The document is a presentation on the antibiotic Cepodem (Cefpodoxime). It discusses the drug's structure, properties, pharmacokinetics, pharmacodynamics, indications, dosage, side effects, contraindications, drug interactions, competitor brands and prices, market analysis, and conclusions. Cepodem is a third-generation oral cephalosporin antibiotic manufactured by Sun Pharmaceutical Industries. It is active against most gram-positive and gram-negative bacteria by inhibiting bacterial cell wall synthesis. The presentation provides details on Cepodem's absorption, metabolism, excretion, mechanisms of action, approved uses, dosing, adverse effects, and comparisons to other similar antibiotics.

1. Presentation on
Cepodem
(Cefpodoxime)
Prepared By:
Sanjay Kumar Yadav
18-Jan-20 On Cepodem 1

2. CONTENTS
1. INTRODUCTION
2. STRUCTURE & PROPERTIES
3. PHARMACOKINETICS
4. PHARMACODYNAMICS
5. INDICATION
6. DOSAGE & SIDE EFFECT
7. CONTRAINDICATION & PRECUSATION
8. DRUG INTERACTION
9. COMPETITOR BRANDS & PRICES
10. MARKET ANALYSIS
11. CONCLUSION
12. REFERENCES
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3. INTRODUCTION
Cepodem manufactured
By - Sun Pharmaceutical
Industries Ltd
Packing - 10 tablets in 1
strip
API - Cefpodoxime
Proxetil (200mg)
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4. INTRODUCTION Conti…
Cefpodoxime
An oral, third-
generation cephalosporin antibiotic.
Active against most Gram-positive and Gram-
negative organisms.
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5. STRUCTURE & PROPERTIES
Structure of Cefprodoxime
proxetil ( C15H17N5O6S2 )
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6. PHARMACOKINETICS
Routes of administration : Oral
Bioavailability : 50%
Protein binding : 21% to 29%
Metabolism : Negligible. Cefpodoxime
proxetil is metabolized to cefpodoxime by
the liver
Elimination half-life : 2 hours
Excretion : Renal, unchanged
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7. PHARMACODYNAMICS
MOA of Cefpodoxime :
 Cefpodoxime
Act as transpeptidase
enzyme
Inhibit transpeptidation
reaction
Block peptidoglycine
synthesis
Increase the permeability of
cell membrane
Cell explodes and lysed
Death of microorganism.
Fig: Structure of Bacteria
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8. PHARMACODYNAMICS Conti…
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9. PHARMACODYNAMICS Conti…
Peptidoglycan (PG) is composed of strands of sugar
molecules (green/blue strips) and very small
proteins (colored circles).
An enzyme (gray) is needed to crosslink the PG
subunits, which makes the cell wall strong.
Cephalosporins (orange P) bind to this enzyme and
deactivate it.
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10. INDICATIONS
In upper respiratory tract infection.
In the treatment of lower respiratory tract
infection including bronchitis , pneumonia , skin
and soft tissue infection.
In the treatment of UTI.
In the treatment of gonorrhoea.
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11. DOSAGE & SIDE EFFECT
DOSAGE
Oral suspension: 50 mg/5 ml , 100 mg/5 ml
Tablet :100 mg , 200 mg
SIDE EFFECT
GI upset.
Diarrhea.
Nausea , Vomiting.
Allergic reaction also occur.
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12. CONTRAINDICATION &
PRECUSATION
CONTRAINDICATION
Cephalosporin sensitivity.
Porphyria.
PRECUSATION
Cefpodoxime may cause diarrhea, and in
some cases it can be severe.
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13. DRUG INTERACTION
S.N Interactant Interaction Effect
1 Antacids or H2 blockers Reduced cefpodoxime proxetil peak blood levels and
the extent of absorption.
2 Probenecid Effectively decrease excreation and increases systemic
level of the drug.
3 Potassium clavulanate Showed higher clinical cure in symptoms of lower RTI
4 Propantheline Slightly delay in drug absorption
5 Anisotropine
methylbromide
Slightly increase in extent of absorption
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14. COMPETITOR BRANDS & PRICES
S.N Company Name Brand Name API (mg) / Tablet Price / Tablet (NC) Bonus (%)
1 Sun pharma Cepodem 200 25.6 20
2 Aristo pharmaceuticals Monoral 200 24.99 20
3 Asian pharmaceuticals Incef 200 25 20
4 Nova genitica Ipod 200 25 10
5 Blue cross Cedon 200 22.72 25
6 Chemi drug industry Cepobact 200 25 20
7 Curex pharmaceuticals Cefdox 200 24 20
8 Alkem Switch 200 24.32 20
9 NPL Proxcef 200 25 20
10 Micro lab Microcef DT 200 25 20
11 FDC limited Zipod 200 24 0
12 Medley Medime 200 24.48 10
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15. MARKET ANALYSIS
S.N Doctor’s Name Department organization Prescribing Brand
1 Dr. Junu shrestha Ganyae Manipal Monoral
2 Dr. Dela joshi singh Ganyae Manipal Ipod
3 Dr. Badri poudel Physician Charak Hospital Monoral
4 Dr. Nabin kumar
shrestha
Ganyae WRH / Sewa
Hospital
Monoral
5 Dr. CP acharya Physician OM Hospital Incef
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16. CONCLUSION
Cepodem is one of the best brand from
Cefpodoxime proxetil product.
It seems to appear there is a slight room for
improvement in areas like advertising and
marketing, which I believe if improved, will
increase demand of the product in future.
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17. REFERENCES
1. Chowk Pharmacy, in front of Manipal Hospital.
2. Yunesh , Shrijana Distributor & Pokhara RMS Stokist,
Pokhara
3. Om Hospital Pharmacy, Sewa Hospital Pharmacy &
Charak Hospital Pharmacy, Pokhara.
4. https://www.slideshare.net/SujeetKumar507/cepodem-
xp-325-tablet
5. https://en.wikipedia.org/wiki/Cefpodoxime
6. https://www.researchgate.net/figure/Interpretation-of-
cefpodoxime-proxetil-FTIR-scan_tbl2_270111718
7. https://en.wikipedia.org/wiki/Cefpodoxime
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18. Thank you sir
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