The document discusses systemic inflammatory response syndrome (SIRS) which can be triggered by infection or non-infectious causes like trauma. SIRS is characterized by changes in vital signs and white blood cell count. If associated with infection, it is called sepsis. Severe sepsis involves organ dysfunction while septic shock requires life support interventions. SIRS leads to an exaggerated inflammatory response that can damage multiple organs and lead to multiple organ dysfunction syndrome (MODS) if not treated promptly with antibiotics, fluids, and other supportive care measures.

1. Systemic Inflammatory Response Syndrome Dr. Vinayak

15. Systems responsible for inflammatory response

17. The complex interactions involved in SIRS with both beneficial and deleterious effects

19. Pathways for recovery from SIRS or progression to MODS