This document provides information about strabismus (squinting):
- It affects 7.5 million people in the US and an estimated 130-260 million worldwide. Strabismus occurs when the eyes are not properly aligned on the point of focus.
- The anatomy of the extraocular muscles that control eye movement is described, including the actions of the six muscles and their nerve supply.
- Paralytic squints can be caused by neurogenic or myogenic factors. The document discusses third and fourth nerve palsies as examples. Treatment options for strabismus include optical devices, botulinum toxin injections, orthoptic exercises, and surgery.
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
When parallel rays of light enter the eye ((with accommodation relaxed) and do) and do not come to a single point focus on or near the retina.
Types of Astigmatism:
Sign & Symptoms:
Management:
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
Congenital Glaucoma is one of the most common causes of irreversible childhood blindness. This presentation covers this topic in detail that can aid physicians in effective patient care.
PS: The slides in the preview look skewed, download the presentation to view the font used in Office 2012 and upwards.
When parallel rays of light enter the eye ((with accommodation relaxed) and do) and do not come to a single point focus on or near the retina.
Types of Astigmatism:
Sign & Symptoms:
Management:
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
It is one of the most viewed document from Pgblaster India website: Disorders of ocular motility with an emphasis on squint. In this document I have tried to give some important concepts of the different types of squints in simple words.At a glance, it is a much harder and complex topic of ophthalmology but I had made it as simpler as I could. Hope it will help you..
Gede Pardianto - Strabismus, binocular vision, 3D vision and visual illusionGede Pardianto
Strabismus, binocular vision, 3D vision and visual illusion
Dr. Gede Pardianto.
SMEC Jakarta Jl Pemuda 36 Rawamangun Jakarta Timur.
Sumatera Eye Center Jl Iskandar Muda 278 Medan.
Tel 628155000300.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. A squint is not a sign of luck, it may
indicate poor vision. Get it checked
immediately.
• Greek strabismos, from
strabizein "to squint,"
from strabos "squinting,
squint-eyed.“
• 7,500,000 people suffer
from strabismus in the
US
• A worldwide estimate
would be 130 to 260
million
3. • Binocular single vision (BSV) is one of the
hallmarks of the human race that has
bestowed on it the supremacy in the hierarchy
of the animal kingdom
• ~ 60% of the brain tissue and more than half
of the twelve cranial nerves subserve the eyes
• BSV is accomplished by a perfect sensorimotor
coordination of the two eyes both at rest and
during movement
5. Anatomy
•
•
•
•
•
The two obliques are abductors
The two recti are adductors (RAD)
The two superiors are intorters (SIN)
The two inferiors are extorters
Each is supplied by 2 anterior ciliary arteries, except
lateral rectus which is supplied only by one.
• Recti muscles pull the eye in the direction of their
name in the abducted position
• Obliques push the eye in the direction opposite to their
name in the adducted position
6.
7.
8.
9. • The eye movements when tested uniocularly –
Ductions (Adduction, abduction, elevation or
sursumduction, depression or deorsumduction,
intorsion or incycloduction, extorsion or
excycloduction)
• In paresis, normal ductions may be observed.
This is due to the extra innervation called in to
compensate for the paresis. In version, this is
picked up as the extra innervation goes to the
yoke muscle, which overacts
10. • The eye movements when tested binocularly –
Versions
– Same direction (Conjugate)
– Opposite directions (Disjugate) - vergence
• Dextroversion, levoversion, dextroelevation,
levoelevation, dextrodepression,
levodepression, sursumversion,
deorsumversion, dextrocycloversion,
levocycloversion
11. • Vergence – Convergence, divergence
– Positive vertical divergence – right up, left down
– Negative vertical divergence – Left up, right down
– Incyclovergence- both intort
– Excyclovergence – both extort
12.
13. Fun fact
• People blink, on
average, once every 5-6
seconds.
• Women blink almost
twice as often as men.
14. Sherrington’s law of reciprocal
innervation
• EOM working in pairs – yoke, synergist,
agonist
• Opposing muscle – antagonist
• For any movement, the synergists receive
equal and simultaneous innervation. In
addition, the respective antagonists are
inhibited to facilitate a smooth and
unobstructed movement
15. • Each fovea has a primary visual direction (the
direction of its straight-ahead gaze)
• The two fovea share a common visual
direction
• Any object imaged on the visual direction of
either of the fovea would be superimposed
and seen in the common visual direction,
which is of neither eyes, but of an imaginary
cyclopean eye
16.
17. • One fovea as well as other areas in the retina
have a corresponding point on the other retina
• Objects imaged on the corresponding areas are
seen binocularly single
• Imaginary plane on which corresponding points
are projected – horopter
• A little area on either sides of horopter, which
allows the sensory fusion, despite the disparity –
Panum’s area of fusion Stereopsis
18.
19. • Normally, the two visual axes meet at the point of
regard or the object of attention – orthophoria /
orthotropia
• If the two visual axes are not aligned to the point
of regard, one eye fixates, other eye does not
Strabismus
• When this tendency is overcome by the fusional
vergence, the person does not manifest squint
Latent squint (heterophoria)
• When the squint is present at times, and
controlled at other times – intermittent squint
20. Classification
• Concomitant (comitant) – when the deviations
are equal in all the different gazes
• Incomitant – When deviations are more in one
gaze than the other
21. Concomitant
• Horizontal strabismus: Exotropia (divergent)
and esotropia (convergent) /
Latent ones (heterophorias) – Esophoria,
exophoria
• Vertical tropias: Hypertropia and hypotropia –
described by the hypertropic eye
• Torsional – Incyclotropia / Excyclotropia
24. • Hering’s law of motor correspondence:
– Whenever an ocular movement is performed,
simultaneous and equal amount of innervation
flows to the corresponding yoke muscles in the
direction of gaze
• Sherrington’s law of reciprocal innervation:
– Whenever an agonist receives an impulse to
contract, an equivalent inhibitory impulse travels
to the antagonist muscle, which actively relaxes
and lengthens
25.
26. Consequences of strabismus
• Strabismus Two fovea get two different images
Rival cortical perception Confusion
Suppression of one image
• Tries to overcome by fusion (converting tropia
into phoria)
• Head posturing other image falls on the
periphery of retina / blind spot
• Sensory adaptations (upto 6-7 years of age)
– Suppression (if in peripheral retina)
– Anomalous retinal correspondence (Fovea with
extrafoveal area)
27.
28. AMBLYOPIA
• Condition with u/l or b/l ↓ of visual functions,
caused by form vision deprivation and / or
abnormal binocular interaction, that cannot
be explained by a disorder of ocular media or
visual pathways itself
• Caused by abnormal visual experience in early
childhood
29.
30. What is Phrenology?
• Phrenology is the study of the morphology of the
skull,
• Developed by Franz Josef Gall (1758 – 1828).
• Gall felt there was a direct link between the
shape of the skull and human character and
intelligence.
• Gall was one of the first to consider the brain the
source of all mental activities.
• People with “high brows” were considered more
intelligent than those with “low brows.”
32. Motor status
• Head posture
• Ocular deviation
• Limitations of movements or extent of
versions
• Fusional vergences
33. Head posture
• 3 components
– Chin elevation / depression
– Face turn to right / left
– Head tilt to right or left shoulder
• Ocular torticollis: Congenital SO palsy
• RSO palsy Chin depression, face turn to left,
head tilt to left shoulder
35. Pseudostrabismus
• A true squint is a misalignment of the two visual axes,
so that both do not meet at the point of regard
• An apparent squint is just an appearance of squint in
spite of the alignment of the two visual axes
• Apparent squint or pseudostrabismus can be due to
abnormality of adnexal structures or due to abnormal
relationship between the visual axis and optical axis of
the eyes
– Telecanthus (broad nasal bridge) / epicanthus
Pseudoesotropia
– Lateral canthoplasty Pseudoexotropia
39. Fun facts
• Eyes can process 36,000 bits of information
every hour.
• Only 1/6th of the eyeball is exposed to the
outside world
40. Cover test
• Proper fixation target – figure / letter of size 6/9
of Snellen’s -- Distance – 33 cm (near) /
6 m (distant)
– Eyes appear to fixate (no apparent squint)
– One appears to fixate as other deviates (apparent
squint)
• Cover the fixating eye
– If the other eye moves to take up fixation Manifest
squint (heterotropia)
– Same eye deviates
41. • Uncover
– Covering breaks the fusion and if there is any
heterophoria, the eye behind the cover deviates
– If it remains deviated latent squint with poor
fusion
– Speed of recovery Ξ strength of fusion
– If uncovered eye reassumes fixation as the other
eye deviates Dominant uncovered eye, visual
acuity unequal
42. Cover tests
• Cover test detects heterotropia
• Prism cover test measures total deviation
• Uncover test detects heterophoria
• Alternate cover test detects total deviation
43.
44.
45. Hirschberg’s test
• Corneal reflection
• In esodeviation, the corneal reflection falls
more temporally and vice versa
• 1 mm shift Ξ 5° deviation
• If reflex falls on nasal limbus, the exodeviation
is 30°
46.
47. Hirschberg test
• Rough measure of deviation
• Note location of corneal light reflex
• 1 mm = 5
Reflex at border of pupil = 15
Reflex at limbus = 45
48. Diplopia testing
• Red and green glasses over the right and left
eyes respectively
• Esodeviations Uncrossed diplopia
• Exodeviations Crossed diplopia
• Esodeviation Image falls on nasal retina
projected on temporal field uncrossed
49. Maddox rod test
• Multiple cylindrical high plus lenses stacked
on top of each other
• Light is seen as linear streak oriented 90° to
the cylindrical ribs
53. • 4 dots Normal binocular response or
anomalous retinal correspondence with
manifest squint
• 5 dots Manifest deviation
– Eso (uncrossed) – red on right
– Exo (crossed) – red on left
• 3 dots Suppression of right eye
• 2 dots suppression of left eye
55. Surgical Treatment
• Surgical procedu res
– R e s e c t io n a n d r ec e s s io n
– S h iftin g o f p o in t o f m u sc l e att ac h m en t
– F ad e n p ro c ed u r e
• Choice of muscles for surgery
• Adjustable sutures
56.
57. Fun facts
• Eyelashes have an average life span of 5
months.
• The eyeball of a human weighs approximately
28 grams.
• Your eye will focus on about 50 things per
second.
59. Forced duction test
• Simple and most useful method for diagnosing the
presence of mechanical restriction of ocular motility.
• 4% lidocaine
• The eye is then moved with two-toothed forceps applied to
the conjunctiva near the limbus in the direction opposite
that in which mechanical restriction is suspected.
• To distinguish between lateral rectus paralysis and
mechanical restriction involving the medial aspect of the
globe, apply the forceps at the 6- and 12-o’clock positions
and move the eye passively into abduction.
– No resistance paralysis of the lateral rectus muscle.
– Resistance + mechanical restrictions do exist medially and
contracture of the medial rectus muscle, conjunctiva, or Tenon’s
capsule or myositis of the medial rectus muscle must be
considered
60.
61. 3rd Nerve Palsy
• Complete, isolated third nerve palsy causes
ipsilateral weakness of elevation, depression,
and adduction of the globe, in combination
with ptosis and mydriasis.
62. • (A) Left ptosis, mydriasis,
exotropia, and right
hypertropia in primary
gaze.
• (B) Absent left elevation.
• (C) Reduced left
depression.
• (D) The left pupil shows
minimal consensual
response to light, with
greater anisocoria.
64. Complete Third Nerve Palsy
• Exotropia with hypotropia, ptosis and possible
dilation of pupil and accommodation palsy
65. • A characteristic feature is that the affected eye
is hypotropic in upgaze but hypertropic in
downgaze, because of the combined
weakness of the superior and inferior rectus
muscles.
66. 3rd N nuclear lesion
• Specifically, there is bilateral ptosis (because
the central caudal nucleus supplies both
levator palpebrae muscles) and
• A bilateral elevation deficit (because the
superior rectus subnucleus sends fibers
through the contralateral third nerve nucleus
to join the opposite nerve)
67. Unilateral nuclear 3rd N palsy
• Ipsilateral mydriasis
• Ipsilateral weakness of the medial rectus,
inferior rectus, and inferior oblique muscles
• Bilateral ptosis and
• Bilateral superior rectus weakness.
68. • Disruption of the superior division causes
ptosis and impaired elevation
• Disruption of the inferior division causes
impaired depression, adduction, and mydriasis
69. Microvascular 3rd nerve palsy
• Risk factors including hypertension, diabetes,
hyperlipidemia, advanced age, and smoking
• This disorder results from impairment of
microcirculation leading to circumscribed,
ischemic demyelination of axons at the core of
the nerve, typically in the cavernous sinus portion
where a watershed territory exists.
• Most of these patients exhibit pupillary sparing,
because the pupillary fibers are located
peripherally, closest to the blood supply provided
by the surrounding vasa nervorum.
70. AN ISOLATED DILATED PUPIL IS NEVER A
MANIFESTATION OF THIRD NERVE
DYSFUNCTION IN AN AWAKE AND ALERT
PATIENT.
71. Treatment
• The treatment of diplopia due to acute third
nerve palsy may include monocular patch-ing or
prisms.
• Once ocular misalignment from third nerve palsy
has been stable for 6 to 12 months, surgical
correction can be considered.
• Supramaximal lateral rectus recession (a
weakening procedure that completely abolishes
abduction), potentially in combination with a
medial rectus resection (a tightening procedure
to augment the muscle’s action).
72.
73. • Under the right conditions, the human eye can
see the light of a candle at a distance of 14
miles.
• The external muscles that move the eyes are
the strongest muscles in the human body for
the job that they have to do. They are 100
times more powerful than they need to be.
74. 4th nerve palsy
• Fourth nerve palsy presents with vertical diplopia and is
commonly accompanied by compensatory contralateral
head tilt.
• Parks-Bielschowsky three-step test
• First, hypertropia suggests weakness of the ipsilateral
superior oblique, ipsilateral inferior rectus, contralateral
inferior oblique, or contralateral superior rectus muscle.
• Second, increased hypertropia in contralateral gaze narrows
the possibilities to the weakness of the ipsilateral superior
oblique or contralateral superior rectus muscles.
• Third, increased hypertropia on ipsilateral head tilt further
reduces the possibilities, ultimately identifying ipsilateral
superior oblique weakness.
75.
76.
77. Bilateral 4th nerve palsy
• Hyperdeviation alternates such that it is
contralateral to the direction of gaze and
ipsilateral to the side of head tilt.
78. Fourth nerve palsy in the setting of
concomitant third nerve palsy
• The failure of adduction prevents complete
testing of superior oblique function. In this
setting, the superior oblique can be evaluated
by assessing its secondary function: intorsion
of the abducted eye on attempted downgaze.
The torsional movement that indicates intact
superior oblique function is best appreciated
by observing a conjunctival vessel
79. Treatment
• Occlusion of the affected eye (or, if diplopia
occurs only in down-and-contralateral gaze,
occlusion of the lower half of the lens over the
affected eye) can serve as a temporary
measure
• IO / SR recession
80. 6th nerve palsy
• Weakness of the lateral rectus due to sixth nerve
palsy leads to horizontal diplopia, worse to the
affected side and at distance. Often, the
abnormal duction is easily observed.
• Nuclear sixth nerve palsy affects the ipsilateral
sixth nerve as well as the interneurons destined
for the contralateral medial rectus subnucleus.
This lesion causes an abduction deficit of the
ipisilateral eye as well as an adduction deficit of
the contralateral eye; together, this is a conjugate
gaze palsy.
81.
82. Duane syndrome
• 3 varieties of Duane syndrome
• A paradoxic co-contraction of the lateral and medial rectus muscles
• A visible retraction of the globe and narrowing of the palpebral
fissure on attempted adduction
– Type 1, abduction is impaired with essen-tially full adduction;
– type 2, adduction is impaired with normal abduction
– Type 3, adduction and abduction are reduced.
• The abduction deficit in types 1 and 3 cause the patient to be
esotropic on lateral gaze to the affected side, but these patients can
be distinguished from those with acquired abduction deficits
because they have normal alignment (rather than esotropia) in
primary gaze.
• Pathologic studies of patients with Duane syndrome show
hypoplasia of the sixth nerve nucleus and abnormalities of the
fascicle, with branches of the third nerve supplying the lateral
rectus muscle.
• Sporadic / familial (CHN1 gene on chromosome 2)
83.
84. • Mobius syndrome describes congenital facial
diplegia that is frequently associated with
sixth nerve palsy
85. ..
Mobius syndrome
Signs
•
Bilateral sixth nerve palsies - • Primary position - 50%
patient looking left
straight, 50% esotropic
• Horizontal gaze palsy in
50%
•
•
Bilateral, usually
asymmetrical facial
palsies sparing lower face
Paresis of 9th and 12th
cranial nerves
86. Treatment
• Occlusion / prism
• Treatment of partial sixth nerve palsy may include
a combined medial rectus recession and lateral
rectus resection on the affected side.
• In cases of complete sixth nerve palsy, the
affected lateral rectus is typically left intact to
preserve anterior segment circulation.
Restoration of abduction on the affected side
may be attempted by transposition procedures
that aim to move the vertically acting rectus
muscles into the horizontal plane.
87.
88. COMBINED THIRD, FOURTH, AND
SIXTH NERVE PALSY
• fungal, or bacterial infection (including
tuberculosis, syphilis, and Lyme disease).
• Inflammatory diseases include sarcoidosis and
idiopathic pachy-meningitis.
• Neoplastic processes include carcinomatous and
lymphomatous meningitis.
• Peripheral demyelinating disorders including
Guillain-Barre syndrome, the Miller Fisher
variant, chronic inflammatory demyelinating
polyneuropathy, and idiopathic cranial
neuropathies
89.
90. Fun facts
• It's impossible to sneeze with your eyes open.
• The eye of a human can distinguish 500
shades of the gray.
• People generally read 25% slower from a
computer screen compared to paper.
91. ‘V’ pattern deviation
Signs
Treatment
‘V’ pattern esotropia
•
•
Difference between up- and
downgaze is 15 or more
Bilateral medial rectus recessions +
downward transposition
‘V’ pattern exotropia
•
Bilateral lateral rectus recessions
+ upward transpositions
92. ‘A’ pattern deviation
Signs
•
Treatment
Difference between up- and ‘A’ pattern esotropia
• Bilateral medial rectus recessions
downgaze 10 or more
+ upward transposition
‘A’ pattern exotropia
•
Bilateral lateral rectus recessions
+ downward transposition