This document provides guidance on the selection and use of personal protective equipment (PPE) in healthcare settings. It defines PPE and outlines regulations from OSHA and recommendations from CDC on appropriate PPE use. The document describes different types of PPE including gloves, gowns, masks, respirators, goggles, and face shields. It provides details on proper donning, use, and removal of PPE to prevent the spread of infectious materials and outlines PPE recommendations for standard and expanded isolation precautions. The overarching goal is to improve personnel safety through appropriate PPE use in healthcare environments.