This document provides guidance on selecting and using personal protective equipment (PPE) in healthcare settings. It outlines the goal of improving safety through appropriate PPE use and describes common types of PPE like gloves, gowns, masks, and respirators. The key recommendations are to follow standard and transmission-based precautions by using PPE based on the anticipated level of exposure, to properly don and remove PPE to avoid contamination, and to always perform hand hygiene when done.