Epi Info is a free public domain software program developed by the CDC for data entry, analysis, and reporting. It allows users to develop electronic data entry forms, enter and analyze data, and produce statistics, graphs, tables, and maps. The main applications in Epi Info include designing data entry forms, entering data using these forms, and analyzing the entered data using a wide range of statistical tests. Sample size calculations can also be performed using Epi Info to determine the necessary sample sizes for different study designs like population surveys, case control studies, and cross-sectional or cohort studies.