Pulmonary embolism (PE), primarily caused by deep vein thrombosis (DVT), is a serious condition characterized by the blockage of pulmonary arteries, leading to potentially life-threatening complications. The document outlines the causes, risk factors, pathophysiology, diagnosis, and treatment options for PE and DVT, emphasizing the importance of anticoagulation therapy and risk stratification. Additionally, it discusses various diagnostic modalities and the classification of PE severity, along with detailed treatment regimens for managing DVT and preventing recurrent events.

1. PULMONARY EMBOLISM
Notes: by Col Bharat Malhotra Senior Advisor Medicine (JAN 2021)
DEFINE
Venous thromboembolism (VTE) = Deep Venous Thrombosis (DVT)
& Pulmonary Embolism (PE)
Pulmonary Embolism: Occlusion or partial occlusion of the pulmonary artery or its branches
Common cause:
An embolized clot from deep vein thrombosis (DVT) involving the lower leg.
Less common causes:
a) Tissue fragments b) Fat embolism c) Air embolism d) Amniotic fluid e) Tumor embolism
EPIDEMIOLOGY
PE is the most common preventable cause of death among hospitalized patients
ETIOLOGY
Stasis
Immobilization, Paralytic stroke
Venous obstruction, Venous
insufficiency, CHF
Endothelial injury
Hip/Knee Surgery,
Fracture lower limbs,
Major Trauma
Central venous lines
Chemotherapy
Infections
Prothrombotic States
factor V Leiden
Prothrombin gene mutation
Antithrombin, protein C, and
protein S deficiency
APLA syndrome
Hyperhomocysteinemia
Cancer, Nephrotic syndrome,
IBD, CHF, COPD,
Autoimmune diseases, Blood
transfusions
OCP, Pregnancy, postpartum
Predisposing factors:
Increase age, Obesity,
cigarette smoking, long-haul
air travel
Activated platelets → proinflammatory mediators → platelet aggregation → platelet-dependent
thrombin generation
Venous thrombi form and flourish in an environment of stasis, low oxygen tension, and
upregulation of proinflammatory genes.

2. PATHOPHYSIOLOGY
Embolize
Deep venous thrombi detach from
their site of formation they
embolize to the vena cava, right
atrium, and right ventricle, and
lodge in the pulmonary arterial
circulation, thereby causing acute
PE.
Many patients with PE have no
evidence of DVT because the clot
has already embolized to the
lungs.
Pulmonary Hypertension, Right Ventricular (RV)
Dysfunction, and RV Microinfarction
Pulmonary artery obstruction and neurohumoral mediators
cause a rise in pulmonary artery pressure and in pulmonary
vascular resistance.
RV wall tension rises → RV dilation and dysfunction ensue,
with release of the cardiac biomarker leading to:
• Compresses the right coronary artery → RV ischemia
• Underfilling of the LV → fall in LV cardiac output and BP
PHYSIOLOGICAL CHANGES
• Arterial hypoxemia
• Increased alveolar-arterial O2 tension gradient, which represents the inefficiency of O2 transfer
across the lungs.
o Increased pulmonary vascular resistance
o Impaired gas exchange
o Alveolar hyperventilation, Increased airway resistance
o Decreased pulmonary compliance due to lung edema, lung hemorrhage, or loss of surfactant
.

3. CLASSIFICATION OF PULMONARY EMBOLISM AND DEEP VENOUS THROMBOSIS
Pulmonary Embolism
Massive PE
5-10%
Extensive thrombosis
affecting at least half of
the pulmonary vasculature
Syncope & collapse, Severe Dyspnea, Central
Chest pain, Cyanosis and hypoxemia
Hypotension
Cardiogenic shock
Die from multisystem organ failure
Sub-massive PE
20-25%
Characterized by RV
dysfunction despite
normal systemic arterial
pressure
Worsening dyspnoea, Anginal chest pain,
Syncope, Haemoptysis
Features of RV dysfunction
Low-risk PE
65-75%
No RV dysfunction
No hypotension
Pulmonary infarction usually indicates a small PE.
This condition is exquisitely painful because the
thrombus lodges peripherally, near the innervation
of pleural nerves.
Deep Venous Thrombosis: Lower extremity DVT usually begins in the calf and propagates
proximally to the popliteal vein, femoral vein, and iliac veins.
DIAGNOSIS
Clinical Evaluation
“the Great Masquerader” Diagnosis is difficult because symptoms and signs are
nonspecific
In some cases, PE may be asymptomatic or discovered incidentally
during diagnostic workup for another disease in predisposed individuals.
The most common symptom is unexplained breathlessness. When occult PE occurs concomitantly
with overt congestive heart failure or pneumonia, clinical improvement often fails to ensue despite
standard medical treatment of the concomitant illness. This scenario presents a clinical clue to the
possible coexistence of PE.
Asymptomatic or discovered incidentally
Worsening dyspnea
Cough, Sputum
Hemoptysis
Syncope
Chest pain – Anginal, Pleuritic
Fever, Diaphoresis
Cardiogenic shock → multiorgan dysfunction
Evidence of DVT
Normal Exam with sinus tachycardia
Sinus Tachycardia
Tachypnoea
Loud S2, RV dysfunction
Crackles, Pleural rub
Hypotension, Cardiogenic shock in massive PE
Evidence of DVT

4. WELLS SCORE – CLINICAL DECISION RULES
DVT
Interpretation of score: High probability if 3 points or more, moderate probability if 1 or 2 points, and low probability if 0 points or less
PULMONARY EMBOLISM
Interpretation of total score:
0-1 point: low probability; 2-6 points: moderate probability; 7 or more points: high probability
DIFFERENTIAL DIAGNOSIS
Not all leg pain is due to DVT, and not all dyspnea is due to PE
Deep Venous Thrombosis (DVT)
Ruptured Baker’s cyst, Muscle strain/injury, Cellulitis, Acute post thrombotic syndrome/venous insufficiency
Pulmonary Embolism (PE)
Costochondritis, Musculoskeletal discomfort, Rib fracture
Pleurisy, Pneumothorax, Pneumonia, Severe asthma, chronic obstructive pulmonary disease
Pericarditis, Congestive heart failure, Acute coronary syndrome, Aortic dissection
Anxiety

5. ALGORITHM OF PE DIAGNOSIS - INTEGRATED DIAGNOSTIC APPROACH
DVT PULMONARY EMBOLISM
Wells score for DVT, ECG, CXR Wells score for Pulmonary Embolism, ECG, CXR
The Great Masquerader – suspect and assess for PE
D Dimer D Dimer Normal → No PE
High → Imaging
USS Doppler venous Leg → CT Angio LL ECHO Sub-massive/Massive PE (RV dysfunction)
CECT Chest → CT Venous angiography for PE
Lung Scan (Second line)
Do USS Doppler venous Leg for DVT
ProBNP: for RV dysfunction
Troponin T: for RV microinfarctions
EVALUATION
NONIMAGING DIAGNOSTIC MODALITIES
plasma D-dimer (ELISA) (> 500 ng/ml or 0.5 mcg/ml)
Rises in the presence of DVT or PE because of the breakdown of
fibrin by plasmin due to endogenous although often clinically
ineffective thrombolysis.
A normal D-dimer is a useful “rule out” test. However, the D-
dimer assay is not specific.
Levels increase in patients due to systemic illness.
Serum troponin – due to RV microinfarction
NT-pro-BNP – myocardial stretch leads to release of Pro-brain
natriuretic peptide.

6. ELECTROCARDIOGRAM
Frequent - sinus tachycardia
RV strain – RBBB, T-wave
inversion in leads V1 to V4
S1Q3T3 sign: S wave in lead
I, Q wave in lead III, and an
inverted T wave in lead III
CHEST ROENTGENOGRAPHY
A normal or nearly normal chest x-ray often
occurs in PE.
Pulmonary opacities
Peripheral wedged-shaped density usually
located at the pleural base (Hampton’s hump)
Horizontal linear opacities
Pleural effusion
Focal oligemia (Westermark’s sign)
Enlarged right descending pulmonary artery
(Palla’s sign).
Elevated hemidiapharm
USS LOWER LIMB VENOUS DOPPLER
Relies on loss of vein compressibility
Loss of normal respiratory variation
thrombus is directly visualized

7. ECHOCARDIOGRAPHY
Echocardiography is not a reliable diagnostic imaging tool for acute PE because most patients with PE
have normal echocardiograms. However, echocardiography is a very useful diagnostic tool for detecting
conditions that may mimic PE
Indirect sign of PE: McConnell’s sign: hypokinesis of the RV free wall with normal or hyperkinetic
motion of the RV apex
CHEST CT WITH VENOUS ANGIOGRAPHY
In patients without PE, the lung parenchymal images
may establish alternative diagnoses not apparent on
chest x-ray that explain the presenting symptoms and
signs
CT of the chest with intravenous contrast is the principal
imaging test for the diagnosis of PE. Sixth-order
branches can be visualized.
When imaging is extended distally below the chest to
the knee, pelvic and proximal leg DVT also can be
diagnosed by CT scanning.
Criteria
Arterial occlusion with failure to enhance the entire lumen due to a large filling defect; the
artery may be enlarged compared with adjacent patent vessels
A partial filling defect surrounded by contrast material, producing the “polo mint” sign on
images acquired perpendicular to the long axis of a vessel and the “railway track” sign on
longitudinal images of the vessel
The diagnosis of PE is very unlikely in patients with normal and nearly normal scans and, in contrast, is about 90% certain in patients with
high-probability scans

8. LUNG SCANNING (second line)
Lung scanning has become a second-line diagnostic test for PE, used mostly for patients who cannot
tolerate intravenous contrast.
INVASIVE PULMONARY ANGIOGRAPHY (not done)
Chest CT with contrast has virtually replaced invasive pulmonary angiography
TREATMENT
Deep Venous Thrombosis
PRIMARY THERAPY
Primary therapy Clot dissolution- catheter-directed thrombolysis
Reserved for patients with extensive femoral, iliofemoral, or upper
extremity DVT leading to less long-term damage to venous valves, with
consequent lower rates of post thrombotic syndrome

9. SECONDARY PREVENTION
Anticoagulation Effective anticoagulation is the foundation for successful treatment of
DVT and PE
Inferior vena caval
(IVC) filter
FDA approved a new retrievable IVC filter that is inserted at the
bedside with ultrasound visualization of the femoral or internal jugular
vein (Angel®
Filter) but without the need for any fluoroscopic or other
radiological imaging.
Indications: Contraindication to anticoagulation, Complication of
anticoagulation necessitating cessation, Propagation/progression of
DVT during therapeutic anticoagulation, Iliocaval or large free-floating
proximal DVT, limited cardiopulmonary reserve, Recurrent PE
Below-knee graduated
compression stockings
Swelling of the legs when acute DVT is diagnosed, may be prescribed,
usually with pressure of 30–40 mmHg, to lessen patient discomfort.
They should be replaced every 3 months because they lose their
elasticity.
Pulmonary Embolism
RISK STRATIFICATION
High risk
of an adverse clinical outcome
Hemodynamic instability, RV dysfunction on echocardiography,
RV enlargement on chest CT, or elevation of the troponin level
due to RV microinfarction
Good clinical outcome RV function remains normal
ANTICOAGULATION
Effective anticoagulation is the foundation for successful treatment of DVT and PE.
There are three major strategies:
1 S/C anticoagulation with (UFH), or (LMWH), or fondaparinux “bridged” 5d → to warfarin
2 S/C anticoagulation with (UFH), or (LMWH), or fondaparinux “bridged” 5d → novel oral
anticoagulant such as dabigatran (a direct thrombin inhibitor) or apixaban (an anti-Xa agent)
3 Oral anticoagulation monotherapy with rivaroxaban (3week) or apixaban (1 week) (both
are anti-Xa agents) loading dose, followed by a maintenance dose without parenteral
anticoagulation.
For patients with VTE in the setting of suspected or proven heparin-induced thrombocytopenia,
one can choose between two parenteral direct thrombin inhibitors: argatroban and bivalirudin

10. Mechanism of Action
PARENTRAL ANTICOAGULANTS
Unfractionated Heparin
Action UFH anticoagulates by binding to and accelerating the activity of
antithrombin, thus preventing additional thrombus formation
Aim UFH is dosed to achieve a target activated partial thromboplastin time
(aPTT) of 60–80 s.
Dose an initial bolus of 80 U/kg, followed by an initial infusion rate of 18 U/kg
per h in patients with normal liver function
Benefit short half-life, which is especially useful in patients in whom hour-to-
hour control of the intensity of anticoagulation
Heparin also has pleiotropic effects that may decrease systemic and local
inflammation.
Low-Molecular-Weight Heparins
These fragments of UFH exhibit less binding to plasma proteins and endothelial cells and
consequently have greater bioavailability, a more predictable dose response, and a longer half-life
than does UFH.
No monitoring or dose adjustment is needed unless the patient is markedly obese or has chronic
kidney disease

11. Fondaparinux
Fondaparinux, an anti-Xa Penta saccharide, is administered as a weight-based once-daily
subcutaneous injection in a prefilled syringe.
No laboratory monitoring is required. Fondaparinux is synthesized in a laboratory and, unlike
LMWH or UFH, is not derived from animal products. It does not cause heparin-induced
thrombocytopenia. The dose must be adjusted downward for patients with renal dysfunction.
ORAL ANTICOAGULANTS
Warfarin Anticoagulation
(Unfractionated heparin, LMWH, and fondaparinux are the usual immediately effective “bridging
agents” used when initiating warfarin) Requires 5–10 days of administration to achieve effectiveness
Warfarin
Action This vitamin K antagonist prevents carboxylation activation of coagulation
factors II, VII, IX, and X
Bridge therapy The full effect of warfarin requires at least 5 days, even if the prothrombin time,
used for monitoring, becomes elevated more rapidly
If warfarin is initiated as monotherapy during an acute thrombotic illness, a
paradoxical exacerbation of hypercoagulability increases the likelihood of
thrombosis. Overlapping UFH, LMWH, fondaparinux, or parenteral direct
thrombin inhibitors with warfarin for at least 5 days will nullify the early
procoagulant effect of warfarin
Dose
Monitor
Usual start dose is 5 mg
Titrate to international normalized ratio (INR), target 2.0–3.0
Continue parenteral anticoagulation for a minimum of 5 days and until two
sequential INR values, at least 1 day apart, achieve the target INR range.
Problems
The warfarin dose is usually titrated empirically to achieve the target INR. Proper
dosing is difficult because hundreds of drug-drug and drug-food interactions
affect warfarin metabolism.
Warfarin can cause major hemorrhage, including intracranial hemorrhage, even
when the INR remains within the desired therapeutic range. Warfarin can cause
“off target” side effects such as alopecia or arterial vascular calcification. Some
patients complain that warfarin makes them feel cold or fatigued
CYP2C9 variant alleles impair the hydroxylation of S-warfarin, thereby lowering
the dose requirement
...

12. Novel Oral Anticoagulants
Novel oral anticoagulants (NOACs) are administered in a fixed dose, establish effective
anticoagulation within hours of ingestion, require no laboratory coagulation monitoring, and have
few of the drug-drug or drug-food interactions
Rivaroxaban and apixaban, direct factor Xa inhibitors, are approved as monotherapy for acute
and extended treatment of DVT and PE, without a parenteral “bridging” anticoagulant.
Dabigatran, a direct thrombin inhibitor, and edoxaban, a factor Xa inhibitor, are approved for
treatment of VTE after an initial 5-day course of parenteral anticoagulation.
Betrixaban, a direct factor Xa inhibitor, was approved by the FDA in 2017 for VTE prophylaxis in
acutely ill medical patients during hospitalization and continuing for a total duration of 5 to 6
weeks.
Non-Warfarin Anticoagulation
Unfractionated heparin, bolus and continuous infusion, to achieve activated partial thromboplastin
time (aPTT) 2–3 times the upper limit of the laboratory normal, or
Enoxaparin 1 mg/kg twice daily with normal renal function, or
Dalteparin 200 U/kg once daily or 100 U/kg twice daily, with normal renal function, or
Tinzaparin 175 U/kg once daily with normal renal function, or
Fondaparinux weight-based once daily; adjust for impaired renal function
Direct thrombin inhibitors: argatroban or bivalirudin (with suspected or proven heparin-induced
thrombocytopenia)
Rivaroxaban 15 mg twice daily for 3 weeks, followed by 20 mg once daily with the dinner meal
thereafter
Apixaban 10 mg twice daily for 1 week, followed by 5 mg twice daily thereafter
Dabigatran 5 days of unfractionated heparin, low-molecular-weight heparin (LMWH), or
fondaparinux followed by dabigatran 150 mg twice daily
Edoxaban 5 days of unfractionated heparin, LMWH, or fondaparinux followed by edoxaban 60 mg
once daily with normal renal function, weight >60 kg, in the absence of potent P-glycoprotein
inhibitors
Complications of Anticoagulants The most serious adverse effect of anticoagulation is hemorrhage.
For life-threatening or intracranial hemorrhage following can be administered
Heparin or LMWH → protamine sulphate Dabigatran → Idarucizumab (NA)
Fondaparinux or factor Xa inhibitors → No reversal Universal anti-Xa antidote → Andexanet (NA)

13. Major bleeding from warfarin is best managed with prothrombin complex concentrate.
With less serious bleeding, fresh-frozen plasma or intravenous vitamin K can be used.
Duration of Anticoagulation
INTERMEDIATE RISK (3-8%) HIGH RISK FACTOR (> 8 %)
Major surgery
Lower limb plaster cast > 3 days
Short-term immobilization for >3 days
Hormonal contraception, pregnancy
Acute infectious disease leading to confinement > 3 days
Inflammatory bowel disease
Active autoimmune disease
Active Cancer
Antiphospholipid syndrome
Previous episodes of VTE
Myeloproliferative disorders
Thrombophilia
For DVT isolated to an upper extremity or calf
that has been provoked by surgery, trauma,
estrogen, or an indwelling central venous
catheter or pacemaker, 3 months of
anticoagulation usually suffice
For an initial episode of provoked proximal leg
DVT or PE, 3–6 months of anticoagulation used
to be the classic teaching
For patients with cancer and VTE, prescribe
LMWH as monotherapy without warfarin and
continue anticoagulation indefinitely unless the
patient is rendered cancer-free.
Patients with antiphospholipid antibody
syndrome may warrant indefinite-duration
anticoagulation, even if the initial VTE was
provoked by trauma or surgery.
Among patients with idiopathic, unprovoked
VTE, the recurrence rate is high after cessation
of anticoagulation. VTE that occurs during long-
haul air travel is considered unprovoked.
Unprovoked VTE may be caused by an
exacerbation of an underlying inflammatory state
and can be conceptualized as a chronic illness,
with latent periods between flares of recurrent
episodes.
American College of Chest Physicians (ACCP) guidelines recommend considering anticoagulation
for an indefinite duration with a target INR between 2 and 3 for patients with idiopathic VTE and
a low bleeding risk.
An alternative approach after the first 6 months of anticoagulation is to reduce the intensity of
anticoagulation and to lower the target INR range to between 1.5 and 2.
Another approach for patients at lower risk of recurrence, especially if there is an important reason
to avoid long-term anticoagulation, is to consider low-dose aspirin after completing the initial
period of standard anticoagulation.

14. INFERIOR VENA CAVA FILTERS (Reserve therapy)
The two principal indications for insertion
of an IVC filter are
(1) active bleeding that precludes
anticoagulation and
(2) recurrent venous thrombosis despite
intensive anticoagulation.
Prevention of recurrent PE in patients with
right heart failure who are not candidates for
fibrinolysis and prophylaxis of extremely
high-risk patients are “softer” indications for
filter placement.
Retrievable filters can now be placed for patients with an anticipated temporary bleeding disorder or
for patients at temporary high risk of PE, such as individuals undergoing bariatric surgery who have a
prior history of perioperative PE. The filters can be retrieved for months after insertion, unless thrombus
forms and is trapped within the filter. The retrievable filter becomes permanent if it remains in place or
if, for technical reasons such as rapid endothelialization, it cannot be removed.
The filter itself may fail by permitting the passage of small- to medium-size clots. Large thrombi may
embolize to the pulmonary arteries via collateral veins that develop. Paradoxically, by providing a nidus
for clot formation, filters increase the DVT rate, even though they usually prevent PE. Therefore, a
common complication is recurrent DVT or caval thrombosis with marked leg swelling.

15. MANAGEMENT OF MASSIVE PE
For patients with massive PE and hypotension, replete volume with 500 mL of normal saline.
Additional fluid should be infused with extreme caution because excessive fluid administration
exacerbates RV wall stress, causes more profound RV ischemia, and worsens LV compliance and
filling by causing further interventricular septal shift toward the LV.
Dopamine and dobutamine are first-line inotropic agents for treatment of PE-related shock. Maintain
a low threshold for initiating these pressors. Often, a “trial-and-error” approach works best; other
agents that may be effective include norepinephrine, vasopressin.
FIBRINOLYSIS
The only Food and Drug Administration–approved indication for PE fibrinolysis is massive PE.
For patients with submassive PE, who have preserved systolic blood pressure but moderate or
severe RV dysfunction, use of fibrinolysis remains controversial
Successful fibrinolytic therapy and may result in a lower rate of death and recurrent PE by
.
Rapidly reverses
right heart
failure and lower
rate of death
(1) dissolving much of the anatomically obstructing pulmonary arterial thrombus,
(2) preventing the continued release of serotonin and other neurohumoral factors
that exacerbate pulmonary hypertension, and
(3) lysing much of the source of the thrombus in the pelvic or deep leg veins,
thereby decreasing the likelihood of recurrent PE
Dose 100 mg of recombinant tissue plasminogen activator (tPA) prescribed as a
continuous peripheral intravenous infusion over 2 h
A popular off-label dosing regimen is 50 mg of TPA administered over 2 h. This
lower dose is widely perceived to be associated with fewer bleeding
complications
Contraindication Intracranial disease, recent surgery, and trauma. The overall major bleeding rate
is about 10%, including a 2–3% risk of intracranial hemorrhage
PHARMACOMECHANICAL CATHETER-DIRECTED THERAPY
Many patients have relative contraindications to full-dose thrombolysis. Pharmaco-mechanical
catheter-directed therapy usually combines physical fragmentation or pulverization of thrombus with
catheter-directed low-dose thrombolysis.

16. EMOTIONAL SUPPORT
PREVENTION OF VTE
Prevention of DVT and PE is of paramount importance because VTE is difficult to detect and poses a
profound medical and economic burden.
• High Risk orthopedic surgery
• Major Orthopedic Surgery
• Cancer Surgery
• Medically ill patients during hospitalization
Low-dose UFH or LMWH is the most common form of in-hospital prophylaxis.
S/C ENOXAPARIN 40 MG OD
Extended-duration prophylaxis with the novel anti-Xa agent, BETRIXABAN, appears to be both
effective and safe in medically ill patients during hospitalization, after hospital discharge, and is
undergoing FDA review.
NOTES: BY COL BHARAT MALHOTRA SENIOR ADVISOR MEDICINE (JAN 2021)
REFERENCES:
DAVIDSON’S PRINCIPLES AND PRACTICE OF MEDICINE 23RD
(2018) CHAPTER 17
HARRISON’S PRINCIPLES OF INTERNAL MEDICINE 20TH
(2018) CHAPTER 273
2019 ESC GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF ACUTE
PULMONARY EMBOLISM.