This document provides guidance on proper use of personal protective equipment (PPE) such as gowns, gloves, masks, eye protection, and footwear when working with infectious materials. It emphasizes selecting the correct size and type of PPE and wearing, removing, and disposing of items properly to avoid contamination. Proper PPE use includes donning from bottom to top (gloves last) and removing from top to bottom (gloves first) while avoiding touching outer surfaces. Reusable PPE should be cleaned and stored properly while disposable PPE should be discarded after use.