This document discusses different classes of diuretic drugs, including their mechanisms of action and therapeutic uses. It covers carbonic anhydrase inhibitors, loop diuretics, thiazide diuretics, potassium-sparing diuretics like spironolactone, and osmotic diuretics like mannitol. The main points are:
- Diuretics work by inhibiting reabsorption of sodium in different regions of the nephron like the proximal tubule, loop of Henle, or distal tubule.
- Major classes include carbonic anhydrase inhibitors, loop diuretics like furosemide, thiazide diuretics, and potassium-sparing di
Diuretics are a class of drugs that cause the kidneys to produce more urine. They help the body eliminate excess fluid and salt. The main types are loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, and osmotic diuretics. Diuretics are used to treat conditions like heart failure, liver cirrhosis, and hypertension by removing extra fluid from the body. Common side effects include impotence, rashes, nausea, dizziness and fatigue.
A drug inspector is responsible for monitoring and ensuring the safety, quality, and effectiveness of drugs from production to sale. To become a drug inspector, candidates must have a pharmacy or pharmaceutical science degree, 18 months of relevant work experience, and pass a written exam consisting of two papers testing knowledge of pharmacy and general knowledge. Drug inspectors have the power to inspect any premises or records involved in drug manufacturing, sample and test drugs, inspect licenses, and cancel licenses of businesses found to have quality or standards issues. The role requires skills in discipline, patience, self-confidence, and keeping updated in the pharmaceutical field.
The document discusses the isolation and properties of alkaloids including atropine and quinine. It provides a history of alkaloid discovery and defines alkaloids as basic heterocyclic nitrogenous compounds found primarily in plants that are physiologically active. Methods of alkaloid isolation from plant materials and chemical tests for identification are described. Key details about the biological sources, isolation, properties, identification and uses of atropine and quinine are also summarized.
The Medical Termination of Pregnancy (MTP) Act legalizes and regulates abortion in India. It defines the circumstances under which abortion is permitted up to 20 weeks gestation. The MTP Act was passed in 1971 in response to the large number of unsafe abortions occurring in India. It aims to improve maternal health by preventing unsafe abortions and reducing mortality and morbidity. Abortions can only be performed by registered medical practitioners in approved facilities with the consent of the woman or guardian if she is a minor. Violations of the Act are punishable by fines or imprisonment.
Revise all Important Medicinal Chemistry Synthesis in 20 minutes|#B.Pharm#Pha...Anjali Bhardwaj
1. Chloroquine is an important anti-malarial drug that is synthesized in two steps from 4-amino-1-diethylamino pentane.
2. It is used to treat and prevent malaria as well as amebiasis, but can cause allergic reactions or severe skin issues.
3. Pamaquine is another anti-malarial drug synthesized from 6-methoxy-quinolin-8-ylamine and (4-chloro-pentyl)-diethyl-amine. It was formerly used to treat malaria but can cause gastrointestinal, blood, or hemolysis issues in some patients.
This document discusses the nomenclature of steroids. It begins by introducing steroids as biologically active organic compounds found in plants and animals that contain four fused rings. The core steroid structure contains 17 carbon atoms arranged in three 6-membered rings and one 5-membered ring. There are five main types of steroid ring structures. Steroids are named based on their ring structure, substituents, and functional groups using IUPAC nomenclature conventions. Substituents are designated as being above or below the plane of the rings. Double bonds in rings are indicated by the number of the carbon atoms involved. IUPAC names specify functional groups and the locations and configurations of any substituents.
GPAT
Niper &
other pharma competative exams...
For more posts, follow us on .... be
@pharmahelpers
@pharmahelpers
@pharmahelpers
Also follow us on...
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The Pharmacy Act of 1948 was implemented to regulate the practice of pharmacy in India by establishing the Pharmacy Council of India and State Pharmacy Councils. The objectives were to provide uniform education and training standards, maintain registration of pharmacists, and regulate the profession. Key points include:
- PCI prescribes minimum education standards and maintains the central register of pharmacists.
- State councils register local pharmacists, inspect premises, and submit reports to PCI.
- Regulations define qualifications, registration process, removal from registers, and penalties for violations.
Diuretics are a class of drugs that cause the kidneys to produce more urine. They help the body eliminate excess fluid and salt. The main types are loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, and osmotic diuretics. Diuretics are used to treat conditions like heart failure, liver cirrhosis, and hypertension by removing extra fluid from the body. Common side effects include impotence, rashes, nausea, dizziness and fatigue.
A drug inspector is responsible for monitoring and ensuring the safety, quality, and effectiveness of drugs from production to sale. To become a drug inspector, candidates must have a pharmacy or pharmaceutical science degree, 18 months of relevant work experience, and pass a written exam consisting of two papers testing knowledge of pharmacy and general knowledge. Drug inspectors have the power to inspect any premises or records involved in drug manufacturing, sample and test drugs, inspect licenses, and cancel licenses of businesses found to have quality or standards issues. The role requires skills in discipline, patience, self-confidence, and keeping updated in the pharmaceutical field.
The document discusses the isolation and properties of alkaloids including atropine and quinine. It provides a history of alkaloid discovery and defines alkaloids as basic heterocyclic nitrogenous compounds found primarily in plants that are physiologically active. Methods of alkaloid isolation from plant materials and chemical tests for identification are described. Key details about the biological sources, isolation, properties, identification and uses of atropine and quinine are also summarized.
The Medical Termination of Pregnancy (MTP) Act legalizes and regulates abortion in India. It defines the circumstances under which abortion is permitted up to 20 weeks gestation. The MTP Act was passed in 1971 in response to the large number of unsafe abortions occurring in India. It aims to improve maternal health by preventing unsafe abortions and reducing mortality and morbidity. Abortions can only be performed by registered medical practitioners in approved facilities with the consent of the woman or guardian if she is a minor. Violations of the Act are punishable by fines or imprisonment.
Revise all Important Medicinal Chemistry Synthesis in 20 minutes|#B.Pharm#Pha...Anjali Bhardwaj
1. Chloroquine is an important anti-malarial drug that is synthesized in two steps from 4-amino-1-diethylamino pentane.
2. It is used to treat and prevent malaria as well as amebiasis, but can cause allergic reactions or severe skin issues.
3. Pamaquine is another anti-malarial drug synthesized from 6-methoxy-quinolin-8-ylamine and (4-chloro-pentyl)-diethyl-amine. It was formerly used to treat malaria but can cause gastrointestinal, blood, or hemolysis issues in some patients.
This document discusses the nomenclature of steroids. It begins by introducing steroids as biologically active organic compounds found in plants and animals that contain four fused rings. The core steroid structure contains 17 carbon atoms arranged in three 6-membered rings and one 5-membered ring. There are five main types of steroid ring structures. Steroids are named based on their ring structure, substituents, and functional groups using IUPAC nomenclature conventions. Substituents are designated as being above or below the plane of the rings. Double bonds in rings are indicated by the number of the carbon atoms involved. IUPAC names specify functional groups and the locations and configurations of any substituents.
GPAT
Niper &
other pharma competative exams...
For more posts, follow us on .... be
@pharmahelpers
@pharmahelpers
@pharmahelpers
Also follow us on...
Facebook @ Pharma Helpers
Whatsapp @ 8421773854 OR https://chat.whatsapp.com/FFVRcxiiqC91PvnEvmK2F1
Instagram @ https://www.instagram.com/p/COM-VYqJ3Xo/?igshid=1ac01ibq2sa2k
The Pharmacy Act of 1948 was implemented to regulate the practice of pharmacy in India by establishing the Pharmacy Council of India and State Pharmacy Councils. The objectives were to provide uniform education and training standards, maintain registration of pharmacists, and regulate the profession. Key points include:
- PCI prescribes minimum education standards and maintains the central register of pharmacists.
- State councils register local pharmacists, inspect premises, and submit reports to PCI.
- Regulations define qualifications, registration process, removal from registers, and penalties for violations.
This document discusses the isolation, identification, and analysis methods for several important phytoconstituents including menthol, citral, curcumin, atropine, quinine, reserpine, caffeine, artemisinin, glycyrrhizin, rutin, and podophyllotoxin. Extraction is typically done using solvent extraction methods like steam distillation or soxhlet extraction. Isolation involves separation techniques like chromatography. Identification tests include chemical color reactions and thin layer chromatography to determine Rf values. Analysis uses methods like gas chromatography, high performance liquid chromatography, and confirmation against reference standards.
This document discusses coagulants and factors involved in the coagulation cascade. It describes 13 clotting factors and how deficiencies can cause bleeding disorders. Vitamin K is important for blood clotting as it allows for the carboxylation of factors II, VII, IX, and X. Other coagulants discussed include fibrinogen, antihemophilic factor, desmopressin, and local hemostatics that can control bleeding from specific sites.
Drugs and Cosmetics Act, 1940 and its rules 1945:
Objectives, Definitions, Legal definitions of schedules to the Act and
Rules
Import of drugs – Classes of drugs and cosmetics prohibited from import, Import under
license or permit. Offences and penalties.
Manufacture of drugs – Prohibition of manufacture and sale of certain drugs,
Conditions for grant of license and conditions of license for manufacture of drugs,
Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan
license and repacking license.
Angina pectoris is caused by an imbalance between myocardial oxygen supply and demand. It can result from coronary atherosclerosis, vasospasm, or increased oxygen demand. Several classes of drugs are used to treat angina, including organic nitrates, calcium channel blockers, and beta-blockers. Organic nitrates like nitroglycerin are converted to nitric oxide to relax blood vessels. Calcium channel blockers like nifedipine and diltiazem block calcium channels to dilate arteries. Beta-blockers competitively inhibit beta-adrenergic receptors in the heart to reduce its workload. These drugs provide symptomatic relief for angina by increasing oxygen supply or reducing demand.
Diuretics are drugs that increase urine output. They work by interfering with electrolyte reabsorption in the kidneys, leading to increased excretion of sodium, chloride, potassium, and water. There are several classes of diuretics that work through different mechanisms, targeting different parts of the nephron. Diuretics are used to treat conditions caused by fluid retention like heart failure and liver disease, as well as high blood pressure. Their primary side effects come from electrolyte imbalances.
STUDY OF UTILIZATION OF RADIOACTIVE ISOTOPES IN THE INVESTIGATION OF BIOGENET...Nitu Singh
Accordingg to B Pharm V sem PCI syllabus of Pharmacognosy and Phytochemistry II
This presentation includes Introduction of radioisotopes ,Tracer Techniques,Various methods and about various instrument used for tracing radioactivity in Biogenetic studies
Cardiac glycosides like digoxin are derived from plants like Digitalis lanata and act on the heart by increasing the force of contraction. They work by increasing intracellular calcium levels in heart muscle cells through multiple mechanisms - increasing calcium influx, releasing calcium from intracellular stores, and blocking calcium efflux from cells. This makes the heart muscle contract with more force, increasing cardiac output which benefits patients with heart failure. Digoxin is commonly used for heart failure, atrial fibrillation, and other arrhythmias but has a narrow therapeutic window. Its toxicity can be managed with electrolyte supplementation, drugs to control arrhythmias, and antibodies in severe cases. Drug interactions and dose adjustments based on kidney function are important considerations with
Codes of pharmaceutical ethics
In relation to his trade
In relation to his Job
In relation to his Profession
In relation to Medical Profession
Pharmacist's Oath
Most important questions of Medicinal Chemistry 2Payaamvohra1
This ppt gives you an idea about frequently and most commonly asked questions in pharmacy exams Do follow our slideshare instagram and youtube channel for more info
LINK FOR VIDEO LECTURES
https://youtu.be/-4nzP2vOGdg
DRUG TECHNICAL ADVISORY BOARD IS IN THE PHARMACY SYLLABUS AND THE QUESTIONS ARE ASKED IN THE PHARMACY EXAMS .
SUCH AS GPAT NIPER AND SEMSESTER EXAM/
Cardiac Glycosides (Medicinal Chemistry) MANIKImran Nur Manik
This document discusses cardiotonics, which are drugs that increase the force of contraction of the heart muscle. Cardiotonics have several effects on the heart including improving excitability, automaticity, conduction velocity and refractory period. The main indications for cardiotonics are congestive heart failure, atrial fibrillation, atrial flutter, and paroxysmal atrial tachycardia. Cardiac glycosides are considered cardiotonics and work by inhibiting the sodium-potassium pump in heart cells, increasing intracellular sodium and calcium levels which strengthens muscle contraction. Digoxin and digitoxin are two commonly used cardiac glycosides that are obtained from plant sources and used to treat congestive
This document discusses benzimidazole derivatives as H+/K+ ATPase inhibitors for treating acid-related gastrointestinal disorders. It provides background on drugs like cimetidine and omeprazole that inhibit acid secretion. It then describes the synthesis of new benzimidazole derivatives containing oxycyclic pyridine rings. Introducing 5- or 6-membered oxycyclic rings to the pyridine portion potentiated the inhibitory activity of the compounds against the H+/K+ ATPase, regardless of the size or position of the oxycyclic ring attachment. The document concludes that oxycyclic pyridine-containing benzimidazole derivatives show promise as novel acid secretion inhibitors.
Prohibited Advertisements under the Drug & Magic remedies Act 1954:-
Prohibition of Advertisement of Certain Drugs for Treatment of Certain Diseases and Disorders:-
The procurement of miscarriage in women or prevention of conception in women; or
The maintenance or improvement of the capacity of human beings for sexual pleasure;
The correction of menstrual disorder in women; or
The diagnosis, cure, mitigation, treatment or prevention of any disease, disorder or condition specified in the Schedule, or any other disease, disorder or condition which may be specified in the rules made under this Act (Sch. J).
This document discusses appetite suppressants, carminatives, and digestants. It describes how appetite is regulated by factors like energy expenditure, absorption, and hormones. Obesity results from an imbalance where energy intake exceeds expenditure due to genetic, environmental, neurological, and dietary factors. Several classes of appetite suppressants are listed that work through different mechanisms in the body. Carminatives like sodium bicarbonate, peppermint oil, and ginger help expel gas from the gastrointestinal tract. Digestants contain enzymes to aid digestion and are sometimes used when enzyme production is deficient, though their general use as tonics is irrational. Specific digestive enzymes, their sources, and appropriate uses are outlined.
The document summarizes the acetate mevalonate pathway and its role in producing secondary metabolites. It begins with acetyl-CoA, which is converted through several steps to produce isopentenyl pyrophosphate and dimethylallyl pyrophosphate. These intermediates are precursors for various secondary metabolites like carotenoids, terpenes, sterols, and gibberellins. Carotenoids are tetraterpenoid pigments that can be phytochemical or zoochemical in origin. Statins and bisphosphonates are drugs that target the mevalonate pathway. Diseases associated with defects in this pathway include mevalonic aciduria and hyperimmunoglobulin D
The Medical Termination Of Pregnancy Act, 1971Suresh Murugan
This document outlines the Medical Termination of Pregnancy Act of 1971 in India. It establishes that registered medical practitioners can terminate pregnancies up to 12 weeks, or up to 20 weeks if two practitioners agree it is necessary to protect the woman's life or physical/mental health or to prevent serious abnormality or handicap of the child. Guardians must consent in writing for terminations of minors or lunatics. Terminations can occur in government hospitals or approved places.
Antiarrhythmic drugs medicinal chemistry 5th semester unit 4PHARMA IQ EDUCATION
Antiarrhythmic drugs are used to suppress abnormal heart rhythms such as atrial fibrillation and ventricular tachycardia. They can modify impulse generation and conduction in the heart. Cardiac arrhythmias involve abnormalities in the rate, regularity, or origin of the cardiac impulse or disturbances in conduction that alter the normal sequence of atrial and ventricular activation.
H1 and H2 receptor blockers are important drugs used to treat allergic conditions and reduce acid reflux. H1 receptor blockers such as diphenhydramine are first-generation antihistamines that cause drowsiness, while newer second-generation drugs like cetirizine are less sedating. H2 receptor blockers including cimetidine and ranitidine are used to suppress acid secretion in the stomach and treat ulcers by competitively blocking histamine at H2 receptors on parietal cells. Both classes of drugs can cause side effects like dry mouth but are important therapeutic agents.
This document discusses different classes of diuretic drugs, including their mechanisms of action and therapeutic uses. It covers carbonic anhydrase inhibitors, loop diuretics, thiazide diuretics, potassium-sparing diuretics, and osmotic diuretics. Diuretics work by inhibiting reabsorption of sodium in different regions of the nephron. They are used to treat hypertension, edema, and maintain urine output. Common side effects include electrolyte imbalances like hypokalemia and metabolic alterations. Drug-drug interactions can also occur due to effects on absorption or elimination of other drugs.
This document summarizes different types of diuretic drugs, including their mechanisms of action and classifications. It discusses high ceiling diuretics like furosemide that work by inhibiting sodium reabsorption in the ascending loop of Henle. It covers thiazide diuretics that inhibit sodium reabsorption in the distal tubule. Carbonic anhydrase inhibitors like acetazolamide are discussed, which inhibit the enzyme carbonic anhydrase to reduce bicarbonate and sodium reabsorption. Potassium-sparing diuretics and osmotic diuretics are also summarized.
This document discusses the isolation, identification, and analysis methods for several important phytoconstituents including menthol, citral, curcumin, atropine, quinine, reserpine, caffeine, artemisinin, glycyrrhizin, rutin, and podophyllotoxin. Extraction is typically done using solvent extraction methods like steam distillation or soxhlet extraction. Isolation involves separation techniques like chromatography. Identification tests include chemical color reactions and thin layer chromatography to determine Rf values. Analysis uses methods like gas chromatography, high performance liquid chromatography, and confirmation against reference standards.
This document discusses coagulants and factors involved in the coagulation cascade. It describes 13 clotting factors and how deficiencies can cause bleeding disorders. Vitamin K is important for blood clotting as it allows for the carboxylation of factors II, VII, IX, and X. Other coagulants discussed include fibrinogen, antihemophilic factor, desmopressin, and local hemostatics that can control bleeding from specific sites.
Drugs and Cosmetics Act, 1940 and its rules 1945:
Objectives, Definitions, Legal definitions of schedules to the Act and
Rules
Import of drugs – Classes of drugs and cosmetics prohibited from import, Import under
license or permit. Offences and penalties.
Manufacture of drugs – Prohibition of manufacture and sale of certain drugs,
Conditions for grant of license and conditions of license for manufacture of drugs,
Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan
license and repacking license.
Angina pectoris is caused by an imbalance between myocardial oxygen supply and demand. It can result from coronary atherosclerosis, vasospasm, or increased oxygen demand. Several classes of drugs are used to treat angina, including organic nitrates, calcium channel blockers, and beta-blockers. Organic nitrates like nitroglycerin are converted to nitric oxide to relax blood vessels. Calcium channel blockers like nifedipine and diltiazem block calcium channels to dilate arteries. Beta-blockers competitively inhibit beta-adrenergic receptors in the heart to reduce its workload. These drugs provide symptomatic relief for angina by increasing oxygen supply or reducing demand.
Diuretics are drugs that increase urine output. They work by interfering with electrolyte reabsorption in the kidneys, leading to increased excretion of sodium, chloride, potassium, and water. There are several classes of diuretics that work through different mechanisms, targeting different parts of the nephron. Diuretics are used to treat conditions caused by fluid retention like heart failure and liver disease, as well as high blood pressure. Their primary side effects come from electrolyte imbalances.
STUDY OF UTILIZATION OF RADIOACTIVE ISOTOPES IN THE INVESTIGATION OF BIOGENET...Nitu Singh
Accordingg to B Pharm V sem PCI syllabus of Pharmacognosy and Phytochemistry II
This presentation includes Introduction of radioisotopes ,Tracer Techniques,Various methods and about various instrument used for tracing radioactivity in Biogenetic studies
Cardiac glycosides like digoxin are derived from plants like Digitalis lanata and act on the heart by increasing the force of contraction. They work by increasing intracellular calcium levels in heart muscle cells through multiple mechanisms - increasing calcium influx, releasing calcium from intracellular stores, and blocking calcium efflux from cells. This makes the heart muscle contract with more force, increasing cardiac output which benefits patients with heart failure. Digoxin is commonly used for heart failure, atrial fibrillation, and other arrhythmias but has a narrow therapeutic window. Its toxicity can be managed with electrolyte supplementation, drugs to control arrhythmias, and antibodies in severe cases. Drug interactions and dose adjustments based on kidney function are important considerations with
Codes of pharmaceutical ethics
In relation to his trade
In relation to his Job
In relation to his Profession
In relation to Medical Profession
Pharmacist's Oath
Most important questions of Medicinal Chemistry 2Payaamvohra1
This ppt gives you an idea about frequently and most commonly asked questions in pharmacy exams Do follow our slideshare instagram and youtube channel for more info
LINK FOR VIDEO LECTURES
https://youtu.be/-4nzP2vOGdg
DRUG TECHNICAL ADVISORY BOARD IS IN THE PHARMACY SYLLABUS AND THE QUESTIONS ARE ASKED IN THE PHARMACY EXAMS .
SUCH AS GPAT NIPER AND SEMSESTER EXAM/
Cardiac Glycosides (Medicinal Chemistry) MANIKImran Nur Manik
This document discusses cardiotonics, which are drugs that increase the force of contraction of the heart muscle. Cardiotonics have several effects on the heart including improving excitability, automaticity, conduction velocity and refractory period. The main indications for cardiotonics are congestive heart failure, atrial fibrillation, atrial flutter, and paroxysmal atrial tachycardia. Cardiac glycosides are considered cardiotonics and work by inhibiting the sodium-potassium pump in heart cells, increasing intracellular sodium and calcium levels which strengthens muscle contraction. Digoxin and digitoxin are two commonly used cardiac glycosides that are obtained from plant sources and used to treat congestive
This document discusses benzimidazole derivatives as H+/K+ ATPase inhibitors for treating acid-related gastrointestinal disorders. It provides background on drugs like cimetidine and omeprazole that inhibit acid secretion. It then describes the synthesis of new benzimidazole derivatives containing oxycyclic pyridine rings. Introducing 5- or 6-membered oxycyclic rings to the pyridine portion potentiated the inhibitory activity of the compounds against the H+/K+ ATPase, regardless of the size or position of the oxycyclic ring attachment. The document concludes that oxycyclic pyridine-containing benzimidazole derivatives show promise as novel acid secretion inhibitors.
Prohibited Advertisements under the Drug & Magic remedies Act 1954:-
Prohibition of Advertisement of Certain Drugs for Treatment of Certain Diseases and Disorders:-
The procurement of miscarriage in women or prevention of conception in women; or
The maintenance or improvement of the capacity of human beings for sexual pleasure;
The correction of menstrual disorder in women; or
The diagnosis, cure, mitigation, treatment or prevention of any disease, disorder or condition specified in the Schedule, or any other disease, disorder or condition which may be specified in the rules made under this Act (Sch. J).
This document discusses appetite suppressants, carminatives, and digestants. It describes how appetite is regulated by factors like energy expenditure, absorption, and hormones. Obesity results from an imbalance where energy intake exceeds expenditure due to genetic, environmental, neurological, and dietary factors. Several classes of appetite suppressants are listed that work through different mechanisms in the body. Carminatives like sodium bicarbonate, peppermint oil, and ginger help expel gas from the gastrointestinal tract. Digestants contain enzymes to aid digestion and are sometimes used when enzyme production is deficient, though their general use as tonics is irrational. Specific digestive enzymes, their sources, and appropriate uses are outlined.
The document summarizes the acetate mevalonate pathway and its role in producing secondary metabolites. It begins with acetyl-CoA, which is converted through several steps to produce isopentenyl pyrophosphate and dimethylallyl pyrophosphate. These intermediates are precursors for various secondary metabolites like carotenoids, terpenes, sterols, and gibberellins. Carotenoids are tetraterpenoid pigments that can be phytochemical or zoochemical in origin. Statins and bisphosphonates are drugs that target the mevalonate pathway. Diseases associated with defects in this pathway include mevalonic aciduria and hyperimmunoglobulin D
The Medical Termination Of Pregnancy Act, 1971Suresh Murugan
This document outlines the Medical Termination of Pregnancy Act of 1971 in India. It establishes that registered medical practitioners can terminate pregnancies up to 12 weeks, or up to 20 weeks if two practitioners agree it is necessary to protect the woman's life or physical/mental health or to prevent serious abnormality or handicap of the child. Guardians must consent in writing for terminations of minors or lunatics. Terminations can occur in government hospitals or approved places.
Antiarrhythmic drugs medicinal chemistry 5th semester unit 4PHARMA IQ EDUCATION
Antiarrhythmic drugs are used to suppress abnormal heart rhythms such as atrial fibrillation and ventricular tachycardia. They can modify impulse generation and conduction in the heart. Cardiac arrhythmias involve abnormalities in the rate, regularity, or origin of the cardiac impulse or disturbances in conduction that alter the normal sequence of atrial and ventricular activation.
H1 and H2 receptor blockers are important drugs used to treat allergic conditions and reduce acid reflux. H1 receptor blockers such as diphenhydramine are first-generation antihistamines that cause drowsiness, while newer second-generation drugs like cetirizine are less sedating. H2 receptor blockers including cimetidine and ranitidine are used to suppress acid secretion in the stomach and treat ulcers by competitively blocking histamine at H2 receptors on parietal cells. Both classes of drugs can cause side effects like dry mouth but are important therapeutic agents.
This document discusses different classes of diuretic drugs, including their mechanisms of action and therapeutic uses. It covers carbonic anhydrase inhibitors, loop diuretics, thiazide diuretics, potassium-sparing diuretics, and osmotic diuretics. Diuretics work by inhibiting reabsorption of sodium in different regions of the nephron. They are used to treat hypertension, edema, and maintain urine output. Common side effects include electrolyte imbalances like hypokalemia and metabolic alterations. Drug-drug interactions can also occur due to effects on absorption or elimination of other drugs.
This document summarizes different types of diuretic drugs, including their mechanisms of action and classifications. It discusses high ceiling diuretics like furosemide that work by inhibiting sodium reabsorption in the ascending loop of Henle. It covers thiazide diuretics that inhibit sodium reabsorption in the distal tubule. Carbonic anhydrase inhibitors like acetazolamide are discussed, which inhibit the enzyme carbonic anhydrase to reduce bicarbonate and sodium reabsorption. Potassium-sparing diuretics and osmotic diuretics are also summarized.
This document provides information on loop diuretics and potassium sparing diuretics. It begins with an overview of normal urine formation and sites of renal reabsorption. It then classifies diuretics and discusses the mechanisms and sites of action of loop diuretics like furosemide and torsemide as well as potassium sparing diuretics like spironolactone and amiloride. It notes their therapeutic uses, interactions, and resistance. In recent years, new loop diuretic compounds like CRE 10904 have been developed.
The document discusses various classes of diuretics including loop diuretics, thiazide diuretics, potassium sparing diuretics, carbonic anhydrase inhibitors, and osmotic diuretics. It focuses on the mechanisms of action, indications, and side effects of specific drugs within each class. It provides details on the pharmacology of spironolactone, amiloride, triamterene, acetazolamide, and mannitol. Clinical uses and precautions for different diuretics in conditions like edema, hypertension, heart failure, and kidney stones are also reviewed.
Diuretics : Dr Renuka Joshi MD,DNB, (FNB )Renuka Buche
This document discusses different classes of diuretic drugs, including their mechanisms of action, examples, effects, dosages, and interactions. It covers loop diuretics like furosemide and bumetanide that act in the thick ascending loop of Henle; thiazide diuretics like hydrochlorothiazide that act in the distal convoluted tubule; and potassium-sparing diuretics like spironolactone and amiloride that act in the collecting duct. It provides recommendations for diuretic use and combinations in the treatment of heart failure and fluid overload.
This document provides information about different types of diuretic drugs, including their mechanisms of action, therapeutic uses, and side effects. It discusses loop diuretics like furosemide that act in the thick ascending limb of the loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal convoluted tubule, potassium-sparing diuretics like spironolactone that act in the collecting duct, and carbonic anhydrase inhibitors like acetazolamide. The document explains how each class of diuretic increases urine output and outlines their applications in conditions like heart failure, hypertension, and edema. It also notes common adverse effects like hypokalemia, hy
Diuretics act at different sites along the nephron to promote the excretion of sodium, chloride, and water. The main classes are carbonic anhydrase inhibitors, loop diuretics, thiazides, potassium-sparing diuretics, and osmotic diuretics. They are used to treat conditions like edema, hypertension, and liver cirrhosis. Each class has a distinct mechanism of action and side effect profile. For example, loop diuretics inhibit sodium reabsorption in the loop of Henle but can cause ototoxicity, while thiazides target the distal tubule and cause hypokalemia. The site and mechanism of the drug determines its clinical applications and adverse effects
This document discusses diuretics, which are medications that increase urine output. It covers the four anatomical sites in the nephron where diuretics act: the proximal convoluted tubule, the thick ascending loop of Henle, the distal tubule, and the connecting tubule and collecting duct. It provides details on the classes of diuretics that act at each site, including their mechanisms of action, structure-activity relationships, examples of medications, uses, and adverse effects. Thorough understanding of diuretic medicinal chemistry helps clinicians appropriately tailor diuretic therapy to individual patients.
Diuretics work by inhibiting sodium reabsorption in the kidney, which increases water excretion and urine output. They are classified based on their site of action along the nephron. Loop diuretics like furosemide act in the ascending loop of Henle. Thiazides such as hydrochlorothiazide act in the distal convoluted tubule. Potassium-sparing diuretics including spironolactone and amiloride act in the collecting duct. Each class of diuretic has distinct mechanisms of action, pharmacokinetics, indications, and toxicities.
This document provides information about diuretic drugs, including their classification, mechanisms of action, effects, uses, and challenges. It discusses diuretics that act at different sites in the nephron (proximal tubule, thick ascending loop of Henle, distal convoluted tubule), including carbonic anhydrase inhibitors, loop diuretics, thiazides, potassium-sparing diuretics, and osmotic diuretics. It also lists examples of prescribed diuretic drugs, drugs that have been withdrawn, and summarizes some clinical studies on diuretic use.
This document provides an overview of diuretics, including their definition, classification, mechanisms of action, and pharmacology. It focuses on the physiology of urine formation and the mechanisms and sites of action of thiazide and loop diuretics. Thiazide diuretics act in the early distal tubule by inhibiting sodium-chloride reabsorption, while loop diuretics act in the thick ascending limb of the loop of Henle by blocking the sodium-potassium-chloride transporter. The document compares the mechanisms, indications, doses, side effects and drug interactions of thiazide and loop diuretics.
This document summarizes various drugs that affect renal excretory function. It discusses diuretics such as loop diuretics, thiazide diuretics, and potassium-sparing diuretics that act on different parts of the nephron. It also covers drugs that affect antidiuretic hormone like desmopressin and vaptans. Other miscellaneous drugs discussed include probenecid, sulfinpyrazone, and SGLT2 inhibitors. The document provides details on the mechanisms, uses, and side effects of these classes of renal excretory drugs.
This document presents information on diuretics, which are substances that increase urine output and reduce blood volume. It discusses the mechanisms and sites of action of various classes of diuretics, including loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, and osmotic diuretics. It also provides references for further reading on diuretics and kidney function.
Drugs used for enhance excretion ( Diuretics)Adarsh SA
Diuretics enhances the urine output. It is mainly used in treatment of hypertension, hypervolumia, edema, congestive cardiac failure, electrolyte imbalances etc. They have some adverse reactions like hypotension, dehydration, hypovolumia, etc.
Diuretics are drugs that promote increased production of urine. The main classes of diuretics are loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, osmotic diuretics, and aldosterone antagonists. Loop diuretics such as furosemide act on the loop of Henle and are highly effective. Thiazide diuretics such as hydrochlorothiazide are commonly used to treat hypertension and edema. Carbonic anhydrase inhibitors reduce fluid production in various tissues. Osmotic diuretics work by increasing osmotic pressure in the kidney tubules. Aldosterone antagonists such as spironolactone counteract sodium retention caused by
This document discusses different classes of diuretic drugs, including their mechanisms of action, sites of action in the kidney, therapeutic uses, and side effects. It covers loop diuretics, thiazide diuretics, potassium-sparing diuretics, and osmotic diuretics. Loop diuretics act in the thick ascending limb of the loop of Henle and have the highest efficacy for increasing sodium excretion. Thiazide diuretics act in the early distal convoluted tubule and have medium efficacy. Potassium-sparing diuretics and osmotic diuretics have various mechanisms of action and are used to treat conditions like hypertension, heart failure, and edema. All diure
This document summarizes different classes of diuretic drugs, including their mechanisms of action, effects, uses, and adverse effects. It discusses loop diuretics, thiazide diuretics, potassium-sparing diuretics, carbonic anhydrase inhibitors, and osmotic diuretics. Loop and thiazide diuretics inhibit sodium reabsorption in the kidneys, increasing sodium and water excretion. Potassium-sparing diuretics and carbonic anhydrase inhibitors have mild diuretic effects but prevent hypokalemia. Osmotic diuretics extract water from tissues, increasing urine output. The major classes of diuretics are used to treat hypertension, heart failure
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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2. • Diuretics are the drugs or agents which promotes
diuresis i.e. increased urine production and
increased rate of urine flow
• The site of action is kidney, specifically different
parts of a nephron
• Diuretic action is achieved by increasing excretion
of Na+ ions (natriuretic) which increases excretion
of water
• However some diuretics (osmotic diuretics) have
no natriuretic but only aquaretic action
• Na+ ions are excreted accompanied with other
ions, particularly Cl- ions, also Ca++, Mg++, K+ etc.
3. THERAPEUTIC USES
• As antihypertensive agent (decreases blood
volume)
• In treatment of edema (by mobilizing
extracellular fluids as NaCl is the major
determinant of extracellular volume)
• To maintain urine volume
11. CARBONIC ANHYDRASE INHIBITORS
• Weak type of diuretics
• Act by inhibiting carbonic anhydrase enzyme
• Examples: Acetazolamide, Methazolamide,
Dorzolamide
12. ACTION OF CARBONIC ANHYDRASE
• Catalyzes the following reaction
• Located in proximal convoluted tubule; both
in the cytoplasm of tubular cells and on
luminal membrane
• Plays a key role in NaHCO3 reabsorption
14. • Basolateral Na+ pump maintain a lesser
concentration of Na+ inside the tubular cells
which activated Na+/H+ exchanger present on
luminal membrane
• H+, transported into lumen in exchange of Na+,
bind with HCO3
- to form H2CO3 which in presence
of luminal CA breaks down into H2O and CO2
• CO2 diffuses into tubular cells where it binds with
H2O and then breaks into HCO3
- via cytoplasmic
CA enzyme
• This creates electrochemical gradient of HCO3
-
across basolateral membrane which is used by
Na+/HCO3
- symporter present on basolateral
membrane resulting in reabsorption of NaHCO3
followed by water reabsorption isotonically
15. MOA OF CARBONIC ANHYDRASE
INHIBITORS (ACETAZOLAMIDE)
• Inhibition of both luminal and cytoplasmic
carbonic anhydrase enzyme results in
blockage of NaHCO3 reabsorption in PCT
• And thereby increase excretion of water
• Besides Na+ and HCO3
-, CA inhibitors also
increase excretion of Cl- and K+ ; but have no
effect on Ca++ and Mg++ reabsorption
• It shows self limiting diuretic action
16. EXTRARENAL ACTIONS OF CA
INHIBITORS
• Ciliary processes of eye:
– CA mediates formation of HCO3
- in aqueous
humor
– CA inhibitors decrease rate of formation of
aqueous humor and decrease IOP
• CNS
– Lowering of pH resulting in sedation and elevation
of seizure threshold
17. THERAPEUTIC USES
• Because of self limiting action, production of
acidosis and hypokalemia, it is not used as
diuretic
• Edema (in combination with other distal
diuretics)
• Used in glaucoma
• To alkalinize urine (during UTI and to promote
excretion of acidic drugs)
• Altitude sickness (for symptomatic relief as well
as prophylaxis; due to reduced CSF formation as
well lowering of brain and CSF pH)
• Epilepsy
• To treat metabolic alkalosis
19. Contraindications
• Liver cirrhosis
– May precipitate hepatic coma by interfering with
urinary elimination of NH3 due to alkaline urine
• COPD
– Increased risk of acidosis
20. DOSE
• Adult dose for Glaucoma
– Open angle glaucoma: tab or inj. 250 mg 1 to 4
times a day
– Closed angle glaucoma: 250 to 500 mg PO/IV
followed by 125-250 mg PO q 4 hrs
• For altitude sickness: 125 to 250 mg orally q
6-12 hrs
• For seizure prophylaxis: 8 to 30 mg/Kg/day in
1 to 4 divided doses
21. Drug – Drug Interactions
• Acetazolamide + Aspirin
– Inhibit each others renal tubular secretion resulting
increased plasma levels; also CAIs displace salicylates
from plasma to CNS resulting to neurotoxicity
• Acetazolamide + Carbamazepine
– Increased levels of carbamazepine, due to inhibition
of CYP3A4 by acetazolamide
• Acetazolamide + ephedrine
– Increase tubular reabsorption of ephedrine
22. LOOP DIURETICS
• Also called high ceiling diuretics
• High efficacy diuretics
• Site of action is thick ascending limb of loop of
Henle, specifically Na+/K+/2Cl- symporter
• Ex: Furosemide, Torasemide, Bumetanide
25. • Na+/K+/2Cl- symporter present on luminal
membrane of TAL is responsible for
reabsorption of NaCl and KCl
• By inhibiting this symporter, furosemide
inhibits the reabsorption of Na+, K+ and Cl-
thereby resulting in diuretic action
• TAL is responsible for reabsorption of 35% of
Na+; hence inhibition at this site helps in
achieving highly efficacious diuretic action
• Besides, it also inhibits reabsorption of Ca++
and Mg++
26. THERAPEUTIC USES
• Edema (Drug of choice for edema in nephrotic
syndrome)
• Acute pulmonary edema
• Cerebral edema
• Hypertension
• Hypercalcaemia
29. DOSE
• For edema
– 20 to 80 mg PO OD
• For hypertension
– 20-80 mg PO q 12hr
• Acute pulmonary edema
– 0.5-1 mg/Kg IV over 1-2 minutes
30. DRUG-DRUG INTERACTION
• Furosemide + Aminoglycoside antibiotics
(amikacin, gentamycin, streptomycin)
– Synergistic pharmacological effects results in
ototoxicity and nephrotoxicity
• Furosemide + NSAIDS
– Diminished action of furosemide
• Furosemide + Probenecid
– Inhibit tubular secretion of furosemide decreasing
their action
– Diminish uricosuric action of probenecid
31. • Furosemide + Lithium
– Increased plasma levels of Lithium due to
enhanced reabsorption
• Furosemide + cardiac glycosides
– Enhances digitalis toxicity
32. THIAZIDE AND THIAZIDE LIKE
DIURETICS
• These are diuretics of medium efficacy
• Site of action is distal convoluted tubule;
specifically Na+/Cl- symporter
• E.g.: Hydrochlorthiazide, Benzthiazide,
Metalozone, etc.
34. • Na+/Cl- symporter, present on luminal
membrane of DCT, is responsible for Na+
reabsorption at this site (about 5%)
• Thiazides compete for Cl- binding site of this
symporter and by blocking this, it inhibits Na+
reabsorption
• Simultaneously, it also inhibit reabsorption of
Cl-, K+ and Mg++
• It increases the reabsorption of Ca++
35. THERAPEUTIC USES
• To treat edema associated with heart
(congestive heart failure), liver (cirrhosis), and
renal (nephrotic syndrome, chronic renal
failure, and acute glomerulonephritis) disease
• As antihypertensive agents (mainly used
diuretics)
• Osteoporosis
38. DOSE
• For hypertension
– 12.5-50 mg PO OD
• For edema
– 25-100 mg PO OD or BD
• For osteoporosis
– 25 mg PO OD
39. DRUG-DRUG INTERACTION
• Thiazides + NSAIDS/Bile acid sequestrants
– Reduced activity of thiazides due to reduced
absorption
• Thiazides + antiarrythmic drugs (Quinidine)
– Increased risk of polymorphic ventricular tachycardia
due to hypokalaemia induced by thiazides
• Thiazides + Probenecid
– Inhibit tubular secretion of furosemide decreasing
their action
– Diminish uricosuric action of probenecid
40. POTASSIUM SPARRING DIURETICS
• These are the diuretics that have are able to
conserve K+ while inducing mild natriuresis
• Includes:
1. Aldosterone antagonists
– E.g.: Spironolactone, Eplerenone
2. Renal epithelial Na+ channel inhibitors
– E.g.: Triamterene, Amiloride
44. MOA OF SPIRONOLACTONE
• Aldosterone penetrates the late DT and CD
cells
• Bind to intracellular mineralocorticoid
receptor (MR)
• Induces formation of aldosterone induced
proteins (AIP)
• AIPS promote Na+ reabsorption by a number
of mechanism and K+ secretion
45. • Spironolactone binds to MR and inhibits
formation of AIPs
• As a result it increases Na+ and decreases K+
excretion
46. THERAPEUTIC USES
• In combination with other diuretics to
counteract K+ loss
• Edema
• Hypertension
• Congestive heart failure
• Primary Hyperaldosteronism
50. DRUG-DRUG INTERACTION
• Spironolactone + Salicylates
– Inhibit tubular secretion of spironolactone thus
reducing its action
• Spironolactone + Cardiac glycosides
– Increase plasma levels of cardiac glycosides by
altering its elimination
51. MANNITOL
• It is a osmotic diuretic
• Its major site of action is loop of henle
• Chemically it is sugar alcohol
• It is a nonelectrolyte of low molecular weight
• Pharmacologically inert
52. MOA OF MANNITOL
• Mannitol is freely filtered at glomerulus, undergo
limited reabsorption
• Being a hypertonic solute, it increase intraluminal
osmotic pressure
• This OP extract from the tubular cells and also
prevents water reabsorption
• Thereby increasing the urine volume
• Though primary action is to increase urinary
volume, mannitol also results in enhanced
excretion of all ions
53. THERAPEUTIC USES
• To treat increased intracranial or intraocular
pressure
• Drug of choice for cerebral edema
• In acute renal failure
58. REFERENCES
• TRIPATHI, K.D., (2014). Essentials of Medical
Pharmacology. 7th Edition. New Delhi, India:
Jaypee Brothers Medical Publishers Pvt. Ltd.
• BRUNTON, L.L., PARKER, K.L., BLUMENTHAL,
D.K., BUXTON, I.L.O, (2006). Goodman and
Gilman’s Manual of Pharmacology and
Therapeutics. 11th Edition. USA: The McGraw-
Hill Companies, Inc.