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Structure of Hemoglobin
- 1. Structure Of Hemoglobin V.S.RASHMIPRIYEM ULTRA’S BEST DENTAL SCIENCE COLLEGE
- 2. HEMOGLOBIN • CONJUGATED PROTEIN •CONTAINING HEME AND GLOBIN • TETRAMERIC ALLOSTERIC PROTEIN
- 3. HEME • NON PROTEINPART • PROSTHETIC PART
- 4.
- 5. RBCs • RED BLOODPIGMENT IN ERYTHROCYTES
- 6. NORMAL CONCENTRATION • MALES ▫14-16 g/dL • FEMALES ▫ 13-15 g/dL
- 7. BIOCHEMICAL FUNCTION • ASSOCIATEDWITH RESPIRATION • DELIVERY OF O2 FROM LUNG TO TISSUES • TRANSPORT OF CO2 AND PROTONS FROM TISSUES AND LUNGS
- 8. SHAPE • HEMOGLOBIN ISGLOBULAR IN SHAPE
- 9. HbA • MADE UPOF ▫ 2 α CHAINS ▫ 2 β CHAINS • NORMAL BLOOD CONTAINS 97% HbA
- 10. HbA2 • MADE UPOF ▫ 2 α CHAINS ▫ 2 δ CHAINS • NORMAL BLOOD CONTAINS 2% HbA2
- 11. HbF • MADE UPOF ▫ 2 α CHAINS ▫ 2 γ CHAINS • NORMAL BLOOD CONTAINS 1% HbF
- 12. GENES RESPONSIBLE • ALPHACHAIN GENE IS PRESENT ON CHROMOSOME 16 • BETA, GAMMA AND DELTA CHAIN GENES ARE PRESENT ON CHROMOSOME 11
- 14. AMINO ACIDS • EACHALPHA CHAIN HAS 141 AMINO ACIDS • EACH BETA, GAMMA AND DELTA CHAINS HAVE 146 AMINO ACIDS • ON A TOTAL HEMOGLOBIN CONTAINS 574 AMINO ACIDS
- 15. STRUCTURE OF HEME •CONTAINS PORPHYRIN RING • CONSISTS OF 4 PYRROLE RINGS LINKED BY METHYLENE BRIDGES • WITH IRON(FERROUS STATE) AT ITS CENTER
- 16. STRUCTURE OF GLOBIN •CONSISTS OF 4 POLYPEPTIDE CHAINS • CONTAINS 574 AA RESIDUES
- 17. BUFFERING ACTION • CONTAINS36 HISTIDINE RESIDUES • IMP. IN BUFFERING ACTION
- 19. DISTAL HISTIDINE • 58THAA IS HISTIDINE • KNOWN AS DISTAL HISTIDINE • AWAY FROM IRON ATOM
- 20. PROXIMAL HISTIDINE • 87THAA IS HISTIDINE • KNOWN AS PROXIMAL HISTIDINE • NEAR TO IRON ATOM
- 21. BONDING • 4 SUBUNITSHELD TOGETHER BY NON- COVALENT INTERACTIONS • HYDROPHOBIC, IONIC AND HYDROGEN BONDING
- 22. HYDROPHOBIC CLEFT • THEREARE 4 HEME RESIDUES PER Hb, ONE FOR EACH SUBUNIT IN Hb • HEME IS LOCATED IN A HYDROPHOBIC CLEFT OF GLOBIN CHAIN