Powder Technology
Particle analysis in pharmaceuticals
Determination of particle size and surface area
Large scale equipment for powders
Types of powders
The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts.
This theory is explain by Derjaguin , Landau , Verway , Overbeek So it is known as DLVO Theory.
According to this theory , The forces on colloidal particles in a dispersion medium are due to –
1. Electrostatic Repulsion
2. London type Vander Waals Attraction
In this slide contains introduction, copmpression, consolidation, compaction, heckel plots and equation, interpretation and application.
Presented by: NARAYAN SINGH UDIT (Department of pharmaceutics).
RIPER, anantapur
Powder Technology
Particle analysis in pharmaceuticals
Determination of particle size and surface area
Large scale equipment for powders
Types of powders
The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts.
This theory is explain by Derjaguin , Landau , Verway , Overbeek So it is known as DLVO Theory.
According to this theory , The forces on colloidal particles in a dispersion medium are due to –
1. Electrostatic Repulsion
2. London type Vander Waals Attraction
In this slide contains introduction, copmpression, consolidation, compaction, heckel plots and equation, interpretation and application.
Presented by: NARAYAN SINGH UDIT (Department of pharmaceutics).
RIPER, anantapur
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
Qualitative analysis of inorganic salts, Identification of anions and cations,Conversion of different water insoluble or sparingly soluble substances into water soluble form.
Name of the Experiment: Manufacture of Aluminium Hydroxide Gel from the supplied material.
Qualitative analysis (identification) of anions from inorganic salt solutions.
Qualitative analysis (identification) of group I & group II cations.
Qualitative analysis (identification) of group III cation.
Qualitative analysis (identification) of group IV & group V cations.
How to test the Ammonium with Litmus paper?
How to Clean a Platinum Wire?
What is Qualitative Analysis?
A Review Solubility Enhancement and its Techniqueijtsrd
Solubility are often defined because the amount of solute dissolved during a solvent at certain conditions to yield a single ¬phase system. Solubility of active pharmaceutical ingredients is taken into account the foremost parameter to urge the most desired drug concentration generally circulation so as to realize the specified therapeutic effect. Poor aqueous solubility considered the most problem occurs within the formulation progress of latest chemical entities additionally to the quality improvement solubility is that the main dispute for formulation scientists. The drug must appear as solution at the location of absorption so as to be absorbed. Many physical or chemical modification techniques are wont to improve the solubility of low aqueous soluble drugs, in addition to other techniques like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant and complexation. The selection of the solubility improvement methods depends on drug characteristics, location of absorption and therefore the features of the administered dosage form. Utkarsha R. Gavhane | Trusha P. Shangrapawar | Ashok Bhosale "A Review: Solubility Enhancement and its Technique" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42415.pdf Paper URL: https://www.ijtsrd.compharmacy/pharmaceutics/42415/a-review-solubility-enhancement-and-its-technique/utkarsha-r-gavhane
Sl. No. Date Name of the experiment Page No.
01 Conversion of different water insoluble or sparingly soluble substances into water soluble form. 01 – 07
02 Name of the Experiment: Manufacture of Aluminium Hydroxide Gel from the supplied material. 08 – 10
03-A Qualitative analysis (identification) of anions from inorganic salt solutions. 11 – 15
03-B Qualitative analysis (identification) of group I & group II cations. 16 – 20
03-C Qualitative analysis (identification) of group III cation. 21 – 27
03-D Qualitative analysis (identification) of group IV & group V cations. 28 – 31
Appendix 32
Safety Rules for chemistry laboratory 33
solubility enhancement and cosolvency by madhavishaikhazaroddin
“cosolvency and soluility enhancement” Pharmatech 2003, 160-166. They had developed simultaneous determination of sitagliptin phospate monohydrate and metformin by ultra performance liquid chromatographic (uplc)method.
Prepare by Dhanashree R. Kavhale. M.Pharm.(Pharmaceutical Chemistry) I year. Various solubility enhancement techniques are used for gaining desired pharmacological effect. Naming Physical , chemical modification, pH adjustment, supercritical fluid etc.
This above presentation gives us complete information about solubility, reasons for determining solubility, types of solubility, pre-formulation solubility studies, determination of solubility, and analytical methods for solubility.
The solubility of a substance refers to the amount of substance that passes into the solution to achieve a saturated solution at constant temperature and pressure.
NOVEL DRUG
1.INTRODUCTION: Novel Drug delivery system is the advance drug delivery system which improve drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue.
2.ADVANTAGES
3.DISADVANTAGES
4.SELECTION OF DRUG CANDIDATES FOR CONTROL RELEASE DOSAGE FORM
5.APPROACHES TO DESIGN CONTROLLED RELEASE FORMULATIONS
6.FACTORS INFLUENCING THE DESIGN AND ACT OF CONTROLLED RELEASE PRODUCTS
DELIVERY SYSTEM
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
2. CONTENTS
INTRODUCTION
PROCESS OF SOLUBILIZATION
IMPORTENCE OF SOLUBILITY
DETERMINATION OF SOLUBILITY
FACTORS EFFECTING SOLUBILITY
TECHNIQUES OF SOLUBILITY ENHANCEMENT
3. INTRODUCTION
DEFINITION:
The amount of substance (solute) that dissolves in a unit volume of a liquid
substance(solvent) to form a homogenous saturated solution under
specific conditions of temperature and pressure this phenomenon is known
is solubility.
The solubility of a drug is represented as parts, percentage, molarity,
molality.
5. Depending up on solubility and permeability drugs are classified into
four classes They are as follows:
6. PROCESS OF SOLUBILIZATION
Step 1: Holes open in the solvent
Step2: Molecules of the solid breaks away from the bulk
Step 3:The freed solid molecule is integrated into the hole in the solvent
7. IMPORTENCE OF SOLUBILITY
Therapeutic effectiveness of a drug depends upon the bioavailability and
ultimately upon the solubility of drug molecules
Solubility is one of the important parameter to achieve desired
concentration of drug in systemic circulation for pharmacological
response.
Low aqueous solubility is a major problem encountered with formulation
development of new chemical entities.
Any drug to be absorb must be present in the form of an aqueous solution
at the sight of absorption.
Most of the drugs are weakly acidic or basic having poor aqueous
solubility .
More than 40% of NCEs developed in pharmaceutical industry are
particularly insoluble in water.
8. Continued
These poorly water soluble drugs having slow drug absorption leads to
inadequate and variable bioavailability and GIT mucosal toxicity.
