, diagnosis and treatment of hypothyroidism
Presentatie 4. Jochen Cremer - TU Delft 28 mei 2024
Dutch Power Event
“AI – Navigeren naar de toekomst?”
Op 28 mei 2024 bij Info Support.
Carrer goals.pptx and their importance in real life
Career goals serve as a roadmap for individuals, guiding them toward achieving long-term professional aspirations and personal fulfillment. Establishing clear career goals enables professionals to focus their efforts on developing specific skills, gaining relevant experience, and making strategic decisions that align with their desired career trajectory. By setting both short-term and long-term objectives, individuals can systematically track their progress, make necessary adjustments, and stay motivated. Short-term goals often include acquiring new qualifications, mastering particular competencies, or securing a specific role, while long-term goals might encompass reaching executive positions, becoming industry experts, or launching entrepreneurial ventures.
Moreover, having well-defined career goals fosters a sense of purpose and direction, enhancing job satisfaction and overall productivity. It encourages continuous learning and adaptation, as professionals remain attuned to industry trends and evolving job market demands. Career goals also facilitate better time management and resource allocation, as individuals prioritize tasks and opportunities that advance their professional growth. In addition, articulating career goals can aid in networking and mentorship, as it allows individuals to communicate their aspirations clearly to potential mentors, colleagues, and employers, thereby opening doors to valuable guidance and support. Ultimately, career goals are integral to personal and professional development, driving individuals toward sustained success and fulfillment in their chosen fields.
Pro-competitive Industrial Policy – LANE – June 2024 OECD discussion
Pro-competitive Industrial Policy – LANE – June 2024 OECD discussionOECD Directorate for Financial and Enterprise Affairs
This presentation by Nathaniel Lane, Associate Professor in Economics at Oxford University, was made during the discussion “Pro-competitive Industrial Policy” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/pcip.
This presentation was uploaded with the author’s consent.
Competition and Regulation in Professions and Occupations – ROBSON – June 202...
Competition and Regulation in Professions and Occupations – ROBSON – June 202...OECD Directorate for Financial and Enterprise Affairs
This presentation by Professor Alex Robson, Deputy Chair of Australia’s Productivity Commission, was made during the discussion “Competition and Regulation in Professions and Occupations” held at the 77th meeting of the OECD Working Party No. 2 on Competition and Regulation on 10 June 2024. More papers and presentations on the topic can be found at oe.cd/crps.
This presentation was uploaded with the author’s consent.2024-05-30_meetup_devops_aix-marseille.pdf
Slides de notre meetup DevOps AixMarseille du 30 mai 2024 chez SmarTribune
Sujets: platform engineering / terragrunt / test containers
Artificial Intelligence, Data and Competition – LIM – June 2024 OECD discussion
Artificial Intelligence, Data and Competition – LIM – June 2024 OECD discussionOECD Directorate for Financial and Enterprise Affairs
This presentation by Yong Lim, Professor of Economic Law at Seoul National University School of Law, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
原版制作贝德福特大学毕业证（bedfordhire毕业证）硕士文凭原版一模一样
原版一模一样【微信：741003700 】【贝德福特大学毕业证（bedfordhire毕业证）硕士文凭】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
Recently uploaded (20)
ASONAM2023_presection_slide_track-recommendation.pdf
ASONAM2023_presection_slide_track-recommendation.pdf
Artificial Intelligence, Data and Competition – OECD – June 2024 OECD discussion
Artificial Intelligence, Data and Competition – OECD – June 2024 OECD discussion
Artificial Intelligence, Data and Competition – ČORBA – June 2024 OECD discus...
Artificial Intelligence, Data and Competition – ČORBA – June 2024 OECD discus...
Presentatie 8. Joost van der Linde & Daniel Anderton - Eliq 28 mei 2024
Presentatie 8. Joost van der Linde & Daniel Anderton - Eliq 28 mei 2024
Pro-competitive Industrial Policy – OECD – June 2024 OECD discussion
Pro-competitive Industrial Policy – OECD – June 2024 OECD discussion
Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie Wells
Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie Wells
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
Updated diagnosis. Cause and treatment of hypothyroidism
Updated diagnosis. Cause and treatment of hypothyroidism
Presentatie 4. Jochen Cremer - TU Delft 28 mei 2024
Presentatie 4. Jochen Cremer - TU Delft 28 mei 2024
Carrer goals.pptx and their importance in real life
Carrer goals.pptx and their importance in real life
Pro-competitive Industrial Policy – LANE – June 2024 OECD discussion
Pro-competitive Industrial Policy – LANE – June 2024 OECD discussion
Competition and Regulation in Professions and Occupations – ROBSON – June 202...
Competition and Regulation in Professions and Occupations – ROBSON – June 202...
Artificial Intelligence, Data and Competition – LIM – June 2024 OECD discussion
Artificial Intelligence, Data and Competition – LIM – June 2024 OECD discussion
Synthesis of aquasomes
- 1. SYNTHESIS OF AQUASOMES R.SUSHMA ASSISTANT PROFESSOR GEETHANJALI COLLEGE OF PHARMACY
- 2. AQUASOMES • Three layered self assembled structures, containing the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film to which biochemically active molecules are adsorbed . • Aquasomes are spherical 60-300nm particles used for drug and antigen delivery. • It was first developed by NIR KOSSOVSKY. • Aquasomes are called as “ bodies of water ’’ • 1] Their water like properties. • 2] Protect and preserve fragile biological molecules. • 3] This property of maintaining conformational integrity as well as high degree of surface exposure and in targeting of bio-active molecules like peptide and protein hormones, antigens and genes to specific sites. • The carbohydrate stabilize nanoparticle of ceramic are known as “Aquasomes “
- 3. SYNTHESIS • PREPARATION OF THE CORE • Fabrication of the ceramic core by colloidal precipitation and sonication. • CARBOHYDRATE COATING • Coating by carbohydrate on the surface of ceramic cores. • Addition of polyhydroxyl oligomer , sonication and then lyophilization. • Coating material used are cellobiose, citrate, sucrose and trehalose. • Immobilization of drug molecule.
- 5. • Carbohydrate coating • The second step involves coating by carbohydrate on the surface of ceramic cores. • There are number of processes to enable the carbohydrate (polyhydroxy oligomers) coating to adsorb epitaxially on to the surface of the Nano crystalline ceramic cores. • Process generally detail: • Addition of poly hydroxy oligomer, To a dispersion of core in ultra pure water. Lyophilization (to promote the adsorption of carbohydrate on the surface of ceramic core) Excess of carbohydrate is removed by stir cell ultrafilteration. • Commonly used coating material, • Cellobiose - Citrate - Sucrose - Trihalose - Pyridoxal -5- phosphate. • (3) Immobilization of drug • The surface modified Nano crystalline core provide the solid phase for subsequent non denaturing self assembly for a broad range of biological active molecule. • Drug can be loaded by partial adsorption
- 6. • APPLICATIONS OF AQUASOMES • Aquasomes has got a quite versatile application potential as a carrier for delivery of vaccines, hemoglobin, drugs, dyes, enzymes. • 1) Aquasomes used as vaccines for delivery of viral antigen • 2) Aquasomes as red blood cell substitutes can effectively deliver the large, complex labile molecule, haemoglobin. By incorporating in aquasome carriers, the toxicity of haemoglobin is reduced, biological activity is preserved, haemoglobin concentration of 80% can be achieved and is reported to deliver oxygen in a non linear manner like natural red blood cells. • 3) Aquasomes for pharmaceuticals delivery i.e. insulin, developed because drug activity is conformationally specific. Bio activity preserved and activity increased to 60% as compared to i.v. administration and toxicity not reported . ) Aquasomes are used for oral delivery of acid labile enzyme, serratiopeptidase. Enzyme loaded aquasome was further protected by encapsulating in alginate gel. They protected structural integrity of enzymes and better therapeutic efficacy was observed .