1. A 75-year-old woman presented to the emergency department with sudden onset of left-sided weakness and headache, consistent with symptoms of a stroke.
2. A 15-year-old boy developed worsening headache and seizures hours after being hit in the temple with a baseball bat during a game, suggesting a possible head injury or intracranial bleed.
3. A 40-year-old businessman reported a 2-month history of intermittent headaches, fever, diarrhea, and mouth sores, with a history of drug use, raising concerns for an infectious etiology like meningitis given his symptoms.
adalah kondisi medis darurat yang dapat mengancam jiwa bila tidak ditangani secara tepat. Ketoasidosis diabetikum disebabkan oleh penurunan kadar insulin efektif di sirkulasi yang terkait dengan peningkatan sejumlah hormon seperti glukagon, katekolamin, kortisol, dan growth hormone.
adalah kondisi medis darurat yang dapat mengancam jiwa bila tidak ditangani secara tepat. Ketoasidosis diabetikum disebabkan oleh penurunan kadar insulin efektif di sirkulasi yang terkait dengan peningkatan sejumlah hormon seperti glukagon, katekolamin, kortisol, dan growth hormone.
Laporan Kasus Tinea (Pityriasis) versicolorazmiarraga
Laporan kasus mengenai Pityriasis versicolor. Bahasan di dalamnya meliputi definisi, faktor risiko, epidemiologi, etiologi, patofisiologi, penegakan diagnosis (anamnesis dan pemeriksaan klinis, serta pemeriksaan penunjang), prognosis, dan pencegahan Pityriasis versicolor
Muntah pada Anak
Dipresentasikan oleh DR. dr. Dwi Prasetyo, SpA(K), M.Kes
Departemen Ilmu Kesehatan Anak
FK UNPAD/ RS Hasan Sadikin Bandung
pada PIT VI IDI Kota Bogor | 10 Nopember 2013
Laporan Kasus Tinea (Pityriasis) versicolorazmiarraga
Laporan kasus mengenai Pityriasis versicolor. Bahasan di dalamnya meliputi definisi, faktor risiko, epidemiologi, etiologi, patofisiologi, penegakan diagnosis (anamnesis dan pemeriksaan klinis, serta pemeriksaan penunjang), prognosis, dan pencegahan Pityriasis versicolor
Muntah pada Anak
Dipresentasikan oleh DR. dr. Dwi Prasetyo, SpA(K), M.Kes
Departemen Ilmu Kesehatan Anak
FK UNPAD/ RS Hasan Sadikin Bandung
pada PIT VI IDI Kota Bogor | 10 Nopember 2013
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Headache/ Nyeri Kepala
18,9% kunjungan ke RSDS
17,4% kunjungan ke RSCM
42% kunjungan praktek sore Sp.S
90% merupakan primary headache
2
3. NYERI
Pengalaman sensorik & emosional yg tidak
menyenangkan terkait kerusakan jaringan,
baik aktual maupun potensial atau yang
digambarkan dalam bentuk kerusakan tsb.
5. DEFINITION
Pain on head area
Pain in face, pharynx, larynx & neck are not
include.
Osteo arthritis cervicalis is include
Epidemiology
TTH 35-78% (CTTH 3%)
Migrain 18% female, 6% men
Cluster 0.015%
5
HEADACHE/ Nyeri Kepala
6. Derajat Nyeri Kepala
(Praktis)
Ringan : pekerjaan/aktifitas sehari2
normal.
Sedang : aktifitas berat terganggu
Berat : aktifitas sehari-hari terganggu
6
7. STRUCTURE PAIN SENSITIVE
I. STRUCTURE Intra Kranial
a. sinus, vein besar & aferennya
b. artery dura mater
c. artery basis cranium
d. duramater
II. STRUCTURE ekstra kranial
a. skin, skin head, jar. Sub.kutan, fasia, muscle
head/neck.
b. mukosa
c. artery-artery
d. Structure from eye, ear & nose
III. Nervous: V, VII, IX, X, C1 C2 C3
7
14. DIAGNOSIS AND TESTING
Detailed History and Examination
Primary Headache?
Preliminary Diagnosis
NO
Secondary
Headache
Diagnostic
Testing
Atypical
Features
YES
14
15. RED FLAGS “SNOOP T”
Older: new onset and progressive headache, especially in
middle-age >50
Systemic symptoms (fever, weight loss) or
secondary risk factors (HIV, systemic cancer)
Neurologic symptoms or abnormal signs (confusion, impaired
alertness, or consciousness)
Onset: sudden, abrupt, or progressively worsening
Previous headache history: first headache or different
(change in attack frequency, severity, or clinical features)
Triggered headache (valsava, exertion)
15
16. Classification of headaches
• Primary headaches
• OR Idiopathic headaches
– THE HEADACHE IS ITSELF
THE DISEASE
– NO ORGANIC LESION IN THE
BEACKGROUND
– TREAT THE HEADACHE!
• Secondary headaches
• OR Symptomatic headaches
– THE HEADACHE IS ON LY A
SYMPTOM OF AN OTHER
UNDERLYING DISEASE
– TREAT THE UNDERLYING
DISEASE!
16
17. HEADACHE QUALITY LOCATION DURATION FREQUENCY
ASSOCIATED
SYMPTOMS
Common
migraine
Throbbing Unilateral head /
Ifteral head
6 – 48 hours Sporadic (often
several times
montlly)
Nausea, vomiting,
malaise,
photophobia
Classic
migraine
Throbbing Unilateral head 3 – 12 hours Sporadic (often
several times
monthly)
Visual prodrome,
vomiting, nausea,
malaise,
photobhobia
Cluster Boring, sharp Unilateral head
(especially orbit)
12 – 120
minutes
Closely bunched
clusters with
long remissions
Ipsilateral tearing,
facial flushing, nasal
stuffiness, Horners’s
syndrome
Psychogenic/
Chronic TTH
Dull, pressure Diffuse, Ifteral
Frontal, temporal
suboccipital
Oftem
unremitting
May be constant
Almost daily
Depression, anxiaty
Pericranial
tenderness
Trigeminal
meuralgia
Lancinating Fifth nerve
distribution
Brief (15-60
second)
Many times daily Identifiable trigger
zone
Tabel 1 . Important features of pain in the evaluation of chronic
recurrent headaches
17
18. PHYSICAL FINDING POSSIBLE ETIOLOGY
Optic atropy, papiledema Mass lesion, hydrocephalus, benign
intracranial hypertensionon
Focal neurologic abnormality (hemiparese
aphasia)
Mass lesion
Stiff neck Subarachnoid hemorrhage, meningitis,
cervical arthritis
Retinal hemorrhages Ruptured aneurysm, malignant
hypertensionon
Cranial bruit arteryovenous malformation
Thickened, tender temporal arteryes Temporal arterytis
Trigger point for pain Trigeminal neuralgia
Lid ptosis, third nerve palsy, dilated pupil Cerebral aneurysm
Spasm and tenderness of Pericranial
muscle
TTH/Muscle Contraction Headache
18
19. TTH (Headache Type Spasm/
Tension Type Headache TTH)
OVERVIEW:
The most common (90%) headache
Responsive to over the counter med
5% visits
When disabling conjunction with migraine
Spectrum of migraine
Beware of medication overuse headache (MOH)
19
20. Tension Type headache
• 10 attacks lasting 30 min–7 days
• 2 of the following 4
– Bilateral
– Not pulsating
– Mild or moderate intensity
– Not aggravated by routine physical activity
• No nausea or vomiting
• One or neither photophobia or phonophobia
• Not attributable to another disorder
20
23. Treatment of TTH
Evidence A : multipel RCT
B : 1 RCT
C : Consensus
Clinical effect :
+ few people improved
++ Some people improved
+++ Most people improved
23
24. Drug evidence Clinical effect Role Route
Analgesic & NSAID
Asetaminofen A ++ Acute PO
Aspirin A ++
Mefenamic acid A ++
Ibuprofen A ++
Naproxen A ++
Ibuprofen+caffein A ++
Antidepresan
Amitriptilin A +++ preventive PO
Maprotilin B +
Mianserin B ++
Sulpride C +
Fluvoxamine B ++
Muscle relaxants
Tizanidine B ++ Acute&preventive PO
Eperisone B ++
Others
Alprazolam B ++ Acute&preventive PO
Etizolam C ++
prochloperazine C ? Acute IV
chlorpromazine C ?
24
26. Migraine
• The most common disabling headache
• The most common headache visits
• Unknown causes
26
27. Migraine Criteria
• 5 attacks lasting 4–72 h
• 2 of the following 4
– Unilateral
– Pulsating
– Moderate or severe intensity
– Aggravation by routine physical activity
• 1 of the following
– Nausea and/or vomiting
– Photophobia and phonophobia
• Not attributable to another disorder
27
29. SULTANS: two from column A, one from
column B
• evere
• ni
• ateral
• hrobbing
• Ctivity worsens
• ausea
• Lite and sound
ensitivity
29
30. World prevalence of migraine
1-year prevalence rates
Population-based studies
IHS criteria (or modified)
USA 12%
Chile 7%
Japan 8%
Italy 16%
Denmark 10%
France 8%†
Switzerland 13%
Rasmussen and Olesen (1994); Rasmussen (1995);
Lipton et al (1994); Lavados and Tenhamm (1997); Sakai
and Igarashi (1997)†Prevalence measured over a few years
30
31. Prevalence of migraine by
sex and age
Females
Males30
25
20
15
10
5
0
20 30 40 50 60 70 80 100
Migraine prevalence (%)
Age (years)
Lipton and Stewart (1993)
The American Migraine Study (n=2479 migraine sufferers)
31
36. Pencetus Migraine
• Kurang atau kebanyakan tidur
• Kelelahan
• Stres dan kecemasan
• Terlambat makan
• Perubahan hormonal
• Makanan (MSG, nitrit (pengawet) ,aspartam(pemanis
buatan))
• Cahaya terang
36
37. Terapi abortif non spesifik
Obat Dosis, mg Evidence
ASA 1000 mg oral A
ASA 1000 mg IV A
ibuprofen 200-800mg, oral A
Naproxen 500-1000mg oral A
Parasetamol 1000 mg oral,supp A
Diklofenac 50-100 mg oral A
37
38. Terapi abortif spesifik
Ergot
Angka rekurensi rendah
Menginduksi drug overuse headache dg cepat
Maksimal diberikan10 hari/bulan
Efek samping : parestesi, muntah
Kontra indikasi
Penyakit kardio, serebrovaskular, hipertensi,
gagal ginjal, kehamilan dan laktasi
38
39. TRIPTAN
Efikasi lebih baik dibanding ergot
Sediaan obat di Indonesia sulit di dapat (hanya
ada sumatriptan)
Efek samping : nyeri dada, parestesi, fatik
Kontra indikasi : Penyakit kardio, serebrovaskular,
hipertensi, gagal ginjal, kehamilan dan laktasi
39
40. Terapi prevensi migrain
1. Serangan >2-8 kali/bln
2. Berlangsung >48 jam
3. Pengobatan akut tdk efektif
4. Ada kontra indikasi terapi abortif, efek
samping, atau cenderung overuse
5. Gejala luar biasa ( migrain basiler, hemiplegi,
aura memanjang)
6. Permintaan pasien
40
41. Terapi prevensi migrain
Konsensus Nasional III Nyeri Kepala PERDOSSI 2010
Obat Dosis mg/hari evidence
betablocker
metoprolol 50-200 A
propanolol 40-240 A
Calcium channel blocker
Flunarizine (Frego) 5-10 A
Anti epileptic
Valproic acid 500-1800 A
Topiramat 25-100 A
41
43. stroke
• Wanita 75 th di bawa ke IRD
RS krn mendadak sakit
kepala, hemiparese kiri
44. Trauma
• Anak 15 th terkena pemukul
baseball di pelipis. Sesaat
setelah terkena pukulan ia
tidak sadar sebentar ± 15
mnt lalu bangun lagi. Ia
mengeluh sakit kepala
namun keadaannya saat itu
baik saat dibawa ke IRD.
Empat jam kemudian saat
diobservasi ia mengeluhkan
sakit kepalanya bertambah
hebat dan kejang. Pupil
sebelah kanan midriasis
45. Infeksi
• Pria 40 th , pengusaha
mengeluh sakit kepala 2
bln, disertai demam
sumer-sumer, sering
diare dan sariawan .Ia
mengkonsumsi narkoba
berhenti sjk 1 th silam.
Dibawa ke IRD oleh
keluarganya krn bicara
meracau.
46. Tumor
• Wanita 35 th, sakit
kepala 8 bln bertambah
hebat terutama saat
bangun dan bersin,
memakai kontrasepsi
suntik 3 bulan
47. Degenerasi
• Wanita 79 th datang ke
poli dengan keluhan
sakit kepala hilang
timbul ± 2 th.Sering
lupa ± 3-4 th dan tidak
mampu berbelanja lagi
krn kesulitan melakukan
perhitungan ringan.
Sekarang sulit tidur dan
sering terlihat seperti
berbicara sendiri