Bile duct injuries are a complex complication seen more frequently with laparoscopic cholecystectomies due to aberrant anatomy and increased procedures. They can involve the cystic duct, gallbladder bed, or major bile ducts. Various classification systems exist to describe the level and extent of injury. Injuries may be detected intraoperatively by cholangiogram abnormalities, bile drainage from unusual locations, or anomalous anatomy. Prevention strategies include proper case selection, opening retroperitoneal folds, dissecting close to the gallbladder, achieving the critical view of safety, and using intraoperative cholangiography.
Bile duct injuries represent a complex clinical scenario seen with increased frequency owing to
aberrant anatomy
more lap cholecystectomies being performed
Incidence :
0.1-0.2 % in open cholecystectomy
0.4-0.6 % in lap cholecystectomy
Bile duct injuries represent a complex clinical scenario seen with increased frequency owing to
aberrant anatomy
more lap cholecystectomies being performed
Incidence :
0.1-0.2 % in open cholecystectomy
0.4-0.6 % in lap cholecystectomy
Extended totally extraperitoneal repair (eTEP) is a novel technique that was first introduced by Jorge Daes in 2012 to address difficult inguinal hernias.
This is very important topic for Laparoscopic surgeons,as bile injury is not uncommon,how to approach such biliary injuries is prime to know for evolving surgeons.This slide would also helpful for surgery residents.
Lt hemicolectomy - Surgical Approach, Complications.Vikas V
This is a detailed Presentation of the surgical procedure - Left Hemicolectomy. It deals with the Surgical anatomy, Indications, Surgical Steps, Complications of the Procedure
Component seperation technique for the repair of very large ventral hernias nikhilameerchetty
Includes all the ventral hernia repairs with the loss of domain and the various methods of component separation technique with their success rate for their repair ,few videos showing the methods of repair in addition to the latest techniques of repair .
In this presentation, I have shown how to do open anterior resection both high and low varieties in a step-by-step manner with clear pictures as if reading an atlas of operative surgery.
The incidence of biliary injury after laparoscopic cholecystectomy (LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated with significant morbidity. As prevention is the best strategy, the concept of a culture of safe cholecystectomy has been recently introduced to educate surgeons and apprise them of basic tenets of safe performance of LC. Various aspects of safe cholecystectomy include: (1) thorough knowledge of relevant anatomy, various anatomical landmarks, and anatomical variations; (2) an understanding of the mechanisms involved in biliary/vascular injury, the most important being the misidentification injury; (3) identification of various preoperative and intraoperative predictors of difficult cholecystectomy; (4) proper gallbladder retraction; (5) safe use of various energy devices; (6) understanding the critical view of safety, including its doublet view and documentation; (7) awareness of various error traps (e.g., fundus first technique); (8) use of various bailout strategies (e.g., subtotal cholecystectomy) in difficult gallbladder cases; (9) use of intraoperative imaging techniques (e.g., intraoperative cholangiogram) to ascertain correct anatomy; and (10) understanding the concept of time-out. Surgeons should be facile with these aspects of this culture of safety in cholecystectomy in an attempt to reduce the incidence of biliary/vascular injury during LC.
Extended totally extraperitoneal repair (eTEP) is a novel technique that was first introduced by Jorge Daes in 2012 to address difficult inguinal hernias.
This is very important topic for Laparoscopic surgeons,as bile injury is not uncommon,how to approach such biliary injuries is prime to know for evolving surgeons.This slide would also helpful for surgery residents.
Lt hemicolectomy - Surgical Approach, Complications.Vikas V
This is a detailed Presentation of the surgical procedure - Left Hemicolectomy. It deals with the Surgical anatomy, Indications, Surgical Steps, Complications of the Procedure
Component seperation technique for the repair of very large ventral hernias nikhilameerchetty
Includes all the ventral hernia repairs with the loss of domain and the various methods of component separation technique with their success rate for their repair ,few videos showing the methods of repair in addition to the latest techniques of repair .
In this presentation, I have shown how to do open anterior resection both high and low varieties in a step-by-step manner with clear pictures as if reading an atlas of operative surgery.
The incidence of biliary injury after laparoscopic cholecystectomy (LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated with significant morbidity. As prevention is the best strategy, the concept of a culture of safe cholecystectomy has been recently introduced to educate surgeons and apprise them of basic tenets of safe performance of LC. Various aspects of safe cholecystectomy include: (1) thorough knowledge of relevant anatomy, various anatomical landmarks, and anatomical variations; (2) an understanding of the mechanisms involved in biliary/vascular injury, the most important being the misidentification injury; (3) identification of various preoperative and intraoperative predictors of difficult cholecystectomy; (4) proper gallbladder retraction; (5) safe use of various energy devices; (6) understanding the critical view of safety, including its doublet view and documentation; (7) awareness of various error traps (e.g., fundus first technique); (8) use of various bailout strategies (e.g., subtotal cholecystectomy) in difficult gallbladder cases; (9) use of intraoperative imaging techniques (e.g., intraoperative cholangiogram) to ascertain correct anatomy; and (10) understanding the concept of time-out. Surgeons should be facile with these aspects of this culture of safety in cholecystectomy in an attempt to reduce the incidence of biliary/vascular injury during LC.
The lecture overviews the different situations where cholecystitis can be fatal,if not accurately diagnosed.Different types of dangerous cholecystitis are illustrated with their imaging findings.
Surgical management of pancreatic pseudocyst..by dr chris alumonaCHRIS ALUMONA
Pancreatic pseudocyst is the commonest cystic lesion of the pancreas but generally rare. It commonly complicates pancreatitis and resolves spontaneously with conservative management. Indications for intervention include complications and to rule out malignancy
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. • Bile duct injuries represent a complex clinical
scenario seen with increased frequency
owing to
– aberrant anatomy and
– more lap cholecystectomies being performed
• Incidence :
– 0.1-0.2 % in open cholecystectomy
– 0.4-0.6 % in lap cholecystectomy
4. • Earliest known gall stones - Priestess of
Arnan (1085-945 BC) - Egyptian
• Recognition of gallstones was first
recorded by a Greek physician Alexander
Trallianus (525-605 BC)
• The first clinical description of gallstone
disease - Gordon Taylor, in his description
of the symptoms manifested by
Alexander the Great in 323 BC
5. • Observations of human gallstones were first
demonstrated during autopsy by Gentile da
Foligno (1341) in Padua
• In 1667, Michael Entmuller said, “There are no
medicine which will cure gallstones”.
• Jean Lovis Petit (1674-1750) –
– identifying the biliary colic and other signs
of this disease
– removing the gallstones after puncturing
the gall bladder with trocar and cannula in
1743.
6. • John Stough Bobbs first elective
cholecystostomy in
Indianapolis for
hydrops of the
gallbladder
• In 1878 Kocher
drained an empyema
of gallbladder.
7. • Ludwig Georg
Courvoisier (18431918).
– Law (Statistical
article on the
pathology and
surgery of the biliary
system)
– First
choledocholithotomy
– Butterflies
11. • The first laparoscopic cholecystectomy in India
was done in 1990 at the J.J. Hospital, Mumbai
12. "The pleasure of a physician is little,
the gratitude of patients is rare and
even rarer is material reward, but,
these things never deter the student
who feels the call within him”
–BILLROTH
15. Extra hepatic biliary tract
• Left hepatic duct – segment 2,3,4.
• Right hepatic duct
Right anterior: 5,8
Right posterior:6,7
• Hilar plate : seperates biliary confluence from
posterior aspect of caudate lobe.
• Common hepatic duct lies anterolateral to
hepatic artery and vein in the hepatoduodenal
ligament.
16. • Common bile duct :
– Length : 5 to 9cm
– Diameter : 6 to 8 mm
– Supraduodenal , retroduodenal &
intrapancreatic .
• Gall bladder :
– 7 to 10 cm length.
– 30 to 60 ml capacity.
– Fundus ,body infundibulum and neck
17. • Cystic duct :
– Length : 1 to 5 cm
– Diameter : 3 to 7 mm
• Blood supply :
– Distal : Gastroduodenal,retroduodenal,
pancreatoduodenal arteries
– Proximal : Right hepatic and cystic arteries.
Arteries run parallel to each other at
3 & 9 o’clock position.
25. Multiple Gall Bladder
• 1 in 3800.
• Should be removed
even when normal.
• Magnetic or CT
cholangiography
26. Ectopic Gall Bladder
• Normally formed gall bladder in an
abnormal site.
• Intrahepatic , left sided , transverse or
retrodisplaced.
• Floating gall bladder : suspended via a
mesenteriole.
28. Cystic duct Anomalies
• Only 33% have classical anatomic position and
course.
• Most important : junction of cystic duct with
CHD
• Length varies : 20% < 2cm ,majority 2-4cm.
• Careful dissection of the Calot’s triangle.
32. Variations of CBD & Extra hepatic
confluence.
• Convergence of hepatic ducts vary greatly.
• Sectoral ducts: nonconfluence of the ducts
with independent ending for each duct in
duodenum.
• Length of CBD varies from person to person.
44. CYSTIC DUCT INJURIES AND BILE LEAK
• Cystic duct : 50%
• Subvesical or Gallbladder bed : 25%
• Major bile duct :25%
45. • Cystic duct leak
– failure to safely ligate the cystic duct
– failed application of endoscopic clips.
• Acute cholecystitis : wide and friable
cystic duct.
• Intraoperative cholangiogram
• Endo-loop application is better.
46. Clinical features and investigation
• Excessive right upper quadrant pain and
elevated bilirubin.
• Ultrasound or CT
• HIDA (hepatobiliary iminodiacetic acid)
• ERCP : procedure of choice
47. Extra hepatic bile duct injuries
• Common hepatic duct most commonly
injured.
• During dissection of Calot’s triangle &
inadequate identification of the structures.
• Either partial lacerations or complete
transections.
48. Intrahepatic bile duct injuries
• During dissection of gallbladder off the liver
bed.
• Right hepatic duct more commonly injured
than left.
• Inadequate / incomplete cholangiogram :
convert to open.
49. Cause of biliary strictures
•
•
•
•
•
Direct injury
Clipping of duct
Thermal injury
Ischaemia
Inflammation and scarring secondary to
bile leakage.
50. Mechanisms of injury and risk factors
• Anatomic variations.
• Complicated pathology.
• Technical error.
• Thermal and laser injuries.
51. Complicated pathology
• Acute inflammation and scarring of the
triangle of calot.
• Acute cholecystitis.
• Acute pancreatitis.
• Chronic cholecystitis.
• Mirizzi syndrome
• Perforated duodenal ulcer.
52. Technical errors
• Cephalad and lateral retraction of gall bladder
is necessary to expose the structures.
• Cautious retraction in case of acute
inflammation or gangrenous gall bladder.
• Avoid application of clips too close to the
cystic duct CBD junction.
53. • Avoid strenous dissection too close to
the CBD.
• Blind application of clips to achieve
hemostasis.
• Willingness to convert to open
technique.
• Early in the surgeons learning curve.
54. Thermal and laser injuries
• Use of electrocautery
• Avoided near the CBD
• Bipolar cautery is better.
• Laser : severe injuries with tissue loss.
• Avoid usage near metallic clips
• Low intensity for short duration
60. A drawback of the
Bismuth
classification is that
patients with limited
strictures, isolated
right hepatic duct
strictures, or cystic
duct leaks cannot be
classified
61.
62.
63. Strasberg
classification is able
to classify all types
of injury and is used
extensively in
describing bile duct
injuries associated
with laparoscopic
cholecystectomy
64.
65.
66. • McMahon
• Amsterdam Academic Medical Center's
classification (1996)
• Neuhaus' classification (2000)
• Csendes' classification (2001)
• CUHK (Chinese University of Hong Kong), 2007
67. What are the clinical features and how
to detect these injuries?
68. • Most class I injuries are recognized
intraoperatively (about 60–70%).
• Those unrecognised present with mild
abdominal pain, abdominal distention,
ileus, with mild elevations in ALP (average
250 U/l) and bilirubin (average 2.3 mg/dl)
• Ultrasound and CT scans demonstrate an
abdominal fluid collection without dilated
bile ducts
• ERCP reveals an intact biliary tree with a
fistula
69.
70. • The majority of class II injuries (60–70%) present
with
– Obstructive jaundice, pruritus, cholangitis, ↑
bilirubin and alkaline phosphatase levels.
• The remainder of the patients, who have
associated biliary fistulas, present similar to class
I injuries.
• Some patients may have a prolonged bile leak
from surgically placed drain that then closes,
with the subsequent development of a biliary
stricture and jaundice
71. • CT and USS –
– dilated bile ducts in patients without biliary
fistulas
– non-dilated ducts and abdominal fluid
collections in patients with associated biliary
fistulas.
• ERCP shows the lesion, invariably with
multiple clips overlying it with or without a
fistula.
72.
73. • Patients with class III injuries present like class
I injuries, only they can have a more toxic
illness.
• About 25% of these injuries are recognized
during the index operation when bile is seen
to drain from the common (or hepatic) duct.
• The remainder of patients present later with
abdominal pain, abdominal distention, ileus,
and cholangitis
74. • Laboratory abnormalities are highly
variable
• Total bilirubin can be normal or
elevated (average of 4–5 mg/dl)
• Alkaline phosphatase can be normal
to elevated (average of 225 U/l)
• White blood cell count similarly can
be normal to mildly elevated (average
13 000/cm2)
75. • CT and ultrasound scans - an abdominal
fluid collection and nondilated bile ducts.
• ERCP distinguishes class III from other bile
duct injuries involving a biliary fistula.
• The findings in class III injuries consist of a
truncated common bile duct that is
occluded with a clip, and non-filling of the
biliary radicles .
• PTC demonstrates the proximal extent of
these injuries.
76.
77. • Class IV injury patients present with abdominal
pain, abdominal distention, ileus, cholangitis,
hepatic abscess (20–25%)
• Unlike the other injuries, many (45%) of these
patients can have associated severe hemorrhage
requiring blood transfusions.
• CT and USS – non-dilated ducts and fluid
collections
• ERCP - injury to or occlusion of the right hepatic
duct (or a right sectoral duct) by a clip
• PTC - a fistula from the right hepatic ductal
system
78. Routine intraoperative
cholangiography
• Fletcher et al. in 1999 found that
intraoperative cholangiography had a
protective effect for complications of
cholecystectomy in a retrospective study
of 19,000 cholecystectomies.
79. Is it possible to detect these
injuries intra operatively?
80. Intraoperative clues to a bile duct injury
• Cholangiogram abnormalities:
– Failure to opacify the proximal hepatic ducts
– Narrowing of the CBD at the site of cholangiogram
catheter insertion
• Bile drainage:
– Drainage of bile from any location other than a lacerated
gallbladder
– Bile draining from a tubular structure
81. • Atypical features of cystic duct:
– A ‘cystic duct’ that is not completely
encompassed by the standard M/L. clip, which
measures 9mm in the closed position, the
structure may be the common duct
– A ‘cystic duct’ that can be traced without
interruption behind the duodenum, that will
prove to be the common duct, not the cystic
duct
82. • Anomalous anatomy:
– Second cystic duct, aberrant duct, accessory duct, or
suspected duct of Lushka, these are generally the
common duct or a hepatic duct
– Second cystic artery, this may be the right hepatic
artery
– Lymphatics surrounding the ‘cystic duct’ or more
tissue around the cystic duct than is usually
encountered, this indicates that the dissection is in
the porta
– Fibrous tissue in the gallbladder bed, indicates
transection of the proximal hepatic ducts
84. • Proper selection of cases
• In obese patients place the optical port little
higher up from the umbilicus to avoid the
tangential view of the Calot’s triangle.
• Posterior peritoneal fold should be opened
before approaching the Calot’s triangle
anteriorly. This provides an extra mobility to
GB and helps the CHD to fall away from the CD
thereby avoiding proximal BDI during the
dissection of Calot’s triangle.
• Always dissect to the right of the line joining
the right free margin of lesser omentum to
cystic node.
85. • While dissecting the Calot’s triangle stay close
to the GB.
• It is advised that Calot’s triangle is dissected in
such a way that the retro-infundibular window
is opened first and then the window between
the cystic artery and duct is opened.
Visualisation of the double window is called
“Critical view of Strasberg”.
86. • The technique of
“critical view of
safety” of Strasberg
• Calot’s triangle is
completely unfolded
by mobilizing the
gallbladder neck
from the gallbladder
bed of the liver
before transecting
the cystic artery and
duct
87.
88. • Always dissect to the right of the line joining the
right free margin of lesser omentum to cystic
node.
• Vessels pulsating before clipping should be
considered as hepatic artery until proved
otherwise.
• While dissecting GB from the liver bed stay close
to the GB and avoid any injury to superficial
portal radical or abnormally superficial right
anterior sectoral duct.
• Intra-operative cholangiogram may be used
routinely in order to better identify the anatomy
after dissection of Calot’s triangle.
89. • Once the Calot’s triangle is fully dissected and
cystic artery has been clipped and cut, GB is
left attached medially to only one structure,
CD.
• If the plane between the liver and GB is
absent, it might be better to leave a part of
posterior GB wall adhered to the liver bed and
cauterise its mucosa than to cause an
inadvertent injury to hepatic parenchyma
resulting in bleeds and postoperative biliary
fistula.
90. • The cystic duct and the
GB neck and
infundibulum together
looks like Lord
Ganesha’s trunk and
head (or elephant’s
trunk and head)
respectively and so also
called as Lord Ganesha’s
sign.
91. • Use the suction-irrigation cannula to aid
in dissection. The oozing surface absorbs
light with a resultant darker picture.
• In case of impacted stone in the neck, it
may be safer to transect the Hartman’s
pouch and remove the stone. The left out
mucosa can be cauterised and stump is
sutured.
• In case of a dilated CD where clip cannot
adequately close its lumen, it is advised
to use endoloop or intracorporeal
suturing for safe closure of the stump.
92. In case of excessive bleeding during the surgery:
• Have a low threshold for conversion.
• If there is continuous ooze from the
inflammed surface, liberal irrigation and
aspiration should be used.
• If there is sudden arterial spurt, compress the
area temporary with small gauge or
atraumatic grasper. Irrigate / aspirate and
clean the operative field. Effectively control
the bleeding vessel with left hand grasper,
identify the vessel and arrest bleeding with
clips or bipolar electrocautery.
93. “I would like to see the day when
somebody would be appointed
surgeon somewhere who had no
hands, for the operative part is the
least part of the work”
-Letter to Dr Henry Christian Nov 20, 1911
96. • Most bile duct injuries or strictures occur as a
result of cholecystectomy for symptomatic
gallstone disease.
• The majority of these patients are young (40–
50 years), female, have a long life expectancy,
and are in the most productive years of their
life.
97. • Biliary strictures may result in significant
morbidity and mortality secondary to
complications such as biliary cirrhosis ,
cholangitis,portal hypertension.
• Because of this, it is essential that these
patients have prompt recognition of their
problem and a reliable treatment with a longterm success rate.
98. WHAT ARE THE FACTORS ONE SHOULD
CONSIDER BEFORE TREATING BILE DUCT
INJURIES?
99. 1.Timing of diagnosis -
Intra-operative
-
Early post-op
-
Late post-op
2.Extent and level of injury
3.Patient presentation
4.Hospital setup
101. • A multidisciplinary approach
• The team consisting of experienced
interventional radiologists, endoscopists, and
surgeons, coordinated by an experienced
hepatobiliary surgeon
102. 1) Surgical Management
2) Interventional Radiologic Techniques
3) Endoscopic Techniques
• Most of these injuries and strictures are best
repaired surgically.
SURGERY - GOLD STANDARD
103. "Surgery is the first and the highest
division of the healing art, pure in
itself, perpetual in its applicability, a
working product of heaven and sure
of fame on earth"
- Sushruta (400 B.C.)
105. • Early post-op period
Sepsis /SIRS
Treat with –Broad spectrum antibiotics
-Percutaneous biliary drainage
- Percutaneous/operative drainage
of bilomas
No hurry for surgical repair - friable tissue
-retraction of
small ducts
106. • Next step- Pre-op cholangiography (to define
anatomy)
Control bile leak with percutaneous stents
Delayed surgical repair
108. • If patient presents only with jaundice & no
cholangitis
ERC / PTC -
to define anatomy
In these cases biliary decompression has not
been demonstrated to improve outcome
Surgical repair
110. • Intra-operatively, any suspicious biliary injury
1) Intra-op cholangiography
+/Careful dissection
2) Lap to open conversion is often necessary
• Isolated, small, non–cautery-based partial lateral bile
duct injury
Placement of a T tube
111. • Injury involves <50% of the circumference of
the bile duct wall
Primary closure over a T-tube
112. • More extensive biliary injury
• Significant thermal damage owing to cauterybased trauma
• Injury involving >50% of the circumference of
the bile duct wall
End-to-side choledochojejunostomy with a
Roux-en-Y loop of jejunum should be
performed
114. • Major bile duct injuries, including transections of
the common common hepatic duct, can be
repaired.
• Isolated hepatic ducts smaller than 3 mm or
those draining a single hepatic segment can be
safely ligated.
• Ducts larger than 3 mm are more likely to drain
several segments or an entire lobe and need to
be reimplanted.
116. SURGICAL REPAIR
• The blood supply of the common duct is axial
running at 3:00 and 9:00 on the duct.
• These vessels are small and easily damaged during
extensive mobilization of the duct.
• In addition, the majority of the blood supply (60%)
comes from below, while only 38% comes from
above, further contributing to ischemia in the
proximal portion of the duct
117. • The choice and technique of repair
correlates with the success rate.
• End-to-end anastomosisThe common duct (or common hepatic
duct) has been divided and there is
sufficient length to perform an end-toend anastomosis without tension
118. Unsuccessful :
1.When repaired at the initial open
cholecystectomy
2. Class III injuries, especially laparoscopic.
• The reasons for the high failure rate of end-toend biliary anastomoses relate to ischemia
and tension.
121. Certain technical factors for a successful
hepaticojejunostomy are
• Preoperative eradication of intra-abdominal
infection
• Viable ductal tissue (excise damaged ductal
tissue)
• Single-layer mucosa-to-mucosa anastomosis
• Fine, monofilament, absorbable suture
• Alleviate tension on the anastomoses
122. Stenting
• Stenting is useful, however, when very small
ducts are repaired (class IV injuries or class III
injuries where the resection has been carried
high into the porta).
• For other injuries stenting may not be
required.
124. • The management of postoperative
biliary strictures following ductal
injury depends on the degree of
injury, the presence of strictureinduced complications, and the
operative risk of the patient.
125. • After recognition of a bile duct injury or
stricture, a multidisciplinary team consisting of
experienced interventional radiologists,
endoscopists, and surgeons, coordinated by an
experienced hepatobiliary surgeon, should
plan the following specific goals:
1. Control the infection (abscess or
cholangitis)
2. Drain the biloma
3. Complete the cholangiography
4. Provide definitive therapy with controlled
reconstruction or stenting
127. Suspected CBD injury during lap-cholecystectomy
Intra-op cholangiogram
Partial injury(<30%)
Extensive injury(>30%)
Primary repair over T-tube
Roux en Y
choledochojejunostomy
Roux en Y.
Complete transection
Injury to isolated hepatic duct
>3mm
Reimplantation or reconstruction by
Roux en Y hepaticojejunostomy
<3mm
Ligate
130. • These techniques allow
1)Percutaneous drainage of abdominal fluid
collections
2)Preoperative identification of the ductal
anatomy through percutaneous transhepatic
cholangiography
3)Stricture dilation with or without placement of
palliative stents for bile drainage in the patient
whose overall physiologic status precludes a
major operation.
131. • Percutaneous transhepatic biliary
dilatation:
– Intrahepatic ductal disease
– ERCP is not possible
– Adjunct to operative repair in order to assist
with identification of the proximal biliary
tree for reconstruction and for the dilation
of anastomotic strictures
133. • Adjunctive option in patents with a
dominant extrahepatic stricture causing
clinical symptoms.
• Requires multiple sessions of dilations
• Nonischemic strictures (anastomotic
strictures) respond best.
134. • Metalic stents are more durable than
plastic stents
• Endoscopic dilation also has a low
mortality rate, but it has a significant
morbidity rate.
135. • Complications following endoscopic
biliary interventions:
– Hemobilia
– Bile leak
– Pancreatitis
– Cholangitis
– Re-stricture
139. • To define biliary fistula –
‘ a bilirubin rich drainage lasting for more
than 5 days’
• Most of them resolve spontaneously with
conservative management.
• 3 R’S
141. Resuscitation
The first stage in the management is the
restoration of volume using crystalloid and
colloid products as appropriate to restore
oxygen carrying capacity and plasma oncotic
pressure.
Blood PCV 30%
Albumin -3
142. • Control of sepsis
• Per cutaneous drainage
• Antibiotcs should only be given for defined
infections and for a set duration of therapy
• Nutritional support
• Cholangiography
145. References
•
•
•
•
Surg Clin N Am 90 (2010) 787-802
Surg Clin N Am 88 (2008) 1329-1343
Schwartz's Principles of Surgery, 9e
Sabiston Textbook of Surgery, 17e