Glyoxysomes are specialized peroxisomes found in plant seeds that play key roles in lipid breakdown and gluconeogenesis. They contain the enzymes for beta-oxidation of fatty acids into acetyl-CoA, the glyoxylic acid cycle which converts acetyl-CoA into succinate, and gluconeogenesis which generates glucose from non-carbohydrate carbon sources. Lipids are broken down into fatty acids and glycerol by lipases, then enter the glyoxysome where the fatty acids undergo beta-oxidation in four steps to produce acetyl-CoA.

1. Topic:-
ROLE OF GLYOXYSOME
IN
GLYOXYLIC ACID CYCLE
Submitted to:
Dr Javed Iqbal Sidiqui
Submitted by:
Mujahid Umar Roll # 4056
&
Sufyan Ahmad Roll # 4058

2. Glyoxysome:-
• Special type of peroxysome
• Found in plant seeds
• Single membrane bounded

4. Functions:-
• Beta-Oxidation
• Glyoxylic Acid cycle
• Gluconeogenesis

5. Beta-Oxidation:-
• Lipids are broken down into fatty acids and
glycerol by lipase enzyme
• The products acylated by acyle-CoA
synthetase and form fatty Acyl-CoA
• Enter into Glyoxysome and beta-oxidation
starts

6. • FATTY ACYL-COA OXIDIZED BY ACYL-COA
DEHYDROGENASE AND FORM TRANS ENOYL COA
• Hydration by Enoyl-CoA Hydratase and form
Hydroxy acyl-CoA

7. •Hydroxyacyl CoA oxidize by Hydroxyacyl CoA
dehydrogenase and form ketoacyl CoA
•Finally Acetyl CoA is formed by Thiolase

9. Glyoxylic Acid Cycle
• Occur in germinated fatty seeds
• Convert acetyl-CoA into succinate
• Succinate form carbohydrates
• Simple carbon is used when glucose is not
available

10. Enzymes
• Citrate synthase
• Aconitase
• Isocitrate lyase
• Malate synthase
• Malate dehydrogenase

12. Gluconeogenesis:-
• Process in which glucose generate from non-carbohydrate
carbon substances e.g pyruvate

13. Enzymes:-
• Pyruvate Carboxylase
• Dehydrogenase
• PEP carboxylase
• Decarboxylase
• Phosphorylase