This document summarizes progress made in addressing social determinants of health since the 2008 WHO Commission on Social Determinants of Health report and 2011 Rio Political Declaration. It outlines global health inequalities, defines social determinants of health, and discusses the Commission's recommendations. It then summarizes implementation of the Rio Declaration's five action areas, including regional and country initiatives, and calls for continued efforts to build capacity, integrate social determinants into public health programs, and achieve health equity for all.