This document summarizes a systematic review that analyzed 104 studies on the effectiveness of case-based learning (CBL) in health professional education. The review found CBL is widely used in medical education and students generally enjoy it and feel it enhances learning. However, the empirical evidence is inconclusive as to whether CBL improves learning outcomes compared to other methods. CBL appears to foster small group learning, but it is unclear if this is due to the delivery method or group work itself. Overall, the review could not determine if CBL is definitively more effective than other approaches.