Lec 9&10 covered soft tissue tumors. Lipomas are benign fatty tumors that are usually solitary, well-encapsulated masses of mature adipocytes. Liposarcomas are malignant tumors of adipocytes that typically present as large, infiltrative masses with areas of necrosis. Nodular fasciitis is a self-limited reactive lesion, while fibromatoses are locally aggressive fibroblastic proliferations. Fibrosarcomas are highly malignant fibrous tumors. Leiomyomas are benign smooth muscle tumors that can occur anywhere, while leiomyosarcomas are malignant variants. Rhabdomyosarcoma is the most common soft tissue sarcoma in children that can vary considerably in
Sites of the highest risk are the duodenum, for adenocarcinomas, and the ileum, for carcinoids and lymphomas.
In industrialized countries, small bowel cancers are predominantly adenocarcinomas;
In developing countries, lymphomas are much more common.
The incidence of small bowel cancer rises with age and has generally been higher among males than among females.
The risk factors for small bowel cancer include
Dietary factor
Cigarette smoking,
Alcohol intake,
Medical conditions -Crohn's disease, familial adenomatous polyposis, cholecystectomy, peptic ulcer disease, and cystic fibrosis.
The protective factors may include rapid cell turnover, a general absence of bacteria, an alkaline environment, and low levels of activating enzymes of precarcinogens.
Sites of the highest risk are the duodenum, for adenocarcinomas, and the ileum, for carcinoids and lymphomas.
In industrialized countries, small bowel cancers are predominantly adenocarcinomas;
In developing countries, lymphomas are much more common.
The incidence of small bowel cancer rises with age and has generally been higher among males than among females.
The risk factors for small bowel cancer include
Dietary factor
Cigarette smoking,
Alcohol intake,
Medical conditions -Crohn's disease, familial adenomatous polyposis, cholecystectomy, peptic ulcer disease, and cystic fibrosis.
The protective factors may include rapid cell turnover, a general absence of bacteria, an alkaline environment, and low levels of activating enzymes of precarcinogens.
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
Please find the power point on Carcinoma of rectum. I tried present it on understandable way and all the contents are reviewed by experts and from very reliable references.
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
Please find the power point on Carcinoma of rectum. I tried present it on understandable way and all the contents are reviewed by experts and from very reliable references.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Definition
Mesenchymal proliferations that occur in the
extraskeletal, nonepithelial tissues of the body,
excluding the viscera, coverings of the brain, and
lymphoreticular system.
- Soft tissue benign tumours outnumber malignant
Tumours 100:1
-They are aggressive if malignant
4. CAUSES
• MOSTLY UNKNOWN
• RADIATION association
• CHEMICAL BURN association
• THERMAL BURN association
• TRAUMA association
• VIRUS association (HHV8 for Kaposi)
• GENETICS
• Parts of many SYNDROMES
• MANY TRANSLOCATIONS
5.
6. TUMORS OF ADIPOSE TISSUE
LIPOMA
Lipomas most common soft tissue tumors.
Site: anywhere in the body subcutaneous tissues of
adults.
Clinical: slowly enlarging masses.
Most lipomas are solitary , sporadic.
Rare familial multiple lipomas.
7. TUMORS OF ADIPOSE TISSUE
LIPOMA cont….
Morphology:
Gross: soft, yellow encapsulated mass. Superficial are well
circumscribed, deep lesions be less demarcated.
Microscopically: composed of mature adipose tissue.
Variants:
- Vasculare tissue (angiolipoma) give local pain
- Smooth muscle (myolipoma)
- Bone marrow (myelolipoma of adrenal gland)
- Angiomyolipoma, containing a mixture of adipose tissue,
smooth muscle, and blood vessels. Occur in kidneys of patients
with tuberous sclerosis.
Treatment: Complete excision is usually curative.
8.
9. Lipomas
Conventional lipomas are soft, yellow, well-
encapsulated masses of mature adipocytes; they
can vary considerably in size.
11. Liposarcoma
• Liposarcomas are malignant neoplasms of adipocytes.
• AGE: They occur most commonly in the fifth and sixth
decades.
• SITE: Most liposarcomas arise in the deep soft tissues or
in visceral sites.
• The prognosis:
• is greatly influenced by the histologic subtype;
• well-differentiated types have a more favorable outlook
than do the more aggressive poorly differentiated
tumors.
• Metastasis: metastasize to lungs.
12. Liposarcoma
morphology
• Several different histologic subtypes are recognized,
• 1- Low-grade variants;
• the well-differentiated liposarcoma
• the myxoid/round cell liposarcoma, [ abundant, mucoid extracellular
matrix].
• Some well-differentiated lesions can be difficult to distinguish
histologically from lipomas,
• 2- Poorly differentiated tumors;Pleomorphic variant
• resemble various other high-grade malignancies.
• In most cases, cells indicative of fatty differentiation are present.
Such cells are known as lipoblasts; they recapitulate fetal fat cells
with cytoplasmic lipid vacuoles that scallop the nucleus
15. TUMORS AND TUMOR-LIKE
LESIONS OF FIBROUS TISSUE
• Nodular fascitis, reactive, self-limited lesion.
• Fibromatoses, aggressive local growth that may defy
surgical excision.
• Fibrosarcomas, highly malignant, recur locally, and
metastasize.
16. TUMORS OF FIBROUS TISSUE
Nodular Fascitis
Nodular fascitis is a self-limited, reactive fibroblastic
proliferation mistaken for a sarcoma.
Age: young adults.
Clinically: rapidly enlarging, painful mass of several
weeks duration.
10% to 15% of cases, a history of local trauma.
Site: Any part of the body, most common in the
upper extremities(Forearm) and trunk.
Treatment: excision
17. TUMORS OF FIBROUS TISSUE
Nodular Fascitis
Morphology
Grossly: unencapsulated lesion in the subcutaneous
tissue, muscle, or deep fascia. Superficial locations, well
circumscribed, nodular with poorly defined margins .
Microscopically, composed of immature
fibroblastic cells with bland cytology in myxoid matrix
containing lymphocytes and extravasated red blood cells.
Mitotic figures present, but not abnormal.
18. Nodular fasciitis
• Characteristically, the lesion
is several centimeters in
greatest dimension and
nodular with poorly defined
margins.
• Histologically, it is richly
cellular and consists of
plump, randomly arranged,
immature-appearing
fibroblasts in an abundant
myxoid stroma .
• The cells vary in size and
shape (spindle to stellate)
and have conspicuous
nucleoli and numerous
mitoses.
19. TUMORS OF FIBROUS TISSUE
FIBROMATOSES
Definition: Is a fibroblastic proliferation with
aggressive local growth and infiltrative margins.
recur after surgical excision and do not metastasize.
Two major groups:
Superficial fibromatoses, include palmar fibromatosis
(Dupuytren’s contracture) and penile fibromatosis
(Peyronie’s disease), occur in superficial fascia and are
benign, have abundant collagen and result in
deforming contractures in palms or soles.
Deep fibromatoses, called desmoid tumors, arise in
the abdomen, muscle of the trunk and extremities,
they recur and show local aggressive growth.
20.
21. TUMORS OF FIBROUS TISSUE
FIBROMATOSES cont.
MORPHOLOGY
Gross: either well-defined nodules, infiltrative
masses
without margins.
Microscopically: composed of proliferating
Fibroblasts have uniform appearance.
Superficial
fibromatoses, contain abundant collagen.
22. TUMORS OF FIBROUS TISSUE
FIBROSARCOMAS
Fibrosarcomas are malignant neoplasms
composed of malignant fibroblasts.
Age: adults
Site: deep tissue of the thigh, knee and trunk.
They grow slowly many years before diagnosis.
23.
24. TUMORS OF FIBROUS TISSUE
FIBROSARCOMAS
MORPHOLOGY
Gross: solitary lesions either infiltrative or
fairly circumscribed.
Histologically: interlacing fascicles of
fibroblasts, arrayed in a herringbone
pattern. Nuclear atypia and mitotic activity
present.
Prognosis: recur locally after excision and
may metastasize by blood to the lungs.
28. TUMORS OF SMOOTH MUSCLE
Leiomyomas are benign smooth muscle tumors,
are common, well-circumscribed neoplasms.
Site: uterus, anywhere in the body.
Leiomyosarcomas are malignant smooth muscle
tumors.
Site:most often in uterus and gastrointestinal
tracts, or any area of the body.
Most arise de novo, than in a preexisting
leiomyoma.
32. Leiomyoma:
Section of tumour shows:
A well demarcated tumour mass in the muscle coat
of uterus without a definite capsule.
Tumour consists of interlacing bundles of smooth
muscle and fibrous tissue.
The muscle cells are spindle shaped with
elongated nuclei and eosinophilic cytoplasm.
33. TUMORS OF SMOOTH MUSCLE
LEIOMYOSARCOMA
Morphology:
Have infiltrative growth, greater cellularity
and pleomorphism, greater mitotic activity
(mitotic activity used to differentiate benign
SMC tumor from malignant).
34. Cut surface of this leiomyosarcoma showing ill
defined pale and soft large fleshy mass with
hemorrhage and necrosis.
35.
36. TUMORS OF SKELETAL MUSCLE
Rhabdomyoma
Is a benign skeletal muscle tumor.
Is an uncommon tumor.
The cardiac rhabdomyoma associated with
tuberous sclerosis.
37. TUMOR OF SKELETAL MUSCLE
RHABDOMYOSARCOMA
Rhabdomyosarcoma is a malignant aggressive
skeletal muscle tumor.
Age: infancy, childhood, and adolescence
The most common soft tissue sarcoma in
pediatric age.
38. TUMORS OF SKELETAL MUSCLE
MORPHOLOGY
Gross: is variable.
Tumor (sarcoma botryoides) arising near the
mucosal surfaces of the lower genitourinary tract
and in the head and neck.
Are soft, gelatinous, grape-like masses, other
variant may present as poorly defined mass or as
infiltrating mass.
39. TUMORS OF SKELETAL MUSCLE
Microscpically:
*Embryonal variants and sarcoma botryoides,
are composed of malignant small round cells
and eosinophilic large cells with evidence of
myoblastic differentiation.
They are subclassified into the embryonal,
alveolar, and pleomorphic variants.
40. TUMORS OF SKELETAL MUSCLE
Diagnosis:
Depend of the demonstration of skeletal
muscle differentiation, by the electron
microscope (sarcomeres),
or immunocytochemical (desmin).
DDX:
to be distinguished from other small round
cell tumors of childhood.
43. SYNOVIAL SARCOMA
Accounts for 10% of all soft tissue sarcomas.
Synovial sarcoma does not arise from
synovial cells,
rather, it arises form mesenchymal cells
about joint cavities or away from the joint
especially around the knee and thigh
44. SYNOVIAL SARCOMA
MORPHOLOGY
Gross: can be small, circumscribed lesions or
infiltrative sarcomatous masses.
Histologically: biphasic pattern, epithelial
component forming glands, mixed with spindle
cells similar to fibroblast..
Less frequent monophasic, either composed of
epithelial elements that resemble a carcinoma
or,
of spindle cells sarcoma.
45.
46.
47. Assessment
–Which of the following statements is TRUE
for Liposarcoma?
• A. Usually show benign behavior
• B. The most common site is subcutaneous
tissue
• C. Histologically shows mature fat cells
arranged in lobules.
• D. Grossly, shows invasive growth with
hemorrhage and necrosis.
48. Assessment
–The most common soft tissue sarcoma of
infancy and childhood is:
• A. Rhabdomyosarcoma
• B. Liposarcoma
• C. Myositis ossificans
• D. Malignant fibrous histiocytoma