This document provides guidance on selecting and using personal protective equipment (PPE) in healthcare settings. It outlines the goal of improving safety through appropriate PPE use and describes standard and expanded isolation precautions. For standard precautions, it recommends gloves, gowns, masks, and eye protection as indicated by the interaction with the patient. For expanded precautions like contact, droplet or airborne isolation, it provides guidance on additional PPE required. Throughout, it emphasizes properly donning, using, and removing different types of PPE like gloves, gowns, masks and respirators to protect healthcare workers.