Pott's disease, also known as tuberculosis of the spine, is caused by Mycobacterium tuberculosis infection of the vertebrae. Non-operative treatment involves antibiotics and immobilization for early or mild cases to halt progression. Surgery is required for abscesses, neurological issues, or cases that fail to improve with antibiotics. Nursing care focuses on immobilization, pain management, infection prevention, and monitoring for complications like neurological changes.
The Filipino registered nurse believes in the worth and dignity of each human being, recognizes the primary responsibility to preserve health at all cost.
The Filipino registered nurse believes in the worth and dignity of each human being, recognizes the primary responsibility to preserve health at all cost.
Rachel Hutton, Medical Laboratory Scientist at Canterbury Health Laboratories presented this case study on Meningococcal septicaemia at the NZIMLS South Island Seminar in Hokitika in April 2013
Traditional nonsurgical Osteoarthritis therapies have limited utility and the treatment effect on
the disease is very low. Most of the therapies are aimed at controlling the symptoms but have
minimal or no effect on disease progression or repair. On the other hand, surgeries such as Total
knee replacement and partial knee replacement are unwarranted until the disease progresses to
moderate or end-stage.
Stem cell therapy by the Interventional Pain specialist has shown some promising results and has
shown disease modification to prevent knee joint destruction. Stem cell therapy for knee arthritis
has shown a reduction of pain and stiffness, improvement in physical function, and
maintains cartilage quality with minimal side effects. The cost of the procedure and affordability
are a matter of concern and may not be suitable for the masses.
With the DGCI approval of stem cell treatment for Knee osteoarthritis, IPSC is introducing stem
cells into clinical practice. The success of any new treatment depends on strict adherence to
the clinical protocols and research recommendations. In view of the above, IPSC is introducing
its treatment protocol for stem cell therapy.
PHYSIOTHERAPY REHABILITATION IN SURGICAL AND NON SURGICAL ONCOLOGY prasad naik
Physiotherapy is a valuable and often underutilized tools in the management of cancer.
Physiotherapy for cancer patients can occur in the home, an outpatient clinic, an inpatient rehabilitation center, or in an acute care hospital.
Physiotherapy can help them regain their previous quality of life, or even improve upon it.
Therapists who understand the complexities of oncology rehabilitative care can have a huge impact on cancer patients’ ability to tolerate such toxic treatments by working with them to maintain their strength and function.
Ppt paper presentation percutaneous discectomySunil Thakur
This ppt was presented by Dr Sunil Dutt JR Depart. of Anaesthesia IGMC Shimla at NZISACON-2014 at Acharya Shri Chander College of Medical Sciences and Hospital Jammu
Ppt paper presentation percutaneous discectomySunil Thakur
This ppt. was prepared and presented by Dr Sunil D.Thakur at NZISACON 2014 organised by Deptt. of Anaesthesiology and Critical Care Acharya Shri Chander College of Medical Sciences and Hospital Jammu. IT was presented under the guidance of Prof. Surinder Singh Sodhi HOD Anaesthesia IGMC Shimla and Dr Girish Sharma Associate Prof. Department of anaethesia IGMC Shimla.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
1. Pott’s Disease
MEDICAL MANAGEMENT
IDEAL
- Non Operative Treatment:
- if detected early (before collapse of more than 1-2 vertebral body) treatment consists of antibiotics and immobilization;
- even w/ mild kyphosis (but no neurologic deficit), antibiotics & bracing are used;
- w/ adequate medical treatment, there may be significant resolution of neurologic symptoms, and there will be a halt in the progression of kyphosis;
- in young children, there will often be some resolution in the kyphosis, especially if only one of two vertebrae are involved;
- antibiotics for all patients at the outset, reserving surgery for cold abscesses that are palpable posteriorly, as well as for those cases w/ neurological
environment that have failed to improve in response to 2-3 months of antiTB therapy and immobilization;
- 2 months of pyrazinamide, isoniazid, and rifampin given qd, followed by 4 months of INH and rifampin;
- outcomes:
- assessment of outcome should include prevalence of symptoms, amount of physical activity, amount of CNS involvement, presence/absence of sinus
and/or abscess, and radiographic status of the lesion;
Diagnostic Tests
blood tests - elevated erythrocyte sedimentation rate
tuberculin skin test
bone scan
bone biopsy
Imaging
Spinal x-ray may not show early disease as 50% of bone mass must be lost for changes to be visible on x-ray. However, plain radiographs can show
vertebral destruction and narrowed disc space.
MRI is useful to demonstrate the extent of spinal compression and can show changes at an earlier stage than plain radiographs. Bone elements visible
within the swelling, or abscesses, are strongly indicative of Pott’s disease as opposed to malignancy.
CT scans and nuclear bone scans can also be used.
Non-drug
Immobilization of the spine is usually for 2 or 3 months.
Therapy
non-operative - antituberculous drugs
1
2. analgesics
immobilization of the spine region by rod (Hull)
Surgery may be necessary, especially to drain spinal abscesses or to stabilize the spine
Richards intramedullary hip screw - facilitating for bone healing
Kuntcher Nail - intramedullary rod
Austin Moore - intrameduallary rod (for Hemiarthroplasty)
Microbiology
Needle biopsy of bone or synovial tissue. Numbers of tubercle bacilli present are usually low but are pathognomonic.
Acid-fast stain and culture for Mycobacterium tuberculosis, plus fungi and other pathogens, should be performed.
Management of Pott’s disease
Drug treatment is generally sufficient for Pott’s disease, with spinal immobilisation if required. Surgery is required if there is spinal deformity or
neurological signs of spinal cord compression.
Standard antituberculosis treatment is required.
Duration of antituberculosis treatment:
If debridement and fusion with bone grafting are performed, treatment can be for six months
If debridement and fusion with bone grafting are NOT performed a minimum of 12 months’ treatment is required.
P- atient should be reminded to attend check-ups at the nearest…
O- rthopedic center
T- reatment should be taken in a…
T- imely manner
S- ight any symptoms other than the usual and report it to the physician
3. SURGICAL MANAGEMENT
IDEAL
Surgical
Surgery plays an important part in the management. It confirms the diagnosis, relieves compression if it occurs, permits evacuation of pus, and reduces
the degree of deformation and the duration of treatment.
Therapy
immobilization of the spine region by rod (Hull)
Surgery may be necessary, especially to drain spinal abscesses or to stabilize the spine
Richards intramedullary hip screw - facilitating for bone healing
Kuntcher Nail - intramedullary rod
Austin Moore - intrameduallary rod (for Hemiarthroplasty)
Surgery includes ADSF ( Anterior Decompression Spinal Fusion).
- Operative Indications Treatment:
- surgery is indicated for cold abscesses that are palpable posteriorly;
- with cord compression surgery is required if neurological status deteriorates in spite of chemotherapy and immobilization;
- attempt to give non operative treatment 2-3 months before determining the response;
- w/ abscess and kyphosis operative intervention is required especially if kyphosis is progressive;
- advantages include less progressive kyphosis, earlier healing, and decrease sinus formation;
- patients younger than 15 years w/ kyphosis greater than 30 deg are at high risk for progression of kyphosis are also good candidates for surgery;
- children aged less than 10 yrs with destruction of vertebral bodies who have partial or no fusion even during the adolescent growth spurt;
- surgery may include;
- requires anterior abscess drainage;
- anterior spinal arthrodesis w/ iliac strut grating;
- anterior arthrodesis allows better correction of the kyphosis, whereas debridement alone may actually have worsening of the kyphosis;
- posterior spinal arthrodesis (indications unclear)
- adjuvant chemotherapy beginning 10 days before surgery is essential;
4. NURSING MANAGEMENT
Nursing diagnoses
Ineffective airway clearance
Risk for aspiration
Ineffective breathing pattern
Acute pain
Risk for infection
Risk for impaired skin integrity
Autonomic dysreflexia
Deficient fluid volume
Risk for disuse syndrome
Anxiety
Impaired physical mobility
Disturbed body image
Nursing interventions
As with all spinal injuries, suspect cord damage until proved otherwise. Apply a properly sized cervical collar if cervical injury is suspected.
During the initial assessment and X-rays, immobilize the patient on a firm surface.
Offer the patient comfort and reassurance, talking to him quietly and calmly. Remember, the fear of paralysis will be overwhelming. Allow a family member
who isn't too distraught to stay with him.
If the injury necessitates surgery, administer prophylactic antibiotics as ordered. Catheterize the patient, as ordered, to avoid urine retention, and monitor
defecation patterns to avoid impaction.
If the patient has a halo or skull tong traction device, clean the pin sites daily and provide analgesics for headaches. During traction, turn the patient often
to prevent pneumonia, embolism, and skin breakdown. Perform passive range-of-motion exercises to maintain muscle tone. Use a rotating bed, if
available, to facilitate turning and avoid spinal cord injury.
Position the patient properly according to injuries to avoid aspiration.
If necessary, insert a nasogastric tube to prevent gastric distention.
Suggest appropriate diversionary activities to fill the hours of immobility. Offer prism glasses for reading.
Watch closely for neurologic changes. Immediately report changes in skin sensation and loss of muscle strength. Either could point to pressure on the
spinal cord, possibly as a result of edema or shifting bone fragments.
When the patient is able to ambulate, request a physical therapy consultation for ambulation and proper application of a back brace.