The document discusses classical conditioning, a form of learning. Classical conditioning occurs when a previously neutral stimulus becomes associated with an unconditioned stimulus to elicit a conditioned response. Key terms are defined, including unconditioned stimulus, unconditioned response, conditioned stimulus, and conditioned response. Classical conditioning involves pairing a previously neutral stimulus that does not naturally elicit a response with an unconditioned stimulus that reflexively produces a response, so that the formerly neutral stimulus comes to produce a learned response.
A disruptive condition that occurs in response to adverse influences from the internal or external environments
A condition in which the person responds to changes in the normal balanced state
A biological, psychological, social or chemical factor that causes physical or emotional tension and may be a factor in the etiology of certain illnesses.
CH. 4 LEARNING, MEMORY, AND INTELLIGENCELearning is definedMaximaSheffield592
CH. 4 LEARNING, MEMORY, AND INTELLIGENCE
Learning is defined as relatively permanent changes in behavior that result from experience but are not caused by fatigue, maturation, drugs, injury, or disease.
Memory is simply a process of encoding, storing, and retrieving pieces of information.
Everything we are, in our conscious experience, is dependent upon memory. Without memory we would live in a constant state of rediscovery, whereby every instance would be newly learned. Learning and memory are also intricately connected to intelligence.
Intelligence is the overall capacity to think and act logically and rationally within one’s environment.
What is Learning: Approaches to Learning
Learning, psychology tells us, consists of changes in behavior. But not all changes in behavior are examples of learning.
In the most brief explanation, learning is a change in behavior (or the potential for behavior) as a result of experience.
Learning:
A process resulting in a relatively consistent change in behavior or behavioral potential and is based on experience.
Learning is difficult to assess because it cannot be observed directly; instead, inferences are made about learning based on changes in performance.
Learning is not easily separated from other major topics in psychology. Changes in behavior are centrally involved in many aspects of psychology, including motivation, personality, development, and even mental disorders.
Cognitive Theories:
Theories that look at intellectual processes such as those involved in thinking, problem solving, imagining, and anticipating.
Behavioristic Theories:
Theories concerned with objective evidence of behavior rather than with consciousness and mind. Sometimes these are referred to as S-R or associationistic theories because they deal mainly with associations between stimuli and responses (muscular, glandular, or mental reaction to a stimulus).
Stimulus:
Any change in the physical environment capable of exciting a sense organ. Stimuli can also be internal events such as glandular secretions or even thoughts.
Behavioristic Approaches:
Classical Conditioning and Pavlov’s Experiments
An American named Edwin Twitmyer was actually the first person known to have reported the principle of classical conditioning. About a year later, a Russian by the name of Ivan Pavlov presented essentially the same findings—only he had used dogs as subjects whereas Twitmyer had used humans.
Classical Conditioning, sometimes called learning through stimulus substitution, is learning through stimulus substitution as a result of repeated pairings of an unconditioned stimulus with a conditioned stimulus
To clarify the laws of classical conditioning, Pavlov devised a series of experiments (Pavlov, 1927). In the best known of these, a dog is placed in a harness-like contraption. The apparatus allows food powder to be inserted directly into the dog’s mouth or to be dropped into a dish in front of the dog.
The salivation that ...
6LearningRevised by Pauline Davey Zeece, University of.docxfredharris32
6
Learning
Revised by Pauline Davey Zeece, University of Nebraska-Lincoln
Learning
Acquiring new and relatively enduring information or behaviors through experience
Associative learning: Learning that certain events occur together
Events may be two stimuli or a response and its consequences.
Cognitive learning: Acquisition of mental information by observing events, watching others, or through language
2
Forms of Conditioning
Classical conditioning
One learns to link two or more stimuli and anticipate events
Produces respondent behavior
Operant conditioning
One learns to associate an action and its consequence.
Produces operant behavior
Conditioning - A process of learning associations.
Stimulus: Any event or situation that evokes a response.
Respondent behavior: Behavior that occurs as an automatic response to some stimulus.
Operant behavior: Behavior that operates on the environment, producing consequences.
3
Figure 6.1 - Classical Conditioning
4
Figure 6.2 - Operant Conditioning
Retrieve and Remember 1
Why are habits, such as having something sweet with that cup of coffee, so hard to break?
ANSWER: Habits form when we repeat behaviors in a given context and, as a result, learn associations—often without our awareness. For example, we may have eaten a sweet pastry with a cup of coffee often enough to associate the flavor of the coffee with the treat, so that the cup of coffee alone just doesn’t seem right anymore!
6
Classical Conditioning
Pavlov’s experiments
Pavlov’s legacy
Figure 6.3 - Pavlov’s Classic Experiment
Pavlov presented a neutral stimulus (a tone) just before an unconditioned stimulus (food in mouth). The neutral stimulus then became a conditioned stimulus, producing a conditioned response.
8
Classical Conditioning: Terms
Neutral stimulus (NS): Evokes no response before conditioning
Unconditioned stimulus (US): Unconditionally, naturally and automatically, triggers a response
Unconditioned response (UR): Unlearned and naturally occurring response to an unconditioned stimulus (US)
9
Conditioned Response and Conditioned Stimulus
Conditioned response (CR)
Learned response to a previously neutral but now conditioned stimulus
Conditioned stimulus (CS)
Irrelevant stimulus that triggers a conditioned response (CR) after association with an unconditioned stimulus (US)
Pavlov’s Experiments
Explored conditioning processes
Acquisition
Extinction
Spontaneous recovery
Generalization
Discrimination
Ivan Pavlov: “Experimental investigation…
should lay a solid foundation for a future true
science of psychology” (1927).
Retrieve and Remember 2
An experimenter sounds a tone just before delivering an air puff that causes your eye to blink.
After several repetitions, you blink to the tone alone.
What is the NS? The US? The UR? The CS? The CR?
ANSWERS: NS = tone before conditioning; US = air puff; UR = blink to air puff; CS = tone after conditioning; CR = blink to tone
12
Acquisition
I.
A disruptive condition that occurs in response to adverse influences from the internal or external environments
A condition in which the person responds to changes in the normal balanced state
A biological, psychological, social or chemical factor that causes physical or emotional tension and may be a factor in the etiology of certain illnesses.
CH. 4 LEARNING, MEMORY, AND INTELLIGENCELearning is definedMaximaSheffield592
CH. 4 LEARNING, MEMORY, AND INTELLIGENCE
Learning is defined as relatively permanent changes in behavior that result from experience but are not caused by fatigue, maturation, drugs, injury, or disease.
Memory is simply a process of encoding, storing, and retrieving pieces of information.
Everything we are, in our conscious experience, is dependent upon memory. Without memory we would live in a constant state of rediscovery, whereby every instance would be newly learned. Learning and memory are also intricately connected to intelligence.
Intelligence is the overall capacity to think and act logically and rationally within one’s environment.
What is Learning: Approaches to Learning
Learning, psychology tells us, consists of changes in behavior. But not all changes in behavior are examples of learning.
In the most brief explanation, learning is a change in behavior (or the potential for behavior) as a result of experience.
Learning:
A process resulting in a relatively consistent change in behavior or behavioral potential and is based on experience.
Learning is difficult to assess because it cannot be observed directly; instead, inferences are made about learning based on changes in performance.
Learning is not easily separated from other major topics in psychology. Changes in behavior are centrally involved in many aspects of psychology, including motivation, personality, development, and even mental disorders.
Cognitive Theories:
Theories that look at intellectual processes such as those involved in thinking, problem solving, imagining, and anticipating.
Behavioristic Theories:
Theories concerned with objective evidence of behavior rather than with consciousness and mind. Sometimes these are referred to as S-R or associationistic theories because they deal mainly with associations between stimuli and responses (muscular, glandular, or mental reaction to a stimulus).
Stimulus:
Any change in the physical environment capable of exciting a sense organ. Stimuli can also be internal events such as glandular secretions or even thoughts.
Behavioristic Approaches:
Classical Conditioning and Pavlov’s Experiments
An American named Edwin Twitmyer was actually the first person known to have reported the principle of classical conditioning. About a year later, a Russian by the name of Ivan Pavlov presented essentially the same findings—only he had used dogs as subjects whereas Twitmyer had used humans.
Classical Conditioning, sometimes called learning through stimulus substitution, is learning through stimulus substitution as a result of repeated pairings of an unconditioned stimulus with a conditioned stimulus
To clarify the laws of classical conditioning, Pavlov devised a series of experiments (Pavlov, 1927). In the best known of these, a dog is placed in a harness-like contraption. The apparatus allows food powder to be inserted directly into the dog’s mouth or to be dropped into a dish in front of the dog.
The salivation that ...
6LearningRevised by Pauline Davey Zeece, University of.docxfredharris32
6
Learning
Revised by Pauline Davey Zeece, University of Nebraska-Lincoln
Learning
Acquiring new and relatively enduring information or behaviors through experience
Associative learning: Learning that certain events occur together
Events may be two stimuli or a response and its consequences.
Cognitive learning: Acquisition of mental information by observing events, watching others, or through language
2
Forms of Conditioning
Classical conditioning
One learns to link two or more stimuli and anticipate events
Produces respondent behavior
Operant conditioning
One learns to associate an action and its consequence.
Produces operant behavior
Conditioning - A process of learning associations.
Stimulus: Any event or situation that evokes a response.
Respondent behavior: Behavior that occurs as an automatic response to some stimulus.
Operant behavior: Behavior that operates on the environment, producing consequences.
3
Figure 6.1 - Classical Conditioning
4
Figure 6.2 - Operant Conditioning
Retrieve and Remember 1
Why are habits, such as having something sweet with that cup of coffee, so hard to break?
ANSWER: Habits form when we repeat behaviors in a given context and, as a result, learn associations—often without our awareness. For example, we may have eaten a sweet pastry with a cup of coffee often enough to associate the flavor of the coffee with the treat, so that the cup of coffee alone just doesn’t seem right anymore!
6
Classical Conditioning
Pavlov’s experiments
Pavlov’s legacy
Figure 6.3 - Pavlov’s Classic Experiment
Pavlov presented a neutral stimulus (a tone) just before an unconditioned stimulus (food in mouth). The neutral stimulus then became a conditioned stimulus, producing a conditioned response.
8
Classical Conditioning: Terms
Neutral stimulus (NS): Evokes no response before conditioning
Unconditioned stimulus (US): Unconditionally, naturally and automatically, triggers a response
Unconditioned response (UR): Unlearned and naturally occurring response to an unconditioned stimulus (US)
9
Conditioned Response and Conditioned Stimulus
Conditioned response (CR)
Learned response to a previously neutral but now conditioned stimulus
Conditioned stimulus (CS)
Irrelevant stimulus that triggers a conditioned response (CR) after association with an unconditioned stimulus (US)
Pavlov’s Experiments
Explored conditioning processes
Acquisition
Extinction
Spontaneous recovery
Generalization
Discrimination
Ivan Pavlov: “Experimental investigation…
should lay a solid foundation for a future true
science of psychology” (1927).
Retrieve and Remember 2
An experimenter sounds a tone just before delivering an air puff that causes your eye to blink.
After several repetitions, you blink to the tone alone.
What is the NS? The US? The UR? The CS? The CR?
ANSWERS: NS = tone before conditioning; US = air puff; UR = blink to air puff; CS = tone after conditioning; CR = blink to tone
12
Acquisition
I.
In this content consists of 'Learning Theories', presented by Dr. S.S. Srinithi as an Invited Resource Person in the webinar hosted by Department of Education, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu.
Learning in Psychological Perspectives.pdfKhemraj Subedi
In psychology, "learning" refers to a relatively permanent change in behavior, knowledge, or capability resulting from experience. Learning involves the acquisition of new information, skills, attitudes, or behaviors through various processes. Psychologists study learning to understand how individuals or animals acquire, retain, and apply knowledge or behaviors.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. HOLT, RINEHART AND WINSTON
PSYCHOLOGY
PRINCIPLES IN PRACTICE
PRINCIPLES OF CLASSICAL CONDITIONING
Simple form of learning in
which one stimulus calls forth
the response that is usually
called forth by another stimulus
This occurs when the two
stimuli have been associated
with each other
4. HOLT, RINEHART AND WINSTON
PSYCHOLOGY
PRINCIPLES IN PRACTICE
4
Chapter 6
Stimulus-
Something that
triggers a
response.
Example: touching
a hot surface would
be the stimulus to
remove your hand
from that surface.
Conditioning=
learning
Classical Conditioning
5. HOLT, RINEHART AND WINSTON
PSYCHOLOGY
PRINCIPLES IN PRACTICE
5
Chapter 6
Terms that are important in
understanding classical conditioning:
Unconditioned stimulus (US) – a stimulus that
causes a response that is automatic, not learned
Unconditioned response (UR) – the response that is
automatic, not learned
Section 1: Classical Conditioning
8. HOLT, RINEHART AND WINSTON
PSYCHOLOGY
PRINCIPLES IN PRACTICE
8
Chapter 6
Conditioned Stimulus (CS) – a previously
neutral stimulus that, because of pairing with
an unconditioned stimulus, now causes a
conditioned response
Conditioned Response (CR) – a learned
response to a stimulus that was previously
neutral or meaningless
IMPORTANT TERMS (continued)
