This document provides guidance on selecting and using personal protective equipment (PPE) in healthcare settings. It discusses establishing a PPE program with goals of improving safety through appropriate PPE use. The objectives are to provide information on selecting and using PPE, and practicing safe donning and removal techniques. Types of PPE for healthcare include gloves, gowns, masks, respirators, goggles, and face shields. Factors like exposure risk and task determine appropriate PPE. Guidelines are provided for properly donning, using, and removing different types of PPE to prevent exposure according to standard and expanded isolation precaution protocols.