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S
URINARY
INCONTINENCE:
AN APPROACH
DR SUKANDA JAILI
URINARY INCONTINENCE
(UI)
S ANY INVOLUNTARY LOSS OF URINE
S SYMPTOM OR SIGN
S NOT A DIAGNOSIS
WOMAN MAN
CONSEQUENCES
S SOCIALLY
S HYGENIC
S IMPACT QUALITY OF LIFE
S DEPRESSION
S BATHROOM MAPPING
S DISABILITY AND DEPENDENCY
MYTH.....&...FACT
S IF by the patient is bothered by UI,she will tell me..
S UI is “natural after birth”
S UI is normal part of aging
S “If I get surgery for UI, I will end up with a bag..”
AGEING…
S NOT CAUSE OF URINARY INCONTINENCE
S AGE RELATED CHANGES IN LOWER URINARY
TRACT ANATOMY AND PHYSIOLOGY
S CHRONIC ILLNESS – SYSTEMIC
DISTURBANCES
PREDISPOSING …..
S HIGHER PARITY
PREGNANCY,CHILDBIRTH &
PHYSICAL
STRAINING DURING LABOUR
PREDISPOSING …
S MENOPAUSE
S HORMONAL CHANGES
PREDISPOSING
S OBESITY
S WORKLOAD ON PELVIC
FLOOR
PREDISPOSING….
S USE OF SITTING TOILET
PREVALENCE
S ESTIMATED 15 TO 30 %
S 50% STRESS UI
S 15% URGE UI
S 35% MIXED UI
S 5 TO 8% LEAK 1 OR > PER WEEK
S >60 YEARS OLD – WOMAN 2X MORE THAN MAN
In Asia…..
S MALAYSIA 13.1 % 7.9%
S SINGAPORE 11.8% 4.3%
S PHILLIPPINES 13.9% 8%
S THAILAND 20.3% 14.1%
S KOREA 22.6% 28.6%
S Asia Pacific Continence Advisory Board (APCAB) 1998
WOMEN MEN
URINARY INCONTINENCE
S SEVERITY OF INCONTINENCE
S VOLUME
S TYPE OF INCONTINENCE
S NO OF PADS
S CHANGES OF UNDERWEAR REQUIRED IN 24 HRS
CAUSES
S URETHRAL SPHINCTER INCOMPETENCE
S SPHINCTER DYSFUNCTION
S ABNORMAL BLADDER NECK SUPPORT
S DETRUSOR OVERACTIVITY
S IDIOPATHIC
S NEUROGENIC
S MIXED INCONTINENCE
CAUSES
S OVERFLOW INCONTINENCE
S HYPOTONIC DETRUSOR
S URETHRAL OBSTRUCTION (RARE)
CAUSES
S URETHRAL DIVERTICULA
S CONGENITAL ABNOMALY
S ECTOPIC URETER,SPINA BIFIDA OCCULTA
S PHARMACOLOGICAL CAUSE
S DIURETIC,TRANQUILLIZER,CHOLINERGIC AGENTS
S FISTULA
S URETHRAL,VESICAL,URETER
AIM
S DETERMINE THE CAUSE
S DETECT RELATED URINARY TRACT PATHOLOGY
S EVALUATE PATIENT PHYSICAL,MENTAL
STATUS,COMORBIDS,MEDICATION & ENVIRONMENT
HISTORY
S DETAILED PAST AND PRESENT
MEDICAL,SURGICAL,UROLOGIC,GYNAECOLOGY
HISTORY
S TO CHARACTERIZE THE TYPE OF INCONTINENCE
HISTORY
S EVALUATE THE FREQUENCY,SEVERITY,PATTERN
S ESTABLISHED OTHER ASSOCIATED URINARY SYMPTOM
S STRAINING,INCOMPLETE VOIDING AND DYSURIA
HISTORY
S TO ESTABLISH PRECIPITATING FACTORS
S BOWEL HABITS,MEDICATION AND FLUID INTAKE
S VOIDING HABITS
S ASSESSMENT OF MOBILITY,LIVING
CONDITION,MENTAL STATUS,SOCIAL ENVIRONMENT
HISTORY
S DESIRE FOR TREATMENT AND THE EXTENT OF
TREATMENT THAT IS ACCEPTABLE
S ESTABLISH PATIENT SUPPORT INCLUDING
CAREGIVERS
S COGNITIVE FUNCTION
S ABILITY TO DESCRIBE SYMPTOMS,QUALITY OF
LIFE,PREFERENCES AND GOALS FOR CARE
PHYSICAL EXAMINATION
S THE MORE COMPLICATED THE HISTORY & MORE
EXTENSIVE AND/OR INVASIVE THE PROPOSED
THERAPY/INVESTIGATION – THE MORE COMPLETE
THE EXAMINATION
PHYSICAL EXAMINATION
S GENERAL STATUS
S MENTAL STATUS
S BMI
S MOBILITY
S ABDOMINAL EXAMINATION
S MASS
S BLADDER DISTENTION
S SURGICAL SCAR
PHYSICAL EXAMINATION
S PELVIC EXAMINATION
S PERINEUM &EXTERNAL GENITALIA
S TISSUE QUALITY & SENSATION
S COUGH STRESS TEST
S VAGINAL EXAMINATION –
PROLAPSE,CYST,DISCHARGED
S BIMANUAL EXAMINATION
S PELVIC FLOOR MUSCLE EVALUATION
S ANORECTAL EXAMINATION
S ASSOCIATED PELVIC ORGAN PROLAPSE
S PREVIOUS ABDOMINAL OR PELVIC SURGERY
Cough Stress test
S Bladder volume at least 250 cc or symptomatic fullness
S Reliable and simple test for the diagnosis of stress
urinary incontinence
S Screening test before requiring further evaluation with
more urodynamic test
S Recommended for both clinical research and clinical
practice.
S ESTIMATION OF POST VOID RESIDUAL URINE (RU)
S CATHETER OR ULTRASOUND
S GOOD CLINICAL CORRELATION BETWEEN THE TWO
S Coombs GM, Millard RJ (1994). The accuracy of portable us scanning in the measurement of
residual urine. J Urol
S < 30% OF VOIDED VOLUME OR < 150 ML
S RENAL FUNCTION ASSESSMENT
S URINALYSIS
S HIGHLY RECOMMENDED
S URINE DIPSTICK HAS LOW SENSITIVITY AND HIGH
SPECIFICITY TO DETECT UTI
S Pels RJ, Bor DH et all (2000).JAMA . Dispstick urinalysis screening of asymptomatic adults for
urinary tract disorders.
S URINE CULTURE & MICROSCOPIC EXAMINATION
S EXAMINATION ALONE INSUFFICIENT – NEEDS
TOOLS TO SUPPLEMENT INFORMATION OBTAINED
FROM HISTORY & EXAMINATION
S BLADDER DIARY
S QUESTIONNAIRES
BLADDER DIARY
S FREQUENCY VOLUME CHART,VOIDING DIARY
S AMONG BEST POSSIBLE MEANS OF OBTAINING
OBJECTIVE DATA ON SUBJECTIVE SYMPTOMS
S Abrams P, Cardozo L, Magnus F et al (2002). The standardization of terminology of lower urinary
tract function.International Continence Society. Neurourol Urodynam.
USEFUL IN…
S DETERMINE VOLUME FLIUD INTAKE
S NORMAL FLUID VOLUME CONSUMED AT IN
APPROPRIATE TIMES.
S EXCESSIVE INTAKE OF ALCOHOL OR CAFFIENE
S MAXIMAL VOIDED VOLUME – REPRESENT
FUNCTIONAL BLADDER CAPACITY
BLADDER DIARY
BLADDER DIARY
S OPTIMUM DURATION NOT STANDARDISED
S COMPLIANCE DECREASES WITH LENGTH OF THE DIARY
S 72 HOURS DIARY (3 DAYS ) – SIGNIFICANTLY
CORRELATES WITH 7 DAYS DIARY
S Grouttz A,Blaivas JG, Chaikin DC et al (2002).Voiding and incontinence
frequencies:variability of voiding diary data and required dialy length. Neurourol Urodyn
21:205-209
S ENCOMPASS WORK AND LEISURE DAY
Quality of Life measures
S Incontinence Impact Questionnaire (IIQ-7)
S Urogenital Distress Inventory (UDI-6)
S Both specific for incontinence in female population
S Evaluation prior to & success of therapy
S Recommended for clinical studies
S Optional for clinical practise
OTHERS…
S CYSTOSCOPY
S <2% BLADDER LESION FOUND IN INCONTINENCE PATIENTS
S SHOULD NOT BE PERFORMED ROUTINELY IN PATIENTS WITH
URINARY INCONTINENCE TO EXCLUDE NEOPLASM
S Cundiff GW,Bent AE.The contribution of urethrocystoscopy to evaluation of lower
urinary tract dysfunction in women (IUJ 2006).
S RECOMMENDED IF ASSOCIATED WITH
HAEMATURIA,SUSPECTED FISTULA,RECURRENT
CYSTITIS,BLADDER PAIN
S Ludviksson K. The value of cllinical examination of the female incontinence
patient (Acta Obstet Gynecol Scan,2007)
OTHERS..
S IMAGING
S PELVIC AND ABDOMINAL ULTRASOUND
S IMAGING OF UPPER AND LOWER URINARY TRACT
- TRANSPERINEAL ULTRASOUND
S UROFLOWMETRY
S URODYNAMIC STUDY
TREATMENT
S DEPENDS ON THE CAUSE OF UI
S LIFESTYLE MODIFICATION
S MEDICAL TREATMENT
S SURGICAL TREATMENT
S CISC
Conservative treatment
S Pelvic floor rehabilitation
S Bladder retraining
S Pelvic floor exercises
S Voiding techniques
S Vaginal Devices eg tampon, Contiform
S Vaginal oestrogen
Continence devices
S Contiform vaginal device
S Urethral plug not available
S Trials suggest some
improvement in leakage cf no
treatment
Pelvic Floor Rehabilitation
S Supervised PFMT, at least 3 months
S Use of a dedicated pelvic floor physiotherapy
service or continence nurse advisor
S Women receiving supervision more likely to report improvement than
women doing PFMT with little or no supervision
S Cochrane update 2014
S Supports recommendation that PFMT be included in
first-line conservative management for any type of
incontinence
URGE INCONTINENCE
S CONSERVATIVE TREATMENT
S FLIUD INTAKE
S BLADDER TRAINING
S PHARMACOLOGICAL TREATMENT
S BOTOX INJECTION
S NEUROMODULATION
S URINARY STRESS INCONTINENCE
Urinary Incontinent procedures
S Ideal patient
S Urodynamic stress incontinence only
S Normal uroflowmetry
S Normal bladder capacity
S No overactive bladder
S No previous incontinence procedures
S Normal BMI
S No significant medical conditions
S Completed childbearing
Urinary incontinent procedure
S Ideal pre-operative situation
S Initial conservative management
S Exclude pathology, infection
S Bladder diary
S Pelvic floor rehabilitation
S Education regarding diet, fluids, bowel, weight control etc
S Compliance
S Treatment of overactive bladder symptoms
S Confirm diagnosis
S Realistic expectations of outcomes of procedure
S Over 200 surgical techniques
S MMK cyto-urethropexy (1949) and modifications
S Burch colposuspension (1961) – open and laparoscopic
S Anterior colporrhaphy and Kelly plication (1913)
S Needle suspension techniques (Pereyra 1959), Stamey modification (1973)
S Pubovagional sling procedures – gracilis muscle (1907), pyramidalis muscle (1910), fascia
lata (1933)
S Aldridge sling with rectus fascia (1942) - modifications of sling material (autologous,
cadaveric, synthetic) and fixation
S Bone anchors
S Periurethral bulking
S TVT (1995) and modifications
S TOT (2001) and modifications
S Stem cell therapy
Surgical management of USI
S Colposuspension (open or laparoscopic)
S Until recently, considered the Gold Standard
S Midurethral slings (synthetic)
S Retropubic - New Gold Standard
S Bulking agents
S Other surgical options
Surgical options for USI
Vaginal incisions – ‘mid-urethra’ but variations in exit sites, delivery of
sling
S Retropubic – first generation
S eg TVT – first described 1995
S SPARC (2001), Advantage etc
S Transobturator – second generation (2001)
S Eg TVT-O (2005 – de Leval), Monarc
S Modified Transobturator
S eg TVT-Abrevo (2012)
S Single incision “Minislings” – third generation
S eg TVT-S (2006); Mini-Arc (2007)
Midurethral slings
S Periurethral injection to narrow the bladder neck
S Complications – voiding problems long-term
(2%), UTI , denovo urgency (up to 13%)
S Cure rates – 40-60%
S Long-term follow up > 8 years
S 24 women, polyacrylamide hydrogel (Bulkamid)
S 15 no further treatment, 7 mid-urethral slings, 2 top-up
bulking
S No local adverse reaction
S Results of later mid-urethral sling not affected
S Moritsen L et al. Acta Obstet Gynecol Scand 2014
Bulking Agents
Conclusion
S Pre-operative
S Counselling
S Conservative management
S Optimise conditions prior to surgery eg treat OAB
S Surgery
S Choice of surgery – what is best not what is
convenient
S Avoidable complications
S Recognise and treat
S Skill at cystoscopy
S Do not over tension
S Surgical technique
SUMMARY
S ACCURATE HISTORY REQUIRED TO DETERMINE
PATIENT SYMPTOMS AND THOROUGH
EXAMINATION ASCERTAINS PATIENT SIGN
S EXTENT OF EVALUATION MUST BE TAILORED TO
THE INDIVIDUAL PATIENTS
S IMPACT ON PATIENT QUALITY OF LIFE MUST BE
ADDRESS
S

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Understanding Urinary Incontinence: A Comprehensive Approach

  • 2. URINARY INCONTINENCE (UI) S ANY INVOLUNTARY LOSS OF URINE S SYMPTOM OR SIGN S NOT A DIAGNOSIS
  • 4. CONSEQUENCES S SOCIALLY S HYGENIC S IMPACT QUALITY OF LIFE S DEPRESSION S BATHROOM MAPPING S DISABILITY AND DEPENDENCY
  • 5. MYTH.....&...FACT S IF by the patient is bothered by UI,she will tell me.. S UI is “natural after birth” S UI is normal part of aging S “If I get surgery for UI, I will end up with a bag..”
  • 6. AGEING… S NOT CAUSE OF URINARY INCONTINENCE S AGE RELATED CHANGES IN LOWER URINARY TRACT ANATOMY AND PHYSIOLOGY S CHRONIC ILLNESS – SYSTEMIC DISTURBANCES
  • 7. PREDISPOSING ….. S HIGHER PARITY PREGNANCY,CHILDBIRTH & PHYSICAL STRAINING DURING LABOUR
  • 10. PREDISPOSING…. S USE OF SITTING TOILET
  • 11. PREVALENCE S ESTIMATED 15 TO 30 % S 50% STRESS UI S 15% URGE UI S 35% MIXED UI S 5 TO 8% LEAK 1 OR > PER WEEK S >60 YEARS OLD – WOMAN 2X MORE THAN MAN
  • 12. In Asia….. S MALAYSIA 13.1 % 7.9% S SINGAPORE 11.8% 4.3% S PHILLIPPINES 13.9% 8% S THAILAND 20.3% 14.1% S KOREA 22.6% 28.6% S Asia Pacific Continence Advisory Board (APCAB) 1998 WOMEN MEN
  • 13. URINARY INCONTINENCE S SEVERITY OF INCONTINENCE S VOLUME S TYPE OF INCONTINENCE S NO OF PADS S CHANGES OF UNDERWEAR REQUIRED IN 24 HRS
  • 14. CAUSES S URETHRAL SPHINCTER INCOMPETENCE S SPHINCTER DYSFUNCTION S ABNORMAL BLADDER NECK SUPPORT S DETRUSOR OVERACTIVITY S IDIOPATHIC S NEUROGENIC S MIXED INCONTINENCE
  • 15. CAUSES S OVERFLOW INCONTINENCE S HYPOTONIC DETRUSOR S URETHRAL OBSTRUCTION (RARE)
  • 16. CAUSES S URETHRAL DIVERTICULA S CONGENITAL ABNOMALY S ECTOPIC URETER,SPINA BIFIDA OCCULTA S PHARMACOLOGICAL CAUSE S DIURETIC,TRANQUILLIZER,CHOLINERGIC AGENTS S FISTULA S URETHRAL,VESICAL,URETER
  • 17. AIM S DETERMINE THE CAUSE S DETECT RELATED URINARY TRACT PATHOLOGY S EVALUATE PATIENT PHYSICAL,MENTAL STATUS,COMORBIDS,MEDICATION & ENVIRONMENT
  • 18. HISTORY S DETAILED PAST AND PRESENT MEDICAL,SURGICAL,UROLOGIC,GYNAECOLOGY HISTORY S TO CHARACTERIZE THE TYPE OF INCONTINENCE
  • 19. HISTORY S EVALUATE THE FREQUENCY,SEVERITY,PATTERN S ESTABLISHED OTHER ASSOCIATED URINARY SYMPTOM S STRAINING,INCOMPLETE VOIDING AND DYSURIA
  • 20. HISTORY S TO ESTABLISH PRECIPITATING FACTORS S BOWEL HABITS,MEDICATION AND FLUID INTAKE S VOIDING HABITS S ASSESSMENT OF MOBILITY,LIVING CONDITION,MENTAL STATUS,SOCIAL ENVIRONMENT
  • 21. HISTORY S DESIRE FOR TREATMENT AND THE EXTENT OF TREATMENT THAT IS ACCEPTABLE S ESTABLISH PATIENT SUPPORT INCLUDING CAREGIVERS S COGNITIVE FUNCTION S ABILITY TO DESCRIBE SYMPTOMS,QUALITY OF LIFE,PREFERENCES AND GOALS FOR CARE
  • 22. PHYSICAL EXAMINATION S THE MORE COMPLICATED THE HISTORY & MORE EXTENSIVE AND/OR INVASIVE THE PROPOSED THERAPY/INVESTIGATION – THE MORE COMPLETE THE EXAMINATION
  • 23. PHYSICAL EXAMINATION S GENERAL STATUS S MENTAL STATUS S BMI S MOBILITY S ABDOMINAL EXAMINATION S MASS S BLADDER DISTENTION S SURGICAL SCAR
  • 24. PHYSICAL EXAMINATION S PELVIC EXAMINATION S PERINEUM &EXTERNAL GENITALIA S TISSUE QUALITY & SENSATION S COUGH STRESS TEST S VAGINAL EXAMINATION – PROLAPSE,CYST,DISCHARGED S BIMANUAL EXAMINATION S PELVIC FLOOR MUSCLE EVALUATION S ANORECTAL EXAMINATION
  • 25. S ASSOCIATED PELVIC ORGAN PROLAPSE S PREVIOUS ABDOMINAL OR PELVIC SURGERY
  • 26. Cough Stress test S Bladder volume at least 250 cc or symptomatic fullness S Reliable and simple test for the diagnosis of stress urinary incontinence S Screening test before requiring further evaluation with more urodynamic test S Recommended for both clinical research and clinical practice.
  • 27. S ESTIMATION OF POST VOID RESIDUAL URINE (RU) S CATHETER OR ULTRASOUND S GOOD CLINICAL CORRELATION BETWEEN THE TWO S Coombs GM, Millard RJ (1994). The accuracy of portable us scanning in the measurement of residual urine. J Urol S < 30% OF VOIDED VOLUME OR < 150 ML S RENAL FUNCTION ASSESSMENT
  • 28. S URINALYSIS S HIGHLY RECOMMENDED S URINE DIPSTICK HAS LOW SENSITIVITY AND HIGH SPECIFICITY TO DETECT UTI S Pels RJ, Bor DH et all (2000).JAMA . Dispstick urinalysis screening of asymptomatic adults for urinary tract disorders. S URINE CULTURE & MICROSCOPIC EXAMINATION
  • 29. S EXAMINATION ALONE INSUFFICIENT – NEEDS TOOLS TO SUPPLEMENT INFORMATION OBTAINED FROM HISTORY & EXAMINATION S BLADDER DIARY S QUESTIONNAIRES
  • 30. BLADDER DIARY S FREQUENCY VOLUME CHART,VOIDING DIARY S AMONG BEST POSSIBLE MEANS OF OBTAINING OBJECTIVE DATA ON SUBJECTIVE SYMPTOMS S Abrams P, Cardozo L, Magnus F et al (2002). The standardization of terminology of lower urinary tract function.International Continence Society. Neurourol Urodynam.
  • 31. USEFUL IN… S DETERMINE VOLUME FLIUD INTAKE S NORMAL FLUID VOLUME CONSUMED AT IN APPROPRIATE TIMES. S EXCESSIVE INTAKE OF ALCOHOL OR CAFFIENE S MAXIMAL VOIDED VOLUME – REPRESENT FUNCTIONAL BLADDER CAPACITY
  • 33. BLADDER DIARY S OPTIMUM DURATION NOT STANDARDISED S COMPLIANCE DECREASES WITH LENGTH OF THE DIARY S 72 HOURS DIARY (3 DAYS ) – SIGNIFICANTLY CORRELATES WITH 7 DAYS DIARY S Grouttz A,Blaivas JG, Chaikin DC et al (2002).Voiding and incontinence frequencies:variability of voiding diary data and required dialy length. Neurourol Urodyn 21:205-209 S ENCOMPASS WORK AND LEISURE DAY
  • 34. Quality of Life measures S Incontinence Impact Questionnaire (IIQ-7) S Urogenital Distress Inventory (UDI-6) S Both specific for incontinence in female population S Evaluation prior to & success of therapy S Recommended for clinical studies S Optional for clinical practise
  • 35. OTHERS… S CYSTOSCOPY S <2% BLADDER LESION FOUND IN INCONTINENCE PATIENTS S SHOULD NOT BE PERFORMED ROUTINELY IN PATIENTS WITH URINARY INCONTINENCE TO EXCLUDE NEOPLASM S Cundiff GW,Bent AE.The contribution of urethrocystoscopy to evaluation of lower urinary tract dysfunction in women (IUJ 2006). S RECOMMENDED IF ASSOCIATED WITH HAEMATURIA,SUSPECTED FISTULA,RECURRENT CYSTITIS,BLADDER PAIN S Ludviksson K. The value of cllinical examination of the female incontinence patient (Acta Obstet Gynecol Scan,2007)
  • 36. OTHERS.. S IMAGING S PELVIC AND ABDOMINAL ULTRASOUND S IMAGING OF UPPER AND LOWER URINARY TRACT - TRANSPERINEAL ULTRASOUND S UROFLOWMETRY S URODYNAMIC STUDY
  • 37. TREATMENT S DEPENDS ON THE CAUSE OF UI S LIFESTYLE MODIFICATION S MEDICAL TREATMENT S SURGICAL TREATMENT S CISC
  • 38. Conservative treatment S Pelvic floor rehabilitation S Bladder retraining S Pelvic floor exercises S Voiding techniques S Vaginal Devices eg tampon, Contiform S Vaginal oestrogen
  • 39. Continence devices S Contiform vaginal device S Urethral plug not available S Trials suggest some improvement in leakage cf no treatment
  • 40. Pelvic Floor Rehabilitation S Supervised PFMT, at least 3 months S Use of a dedicated pelvic floor physiotherapy service or continence nurse advisor S Women receiving supervision more likely to report improvement than women doing PFMT with little or no supervision S Cochrane update 2014 S Supports recommendation that PFMT be included in first-line conservative management for any type of incontinence
  • 41. URGE INCONTINENCE S CONSERVATIVE TREATMENT S FLIUD INTAKE S BLADDER TRAINING S PHARMACOLOGICAL TREATMENT S BOTOX INJECTION S NEUROMODULATION
  • 42. S URINARY STRESS INCONTINENCE
  • 43. Urinary Incontinent procedures S Ideal patient S Urodynamic stress incontinence only S Normal uroflowmetry S Normal bladder capacity S No overactive bladder S No previous incontinence procedures S Normal BMI S No significant medical conditions S Completed childbearing
  • 44. Urinary incontinent procedure S Ideal pre-operative situation S Initial conservative management S Exclude pathology, infection S Bladder diary S Pelvic floor rehabilitation S Education regarding diet, fluids, bowel, weight control etc S Compliance S Treatment of overactive bladder symptoms S Confirm diagnosis S Realistic expectations of outcomes of procedure
  • 45. S Over 200 surgical techniques S MMK cyto-urethropexy (1949) and modifications S Burch colposuspension (1961) – open and laparoscopic S Anterior colporrhaphy and Kelly plication (1913) S Needle suspension techniques (Pereyra 1959), Stamey modification (1973) S Pubovagional sling procedures – gracilis muscle (1907), pyramidalis muscle (1910), fascia lata (1933) S Aldridge sling with rectus fascia (1942) - modifications of sling material (autologous, cadaveric, synthetic) and fixation S Bone anchors S Periurethral bulking S TVT (1995) and modifications S TOT (2001) and modifications S Stem cell therapy Surgical management of USI
  • 46. S Colposuspension (open or laparoscopic) S Until recently, considered the Gold Standard S Midurethral slings (synthetic) S Retropubic - New Gold Standard S Bulking agents S Other surgical options Surgical options for USI
  • 47. Vaginal incisions – ‘mid-urethra’ but variations in exit sites, delivery of sling S Retropubic – first generation S eg TVT – first described 1995 S SPARC (2001), Advantage etc S Transobturator – second generation (2001) S Eg TVT-O (2005 – de Leval), Monarc S Modified Transobturator S eg TVT-Abrevo (2012) S Single incision “Minislings” – third generation S eg TVT-S (2006); Mini-Arc (2007) Midurethral slings
  • 48. S Periurethral injection to narrow the bladder neck S Complications – voiding problems long-term (2%), UTI , denovo urgency (up to 13%) S Cure rates – 40-60% S Long-term follow up > 8 years S 24 women, polyacrylamide hydrogel (Bulkamid) S 15 no further treatment, 7 mid-urethral slings, 2 top-up bulking S No local adverse reaction S Results of later mid-urethral sling not affected S Moritsen L et al. Acta Obstet Gynecol Scand 2014 Bulking Agents
  • 49. Conclusion S Pre-operative S Counselling S Conservative management S Optimise conditions prior to surgery eg treat OAB S Surgery S Choice of surgery – what is best not what is convenient S Avoidable complications S Recognise and treat S Skill at cystoscopy S Do not over tension S Surgical technique
  • 50. SUMMARY S ACCURATE HISTORY REQUIRED TO DETERMINE PATIENT SYMPTOMS AND THOROUGH EXAMINATION ASCERTAINS PATIENT SIGN S EXTENT OF EVALUATION MUST BE TAILORED TO THE INDIVIDUAL PATIENTS S IMPACT ON PATIENT QUALITY OF LIFE MUST BE ADDRESS
  • 51. S