Precipitation titration.pptx
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This document outlines topics related to non-aqueous titration for a Pharmaceutical Analysis course, including types of non-aqueous solvents, argentimetry, precipitation titration principles and examples like Mohr's method, solubility product constants, end point detection methods like Volhard's method for halogens, and factors that affect solubility of precipitates in non-aqueous titration. The document also discusses leveling effects, argentometric titration examples, non-aqueous titration principles and the estimation of Ephedrine Hydrochloride, and compares the merits and demerits of non-aqueous versus aqueous titration
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Analytical Procedures
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This document summarizes the uses of high-performance liquid chromatography (HPLC) in pharmaceutical sciences. HPLC is widely used in pharmaceutical industries for drug discovery, development, and manufacturing. It is used for separation, identification, and quantification of compounds. Some key applications of HPLC include drug purity testing, stability studies, impurity profiling, and analytical method development and validation. HPLC plays a vital role throughout the drug development process from early research to quality control of final drug products.
Project Presentation m.pharm pharmceutical analysis
This document presents a proposal for developing and validating a new RP-HPLC method for the simultaneous estimation of evogliptin and metformin hydrochloride in bulk and pharmaceutical dosage forms. The objectives are to develop a sensitive and accurate RP-HPLC method, validate the method according to ICH guidelines, and apply the method to analyze samples. The methodology will involve collecting literature on existing methods, developing the separation conditions, and validating the method parameters such as linearity, range, precision, specificity, accuracy, ruggedness and robustness. Data will be collected using HPLC and UV spectrophotometry and analyzed statistically.
A novel validated rphplc method for the estimation of liraglutide in bulk and...
s.susena publication work,M.pharmacy(pharmaceutical analysis & QA) in SSJ college of pharmacy,V.N pally,Hyderabad
Susena
A novel validated RP-HPLC method was developed for the estimation of Liraglutide in bulk and parenteral dosage forms. The method utilized a C18 column, mobile phase of methanol and phosphate buffer with UV detection at 246 nm. The method was validated per ICH guidelines and found to be accurate, precise, specific and linear over a concentration range of 20-80 μg/ml. The method was successfully applied to a liraglutide injection sample with 99.84% assay results. In summary, a novel HPLC method was developed and validated for the analysis of liraglutide in bulk and parenteral dosage forms.
ETORICOXIB AND PREGABALIN OF METHOD DEVLOPMENT IN RPHPLC BY UPEXA BAVADIYA
Development and Validation for Simultaneous Estimation of Etoricoxib and Pregabalin in Bulk and Tablet Dosage Form by RP-HPLC 2K21 GTU MASTER IN PHARMACY BY UPEXA BAVADIYA
Simultaneous estimation of meclizine and nicotinic acid by using RP-HPLC
This document describes the development and validation of a reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Meclizine and Nicotinic acid. The method utilizes a mobile phase of acetonitrile and potassium dihydrogen phosphate buffer with a flow rate of 1.0 mL/min. The retention times were 3.01 minutes for Meclizine and 6.07 minutes for Nicotinic acid. The method was validated and found to be accurate, precise, specific, linear, robust, sensitive and able to quantify the drugs in tablet dosage forms without interference from other components.
Formulation development and evalution of matrix tablet of
The document describes the development of a matrix tablet for oral delivery of an antihypertensive drug (NSL) using pH dependent and independent polymers. It includes sections on introduction, literature review, drug and excipient profiles, aim and objectives, rationale, materials and equipment, experimental work, results, discussion, and references. The key steps involved preformulation studies, formulation of matrix tablets, optimization studies to match the in vitro dissolution profile of a marketed reference product, and stability studies. The optimized formulation was found to release the drug in a controlled manner for 24 hours.
M.pharm thesis
The document discusses the formulation and evaluation of gastro-retentive mucoadhesive microballoons of nizatidine for the management of peptic ulcer. It provides background information on peptic ulcers, drug delivery systems, gastroretentive drug delivery systems, and mechanisms of bioadhesion. The objective is to develop mucoadhesive microballoons of nizatidine to increase its retention time in the stomach and improve the treatment of peptic ulcers.
folic acid chitosan conjugate nanoparticle containing azithromycin for the tr...
The document presents a research proposal for developing folic acid-chitosan conjugate nanoparticles containing azithromycin for treating colorectal diseases. The objectives are to prepare drug-loaded conjugates with desired release characteristics and assess their targeting efficacy and bio-distribution. The plan involves preformulation studies, preparing the folic acid-chitosan conjugate, loading the conjugate with azithromycin, and characterizing the nanoparticles. In vitro and in vivo studies will evaluate particle properties, drug release, cytotoxicity, and the ability to treat colorectal inflammation in a rat model.
Formulation and Evaluation of Pantoprazole Sodium Enteric Coated Tablets
The document summarizes the formulation and evaluation of pantoprazole sodium enteric coated tablets. Pantoprazole is an acid-labile drug that requires enteric coating to protect it from degradation in the stomach. Various enteric coated tablet formulations were prepared using different concentrations of superdisintegrants and enteric coating polymers. Tablets were evaluated for hardness, thickness, weight variation, friability, drug content and in vitro drug release. Formulation EC8, coated with 6% Eudragit RS100, showed the best results with a thickness of 2.2mm, hardness of 3.52kg/cm2, drug release of 100.16% within 2 hours and 45 minutes, and acid resistance
Method Development and Validation for Estimation of Oral Hypoglycaemic Drug D...
HPLC is a chromatographic technique employed in active compound chemistry and biochemistry to separate a mixture and substances with the goal of identifying, measuring, and purifying the different components of the mixture. Its a much better variety of column and traditional chromatography. The objective of the research work is to develop and validate a simple and accurate reverse phase chromatographic method to estimate amount of drug in dosage form. The developed method successfully can be applied to estimate the amount of Dapagliflozin in tablet dosage form. After oral administration of dapagliflozin, the maximum plasma concentration Concentration max under two hours. High performance liquid chromatographic system was alleviated according to the chromatographic settings. After attaining the steady base line, to verify the system suitability, a single 40 µg ml of standard solution proportional to 100 test concentration of dapagliflozin was injected into the HPLC system. The gradient mobile phase flow rate programming assisted in optimising the lengthy run duration and resolution of sample analysis, making the approach more cost effective and quick. Validation of the developed and optimized HPLC method was carried out according to ICH guidelines with respect to parameters such as linearity, specificity, precision and accuracy. Junaid Ahmed | Himanchal Sharma | Shiva Teotia "Method Development and Validation for Estimation of Oral Hypoglycaemic Drug Dapagliflozinina Tablet Dosage form by the Employment of Rp-HPLC" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46395.pdf Paper URL : https://www.ijtsrd.com/pharmacy/analytical-chemistry/46395/method-development-and-validation-for-estimation-of-oral-hypoglycaemic-drug-dapagliflozinina-tablet-dosage-form-by-the-employment-of-rphplc/junaid-ahmed
A Simple and Validated RP-HPLC Method for the Estimation of Methylcobalamin i...
A Simple and Validated RP-HPLC Method for the Estimation of Methylcobalamin in Bulk and Solid Dosage Form
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Method development and validation of Sodium Cromoglycate
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Devlopment and validation of rp hplc method for simultaneous ex.
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Ultra performance liquid chromatographic method for simultaneous quantificati...
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Project Presentation m.pharm pharmceutical analysis
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Method Development and Validation for Estimation of Oral Hypoglycaemic Drug D...
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Precipitation titration.pptx
- 1. By Imtiyaz Bagban M. Pharm. (Pharmacology) Assistant Professor Department of Pharmacology Krishna School of Pharmacy & Research (KSP) Drs. Kiran & Pallavi Patel Global University (KPGU) 1 Precipitation titration B. Pharm. Semester I Subject – Pharmaceutical Analysis Subject Code- BP102T UNIT 3
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- 27. 1. What are nonaqucous titrations? Explain in detail the types of solvents used in non-aqueous titrations. Write the assay of Sodium Benzoate. 2. What is argentimetry? Explain the mechanism of action of indicators in Fajan's method or Discuss Adsorption indicator method 3. What is precipitation titration and give the principle involved in the assay of Sodium Chloride? 4. What is leveling effect in non aqueous titrimetry. Explain in detail. 5. Discuss the principle and applications of Argentometric titrations with Example. 6. What is non-aqueous titration? Give the principle and procedure involved inthe estimation of Ephedrine Hydrochloride. 7. Classify precipitation titration with examples. Discuss the principle with reaction involved in Mohr’s method. 8. Explain the term solubility product constant. Discuss applications of solubility product principle in analysis. 9. Enlist the end point detection methods in precipitation titration. Write a note on the determination of halogen by Volhard’s method. 10.Write note on solvent, titrant and indicator used for weak acid and weak base substance in non-aqueous titration. 11.Give preparation and standardization of 0.1 N Perchloric acid. 12. Explain the factors affecting the solubility of precipitate in details. 13. What is importance of non-aqueous titration? Discuss Differentiating and Leveling effect of solvent. 14. Discuss merits and demerits of non-aqueous titration over aqueous titration.