The document presents the Effective Fragment Molecular Orbital (EFMO) method for calculating interaction energies in large chemical systems. EFMO divides the system into molecular fragments and calculates energies in a fragment-based approach. It computes monomer energies using gas phase self-consistent field calculations to extract properties. It then calculates interaction energies between nearby fragments (within a cutoff distance) using dimer self-consistent field calculations, and long-range electrostatic interactions between all fragment pairs. EFMO provides a parameter-free method for efficiently studying interaction energies in large biochemical systems.