Quantum algorithms like VQE and QAOA were used to analyze the impact of COVID-19 on optimal portfolio selection across different industries. Three time periods were considered - pre-COVID, during COVID, and post-COVID. Results found that COVID disrupted optimal portfolios, with sectors like retail, technology and automotive favored more pre-COVID, while oil/gas and airlines/hospitality favored post-COVID. Quantum algorithms provided comparable results to classical methods like Markowitz for portfolio optimization under changing market conditions from the pandemic.