Personal protective equipment (PPE) like gloves, gowns, masks, and eye protection form barriers that protect healthcare workers from exposure to infectious materials. The proper use of PPE includes donning it in a specific sequence - gown, mask, goggles, then gloves - before entering a patient's room. PPE should be removed in the reverse order, and hand hygiene performed, to prevent the spread of germs. Common types of PPE like surgical masks, N95 respirators, and gloves are described along with guidelines for proper fitting, use, and disposal to protect both healthcare workers and patients.